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Molecular Mechanisms of Neuropsychiatric Disorders

A Special Issue of International Journal of Molecular Sciences (ISSN 1422-0067) belonging to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 30 November 2026 | Viewed by 1110

Editors


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Guest Editor
1. Department of Medical Biochemistry, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovića, 69, 34000 Kragujevac, Serbia
2. Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Svetozar Markovic 69, 34000 Kragujevac, Serbia
Interests: cytotoxicity; cytochrome c; cell line; mitochondria; apoptosis; antitumor; antimicrobial

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Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Interests: neuroscience; neurophysiology; behavior; animal experimental models
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Interests: neuroscience; neurophysiology; behavior; animal experimental models
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Neuropsychiatric disorders are increasingly recognized as leading causes of disease burden and remain among the top ten leading causes of burden worldwide, with no evidence of global reduction. The molecular background of those disorders arises from a dynamic interplay of modifiable and non-modifiable factors, with numerous genetic and environmental factors contributing to triggering and developing this pathology. Despite the heterogeneity of diseases and symptoms, some common key pathophysiological mechanisms have been identified as neuroinflammation, apoptosis, oxidative damage, neurotransmitters, and neurotrophin system imbalance. However, there is still limited evidence for their specific relationship with clinical features, from diagnosis to evaluation of therapy efficiency.

We are pleased to invite you to contribute to this Special Issue that aims to provide a multidisciplinary and integrated view of state-of-the-art research on the molecular mechanisms underlying neurological and psychiatric disorders. Both clinical and preclinical research, including a translational approach, are welcome to improve the knowledge in those increasingly leading health burdens, by providing a comprehensive insight into the topic through original research and review articles.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Neurophysiology;
  • Neuropharmacology;
  • Neurochemistry;
  • Neuroimmunology;
  • Neurogenetics;
  • Neurological disorders;
  • Psychiatric disorders.

We look forward to receiving your contributions.

Prof. Dr. Marina Mitrovic
Prof. Dr. Gvozden Rosic
Prof. Dr. Dragica Selakovic
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurological disorders
  • psychiatric disorders
  • pathophysiological mechanisms
  • apoptosis
  • oxidative stress
  • inflammation
  • neurotransmitters
  • neurotrophins
  • pharmacotherapy
  • transcranial stimulation

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Published Papers (1 paper)

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Review

57 pages, 1822 KB  
Review
Neurotrophin System as a Complex Set of Potential Biomarkers in Psychiatric Disorders and Therapy—Overview of Recent Advances
by Dragica Selakovic, Marina Mitrovic, Vladimir Janjic, Dragan Milovanovic, Nemanja Jovicic, Ermin Fetahovic, Jovan Milosavljevic and Gvozden Rosic
Int. J. Mol. Sci. 2026, 27(14), 6142; https://doi.org/10.3390/ijms27146142 - 9 Jul 2026
Viewed by 698
Abstract
The neurotrophin system has numerous regulatory roles in the central nervous system, including the growth, differentiation, and survival of neurons, the control of neurogenesis, synaptic plasticity, and the mediation of neurotransmitter balance, also with proven anti-inflammatory, anti-apoptotic, and antioxidative actions. These functions are [...] Read more.
The neurotrophin system has numerous regulatory roles in the central nervous system, including the growth, differentiation, and survival of neurons, the control of neurogenesis, synaptic plasticity, and the mediation of neurotransmitter balance, also with proven anti-inflammatory, anti-apoptotic, and antioxidative actions. These functions are seriously affected by numerous pathophysiological processes accompanied by mental illness. The variety of therapeutic protocols (pharmacotherapy, transcranial stimulation, psychotherapy, lifestyle changes, programmed physical activity, dietary interventions), individually or in combination, has been employed in the treatment of psychiatric disorders. To evaluate the effectiveness of therapeutic strategies, specific elements of the neurotrophin system have been quantified to assess their potential as biomarkers. However, data obtained in clinical trials for different psychiatric disorders still do not confirm the reliability of neurotrophin system elements as biomarkers. For this purpose, we aimed this narrative review to explore clinical studies published in the last decade that examined neurotrophin system elements in patients with various psychiatric disorders, with a focus on their association with disease severity, clinical state, and treatment response, which represents a promising avenue for improving our understanding of the underlying mechanisms and for identifying potential clinically relevant biomarkers, as well as sharpening therapeutic protocol outcome analyses. Full article
(This article belongs to the Special Issue Molecular Mechanisms of Neuropsychiatric Disorders)
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