Current Research in DNA Methylation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 153
Special Issue Editor
Special Issue Information
Dear Colleagues,
DNA methylation represents a cornerstone of epigenetic regulation, playing a pivotal role in controlling gene expression, maintaining genomic integrity, and shaping cellular identity. As a key mechanism within Epigenetics, DNA methylation is dynamically regulated across development and in response to environmental stimuli, contributing to both physiological processes and disease pathogenesis.
Recent technological advances, particularly in next-generation sequencing and single-cell epigenomics, have enabled unprecedented insights into methylation landscapes at high resolution. Despite these advances, significant challenges remain in understanding the functional consequences, temporal dynamics, and context-dependent roles of DNA methylation, especially in complex biological systems.
This Special Issue aims to collate cutting-edge research and comprehensive reviews addressing current challenges and emerging trends in DNA methylation research. Particular emphasis will be placed on integrative approaches that combine DNA methylation with other epigenetic and molecular layers, including histone modification, chromatin remodeling, and non-coding RNA regulation. This Special Issue aims to advance knowledge, stimulate debate, and foster innovation in DNA methylation research by compiling contributions from leading experts in the field, ultimately contributing to the development of new diagnostic and therapeutic strategies.
Suggested themes and article types for submissions.
For this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:
- Molecular mechanisms of DNA methylation and demethylation;
- DNA methylation in development, aging, and disease;
- Epigenetic alterations in cancer and other complex diseases;
- DNA methylation as a biomarker for diagnosis and prognosis;
- Advances in epigenomic technologies and bioinformatics tools;
- Environmental and lifestyle influences on the methylome;
- Translational and clinical applications of DNA methylation research.
I look forward to receiving your valuable contributions.
Dr. Mikhail M. Baryshev
Guest Editor
Manuscript Submission Information
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Keywords
- DNA methylation
- cancer-specific DNA methylation
- epigenetics
- lncRNA
- CpG, CHG, CHH, CCWGG methylation types
- chromatin remodeling
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