Advances in Pharmacogenomics and Drug Repositioning
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 77
Special Issue Editors
Interests: gene; non insulin dependent diabetes mellitus; hypertension; bioinformatics; polymorphism; genetic variant; genetic epidemiology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue, “Advances in Pharmacogenomics and Drug Repositioning”, presents emerging evidence at the intersection of genomics-driven precision medicine and translational therapeutics, where the recent advances in pharmacogenomics, including the integration of next-generation sequencing, real-world clinical data, and artificial intelligence for understanding inter-individual variability in drug efficacy and toxicity, are reshaping therapeutic decision-making toward more personalized, genotype-guided interventions. At the same time, drug repositioning, the process of repurposing existing drugs for new indications, has emerged as a cost-effective and time-efficient approach to extend the therapeutic scope of approved or investigational compounds. This Special Issue highlights innovative methodologies such as genome-wide association studies, machine learning-based predictive models, and integrative multi-omics approaches that bridge pharmacogenomic insights with repositioning strategies. Some contributions highlight the importance of biomarkers for stratifying patient populations and maximizing the success rate of drug repurposing, while others delve into regulatory, ethical, and clinical implementation issues.
Notably, the incorporation of pharmacogenomic profiling into drug repositioning frameworks represents a complementary paradigm that can not only identify new drug–disease associations but also optimize drug selection and dosing for genetically defined subgroups, thus enhancing therapeutic precision, minimizing adverse drug reactions, and improving clinical outcomes.
In summary, this Special Issue emphasizes a paradigm shift toward data-driven, patient-centric drug development, reinforcing the potential for combining pharmacogenomics and drug repositioning to accelerate innovation and address unmet medical needs in contemporary healthcare. This Special Issue is led by Dr. Vasudevan Ramachandran and Dr. Suresh Kumar with the assistance of Mr. Venkataramanan Swaminathan (Management and Science University, Selangor, Malaysia). We would like to cover recent advances in this field, and we are delighted to invite you to contribute.
In this Special Issue, original research articles, methods/protocol and reviews are welcome.
Potential Paper Topics: pharmacogenomics; drug repositioning; precision medicine; multi-omics integration; genome-wide association studies (GWASs); artificial intelligence in drug discovery; bioinformatics; biomarker discovery; computational drug repurposing; clinical pharmacogenetics and translational medicine.
We look forward to receiving your contributions.
Dr. Vasudevan Ramachandran
Dr. Suresh Kumar
Guest Editors
Manuscript Submission Information
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Keywords
- risk prediction
- gene–drug interactions
- genetic polymorphisms
- repurposed drugs
- integrative analytics
- variant mapping
- predictive modeling
- molecular docking
- cheminformatics
- genotype-guided therapy
- real-world evidence
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