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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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p53—Oncogene, Tumor Suppressor Gene, Guardian of the Genome and the Cell
edited by Przemyslaw Bozko
submission deadline 30 Jun 2025 | 1 articles | Viewed by 1157 | Submission Open
Keywords: p53; oncogene; tumor suppressor gene; tumor formation; anticancer therapy
(This special issue belongs to the Section Molecular Genetics and Genomics)
Advanced Batteries and Electrochemical Sensors: Design, Development and Application
edited by Zhengkun Xie
submission deadline 30 Jun 2025 | Viewed by 1108 | Submission Open
Keywords: novel electrodes and electrolytes; high-energy density batteries; characterization techniques; advanced electrochemical sensor; key analytes
(This special issue belongs to the Section Materials Science)
Aquatic Biotechnology and Its Application in Genetic Breeding—2nd Edition
edited by
submission deadline 30 Jun 2025 | 2 articles | Viewed by 1094 | Submission Open
Keywords: aquaculture; biotechnology; germplasm improvement; genetic breeding; gene function; genomics; gene editing
(This special issue belongs to the Section Molecular Genetics and Genomics)
Latest Reviews in Molecular Plant Science 2025
edited by and
submission deadline 30 Jun 2025 | 1 articles | Viewed by 1092 | Submission Open
Keywords: gene cloning and gene functional analysis; gene editing; QTL mapping; multi-omics integration analysis; agronomically characteristics; plant development; metabolic pathway; biotic and abiotic stresses
(This special issue belongs to the Section Molecular Plant Sciences)
Plant Metabolism and Natural Product Biosynthesis
edited by
submission deadline 30 Jun 2025 | 1 articles | Viewed by 1022 | Submission Open
Keywords: plant metabolism; natural product; biosynthesis; metabolomics; bioinformatics
(This special issue belongs to the Section Molecular Plant Sciences)
Genetics and Breeding for Sugar Crops
edited by Muqing Zhang
submission deadline 30 Jun 2025 | 1 articles | Viewed by 979 | Submission Open
Keywords: sugarcane; molecular genetics and breeding; plant pathology; stress biology; GWAS; QTL; precision breeding; molecular marker; gene editing; transgene
(This special issue belongs to the Section Molecular Plant Sciences)
Cardiovascular Diseases: Molecular Mechanism and Therapeutic Strategies
edited by
submission deadline 30 Jun 2025 | 1 articles | Viewed by 868 | Submission Open
Keywords: cardiovascular diseases; vascular; atherosclerosis; heart failure; stroke; oxidative stress; personalized medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Viral Diseases of the Respiratory System—Molecular Mechanisms and Pathogenesis: 3rd Edition
edited by
submission deadline 30 Jun 2025 | 1 articles | Viewed by 692 | Submission Open
Keywords: respiratory diseases; pneumonia; pneumotropic viruses; pathogenesis; host– pathogen interaction; pulmonary pathology; immunopathology; immunity; disease prevention; treatment; zoonotic diseases; antiviral therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Wound Repair: From Basic Biology to Tissue Engineering submission deadline 30 Jun 2025 | 1 articles | Viewed by 626 | Submission Open
Keywords: wound healing; tissue engineering; biomaterials; regenerative medicine; chronic wounds
(This special issue belongs to the Section Molecular Biology)
Cutting-Edge Advances in Breast Cancer
edited by
submission deadline 30 Jun 2025 | 1 articles | Viewed by 613 | Submission Open
Keywords: cancer progression and metastasis (dissemination; extravasation; angiogenesis; innervation; and metabolic reprogramming); immunity and inflammation; targeted therapies; early detection and screening; genetics; epigenetics; mi-RNA; tumour microenvironment
(This special issue belongs to the Section Molecular Oncology)
Molecular Insight into Skeletal Muscle Atrophy and Regeneration, 2nd Edition submission deadline 30 Jun 2025 | 1 articles | Viewed by 603 | Submission Open
Keywords: muscle atrophy; muscle regeneration; sarcopenia; cachexia; satellite cells; autophagy; proteolytic system; growth factors; myokines; physical exercise; nutrition; bone metabolism
(This special issue belongs to the Section Molecular Biology)
Gluten/Wheat-Related Disorders: The Role of Nutrition, Gut Barrier, Microbiota, and New Therapeutic Strategies
edited by Lisa Lungaro
submission deadline 30 Jun 2025 | 1 articles | Viewed by 603 | Submission Open
Keywords: gluten-related disorders; celiac disease; non celiac gluten wheat sensitivity; gluten free diet; microbiota; gut barrier; probiotics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research of Abiotic Stress in Plants
edited by Deguo Han
submission deadline 30 Jun 2025 | 2 articles | Viewed by 573 | Submission Open
Keywords: abiotic stress; salt stress; drought stress; plant
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Insights: Transitioning Fertility Research from the Laboratory to Clinical Practice
edited by Ekaterini Domali
submission deadline 30 Jun 2025 | Viewed by 544 | Submission Open
Keywords: IVF/ICSI; male infertility; female infertility; fertility outcomes; endocrine disruptors; oxidative and reductive stress; molecular biology; biomarkers; proteomics; metabolomics; and transcriptomics; cell lines; early pregnancy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Ion Transporter-Based Biomarkers for Sperm Quality
edited by
submission deadline 30 Jun 2025 | Viewed by 533 | Submission Open
Keywords: ion transporters; sperm quality; cryotolerance
(This special issue belongs to the Section Molecular Biology)
Cardiovascular Disease: Molecular Pathologies, and Therapeutic Strategies
edited by Vaia Lambadiari
submission deadline 30 Jun 2025 | 1 articles | Viewed by 527 | Submission Open
Keywords: endothelial dysfunction; lipids; inflammation; genetic mutations; atherosclerosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Novel Insights into Buckwheat Reproductive Biology
edited by
submission deadline 30 Jun 2025 | 1 articles | Viewed by 513 | Submission Open
Keywords: antioxidant properties; biotechnological methods; embryology; seed chemical composition; yield
(This special issue belongs to the Section Molecular Plant Sciences)
Effects of Stressors During Pregnancy and Breastfeeding on the Child: Molecular Perspectives submission deadline 30 Jun 2025 | 1 articles | Viewed by 499 | Submission Open
Keywords: xenobiotics; drugs; gestation; breastfeeding; fetus; placenta; child’ s development; teratogenicity; central nervous system
(This special issue belongs to the Section Molecular Biology)
Antifungal Potential of Botanical Compounds
edited by Francisca Sempere-Ferre
submission deadline 30 Jun 2025 | 1 articles | Viewed by 484 | Submission Open
Keywords: botanical compounds; antifungal agents; natural products; secondary metabolites; fungal growth inhibition; bioactive plant extracts; eco-friendly antifungals; natural product chemistry; sustainable antifungal solutions; plant-derived bioactives
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Next-Generation Hydrogels: Innovations in Biofunctionalization and Personalization for Targeted Biomedical Therapies
edited by and Bohan Yin
submission deadline 30 Jun 2025 | Viewed by 480 | Submission Open
Keywords: biofunctionalization hydrogels; personalized hydrogels; smart hydrogel development; 3D/4D bioprinting of hydrogels; AI-driven hydrogel design; dynamic hydrogel systems; hydrogel-based vaccines and immunotherapies; smart hydrogels for controlled release
(This special issue belongs to the Section Macromolecules)
Molecular Crosstalk in Breast Cancer Progression and Therapies
edited by Giuseppina Daniela Naimo
submission deadline 30 Jun 2025 | Viewed by 479 | Submission Open
Keywords: breast cancer; endocrine therapy; drug resistance; breast tumor microenvironment; targeted therapies; personalized therapies; immunotherapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Retinoids in Ageing and Age-Related Diseases
edited by
submission deadline 30 Jun 2025 | Viewed by 458 | Submission Open
Keywords: retinoids; retinoic acid; ageing; age-related diseases
(This special issue belongs to the Section Molecular Biology)
Green Chemistry Biocatalysis—Advances in the Use of Sustainable Solvents for Biocatalytic Processes submission deadline 30 Jun 2025 | Viewed by 453 | Submission Open
Keywords: biocatalysts; enzymes; sustainability; green solvents; biotechnology; biochemical process engineering
(This special issue belongs to the Section Biochemistry)
Bone Development and Regeneration—4th Edition
edited by
submission deadline 30 Jun 2025 | 1 articles | Viewed by 432 | Submission Open
Keywords: osteoblast; osteocyte; osteoclast; mesenchymal stem cell; cell differentiation; epigenetics; omics; integrative analysis; biomaterials
(This special issue belongs to the Section Molecular Biology)
Cell Membrane Electroporation and Electroosmosis Mechanisms
edited by
submission deadline 30 Jun 2025 | Viewed by 426 | Submission Open
Keywords: nanosecond electroporation; calcium electroporation; small-molecule electrotransfer; abscopal effect; bacterial electroporation; irreversible electroporation; electrochemotherapy; immune response; apoptosis
(This special issue belongs to the Section Biochemistry)
Recent Advances in Bioactive Compounds in Human Health
edited by
submission deadline 30 Jun 2025 | 1 articles | Viewed by 406 | Submission Open
Keywords: bioactive compounds; antioxidants; food by-products; functional foods; innovative food technologies; molecular food science
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Dynamics Simulations of Nanobubble for Different Applications
edited by
submission deadline 30 Jun 2025 | Viewed by 402 | Submission Open
Keywords: cavitation bubble; nanobubble dynamics; hydrodynamic cavitation; molecular dynamics simulations; laser-induced cavitation bubble; cavitation exploitation
(This special issue belongs to the Section Molecular Nanoscience)
Novel Trends in the Research of Molecules Involved in Skin Inflammation and Dermatologic Conditions submission deadline 30 Jun 2025 | 1 articles | Viewed by 398 | Submission Open
Keywords: atopic dermatitis; contact dermatitis; psoriasis; urticaria; eczema; acne; rosacea; seborrheic dermatitis; drug-induced reaction; prurigo nodularis; lichen; hidradenitis suppurativa; alopecia; chronic urticaria; skin tumor; angioedema; venous ulcer; HPV skin manifestations; skin infection; vitiligo
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research on Plant Natural Products
edited by
submission deadline 30 Jun 2025 | 1 articles | Viewed by 397 | Submission Open
Keywords: natural products; plants; molecular mechanism; pharmacokinetics; signaling pathways; metabolites; molecular targets; pharmacodynamics; diseases; anti-inflammation; anticancer; omics; bioactivity; natural compounds; therapeutic
(This special issue belongs to the Section Bioactives and Nutraceuticals)
New Advances in Cystinosis from Basic to Clinical Research
edited by Francesco Bellomo
submission deadline 30 Jun 2025 | Viewed by 384 | Submission Open
Keywords: cystinosis; kidney; Fanconi syndrome; muscles; eyes; autophagy; bioenergetics; inflammation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advancing Redox Biomarkers in Pathological Conditions submission deadline 30 Jun 2025 | Viewed by 360 | Submission Open
Keywords: redox biomarkers; oxidative stress; oxidative status in pathological condition; antioxidant enzyme levels detection; low molecular weight antioxidant detection; macromolecule oxidation; oxidative PTMs
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Insights into the Treatment of Metabolic Syndrome and Diabetes
edited by
submission deadline 30 Jun 2025 | Viewed by 328 | Submission Open
Keywords: metabolic dysfunction; metabolic disorder; diabetes
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in the Molecular Mechanisms and Therapies of Hepatocellular Carcinoma
edited by Lein-Ray Mo
submission deadline 30 Jun 2025 | Viewed by 306 | Submission Open
Keywords: hepatocellular carcinoma (HCC); molecular biology; biomarkers; epigenetic modulators; precision medicine; metabolic strategies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Steatotic Liver Disease: From Bench to Bedside and Back
edited by
submission deadline 30 Jun 2025 | Viewed by 290 | Submission Open
Keywords: MASLD; ALD; MetALD; fibrosis; hepatocellular carcinoma; molecular mechanisms; molecular markers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Structure, Function and Dynamics in Proteins: 3rd Edition
edited by
submission deadline 30 Jun 2025 | Viewed by 283 | Submission Open
Keywords: protein structure and dynamics; protein– protein and protein– DNA interactions; protein folding and misfolding; protein aggregation processes; intermediate/misfolded states; conformational equilibria; DNA and ligand recognition mechanisms; membrane receptors; enzyme dynamics; metal-binding proteins; intrinsically disordered proteins; cell signaling; phase separation mechanims; solution- and solid-state NMR; molecular dynamics simulations; time-resolved X-ray; NMR relaxation; in-/on-cell NMR; cryo-EM; fluorescence polarization; surface plasmon resonance; static and dynamic light scattering; isothermal titration calorimetry; microscale thermophoresis; protein– fragment complementation assay; cross-linking; protein microarray
(This special issue belongs to the Section Molecular Biology)
Chitosan: Structural and Chemical Modification, Properties and Application, 2nd Edition
edited by
submission deadline 30 Jun 2025 | Viewed by 258 | Submission Open
Keywords: chitosan modification; adsorption removal; membrane separation; food preservation; environmental remediation; wastewater treatment; disease treatment; agricultural production; tissue engineering
(This special issue belongs to the Section Macromolecules)
Advances in the Nanoparticles-Based Drug Delivery in Cancer Therapy
edited by
submission deadline 30 Jun 2025 | Viewed by 257 | Submission Open
Keywords: nanoparticle-based drug delivery; stimuli responsive; cancer targeting; theragnostic nanoparticles; protein corona; combinatorial drug therapies; tumor penetration; cancer cells uptake
(This special issue belongs to the Section Molecular Nanoscience)
Endometrial Cancer: From Basic Science to Novel Therapeutics
edited by
submission deadline 30 Jun 2025 | Viewed by 228 | Submission Open
Keywords: endometrial cancer; molecular tumor pathology; tumor microenvironment; cancer epidemiology and prevention; biomarkers; cancer therapy; genomic and proteomic databases and applications
(This special issue belongs to the Section Molecular Oncology)
Phytochemicals: Mechanisms and Applications in Cancer Prevention and Therapy submission deadline 30 Jun 2025 | Viewed by 224 | Submission Open
Keywords: phytochemicals; cancer prevention; cancer therapy; molecular mechanisms; signal transduction pathways; anti-oxidant activity; cell death; gene regulation; therapeutic targets
(This special issue belongs to the Section Biochemistry)
Recent Advances in 3D Tumor Models for Cancer Research
edited by , and Alessandra Lo Cicero
submission deadline 30 Jun 2025 | Viewed by 213 | Submission Open
Keywords: 3D systems; cancer research; spheroids; organoids; organ-on-chip; scaffolds; tissue engineering; biomedical technologies; tumor microenvironment
(This special issue belongs to the Section Molecular Oncology)
Microbiome and Bioactive Compounds: Insights into Health, Disease, and Therapeutic Potential
edited by Eui-Jeong Han and
submission deadline 30 Jun 2025 | Viewed by 211 | Submission Open
Keywords: gut microbiome; bioactive compounds; multi-omics approaches; probiotics
(This special issue belongs to the Section Molecular Microbiology)
Organic and Inorganic Active Substances with Antimicrobial, Anti-Inflammatory, Anti-Cancer and Antioxidant Effects
edited by Jebiti Haribabu
submission deadline 30 Jun 2025 | Viewed by 208 | Submission Open
Keywords: organic compounds; metal complexes; nanomedicine; medicinal chemistry; biological applications
(This special issue belongs to the Section Molecular Pharmacology)
New Optical, Electrical, and Thermal Materials: Recent Advances and Challenges
edited by Luyi Zou
submission deadline 30 Jun 2025 | Viewed by 205 | Submission Open
Keywords: optical materials; electrical materials; thermal materials; molecular structure; molecular composition; structural performance
(This special issue belongs to the Section Materials Science)
Innovations in Organic Framework Materials: Expanding the Horizons of COFs, MOFs, and HOFs for Advanced Applications
edited by Bhausaheb Dhokale
submission deadline 30 Jun 2025 | Viewed by 205 | Submission Open
Keywords: COF; MOF; HOF; synthesis; molecular applications; porous materials; molecular engineering; membranes; theoretical studies; energy
(This special issue belongs to the Section Materials Science)
Polyphenol-Based Nanomaterials: Progress and Challenges submission deadline 30 Jun 2025 | Viewed by 203 | Submission Open
Keywords: polyphenolic small molecules; polyphenolic macromolecules; organic chemistry
(This special issue belongs to the Section Molecular Nanoscience)
Pathophysiology and Molecular Therapy of Brain Tumor
edited by Daizo Yoshida and Akira Teramoto
submission deadline 30 Jun 2025 | Viewed by 187 | Submission Open
Keywords: brain tumor; pathophysiology; molecular therapy; signal cascade
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Research on Alloy Materials Microstructure and Their Functionalization
edited by and Celaletdin Ergun
submission deadline 30 Jun 2025 | Viewed by 182 | Submission Open
Keywords: alloy design; microstructure; production methods; additive manufacturing; sol– gel process; biofunctional materials; magnetic properties; nanoparticles; ceramics; composites
(This special issue belongs to the Section Materials Science)
Marine Natural Compounds: Biotechnological Potential and Pharmacological Targets
edited by
submission deadline 30 Jun 2025 | 1 articles | Viewed by 178 | Submission Open
Keywords: marine natural compounds; structure elucidation; biologic activity; structure-activity relationships; biosynthesis; biotechnology; pharmacology
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Targeted Therapy of Cancer
edited by Da-Liang Ou
submission deadline 30 Jun 2025 | Viewed by 170 | Submission Open
Keywords: pharmacotherapy; targeted therapies; immunotherapy; nanotechnology-based combination therapies; drug repurposing; tumor microenvironment; personalized medicine
(This special issue belongs to the Section Molecular Biology)
Psoriasis: Molecular Pathologies, Lipid Disturbances, Diagnosis and Therapeutic Strategies
edited by Hanna Mysliwiec
submission deadline 30 Jun 2025 | Viewed by 169 | Submission Open
Keywords: psoriasis; pathogenesis; lipid metabolism disturbances; metabolic syndrome; systemic comorbidities; epigenetics; therapeutic strategies; biologic treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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