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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Neurodegenerative Diseases: Research, Challenges, and Perspectives

edited by Constantin Ailioaie

submission deadline 31 Jul 2026 | 2 articles | Viewed by 4988 | Submission Open

Keywords: Alzheimer’s disease; Parkinson’s disease; dementia spectrum disorders; pathogenic mechanisms; biomarkers; advanced imaging; artificial intelligence–guided diagnosis; nanomedicine and targeted drug delivery; photomedicine; precision medicine

(This special issue belongs to the Section Molecular Neurobiology)

Extraction, Isolation and Identification of Natural Chemicals

edited by Jiaozhen Zhang

submission deadline 31 Jul 2026 | 2 articles | Viewed by 4933 | Submission Open

Keywords: extraction; isolation; identification; natural chemicals; biological activities

(This special issue belongs to the Section Biochemistry)

SGLT2 Inhibitors and GLP/GIP/Glucagon Agonists: From Fundamental Mechanisms to Clinical Translation

edited by

Cosmin Mihai Vesa

submission deadline 31 Jul 2026 | 3 articles | Viewed by 4715 | Submission Open

Keywords: SGLT2 inhibitors; GLP-1 receptor agonists; GIP; glucagon; multi-agonists; cardiometabolic disease; renal protection; obesity; translational research

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Health Targeting Cardiovascular and Cerebrovascular Diseases: Molecular Aspects

edited by

Byeong-Wook Song

submission deadline 31 Jul 2026 | 1 articles | Viewed by 4146 | Submission Open

Keywords: cardiovascular disease; cerebrovascular disease; cell therapy; gene therapy; extracellular vesicles; regenerative medicine; brain–heart axis; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Functions of Extracellular Vesicles

edited by

Sigrun Lange

and Jameel M. Inal

submission deadline 31 Jul 2026 | 1 articles | Viewed by 4027 | Submission Open

Keywords: extracellular vesicles; molecular mechanisms; biomarkers; liquid biopsy; cell-communication; cellular function; pathobiology; clinical

(This special issue belongs to the Section Molecular Biology)

New Insights into Chronic Inflammatory Demyelinating Polyneuropathy and Neuroimmunological Diseases

edited by

Fumitaka Shimizu

submission deadline 31 Jul 2026 | 3 articles | Viewed by 3727 | Submission Open

Keywords: chronic inflammatory demyelinating polyneuropathy (CIDP); multiple sclerosis (MS); neuromyelitis optica spectrum disorder (NMOSD); myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD); autoimmune encephalitis; paraneoplastic neurological syndrome; Guillain-Barre syndrome (GBS); myositis; blood-brain barrier; blood-nerve barrier

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights and Regulation Mechanisms of Tea Quality

edited by

Xujun Zhu

submission deadline 31 Jul 2026 | 2 articles | Viewed by 3631 | Submission Open

Keywords: molecular ecology; spectroscopic techniques; tea quality; tea plant growth

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms and Therapies of Gastrointestinal Cancer

edited by

Donatella Delle Cave

submission deadline 31 Jul 2026 | 1 articles | Viewed by 3107 | Submission Open

Keywords: tumor microenvironment; therapy resistance; genetic mutations; oncogenes; molecular diagnostics

(This special issue belongs to the Section Molecular Oncology)

Radiolabeled Compounds for Theranostic Applications in Oncology

edited by

Cyril Fersing

submission deadline 31 Jul 2026 | 1 articles | Viewed by 3084 | Submission Open

Keywords: radiopharmaceuticals; theranostic; cancer therapy; targeted radionuclide therapy; molecular imaging; positron emission tomography; single-photon emission tomography; radiolabeling

(This special issue belongs to the Section Molecular Oncology)

Systems Genetics of Metabolic Disorders: From Omics Signatures to Molecular Mechanisms

edited by

Seong-Hee Maria Ko

submission deadline 31 Jul 2026 | 1 articles | Viewed by 2960 | Submission Open

Keywords: metabolic syndrome; single-nucleotide polymorphism (SNP); genome-wide association study (GWAS); copy number variation; diet; metabolomics; nutritional genetics; lipid metabolism; omics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Signatures in Overt Neurodegenerative Disease: Toward Precision Diagnosis and Classification

edited by

Jose Miguel Laffita-Mesa

submission deadline 31 Jul 2026 | 1 articles | Viewed by 2956 | Submission Open

Keywords: neurodegenerative diseases; molecular biomarkers; disease stratification; Parkinson’s disease; Alzheimer’s disease; spinocerebellar ataxia; precision medicine; digital PCR; circRNA; prognostic biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

The Pathogenesis of Alcohol-Associated Hepatitis and Its Therapies

edited by

Mrigya Babuta

submission deadline 31 Jul 2026 | 1 articles | Viewed by 2893 | Submission Open

Keywords: alcohol-associted hepatitis; acute kidney injury; hepatic encephalopathy; adaptive immune response; innate immune response; neutrophilia

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mechanisms and Innovations in Natural Killer Cell-Based Immunotherapy

edited by

Dipnarine Maharaj

submission deadline 31 Jul 2026 | 3 articles | Viewed by 2391 | Submission Open

Keywords: natural killer cells; immunotherapy; CAR-NK; cancer therapy; adoptive cell transfer; immune modulation; tumor microenvironment; cell engineering; hematologic malignancies; viral infections

(This special issue belongs to the Section Molecular Immunology)

Nanoscience in Plants: Omics Approaches to Elucidate the Role of Nanoparticles

edited by

Setsuko Komatsu

and Zahed Hossain

submission deadline 31 Jul 2026 | 1 articles | Viewed by 2381 | Submission Open

Keywords: nanoparticles; plant; omics-based techniques; bioinformatics; systems biology; nanotoxicology

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Dialogues in the Tumor Microenvironment: Mechanisms, Methods and Therapeutic Implications

edited by

José M. Muñoz-Félix

submission deadline 31 Jul 2026 | 2 articles | Viewed by 2373 | Submission Open

Keywords: tumor microenvironment; blood vessels; immune cells; spatial transcriptomics; histology

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Pathways Involved in Toxicant-Induced Stress

edited by

Maria Giulia Lionetto

and

Maria Elena Giordano

submission deadline 31 Jul 2026 | 3 articles | Viewed by 2287 | Submission Open

Keywords: oxidative stress; cell death; biomarkers; toxicant exposure; environmental toxicology; cell signaling pathways

(This special issue belongs to the Section Molecular Toxicology)

The Role of Non-Coding RNAs in Female Reproduction

edited by

Angela Caponnetto

submission deadline 31 Jul 2026 | 1 articles | Viewed by 2245 | Submission Open

Keywords: microRNAs; long non-coding RNAs; circular RNAs; female reproduction; reproductive aging; molecular biomarkers; ceRNA network

(This special issue belongs to the Section Molecular Genetics and Genomics)

Latest Advances in Gut–Brain Axis Research

edited by Qi Su

submission deadline 31 Jul 2026 | 1 articles | Viewed by 2156 | Submission Open

Keywords: gut-brain axis; microbial metabolites; neuroinflammation; intestinal permeability; neurotransmitter; short-chain fatty acids (SCFAs); vagus nerve signaling; metabolomics

(This special issue belongs to the Section Molecular Neurobiology)

Cellular, Immune and Molecular Pathways of Injury and Disease in Forensic and Legal Medicine

edited by

Sorin Hostiuc

submission deadline 31 Jul 2026 | 1 articles | Viewed by 2139 | Submission Open

Keywords: molecular autopsy; cellular injury pathways; ischemia and hypoxia markers; molecular profiling of fatal injuries; forensic genetics and toxicogenomic

(This special issue belongs to the Section Molecular Biology)

The Brain’s Regeneration Potential: The Role of Neural Progenitor Cells in Neuropsychiatric Therapy

edited by

Beatriz Caballero

and

Yaiza Potes

submission deadline 31 Jul 2026 | 2 articles | Viewed by 2122 | Submission Open

Keywords: neural stem cells; neural progenitor cells; neuropsychiatric disorders; neurodegeneration; neurogenesis; neuroplasticity; melatonin; psychoactive drugs

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms and Treatments Targeting Respiratory Diseases

edited by

Stefanie Dichtl

submission deadline 31 Jul 2026 | 1 articles | Viewed by 2061 | Submission Open

Keywords: respiratory diseases; respiratory infections; COPD; cystic fibrosis; lung tumor; therapy; Afrikaans; Albanian; Amharic; Arabic; Armenian; Azerbaijani; Bengali; Bulgarian; Catalan; Croatian; Czech; Danish; Dutch; English; Estonian; Finnish; French; German; Greek; Gujarati; Haitian Creole; Hebrew; Hindi; Hungarian; Icelandic; Indonesian; Italian; Japanese; Kannada; Kazakh; Khmer; Korean; Kurdish (Kurmanji); Lao; Latvian; Lithuanian; Malagasy; Malay; Malayalam; Maltese; Maori; Marathi; Myanmar (Burmese); Nepali; Norwegian; Pashto; Persian; Polish; Portuguese; Punjabi; Romanian; Russian; Samoan; Simplified Chinese; Slovak; Slovenian; Spanish; Swedish; Tamil; Telugu; Thai; Traditional Chinese; Turkish; Ukrainian; Urdu; Vietnamese; Welsh

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Microbial Omics: Decoding Microbial Life

edited by

Nicole Hansmeier

submission deadline 31 Jul 2026 | 1 articles | Viewed by 2022 | Submission Open

Keywords: omics technologies; omics methodologies; microorganisms; proteomics; genomics; transcriptomics; bioinformatics, artificial intelligence for omics; microbial physiology; microbial adaptation to environmental challenges; interspecies and host-microbe interactions; environmental monitoring

(This special issue belongs to the Section Molecular Microbiology)

The Impact of the Immune System on the Tumor Microenvironment: Relevance to Glioma Development

edited by Gabriela Verónica Salamone

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1858 | Submission Open

Keywords: gliomas
tumor microenvironment
immune

(This special issue belongs to the Section Molecular Oncology)

The Role of Lipids in Health and Diseases: 2nd Volume

edited by

Yutang Wang

submission deadline 31 Jul 2026 | 3 articles | Viewed by 1771 | Submission Open

Keywords: lipids; triglycerides; phospholipids; cholesterol; sphingolipids; steroids; fatty acids; lipid metabolism

(This special issue belongs to the Section Biochemistry)

Cell–Cell Communication Through Extracellular Vesicles

edited by

Federica Fratini

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1696 | Submission Open

Keywords: EV biomarkers; EV biogenesis; EV drug delivery; EV trafficking; EV immuno escape

(This special issue belongs to the Section Molecular Biology)

Molecular Insights in Neuro-Ophthalmology

edited by

Toshiyuki Oshitari

submission deadline 31 Jul 2026 | 2 articles | Viewed by 1677 | Submission Open

Keywords: neuroprotection; neurodegeneration; neuronal cell death; regeneration; cell death and survival pathways; neurovascular unit; oxidative stress; inflammation; advanced glycation end products; ischemia; optic nerve injuries; glaucoma; optic neuritis; retinitis pigmentosa; diabetic retinopathy; age-related macular degeneration; retinal vein/artery occlusion; gene therapy; cell plantation; nutrients; neuroprotectants; drug delivery; translational research

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms Behind Plant–Virus Interactions: Pathogenesis and Defense

edited by

Katarzyna Otulak-Kozieł

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1622 | Submission Open

Keywords: plant viruses; plant resistance; plant signaling; plant defense; biotic stress; plant–virus interactions; molecular mechanism

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular and Genomic Basis of Viral Variation and Host Adaptation

edited by In Ohk Ouh

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1617 | Submission Open

Keywords: viral genome evolution mutation and selection dynamics; structure–function relationships of viral proteins; immune evasion; regulatory mechanisms; comparative viral genomics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Research on PRDM Genes

edited by

Erika Zazzo

Ciro Abbondanza

and

Monica Rienzo

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1615 | Submission Open

Keywords: PRDM; cancer; gene expression regulation; epigenetic modifications; proliferation; differentiation; gene expression regulation; apoptosis; cancer biomarkers; cancer diagnosis

(This special issue belongs to the Section Molecular Genetics and Genomics)

Pathogenesis and Molecular Therapy of Inflammatory Bowel Disease

edited by

Anoop Kumar

submission deadline 31 Jul 2026 | 2 articles | Viewed by 1576 | Submission Open

Keywords: intestinal epithelial barrier; gut microbiota; tight junctions; inflammatory bowel disease; mucosal immunity; autophagy; epithelial restitution; host–microbe interaction; barrier dysfunction; gastrointestinal inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Forensics at Trial

edited by

Guido Viel

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1553 | Submission Open

Keywords: forensic science; molecular biology; evidence; proof; justice; trial; forensic pathology; forensic genetics; forensic histology; forensic toxicology

(This special issue belongs to the Section Molecular Toxicology)

Molecular Pathogenesis and Novel Therapeutic Targets in Oncologic Cardiotoxicity

edited by

Marco Tana

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1546 | Submission Open

Keywords: cardiotoxicity; CTRCD; heart failure; HFrEF; HFpEF

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Liver Transplantation: Pathogenesis, Therapeutic Strategies and Future Challenges

edited by

Francesco Tandoi

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1431 | Submission Open

Keywords: MASLD; transplant oncology; machine perfusion; extended-criteria donors; donors after cardiac death

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Product and Enzyme Inhibition for Disease Management

edited by

Viet Phong Nguyen

and

Le Ba Vinh

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1423 | Submission Open

Keywords: bioactive compounds; natural sources; enzyme inhibition; drug discovery; cancer; cardiovascular diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Anti-Inflammatory Drugs: New and Old Compounds with Novel Delivery Systems Contributing to Improve the Treatment of Inflammatory Diseases

edited by S. Gorzalczany

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1412 | Submission Open

Keywords: inflammation; new compounds; novel formulation; mechanism of action; biological drug; arthritis; inflammatory bowel disease

(This special issue belongs to the Section Molecular Biology)

Autoimmune Disorders: Molecular Mechanisms and Therapeutic Strategies

edited by

Katarzyna Romanowska-Próchnicka

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1411 | Submission Open

Keywords: molecular mechanisms; immune signaling pathways; targeted therapies; biomarkers; autoimmune pathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genomic and Proteomic Advances in Tracking Antibiotic Resistance Evolution

edited by

Vanessa Natália dos Santos Silva

submission deadline 31 Jul 2026 | Viewed by 1359 | Submission Open

Keywords: antibiotic resistance; genomic; proteomic; one health

(This special issue belongs to the Section Molecular Biology)

Next-Gen Biomarkers for Cancer Immunotherapy

edited by

Evangelos Koustas

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1316 | Submission Open

Keywords: cancer biomarkers; immunotherapy; circulating tumor DNA; exosomes; tumor-specific microRNAs; sin-gle-cell sequencing; spatial transcriptomics; precision oncology

(This special issue belongs to the Section Molecular Immunology)

Physiology and Pathophysiology of Neurodegeneration: New Insights and Advances from Molecular to Cellular Level

edited by

Alessandro Romano

and

Amilcare Barca

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1294 | Submission Open

Keywords: central and peripheral nervous systems; neuron homeostasis; neurodegeneration; neurodegenerative disease; neurophysiology; -omic technologies; induced pluripotent stem cell (iPSC); three-dimensional cell culture; organ-on-a-chip (OoC)

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Characterization and Utilization of Plant Genetic Resources

edited by

Roel Rabara

submission deadline 31 Jul 2026 | 2 articles | Viewed by 1187 | Submission Open

Keywords: molecular markers; genetic resources; genomics; transcriptomics; molecular characterization; genetic diversity; transcriptomics; bioinformatics; germplasm enhancement; epigenetics

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms and Therapeutic Strategies in Gastrointestinal Cancer

edited by

Pedro Luiz Serrano Usón Júnior

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1184 | Submission Open

Keywords: gastrointestinal cancers; pancreatic cancer; gastric cancer; colorectal cancer; hepatobiliary cancers; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Advancements in Cytopathology: Challenges and Changes

edited by Panagiota Mikou

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1182 | Submission Open

Keywords: cytopathology; cancer diagnosis; cytology; early cancer detection; exfoliative cytology

(This special issue belongs to the Section Molecular Biology)

Mechanistic Insights into Next-Generation Psychobiotics

edited by

Qi Su

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1149 | Submission Open

Keywords: gut–brain axis; psychobiotics; next-generation psychobiotics; microbiota; probiotics; postbiotics; microbial metabolites

(This special issue belongs to the Section Molecular Microbiology)

Drug Development and Discovery for Alzheimer's Disease

edited by Martha Cecilia Rosales-Hernández

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1130 | Submission Open

Keywords: Alzheimer's disease; drug design; repurposed molecules; therapeutic targets; amyloid-β; β-secretase; acetylcholin-esterase; in silico studies; oxidative stress; chemical synthesis

(This special issue belongs to the Section Molecular Neurobiology)

Recent Advances in Neuroprotective Drug Development and Therapeutic Applications

edited by Jolanta Helena Kotlińska

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1123 | Submission Open

Keywords: neuropharmacology; neuroprotective drugs; dopaminergic and glutamatergic signaling; endocannabinoid system; neurodevelopmental and stress-related disorders

(This special issue belongs to the Section Molecular Neurobiology)

Nanoparticle Toxicity: Beyond Chemical Composition—the Critical Role of Physicochemical Properties

edited by

Karen Khachatryan

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1119 | Submission Open

Keywords: nanotoxicology; engineered nanomaterials; physicochemical properties; risk assessment; reactive oxygen species (ROS); protein corona; cellular uptake; regulatory science; safe-by-design

(This special issue belongs to the Section Molecular Toxicology)

Understanding Cardiotoxicity: From Mechanisms to Therapeutic Implications

edited by

Anna A. Borowiec

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1081 | Submission Open

Keywords: cardiotoxicity; mechanisms of cardiotoxicity; cancer-therapy-related cardiac dysfunction; chemotherapy-related cardiotoxicity; radiotherapy-related cardiotoxicity; immunotherapy-related cardiotoxicity; cardioprotection; molecular pathways; oxidative stress; apoptosis; cardiac biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into Antimicrobial Peptides with Anticancer Activity

edited by

Esther Imperlini

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1046 | Submission Open

Keywords: antimicrobial peptides; cytotoxicity; selective anticancer drugs; omics approaches; anticancer peptide action

(This special issue belongs to the Section Biochemistry)

Post-Transcriptional Gene Regulation of mRNA and Protein Expression

edited by Greco Hernández

submission deadline 31 Jul 2026 | 2 articles | Viewed by 998 | Submission Open

Keywords: translational control; protein synthesis; mRNA biochemistry; signal transduction; mTOR pathway; post-transcriptional regulation

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Insights into Gangliosides

edited by

Sandro Sonnino

and

Massimo Aureli

submission deadline 31 Jul 2026 | 1 articles | Viewed by 896 | Submission Open

Keywords: gangliosides; sphingolipids; plasma membrane; lysosomes; glycohydrolases; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Displaying special issue 51-100 on page 2 of 64.

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