Molecular Mechanisms and Therapies of Gastrointestinal Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 20 January 2026 | Viewed by 869
Special Issue Editor
Interests: pancreatic cancer; cancer stem cells; tumor microenvironment; cancer metabolism; fibrosis; TGF-β signaling; target therapy; drug delivery systems
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Gastrointestinal (GI) cancers remain a major global health challenge due to their high morbidity and mortality rates. Despite advancements in early detection and treatment strategies, the prognosis for many GI cancer patients remains poor, underscoring the urgent need for improved therapeutic approaches. This Special Issue aims to explore the latest research on the molecular mechanisms driving GI cancer initiation, progression, and resistance to therapy, with a focus on identifying novel biomarkers and unraveling key signaling pathways. We seek contributions that delve into the genetic mutations and epigenetic changes that underpin tumorigenesis in these cancers. Key areas of interest include but are not limited to the role of tumor suppressor genes, oncogenes, and molecular networks involved in cell cycle regulation, metastasis, and immune evasion. Additionally, the issue will explore the impact of the tumor microenvironment, including stromal interactions and immune cell dynamics, in shaping cancer behavior. By bringing together cutting-edge research on molecular diagnostics, biomarkers, and treatment resistance, this issue aims to highlight promising therapeutic strategies and molecular targets for improving patient outcomes in GI cancer. We invite original research, reviews, and clinical studies that provide new insights into the molecular biology of GI cancers and innovative therapeutic approaches.
Dr. Donatella Delle Cave
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
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Keywords
- tumor microenvironment
- therapy resistance
- genetic mutations
- oncogenes
- molecular diagnostics
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