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Molecular Mechanisms and Therapies of Gastrointestinal Cancer

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 20 July 2025 | Viewed by 103

Special Issue Editor

Special Issue Information

Dear Colleagues,

Gastrointestinal (GI) cancers remain a major global health challenge due to their high morbidity and mortality rates. Despite advancements in early detection and treatment strategies, the prognosis for many GI cancer patients remains poor, underscoring the urgent need for improved therapeutic approaches. This Special Issue aims to explore the latest research on the molecular mechanisms driving GI cancer initiation, progression, and resistance to therapy, with a focus on identifying novel biomarkers and unraveling key signaling pathways. We seek contributions that delve into the genetic mutations and epigenetic changes that underpin tumorigenesis in these cancers. Key areas of interest include but are not limited to the role of tumor suppressor genes, oncogenes, and molecular networks involved in cell cycle regulation, metastasis, and immune evasion. Additionally, the issue will explore the impact of the tumor microenvironment, including stromal interactions and immune cell dynamics, in shaping cancer behavior. By bringing together cutting-edge research on molecular diagnostics, biomarkers, and treatment resistance, this issue aims to highlight promising therapeutic strategies and molecular targets for improving patient outcomes in GI cancer. We invite original research, reviews, and clinical studies that provide new insights into the molecular biology of GI cancers and innovative therapeutic approaches.

Dr. Donatella Delle Cave
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tumor microenvironment
  • therapy resistance
  • genetic mutations
  • oncogenes
  • molecular diagnostics

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Published Papers

This special issue is now open for submission.
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