Molecular Insights in Neuro-Ophthalmology
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 954
Special Issue Editor
Interests: diabetic retinopathy; neuronal cell death; neurovascular units; axonal degeneration; glial changes; vascular abnormalities; neuroprotection; regeneration; optic coherence tomography; visual function
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neuronal cell death and degeneration are irreversible changes associated with the pathogenesis of all retinal and optic nerve diseases. Because neuronal cell death is directly related to vision loss, neuronal cell death must be prevented before the point of no return. Various types of cell death such as necrosis, apoptosis, pyroptosis, autophagic cell death, ferroptosis, or necroptosis can be associated with the pathogenesis of retina and optic nerve diseases. Thus, multiple neuroprotective therapies against various types of cell death may be required for retinal and optic nerve diseases. To establish neuroprotective therapies, the precise mechanism of neuronal cell death must be elucidated. Otherwise, we cannot identify where the point of no return is. Furthermore, once axons are degenerated, no functional recovery can be obtained. Therefore, molecular pathogenesis of axonal degeneration and regeneration must be elucidated to establish regenerative therapies for retinal and optic nerve diseases.
This Special Issue focuses on the molecular mechanisms of neuronal cell death, as well as neuroprotective and regenerative therapies for retinal and optic nerve diseases. It covers all studies from bench to bed, and thus, clinical studies and trials for neuroprotective therapies are also welcome. We hope this Special Issue contributes to the development of medical science to a considerable degree.
Dr. Toshiyuki Oshitari
Guest Editor
Manuscript Submission Information
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Keywords
- neuroprotection
- neurodegeneration
- neuronal cell death
- regeneration
- cell death and survival pathways
- neurovascular unit
- oxidative stress
- inflammation
- advanced glycation end products
- ischemia
- optic nerve injuries
- glaucoma
- optic neuritis
- retinitis pigmentosa
- diabetic retinopathy
- age-related macular degeneration
- retinal vein/artery occlusion
- gene therapy
- cell plantation
- nutrients
- neuroprotectants
- drug delivery
- translational research
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