Autoimmune Disorders: Molecular Mechanisms and Therapeutic Strategies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 29 November 2025 | Viewed by 30
Special Issue Editor
Interests: rheumatoid arthritis; pathophysiology; biological therapies; systemic connective tissue diseases; scleroderma; interstitial lung disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Autoimmune disorders encompass a broad spectrum of diseases driven by dysregulated immune responses that lead to chronic inflammation, autoantibody production, and progressive tissue damage. Understanding the molecular mechanisms underlying these conditions is crucial for developing targeted therapies that can modulate the immune response while minimizing adverse effects.
This Special Issue, “Autoimmune Disorders: Molecular Mechanisms and Therapeutic Strategies”, aims to provide a comprehensive insight into the pathophysiology of autoimmune diseases.
This Special Issue explores the molecular mechanisms driving autoimmunity, including genetic predisposition, epigenetic modifications, and dysregulated immune signaling. Aberrant activation of T and B cells, defective regulatory T cells, and abnormal cytokine profiles contribute to chronic inflammation and tissue damage.
Advancements in molecular research have identified key signaling pathways involved in autoimmune pathogenesis, such as NF-κB, JAK-STAT, and PI3K-AKT-mTOR. Understanding these pathways has facilitated the development of targeted therapies, including monoclonal antibodies, small-molecule inhibitors, and immune checkpoint modulators. Biologics such as TNF-α inhibitors, IL-6 antagonists, and CD20-targeting therapies have revolutionized treatment approaches, improving disease outcomes in conditions like rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis.
Emerging therapeutic strategies focus on restoring immune tolerance through regulatory T cell expansion, tolerogenic dendritic cells, and antigen-specific immunotherapy. Advances in precision medicine and biomarker discovery are enhancing personalized treatment, optimizing drug responses, and minimizing adverse effects. This Special Issue highlights current molecular insights and therapeutic innovations in autoimmune diseases, emphasizing translational research that bridges basic immunology with clinical applications.
Dr. Katarzyna Romanowska-Próchnicka
Guest Editor
Manuscript Submission Information
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Keywords
- molecular mechanisms
- immune signaling pathways
- targeted therapies
- biomarkers
- autoimmune pathogenesis
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