Physiology and Pathophysiology of Neurodegeneration: New Insights and Advances from Molecular to Cellular Level
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (31 July 2026) | Viewed by 1437
Editors
Interests: molecular biology; genetics; bioinformatics; neurosciences; neurodegeneration; amyotrophic lateral sclerosis (ALS); extracellular vesicles; human induced pluripotent stem cells (hiPSCs); organ-on-a-chip (OoC)
Special Issues, Collections and Topics in MDPI journals
Interests: GI cell physiology and pathophysiology; homeostasis mechanisms; transepithelial and transmembrane transport processes; inflammation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The pathophysiology of neurodegeneration involves complex cellular and molecular mechanisms related to neuronal injury, repair, inflammation, and dysfunction. Understanding the cellular and molecular events leading to the transition from neuronal homeostasis to physiopathological states is a central focus of biomedical research in neurodegenerative diseases. Cutting-edge genomic, transcriptomic, proteomic, and metabolomic technologies, as well as innovative experimental models such as induced pluripotent stem cells (iPSCs), organoids, and organ-on-a-chip systems, represent the current toolbox for defining pathways involved in disease initiation and progression, as well as for allowing identification of novel therapeutic targets for early intervention. This Special Issue highlights innovative research on cellular and molecular dynamics in nervous tissue, including processes such as myelination, neuronal excitability, molecular and cellular turnover, and the modulation of signaling pathways disrupted in neurodegenerative diseases. Topics of interest include, but are not limited to, mechanisms underlying protein misfolding and aggregation, RNA processing dysregulation, proteasome impairment, neuroinflammation, excitotoxicity, and cytoskeletal and mitochondrial dysfunctions. Additionally, this Special Issue will highlight advances in molecular-based drug delivery systems, novel therapeutic targets, and predictive biomarkers. We invite original research articles, communications, and comprehensive reviews to contribute to this crucial field of study.
Dr. Alessandro Romano
Dr. Amilcare Barca
Guest Editors
Manuscript Submission Information
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Keywords
- central and peripheral nervous systems
- neuron homeostasis
- neurodegeneration
- neurodegenerative disease
- neurophysiology
- -omic technologies
- induced pluripotent stem cell (iPSC)
- three-dimensional cell culture
- organ-on-a-chip (OoC)
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