Systems Genetics of Metabolic Disorders: From Omics Signatures to Molecular Mechanisms
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: 10 November 2025 | Viewed by 92
Special Issue Editor
Interests: lipid metabolism; metabolic disorder of post-menopausal women; free radical research; diabetes; obesity; sexual hormonal changes; metabolomics; nutritional genetics; multi omics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Metabolic syndrome is defined as a group of diseases involving impaired glucose metabolism, hypertension, abdominal obesity, low LDL-C, and high triglyceride levels. It promotes a chronic systemic inflammatory state characterized by glucose intolerance and immune cell infiltration, activating the immune system and thus increasing the risk of contracting severe diseases after viral infection. Studies have reported an increase in various metabolic diseases such as non-alcoholic fatty liver disease, psoriasis, and inflammatory bowel disease. These diseases can be induced by hormonal changes that occur naturally with aging, and research is crucial for developing prediction models and formulating preventative strategies to diagnose and treat them. Studies have recently been conducted on the effects of dietary factors (food groups/nutrients/meal patterns), genetic mutations (SNPs), and metabolites on metabolic syndrome, with multi-omics analysis being used to facilitate the prediction of diseases. We therefore seek contributions from fellow researchers that address the treatment and prevention of metabolic diseases. This Special Issue, “Systems Genetics of Metabolic Disorders: From Omics Signatures to Molecular Mechanisms”, aims to focus on the broad effects of dietary factors, genetic variants, and metabolites on metabolic disorders.
We welcome original research papers, short communications, and review articles that cover topics including, but not limited to, the following:
- Understanding the molecular pathways of metabolic disorders in various populations;
- Epidemiological studies relating diet and metabolic disorders;
- Understanding the effects and interactions of dietary interventions and supplementation (i.e., diet, natural-derived extracts, bioactive compounds, or toxicants) on metabolic disorders;
- Investigating nutrients/nutraceuticals that target metabolic disorder-related transcription factors, such as sterol receptor binding proteins, via computational models;
- Studies on metabolic diseases predicated on nutritional genetics and metabolomes, using multi-omics data (genome, transcriptome, metabolome, etc.) and machine learning techniques;
- Studies pertaining to the interaction of dietary factors/genetic variants/metabolites that are related to metabolic syndrome using multi-omics analysis.
We look forward to receiving your contributions.
Dr. Seong-Hee Maria Ko
Guest Editor
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Keywords
- metabolic syndrome
- single-nucleotide polymorphism (SNP)
- genome-wide association study (GWAS)
- copy number variation
- diet
- metabolomics
- nutritional genetics
- lipid metabolism
- omics
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