Molecular Signatures in Overt Neurodegenerative Disease: Toward Precision Diagnosis and Classification
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 1 January 2026 | Viewed by 32
Special Issue Editor
Interests: spinocerebellar ataxias; polyQ disorders; Ataxin-2; molecular pathways in Alzheimer and frontotemporal dementia; epigenetics; neurogenetics of movement disorders; molecular mechanisms of spinocerebellar ataxias and other inherited neurological disorders; molecular techniques; RAN translation; circRNA; RNA processing; functional studies of genetic alterations; biomarker discovery and validation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleague,
This Special Issue, entitled "Molecular Signatures in Overt Neurodegenerative Disease: Toward Precision Diagnosis and Classification", aims to explore the molecular underpinnings of clinically manifest neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Spinocerebellar Ataxias, and repeat expansion disorders. We welcome the submission of studies identifying and validating diagnostic, prognostic, and stratification biomarkers that reflect disease burden, clinical heterogeneity, or therapeutic response. For this Special Issue, we are interested in biomarkers derived from non-coding RNAs, repeat expansions, proteomics, epigenetics, and advanced molecular platforms such as ddPCR, transcriptomics, and proteomics. This Special Issue also aims to highlight computational and AI-based strategies that integrate molecular data with clinical phenotypes, as well as mechanistic studies addressing signaling pathways and molecular interactions relevant to disease classification and therapeutic targeting, thereby advancing precision medicine in neurodegeneration.
Dr. Jose Miguel Laffita Mesa
Guest Editor
Manuscript Submission Information
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Keywords
- neurodegenerative diseases
- molecular biomarkers
- disease stratification
- Parkinson’s disease
- Alzheimer’s disease
- spinocerebellar ataxia
- precision medicine
- digital PCR
- circRNA
- prognostic biomarkers
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