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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Developments in Fluorescent Biosensors

edited by

Chin-Feng Wan

submission deadline 30 Jun 2026 | Viewed by 28 | Submission Open

Keywords: carbon-based luminescent materials; green fluorescent sensors; C-dots; environmental sensing; biomedical applications; green synthesis strategies; fluorescence quenching; heavy metal detection

(This special issue belongs to the Section Molecular Biophysics)

Applications and Advances of Organic Synthesis in the Design of Antiparasitic, Antiviral, and Anticancer Drugs

edited by

Sergio Hernán Szajnman

and Juan B. Rodriguez

submission deadline 30 Jun 2026 | Viewed by 28 | Submission Open

Keywords: antiparasitic agents; antiviral agents; chagas disease; toxoplasmosis; medicinal chemistry

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Perspectives in Lung Diseases: Pathogenesis, Diagnosis, and Treatment—2nd Edition

edited by

Elena Levantini

submission deadline 30 Jun 2026 | Viewed by 27 | Submission Open

Keywords: lung cancer models; cancer stem cells; tumor microenvironment; targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Polymer Composites: Advances and Applications

edited by

Saeid Sahmani

submission deadline 30 Jun 2026 | Viewed by 27 | Submission Open

Keywords: polymer composites; polymer nanocomposites; biocompatible polymer composites; structure-property relationships; interfacial engineering; molecular design; computational modelling; mechanical performance; advanced applications

(This special issue belongs to the Section Materials Science)

Advances in Molecular Pathobiology, Diagnosis, and Treatment of Neurodegenerative Diseases

edited by

Saak V. Ovsepian

, Stergios Boussios and

Jaison Jeevanandam

submission deadline 30 Jun 2026 | Viewed by 27 | Submission Open

Keywords: neurodegenerative diseases; Alzheimer’ s disease; Parkinson’ s disease; dementia with Lewy bodies; motor neuron diseases; molecular pathobiology; diagnosis; treatment

(This special issue belongs to the Section Molecular Neurobiology)

Metabolic Features of Breast Cancer: From Understanding Heterogeneous Biology to Developing New Therapies

edited by

Lyudmila Bel'skaya

submission deadline 30 Jun 2026 | Viewed by 27 | Submission Open

Keywords: breast cancer; heterogeneity; metabolic processes; metabolites; proteins; gene expression; diagnosis; prognosis; treatment response

(This special issue belongs to the Section Molecular Oncology)

Animal‐Derived Bioactive Peptides as Next‐Generation Therapeutics

edited by

Mariana S. Castro

and

Wagner Fontes

submission deadline 30 Jun 2026 | Viewed by 26 | Submission Open

Keywords: venom-derived peptides; animal toxins; antimicrobial peptides; immunomodulation; wound healing; antiparasitic agents; peptide‐based therapeutics; skin secretions

(This special issue belongs to the Section Molecular Toxicology)

Extracellular Vesicles: Biomarkers and Therapeutic Carriers in Human Health and Disease

edited by José Eduardo Vargas

submission deadline 30 Jun 2026 | Viewed by 26 | Submission Open

Keywords: extracellular vesicles; cellular senescence; autophagy; biomarkers; drug delivery; translational medicine; human disease; cell fate

(This special issue belongs to the Section Molecular Biology)

Organoid Models: Advancing the Study of Disease Mechanisms and Nutritional Regulations

edited by

Xi Lin

and Pinghuang Liu

submission deadline 30 Jun 2026 | Viewed by 26 | Submission Open

Keywords: organoids; disease mechanisms; nutritional regulation; disease modeling; stem cells

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Microfluidic-Assisted Synthesis of Nanomaterials: Precise Control of Size, Surface Chemistry and Molecular Interactions

edited by Adelina-Gabriela Niculescu and

Ariana Hudita

submission deadline 30 Jun 2026 | Viewed by 26 | Submission Open

Keywords: microfluidics; nanomaterials; nanocomposites; microreactors; controlled synthesis; surface chemistry; molecular interactions; flow simulation; physicochemical characterization; advanced applications

(This special issue belongs to the Section Molecular Nanoscience)

Zinc Signaling in Immunity

edited by

Lothar Rink

submission deadline 30 Jun 2026 | Viewed by 24 | Submission Open

Keywords: zinc signaling; zinc flux; zinc sparks; zinc wave; zinc transporter

(This special issue belongs to the Section Biochemistry)

Molecular Biomarkers and Therapeutic Targets for Acute Liver and Kidney Injury

edited by

Gang Ye

submission deadline 30 Jun 2026 | Viewed by 23 | Submission Open

Keywords: acute liver injury; acute kidney injury; multi omics technology; network pharmacology; molecular biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Interactions Between Microbes and Hosts: Physiology, Pathology and Treatment—Second Edition

edited by

Emira D’Amico

submission deadline 30 Jun 2026 | Viewed by 23 | Submission Open

Keywords: microbial infection; microbes– host interaction; virulence factors; molecular and cell biology; antimicrobial therapy; antibiotics; antimicrobial peptides; resistance mechanisms

(This special issue belongs to the Section Molecular Microbiology)

Advances in Molecular Research in Animal Reproduction

edited by

He Huang

submission deadline 30 Jun 2026 | Viewed by 22 | Submission Open

Keywords: animal reproduction; molecular regulation; spermatogenesis; embryonic development; epigenetics; reproductive hormones; oogenesis; environmental factors

(This special issue belongs to the Section Molecular Biology)

Emerging Insights into Endothelial Biology and Metabolism

edited by

Hemant Giri

submission deadline 30 Jun 2026 | Viewed by 21 | Submission Open

Keywords: endothelial dysfunction; endothelial activation; vascular biology; endothelial migration; angiogenesis; vascular permeability; shear stress; microvascular and macrovascular remodeling; leukocyte trafficking; mitochondrial function

(This special issue belongs to the Section Molecular Biology)

Host–Microbiome Crosstalk: Mitochondria, Extracellular Vesicles, and Redox Regulation in Aging

edited by

Efthalia Moustakli

submission deadline 30 Jun 2026 | Viewed by 20 | Submission Open

Keywords: gut microbiome; redox homeostasis; mitochondria

(This special issue belongs to the Section Molecular Microbiology)

Alcohol Metabolism: Molecular, Physiological, and Behavioral Consequences from Basic Research to Translational Applications

edited by Analia G. Karadayian

submission deadline 30 Jun 2026 | Viewed by 20 | Submission Open

Keywords: alcohol metabolism; acetaldehyde; mitochondrial dysfunction; oxidative stress; behavioral outcomes; animal models; translational research

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Impact of Microbiome on Gastrointestinal Disorders

edited by

Hirokazu Fukui

submission deadline 30 Jun 2026 | Viewed by 19 | Submission Open

Keywords: gut microbiome; inflammation; functional gastrointestinal disorders; gut hormone; pathology; carcinogenesis; inflammatory bowel disease; mucosal barrier; immunity; gut– bain axis; stress; innate immunity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Autophagy in Physiology and Pathophysiology: Recent Advances

edited by

María Isabel Colombo

and Claudio Marcelo Fader

submission deadline 30 Jun 2026 | Viewed by 19 | Submission Open

Keywords: macroautophagy; microautophagy; chaperone-mediated autophagy (CMA); autophagy-related genes (ATG); xenophagy; mitophagy; pexophagy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Rare Diseases Associated with Short Stature: Genetics, Pathogenesis and Therapy, 2nd Edition

edited by

Michal Ordak

submission deadline 30 Jun 2026 | Viewed by 16 | Submission Open

Keywords: skeletal disorders; dwarfism; skeletal dysplasias; short stature; biomarkers; mutations; rare disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Perspectives on Natural Antioxidants in Health and Disease

edited by

Jinbong Park

submission deadline 30 Jun 2026 | Viewed by 15 | Submission Open

Keywords: natural antioxidants; oxidative stress; molecular mechanisms; polyphenols; NRF2 signaling pathway; mitochondrial homeostasis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Structural Bioinformatics in Receptor-Mediated Toxicology

edited by

Rajesh Kumar Pathak

submission deadline 30 Jun 2026 | Viewed by 10 | Submission Open

Keywords: structural bioinformatics; predictive toxicology; toxicant receptor interactions; molecular docking; molecular dynamics simulation; free energy calculations; in silico risk assessment

(This special issue belongs to the Section Molecular Informatics)

Molecular Insights into Stroke: Biomarkers and Mechanisms

edited by Jae Sang Oh

submission deadline 30 Jun 2026 | Viewed by 9 | Submission Open

Keywords: stroke; glymphatic system; biomarkers; human-derived specimens; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Omega-3 Polyunsaturated Fatty Acids: From Molecular Signaling to Therapeutic Applications

edited by

Feng-Yao Tang

submission deadline 30 Jun 2026 | Viewed by 9 | Submission Open

Keywords: N-3 polyunsaturated fatty acids; bioactive signaling molecules; stem cell; cancer; gut microbiota; precision nutrition

(This special issue belongs to the Section Molecular Biology)

Current Advances in Mesenchymal Stem Cells for Tissue Regeneration

edited by

Dae Joong Kim

submission deadline 30 Jun 2026 | Viewed by 8 | Submission Open

Keywords: MSCs; tissue regeneration; regenerative medicine; biomaterial scaffolds; immune responses; secretome; disease models; osteoarthritis; bone repair; neurological regeneration

(This special issue belongs to the Section Molecular Biology)

Bioactive Peptides: From Discovery and Characterization to Production, Therapeutic Applications, and Mechanistic Elucidation

edited by

Taliana Bezerra

José Lacerda

and

Luiz Juliano

submission deadline 30 Jun 2026 | Viewed by 3 | Submission Open

Keywords: bioactive peptides; mass spectrometry; machine learning; molecular dynamics simulation; synthetic biology; enzymology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Plant Molecular Ecology and Genomic Perspectives

edited by

Peng Zhao

submission deadline 1 Jul 2026 | Viewed by 286 | Submission Open

Keywords: genome assembly and annotaion; genomic structure and function of plants; plant molecular ecology; genome prediction and GWAS; gene-editing technologies; transcriptomics and metabolomics; nuclear and organelle genomics

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Physiopathological Role of Hypoxia

edited by

Michele Aventaggiato

submission deadline 10 Jul 2026 | Viewed by 75 | Submission Open

Keywords: hypoxia; cell metabolism; inflammation; tumor microenvironment; cancer progression; EMT; chronic inflammation; obesity; inflammatory microenvironment; storage disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Breast Cancer: From Molecular Mechanism to Therapeutic Strategy

edited by

Anna Makuch-Kocka

submission deadline 10 Jul 2026 | Viewed by 73 | Submission Open

Keywords: breast cancer; molecular mechanisms; therapeutic strategies; tumor microenvironment; precision oncology

(This special issue belongs to the Section Molecular Oncology)

Molecular Structure and Characterization of Optical Materials

edited by

Andrzej Kruk

submission deadline 10 Jul 2026 | Viewed by 50 | Submission Open

Keywords: luminescence; structure modification; spectroscopy; measurement techniques; Kerr effect; Faraday effects; doping; molecular structure

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Cancer Immunotherapy on Checkpoint Inhibitors: Future Directions

edited by Hui Yen Chuang

submission deadline 10 Jul 2026 | Viewed by 13 | Submission Open

Keywords: immune checkpoint inhibitors (ICIs); PD-1/PD-L1 blockade; combination immunotherapy; immunotherapy resistance; tumor microenvironment (TME); predictive biomarkers; immune-related adverse events (irAEs); novel immune targets (LAG-3/TIM-3); personalized medicine; clinical trials

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanism of Circadian Rhythm

edited by Rosângela Vieira de Andrade

submission deadline 20 Jul 2026 | 3 articles | Viewed by 31087 | Submission Open

Keywords: circadian cycle; exercise; aging; clock genes; health

(This special issue belongs to the Section Molecular Biology)

High-Density Lipoproteins in Health and Disease

edited by

Ilaria Zanotti

submission deadline 20 Jul 2026 | 7 articles | Viewed by 25771 | Submission Open

Keywords: omics; protein; lipid; cardiovascular; neurodegenerative disease; inflammation; preclinical studies; therapy

(This special issue belongs to the Section Molecular Biology)

Interplay Between the Human Microbiome and Diseases

edited by

Tihamer Molnar

and

Zoltán Péterfi

submission deadline 20 Jul 2026 | 9 articles | Viewed by 19278 | Submission Open

Keywords: microbiome; metagenome; gastrointestinal tract; skin; seminal fluid; lung; saliva; oral mucosa; conjunctiva; dysbiosis; fecal microbiota transplantation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into Immunity and Inflammation in Cardiovascular Diseases

edited by

David J. Vigerust

submission deadline 20 Jul 2026 | 6 articles | Viewed by 18424 | Submission Open

Keywords: pathogens; oxidative stress; cytokines; chemokines; immunity; chronic inflammation

(This special issue belongs to the Section Molecular Immunology)

Molecular Research in Prebiotics, Probiotics and Postbiotics: 2nd Edition

edited by

Julio Villena

and Haruki Kitazawa

submission deadline 20 Jul 2026 | 6 articles | Viewed by 17772 | Submission Open

Keywords: probiotics; prebiotics; postbiotics; symbiotics; immunobiotics; functional foods; health improvement; mucosal immunology; microbiota

(This special issue belongs to the Section Molecular Microbiology)

Plant Genome Editing

edited by Lei Gao

submission deadline 20 Jul 2026 | 5 articles | Viewed by 14992 | Submission Open

Keywords: plant genome editing; Cas9/Cas12a; CRISPR/CRISPRa/CRISPRi; anti-CRISPR; gene editing; off target impact; prime editing; bioinformatics/database

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Research for Legume Genomics, Genetics, and Breeding, 2nd Edition

edited by

Naoufal Lakhssassi

submission deadline 20 Jul 2026 | 5 articles | Viewed by 11388 | Submission Open

Keywords: legumes; genomics; plant breeding; seed composition; gene function; biotic and abiotic stress; legume pathogen resistance/mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Progression of Genome-Related Diseases: 2nd Edition

edited by

Salvatore Saccone

submission deadline 20 Jul 2026 | 3 articles | Viewed by 10760 | Submission Open

Keywords: next-generation sequencing; genetic diseases; multifactorial diseases; diagnostic tolls; human health

(This special issue belongs to the Section Molecular Genetics and Genomics)

Nanoparticles in Molecular Pharmaceutics

edited by

Qingxin Mu

submission deadline 20 Jul 2026 | 6 articles | Viewed by 9840 | Submission Open

Keywords: nanoparticles; molecular pharmaceutics; drug delivery; nanomedicine; nanoformulation

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Insights into Bioactive Compounds from Agro-Industrial Waste Biomass

edited by

Ana Lima

and

Elisabete Maria de Castro Lima

submission deadline 20 Jul 2026 | 3 articles | Viewed by 8535 | Submission Open

Keywords: by-product; biocompound; bioactivity; component analysis; in vitro/in vivo experiments; circular economy; sustainability; biomass residues valorization

(This special issue belongs to the Section Biochemistry)

Animal Models for Human Diseases

edited by Yuning Song

submission deadline 20 Jul 2026 | 4 articles | Viewed by 7585 | Submission Open

Keywords: animal models; translational research; preclinical studies; biomedical innovation; reproducibility

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Hypoxia: Molecular Mechanism and Health Effects

edited by

Pinar Uysal-Onganer

submission deadline 20 Jul 2026 | 4 articles | Viewed by 6574 | Submission Open

Keywords: hypoxia; inflammation; oxidative stress; metabolic conditions; hypoxia-inducible factors (HIFs); oxidative stress; mitochondrial dysfunction; angiogenesis; metabolic reprogramming; apoptosis

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into Glioblastoma Pathogenesis and Therapeutics

edited by

Claudia Desiderio

Giovanni Sabatino

and

Edoardo Mazzucchi

submission deadline 20 Jul 2026 | 4 articles | Viewed by 6466 | Submission Open

Keywords: glioblastoma; proteomics; immunopeptidomics; genomics; extracellular vesicles; biomarkers; molecular mechanisms; i-knife mass spectrometry; intra-operative imaging; cancer stem cells; cancer progression; neurosurgery; radiomics; personalized medicine

(This special issue belongs to the Section Molecular Oncology)

Molecular Insights into Placental Pathology

edited by

Mary Wallingford

and Ana Correia-Branco

submission deadline 20 Jul 2026 | 4 articles | Viewed by 5776 | Submission Open

Keywords: placenta; trophoblast; implantation; obstetrics; pre-eclampsia; placentation; maternal– fetal interface; pregnancy health; placenta diagnostics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bone Metabolism and Bone Diseases

edited by

Giacomina Brunetti

submission deadline 20 Jul 2026 | 5 articles | Viewed by 5765 | Submission Open

Keywords: bone metabolism; bone diseases; osteoclast; osteoblasts and osteocytes; bone remodelling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Power Up Plant Genetic Research with Genomic Data: 3rd Edition

edited by

Hon-Ming Lam

Sachiko Isobe

and

Man-Wah Li

submission deadline 20 Jul 2026 | 2 articles | Viewed by 4473 | Submission Open

Keywords: genome sequencing; optical mapping; genome editing; population genomics; genome-wide; association mapping; functional genomics; epigenomics; genetic interaction; chromatin; biodiversity

(This special issue belongs to the Section Molecular Genetics and Genomics)

Physicochemical Properties and Applications of Nanomaterials in Biology and Medicine

edited by

Gangho Lee

submission deadline 20 Jul 2026 | 5 articles | Viewed by 3559 | Submission Open

Keywords: nanoparticle; nanomaterial; biomedicine; synthesis; physicochemical properties; imaging; therapy; contrast agent; therapeutic agent

(This special issue belongs to the Section Molecular Nanoscience)

Innovative Strategies in Cancer Therapy

edited by

Paolo Coghi

and

Carmine Coluccini

submission deadline 20 Jul 2026 | 1 articles | Viewed by 3443 | Submission Open

Keywords: tumor microenvironment; small molecules; IDO1 inhibition; checkpoint inhibitor therapy; adoptive T cell therapy; metabolic reprogram; resistance mechanisms; immune modulation; immune reconstitution; combination therapy; immunosuppression

(This special issue belongs to the Section Molecular Oncology)

Epigenetic Regulation and Molecular Mechanisms in Cardiovascular Diseases

edited by

Paschalis Karakasis

submission deadline 20 Jul 2026 | 2 articles | Viewed by 3037 | Submission Open

Keywords: epigenetic regulation; cardiovascular disease; DNA methylation; histone modifications; non-coding RNAs; vascular inflammation; myocardial remodeling; molecular mechanisms; thera-peutic targets

(This special issue belongs to the Section Molecular Genetics and Genomics)

Displaying special issue 2951-3000 on page 60 of 64.

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