Molecular Biomarkers and Therapeutic Targets for Acute Liver and Kidney Injury
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 June 2026 | Viewed by 1
Special Issue Editor
Interests: natural product; toxicology; network pharmacology; microbiology and intestinal health
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Acute liver injury and acute kidney injury are common clinical critical syndromes, and their etiologies are complex and diverse and include drug toxicity, ischemia, infection, and sepsis. Despite the progress made in intensive and supportive care, the morbidity and mortality of these diseases remain high, constituting a heavy burden for global health.
Due to the rapid recent development of molecular biology and precision medicine, it is expected that molecular diagnosis will allow real-world early intervention through the quick identification of high-risk patients, real-time dynamic monitoring of disease conditions, and accurate classification of disease subtypes. At the same time, targeted therapeutic strategies for key molecular pathways are providing unprecedented opportunities for the development of more effective therapies with fewer side effects.
The core aim of this Special Issue is to identify and verify new molecular therapeutic targets for acute liver injury and kidney injury and explore the key signaling pathways regulating cell death (such as necroptosis and ferroptosis), inflammatory cascade, mitochondrial dysfunction, and stress response. By integrating cutting-edge omics technology (including interactomics) and mechanism research and further elucidating the impact of alternative splicing, post-translational modifications (e.g., haptenation), and protein moonlighting activities, this Special Issue will present a molecular roadmap from basic research to translational applications and ultimately explore a new path for targeted molecular intervention and individualized medical strategies for these critical syndromes.
This Special Issue will bring together cutting-edge research works in this field, focusing on, but not limited to, the following topics:
- The use of multi-omics technology (genomics, transcriptomics, proteomics, metabolomics, interactomics) to screen and identify new molecular markers for early diagnosis, classification, and prognosis evaluation in acute liver/kidney injury, including those influenced by alternative splicing events and post-translational modifications;
- Biomarker model construction and data analysis based on bioinformatics and artificial intelligence;
- Preclinical studies on candidate drugs, natural compounds, or biological agents targeting the above key molecular pathways and targets, considering protein moonlighting activities;
- The specific role and regulatory networks of new forms of programmed cell death (such as pyroptosis, ferroptosis, and cuproptosis) in organ injury.
Dr. Gang Ye
Guest Editor
Manuscript Submission Information
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Keywords
- acute liver injury
- acute kidney injury
- multi omics technology
- network pharmacology
- molecular biomarkers
- therapeutic targets
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