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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Therapeutics and Pathophysiology of Cognitive Dysfunction

edited by

Maheedhar Kodali

submission deadline 20 Apr 2026 | 3 articles | Viewed by 9626 | Submission Open

Keywords: cognition; neurologic diseases; neuroinflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Editorial Board Members’ Collection Series: “Selenium and Sulfur Chemistry”

edited by

Claudio Santi

and

Narimantas K. Cenas

submission deadline 20 Apr 2026 | 3 articles | Viewed by 9483 | Submission Open

Keywords: selenium; sulfur; redox; catalysis; selenoproteins; green chemistry; materials; stereoselective synthesis

(This special issue belongs to the Section Biochemistry)

Biomarkers, Treatments, and Clinical Outcomes for Meningiomas and Other Skull Base Tumors

edited by

Michael Graner

and Philip David Tatman

submission deadline 20 Apr 2026 | 3 articles | Viewed by 9080 | Submission Open

Keywords: skull base tumor; meningioma; biomarkers; diagnosis; prognosis; radiology; surgery; pharmacotherapy; immunology

(This special issue belongs to the Section Molecular Oncology)

Prostate Cancer Research Update: Molecular Diagnostic Biomarkers

edited by Mikhail Baryshev

submission deadline 20 Apr 2026 | 4 articles | Viewed by 9055 | Submission Open

Keywords: prostate cancer; molecular biomarkers; cancer-specific DNA methylation; non-coding genes; gene fusions; lncRNA

(This special issue belongs to the Section Molecular Oncology)

Research Advances in Reproductive Immunology

edited by

Monika Kniotek

submission deadline 20 Apr 2026 | 2 articles | Viewed by 8945 | Submission Open

Keywords: reproductive immunology; immune regulation; fertility; pregnancy; immunocontraception

(This special issue belongs to the Section Molecular Immunology)

The Role of Cytokines in Health and Diseases

edited by Hung-Jen Liu

submission deadline 20 Apr 2026 | 5 articles | Viewed by 8868 | Submission Open

Keywords: cytokines; immune regulation; disease management; signaling pathways; translational research; clinical applications

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Chloroplasts and Mitochondria: Key Organelles for Sustainable Agriculture

edited by

Nunzia Scotti

submission deadline 20 Apr 2026 | 4 articles | Viewed by 8772 | Submission Open

Keywords: ‘ omics’ ; photosynthesis; energy production; crops; climate change; sustainable agriculture; stress response; inter-organelle crosstalk; signaling networks; genetic engineering

(This special issue belongs to the Section Molecular Plant Sciences)

The Role of Protein Kinase in Health and Diseases

edited by

Manuela Loi

submission deadline 20 Apr 2026 | 4 articles | Viewed by 8446 | Submission Open

Keywords: protein kinases; phosphorylation; cancer; neurological disorder; targeted therapies; metabolic diseases

(This special issue belongs to the Section Biochemistry)

Pathophysiology and Pharmacology in Psychiatry

edited by

Galila Agam

submission deadline 20 Apr 2026 | 3 articles | Viewed by 8255 | Submission Open

Keywords: psychiatric disorders; mental health; pathophysiology; neuropsychopharmacology; brain

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Advances in Blood Disorders

edited by

Tadej Pajič

submission deadline 20 Apr 2026 | 4 articles | Viewed by 8248 | Submission Open

Keywords: acquired and inherited blood disorders; diagnostic; prognostic and predictive biomarkers; molecular profiling; molecular monitoring; targeted therapy; leukaemia; lymphoma; disorders of haemostasis and thrombosis; genetic predisposition; germline pathogenic variants; molecular mechanisms; (epi)genomics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Gynecologic Oncology: Molecular Mechanisms and Therapies

edited by

Angel Yordanov

submission deadline 20 Apr 2026 | 4 articles | Viewed by 8245 | Submission Open

Keywords: cervical cancer; endometrial cancer; ovarian cancer; vulvar cancer; carcinogenesis; microinvairment; immunotherapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Progress in Molecular Mechanisms of Sperm Metabolism and Development

edited by Karl Kerns

submission deadline 20 Apr 2026 | 3 articles | Viewed by 7994 | Submission Open

Keywords: sperm development ; germ cell proliferation ; sperm cell metabolism ; seminal fluid biochemical composition ; spermatogenesis ; epididymal maturation ; sperm capacitation ; oocyte activation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Nanofibrous Biomaterials for Biomedicine and Medical Applications

edited by Jong-Young Kwak

submission deadline 20 Apr 2026 | 3 articles | Viewed by 7447 | Submission Open

Keywords: nanofibers; biomaterials; 3D scaffold; 3D cell culture; tissue engineering; drug release

(This special issue belongs to the Section Materials Science)

Molecular Insights into Antioxidant and Anti-Inflammatory Properties of Bioactive Compounds

edited by

Gang Ye

submission deadline 20 Apr 2026 | 2 articles | Viewed by 7139 | Submission Open

Keywords: antioxidant; anti-inflammatory; bioactive compounds; artificial intelligence; multiomics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advanced Therapy Using Human Mesenchymal Stem Cells (MSCs) and MSC Extracellular Vesicles

edited by Tong Ming Liu and Xiaoman Luo

submission deadline 20 Apr 2026 | 3 articles | Viewed by 7098 | Submission Open

Keywords: mesenchymal stem cells; extracellular vesicles; MSCs; MSC-EVs; regenerative medicine

(This special issue belongs to the Section Molecular Biology)

Advances in Epigenetics of Mental Disorders

edited by

Claudio Brasso

submission deadline 20 Apr 2026 | 1 articles | Viewed by 7052 | Submission Open

Keywords: mental disorders; epigenetic; epigenomic; gene– environment interactions

(This special issue belongs to the Section Molecular Neurobiology)

Mitochondrial Functions and Dynamics

edited by

Raffaella Isola

submission deadline 20 Apr 2026 | 1 articles | Viewed by 6926 | Submission Open

Keywords: bioenergetics; mitochondrial biogenesis; mitochondrial morphology; apoptosis; mitophagy; reactive oxygen species; calcium homeostasis; cardiovascular diseases; neurodegenerative diseases; in vitro; cellular; and animal models; myopathies; mitochondria and immune system

(This special issue belongs to the Section Molecular Biology)

Microbiome Modulation Through Probiotics: Molecular Insights and Therapeutic Applications

edited by

Satya Prakash

submission deadline 20 Apr 2026 | 2 articles | Viewed by 6858 | Submission Open

Keywords: live bacterial cells; prebiotic agents; synbiotic formulations; probiotic formulations; microbial dysbiosis; inflammation; oxidative stress; host– microbe interactions

(This special issue belongs to the Section Molecular Microbiology)

Genetic and Epigenetic Analyses in Cancer

edited by Jing Gong

submission deadline 20 Apr 2026 | 6 articles | Viewed by 6724 | Submission Open

Keywords: epigenetics; genetic mutations; chromosomal instability; DNA methylation; histone modifications; non-coding rnas; multi-omics; transcriptomics; proteomics; drug resistance in cancer; cancer biomarkers; therapeutic targets in cancer

(This special issue belongs to the Section Molecular Genetics and Genomics)

Newer Pharmacological Treatment Concepts for Patients with Acute Coronary Syndrome

edited by

Dimitrios Patoulias

submission deadline 20 Apr 2026 | 2 articles | Viewed by 6597 | Submission Open

Keywords: acute coronary syndrome (ACS); molecular studies; antiplatelet; anticoagulant drugs; lipid-lowering therapies

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Signalling in Multitrophic Systems Involving Arthropods

edited by

Francesca Barbero

submission deadline 20 Apr 2026 | 4 articles | Viewed by 6584 | Submission Open

Keywords: insects; plants; microorganisms; communication; symbioses; eavesdropping

(This special issue belongs to the Section Molecular Biology)

The Role of Glycans in Immune Regulation

edited by Senlian Hong

submission deadline 20 Apr 2026 | 2 articles | Viewed by 6443 | Submission Open

Keywords: glycoimmunology; glycotherapy; vaccines; glycan synthesis; immune tolerance

(This special issue belongs to the Section Molecular Immunology)

Protein Folding, Misfolding, and Related Diseases

edited by

Ludmilla Morozova-Roche

submission deadline 20 Apr 2026 | 3 articles | Viewed by 6323 | Submission Open

Keywords: protein folding; misfolding; amyloid; neurodegenerative diseases; chaperons; mechanisms; regulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Molecular Breeding for Drought and Salt Stress Tolerance in Crops: 2nd Edition

edited by

Zhaoshi Xu

submission deadline 20 Apr 2026 | 4 articles | Viewed by 6322 | Submission Open

Keywords: drought; salt; heat; cold; gene regulation; genomic research; multiomics; epigenetics; stress signal transduction

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Antibody–Drug Conjugates

edited by Bing Sun

submission deadline 20 Apr 2026 | 1 articles | Viewed by 6319 | Submission Open

Keywords: antibody– drug conjugate (ADC); cancer treatment; non-oncology indications; antibody selection; payload; linker; conjugation chemistry

(This special issue belongs to the Section Molecular Immunology)

Wheat Genetics and Genomics: 3rd Edition

edited by

Xiaojun Nie

submission deadline 20 Apr 2026 | 4 articles | Viewed by 6270 | Submission Open

Keywords: wheat; genetics; molecular breeding; genome variation; multiomics

(This special issue belongs to the Section Molecular Plant Sciences)

Recent Research of Phytochemicals in Health and Disease

edited by Sachiko Koyama,

Thomas Heinbockel

and

Vonnie Shields

submission deadline 20 Apr 2026 | 2 articles | Viewed by 6260 | Submission Open

Keywords: phytochemicals with bioactive properties; health; brain function; regeneration; wound healing; treatment; and prevention of diseases; delivery routes and delivery methods; formulation of phytochemicals to overcome their hydrophobic nature and enhance their stability; drugs; supplements to drugs; and supplements for health maintenance; nourishment and phytochemicals; drug side effects; COVID-19

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecules and Mechanisms of Oxidative Stress Relevant in the Pathophysiology of Diseases

edited by

Cinzia Signorini

submission deadline 20 Apr 2026 | 5 articles | Viewed by 6212 | Submission Open

Keywords: redox-active iron; reactive oxygen species; antioxidants; oxidative damage; biomarkers; degenerative disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Understanding of Allergen Exposome

edited by

Fernando Pineda

and

Ruperto Gonzalez-Perez

submission deadline 20 Apr 2026 | 4 articles | Viewed by 6129 | Submission Open

Keywords: allergen exposome; profile allergen exposures; climatic change; airborne allergens; molecular triggers; microbial allergens

(This special issue belongs to the Section Molecular Immunology)

Stem Cells in Health and Disease: 3rd Edition

edited by

Maja Ludvigsen

submission deadline 20 Apr 2026 | 4 articles | Viewed by 5914 | Submission Open

Keywords: stem cell regulation; differentiation; pluripotency; reprogramming; stem cell therapy; cancer stem cell/tumor-initiating cell; therapy resistance; regenerative medicine; metabolic plasticity

(This special issue belongs to the Section Molecular Biology)

Natural Medicines and Functional Foods for Human Health

edited by Qiong Wang

submission deadline 20 Apr 2026 | 2 articles | Viewed by 5781 | Submission Open

Keywords: functional food; natural medicine; traditional Chinese medicine; memory; depression; dementia; Alzheimer’ s disease; Parkinson’ s disease; space medicine; sleeplessness; anti-inflammation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Genetic, Epigenetic and Microbiota Molecular Insights for Crop Resilience to Abiotic Stress

edited by

Aliki Kapazoglou

submission deadline 20 Apr 2026 | 2 articles | Viewed by 5635 | Submission Open

Keywords: abiotic stress; tolerance; crop resilience; crop sustainability; environmental conditions; climate change; gene regulation; epigenetic mechanisms; microbiota communities; microbiome

(This special issue belongs to the Section Molecular Plant Sciences)

Musculoskeletal Diseases: Advances in Molecular Mechanisms and Therapeutic Approaches

edited by

Jung Eun Kim

submission deadline 20 Apr 2026 | 3 articles | Viewed by 5517 | Submission Open

Keywords: bone; muscle; tendon; cartilage; osteoporosis; sarcopenia; tendinopathy; osteoarthritis; musculoskeletal pathophysiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Approaches for Tissue Repair and Tissue Regeneration

edited by Srinivas Madduri

submission deadline 20 Apr 2026 | 2 articles | Viewed by 5363 | Submission Open

Keywords: injuries; tissue repair; tissue regeneration; tissue engineering; tissue bioengineering; bioactive biomaterial; cell and gene therapeutics; hydrogel; immune modulation

(This special issue belongs to the Section Molecular Biology)

Natural Products for Neuroprotection and Neurodegeneration

edited by

Patrycja Kupnicka

submission deadline 20 Apr 2026 | 4 articles | Viewed by 5304 | Submission Open

Keywords: natural products; bioactive compounds; neuroprotection; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Plant Breeding and Genetics: New Findings and Perspectives

edited by

Andrés J. Cortés

submission deadline 20 Apr 2026 | 7 articles | Viewed by 5220 | Submission Open

Keywords: quantitative genetics; classical plant breeding; marker-assisted selection; genomic selection; speed breeding; gene editing and biotechnology

(This special issue belongs to the Section Molecular Plant Sciences)

Natural Active Substances in Human Diseases

edited by

Hyeung-Jin Jang

submission deadline 20 Apr 2026 | 2 articles | Viewed by 5176 | Submission Open

Keywords: natural active substances; bioactive compounds; molecular mechanisms; traditional medicine; metabolic disorders; inflammatory diseases; neurodegenerative diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Germline Stem Cells: New Insights

edited by

Thomas Skutella

submission deadline 20 Apr 2026 | 1 articles | Viewed by 5170 | Submission Open

Keywords: signaling pathway; spermatogonia development; oocyte development; microarray analysis; single-cell sequencing; epigenetic mechanisms; germline stem cell

(This special issue belongs to the Section Molecular Biology)

Micro-Nano Materials for Drug Delivery and Disease Treatment

edited by

Maoquan Chu

submission deadline 20 Apr 2026 | 3 articles | Viewed by 5099 | Submission Open

Keywords: biomaterials; nanoparticle-loaded bacterial cells; nanoparticle-loaded cells; bioimaging and diagnosis; therapy

(This special issue belongs to the Section Molecular Nanoscience)

Tea and Health

edited by

Mingzhe Yao

and

Kang Wei

submission deadline 20 Apr 2026 | 3 articles | Viewed by 5097 | Submission Open

Keywords: tea plant (Camellia sinensis); molecular mechanism; human health; nutrients; quality-related component; genes identification

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Plant Genomics and Genetics: 3rd Edition

edited by

Hengling Wei

submission deadline 20 Apr 2026 | 6 articles | Viewed by 5093 | Submission Open

Keywords: plant genomics; plant genetics; abiotic stresses; salt resistance; genome; next-generation sequencing

(This special issue belongs to the Section Molecular Genetics and Genomics)

Type 1 Diabetes: Molecular Mechanisms and Therapeutic Approach

edited by Preeti Chhabra

submission deadline 20 Apr 2026 | 2 articles | Viewed by 5061 | Submission Open

Keywords: type 1 diabetes; microbiome; proteomics; immunotherapy; β -cell replacement; single-cell sequencing; stem cells; gene editing technologies; tolerance

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Blood–Brain Barrier and Neuroprotection

edited by Aruna Sharma and Hari Shanker Sharma

submission deadline 20 Apr 2026 | 3 articles | Viewed by 5024 | Submission Open

Keywords: blood– brain barrier; neurodegenerative diseases; nanoformulations; drug development; delivery systems

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Genetics, Breeding, and Multi-Omics Approaches in Rice Research

edited by

Zakaria Prodhan

submission deadline 20 Apr 2026 | 4 articles | Viewed by 4953 | Submission Open

Keywords: rice genetics and breeding; molecular breeding of rice; rice genomics and proteomics; genes related to abiotic stress tolerance in rice; molecular biology and multi-omics in rice research

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Microbiology in the Omics Era: Genomics, Metagenomics and Computational Insights

edited by

Fei Liu

submission deadline 20 Apr 2026 | 2 articles | Viewed by 4933 | Submission Open

Keywords: microbial genomics; metagenomics; computational biology; antimicrobial resistance; host– microbe interactions; multi-omics integration; bioinformatics tools; machine learning in microbiology

(This special issue belongs to the Section Molecular Microbiology)

Molecular Targets and Immunotherapy for Autoimmune Diseases

edited by

Neetu Srivastava

submission deadline 20 Apr 2026 | 1 articles | Viewed by 4862 | Submission Open

Keywords: autoimmunity; autoimmune diseases; immunotherapy; signaling pathway; molecular targets; antibody; T cells; B cells

(This special issue belongs to the Section Molecular Immunology)

Molecular Perspectives in Nanomedicine

edited by

Stefano Leporatti

submission deadline 20 Apr 2026 | 1 articles | Viewed by 4805 | Submission Open

Keywords: nanomedicine; drug delivery; nano therapy and diagnostics; micro and nanofluidic tools; hybrid nanoparticles; CAR-T nanotechnologies

(This special issue belongs to the Section Molecular Nanoscience)

Isolation and Biological Activities of Natural Products: Focus on Molecular Advance

edited by Pedro Ferreira and

Patricia Reboredo-Rodríguez

submission deadline 20 Apr 2026 | 4 articles | Viewed by 4656 | Submission Open

Keywords: natural products; sustainable isolation; biological activities; therapeutic potential; structure-activity relationships; omics technologies; bioavailability; functional foods; green chemistry; molecular docking

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Techniques and Strategies in Drug Design and Discovery, 3rd Edition

edited by