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Gynecologic Oncology: Molecular Mechanisms and Therapies

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 October 2025 | Viewed by 526

Special Issue Editor


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Guest Editor
Department of Gynecological Oncology, Medical University Pleven, 5800 Pleven, Bulgaria
Interests: cervical cancer; endometrial cancer; treatment

Special Issue Information

Dear Colleagues,

This is our first Special Issue of the topic “Gynecologic Oncology: Molecular Mechanisms and Therapies”.

Gynecological cancers with major clinical significance and incidence that arise in the female reproductive organs include endometrial, cervical, ovarian, vaginal, and vulval cancers, along with gestational trophoblastic disease. Gynecological cancers implicate an important public health issue, with a spread among women of all ages. The disease is sometimes diagnosed at a late stage due to a lack of notice of specific symptoms, scarce screening, and sometimes misdiagnosis. Late diagnosis, together with limited treatment options for the advanced stages of cancer, play a pivotal role in the high mortality rate, and we are all aware of the necessity for further advancement in this sphere.

Recently, molecular mechanisms that influence the biological pathways involved in different cancers and regulate cancer-relevant processes have been demonstrated. The emergence of new genetic techniques has improved the understanding of the mechanisms essential for pathology. Such molecules and their interactions in the pathogenesis of gynecological malignancies have considerably ameliorated the management of the diagnosis and personalized treatment for different forms of cancer.

We are inviting submissions of original research articles, reviews, and communication on topics relevant to any aspect of gynecological cancer: molecular mechanisms in the pathogenesis of gynecological malignancies, diagnosis, and treatment for different forms of gynecological cancers.

Dr. Angel Yordanov
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Keywords

  • cervical cancer
  • endometrial cancer
  • ovarian cancer
  • vulvar cancer
  • carcinogenesis
  • microinvairment
  • immunotherapy

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Published Papers (1 paper)

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Research

17 pages, 2362 KiB  
Article
Gemcitabine–Doxorubicin Combination Polymer-Drug Conjugate Prepared by SPAAC Click Chemistry: In Vitro Characterization
by Omotola D. Gbadegesin and Simeon K. Adesina
Int. J. Mol. Sci. 2025, 26(6), 2798; https://doi.org/10.3390/ijms26062798 - 20 Mar 2025
Viewed by 307
Abstract
Combination chemotherapy is preferred for the treatment of ovarian cancer (OC). Systemic toxicity, however, frequently limits the effectiveness of treatment. Polymer–drug conjugates (PDCs) containing synergistic combinations of chemotherapeutic drugs can be used to enhance therapeutic efficacy. We earlier reported the use of a [...] Read more.
Combination chemotherapy is preferred for the treatment of ovarian cancer (OC). Systemic toxicity, however, frequently limits the effectiveness of treatment. Polymer–drug conjugates (PDCs) containing synergistic combinations of chemotherapeutic drugs can be used to enhance therapeutic efficacy. We earlier reported the use of a strain-promoted [3 + 2] azide–alkyne cycloaddition (SPAAC)-mediated polymerization method for the preparation of single-drug PDCs. In this report, the polymerization method was used to prepare gemcitabine–doxorubicin combination PDC. The PDC had a high molecular weight (Mw 1360 kDa) and high drug loading (36.6% weight gemcitabine; 7.0% weight doxorubicin). It demonstrated cathepsin B-catalyzed drug release at pH 5.0 and good hydrolytic stability at pH 7.4. The combination index analysis of free gemcitabine and free doxorubicin showed a concentration-dependent synergism (combination index < 1) in OVCAR-3 OC cells. Compared to individual gemcitabine PDC (the concentration that inhibited 50% growth (IC50) > 50 µg/mL) and doxorubicin PDC (IC50 = 1.79 µg/mL), the combination PDC (IC50 = 0.99 µg/mL) showed greater cytotoxicity against OVCAR-3 cells and was less cytotoxic than the equivalent free drug combination (IC50 = 0.11 µg/mL). The gemcitabine–doxorubicin combination PDC is promising for targeted combination chemotherapy of OC. Full article
(This article belongs to the Special Issue Gynecologic Oncology: Molecular Mechanisms and Therapies)
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