Therapeutics and Pathophysiology of Cognitive Dysfunction
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 November 2025 | Viewed by 834
Special Issue Editor
Interests: neurodegenerative diseases; therapeutic strategies; cognitive function; cellular and transcriptomic alterations
Special Issue Information
Dear Colleagues,
Cognitive dysfunction typified by impaired attention, learning, memory, and problem-solving skills is generally referred to as ‘brain fog’ associated with neuroimmune imbalance in multiple neurodegenerative diseases, malignancies, and associated metabolic conditions. In neuropsychiatric diseases, cognitive impairments are associated with suicidal tendencies, which are predictive of depression relapse and are frequently retained in individuals in remission from depressive episodes. Nonetheless, cognitive dysfunction has a significant effect on quality of life but is clinically underreported, likely due to its limitation in detection at subclinical levels. Therefore, strategies aimed at enhancing the detection threshold of cognitive impairments and attenuating these deficits through modulating the underlying pathologies, such as diminishing neuroinflammation, enhancing neurogenesis, and metabolic fitness have garnered significant attention. The possibility of non-pharmacological methods like music therapy and pharmaceutical methods, particularly those that target the GABAergic system, to alleviate cognitive symptoms has recently been investigated. To increase the quality of life, however, this domain requires more attention.
Dr. Maheedhar Kodali
Guest Editor
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Keywords
- cognition
- neurologic diseases
- neuroinflammation
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