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Nanofibrous Biomaterials for Biomedicine and Medical Applications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 20 September 2025 | Viewed by 1617

Special Issue Editor


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Guest Editor
Department of Pharmacology, School of Medicine & Three-Dimensional Immune System Imaging Core Center, Ajou University, Suwon 16499, Gyeonggi-do, Republic of Korea
Interests: 3D cell culture and tissue engineering; immune microenvironment
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Special Issue Information

Dear Colleagues,

Creating an ideal biomaterial for replacing the extracellular matrix (ECM) in 3D cell cultures and tissue engineering provides in vivo-like ECM protein–cell interactions. Cell–ECM interactions are crucial for maintaining cell adhesion, growth, and other functions. Nanofibrous biomaterials exhibit the physical and biological characteristics of the ECM. Recently, 3D cell cultures and tissue engineering of primary cells from tissues in experimental animal models and patients are being investigated to replace stem-cell-derived organoids. This Special Issue aims to define some suitable biomaterials for the construction of 3D cell culture systems and engineered tissues for modeling a specific disease. Platform technology using synthetic and natural biopolymers can be useful in drug screening and delivery, cancer and stem cell research, toxicity tests, and regenerative medicine. Suitable topics include, but are not limited to, the following: the synthesis, characterization, functionalization, and processing of nanofibrous biomaterials and composites for different biomedical applications; polymers for the release of drug and bioactive materials; synthetic and natural biomaterials for tissue replacement and 3D cell cultures; nanofibrous biomaterials combined with cell printing; and nanofibrous materials for drug screening.

Dr. Jong-Young Kwak
Guest Editor

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Keywords

  • nanofibers
  • biomaterials
  • 3D scaffold
  • 3D cell culture
  • tissue engineering
  • drug release

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Published Papers (1 paper)

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Review

40 pages, 8550 KiB  
Review
Current Paradigms and Future Challenges in Harnessing Nanocellulose for Advanced Applications in Tissue Engineering: A Critical State-of-the-Art Review for Biomedicine
by Mudasir A. Dar, Rongrong Xie, Jun Liu, Shehbaz Ali, Kiran D. Pawar, I Made Sudiana and Jianzhong Sun
Int. J. Mol. Sci. 2025, 26(4), 1449; https://doi.org/10.3390/ijms26041449 - 9 Feb 2025
Viewed by 1496
Abstract
Nanocellulose-based biomaterials are at the forefront of biomedicine, presenting innovative solutions to longstanding challenges in tissue engineering and wound repair. These advanced materials demonstrate enhanced mechanical properties and improved biocompatibility while allowing for precise tuning of drug release profiles. Recent progress in the [...] Read more.
Nanocellulose-based biomaterials are at the forefront of biomedicine, presenting innovative solutions to longstanding challenges in tissue engineering and wound repair. These advanced materials demonstrate enhanced mechanical properties and improved biocompatibility while allowing for precise tuning of drug release profiles. Recent progress in the design, fabrication, and characterization of these biomaterials underscores their transformative potential in biomedicine. Researchers are employing strategic methodologies to investigate and characterize the structure and functionality of nanocellulose in tissue engineering and wound repair. In tissue engineering, nanocellulose-based scaffolds offer transformative opportunities to replicate the complexities of native tissues, facilitating the study of drug effects on the metabolism, vascularization, and cellular behavior in engineered liver, adipose, and tumor models. Concurrently, nanocellulose has gained recognition as an advanced wound dressing material, leveraging its ability to deliver therapeutic agents via precise topical, transdermal, and systemic pathways while simultaneously promoting cellular proliferation and tissue regeneration. The inherent transparency of nanocellulose provides a unique advantage, enabling real-time monitoring of wound healing progress. Despite these advancements, significant challenges remain in the large-scale production, reproducibility, and commercial viability of nanocellulose-based biomaterials. This review not only underscores these hurdles but also outlines strategic directions for future research, including the need for bioengineering of nanocellulose-based wound dressings with scalable production and the incorporation of novel functionalities for clinical translation. By addressing these key challenges, nanocellulose has the potential to redefine biomedical material design and offer transformative solutions for unmet clinical needs in tissue engineering and beyond. Full article
(This article belongs to the Special Issue Nanofibrous Biomaterials for Biomedicine and Medical Applications)
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