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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Circulating Non-Coding RNAs as Diagnostic and Prognostic Markers of Human Diseases: 3rd Edition

edited by

Kyriacos N. Felekkis

and

Christos Papaneophytou

submission deadline 20 Feb 2026 | 6 articles | Viewed by 5296 | Submission Open

Keywords: miRNA; gene expression regulation; diagnosis; prognosis; therapy; biomarkers

(This special issue belongs to the Section Biochemistry)

Molecular and Neuromuscular Mechanisms in Skeletal Muscle Aging, 2nd Edition

edited by

Rosa Mancinelli

submission deadline 20 Feb 2026 | 5 articles | Viewed by 5247 | Submission Open

Keywords: aging; sarcopenia; neuromuscular junction; molecular muscle modifications; myokines

(This special issue belongs to the Section Molecular Biology)

Advancing Climate Resilience in Horticultural Crops Through Omics Technologies

edited by

Yonghua Qin

and

Guibing Hu

submission deadline 20 Feb 2026 | 4 articles | Viewed by 5190 | Submission Open

Keywords: horticultural crops; climate change; omics technologies; stress responses; abiotic stresses; food security; agricultural sustainability; genomics; transcriptomic; proteomics

(This special issue belongs to the Section Molecular Plant Sciences)

Exploring the Molecular, Physiological, and Biochemical Responses of Crops to Stress

edited by

Hakim Manghwar

submission deadline 20 Feb 2026 | 4 articles | Viewed by 5180 | Submission Open

Keywords: molecular signaling pathways in response to biotic stresses (e.g.; bacteria; viruses; fungi; and insects); plant responses to abiotic stresses (e.g.; salinity; cold; drought; waterlogging; heat; heavy metals; and UV light); mechanisms of stress adaptation and tolerance; stress adaptation

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research Progress of Cereal Crop Disease Resistance

edited by

Hongjie Li

and Zhenqi Su

submission deadline 20 Feb 2026 | 3 articles | Viewed by 5172 | Submission Open

Keywords: cereal crops; disease resistance; resistance genes; breeding; molecular marker-assisted selection; molecular regulatory network

(This special issue belongs to the Section Molecular Plant Sciences)

The Interplay Between Cellular Stress and Human Diseases

edited by

Daniele Vergara

submission deadline 20 Feb 2026 | 3 articles | Viewed by 4987 | Submission Open

Keywords: cellular stress; DNA damage response; unfolded protein response; autophagy; senescence; apoptosis; repair pathways; mitochondrial stress; nutrient deprivation; oxidative stress

(This special issue belongs to the Section Biochemistry)

Molecular Pharmacology of Medicinal Plants

edited by

Bruno Eto

submission deadline 20 Feb 2026 | 2 articles | Viewed by 4914 | Submission Open

Keywords: medicinal plants; drug development; molecular pharmacology; clinical phytopharmacology

(This special issue belongs to the Section Molecular Pharmacology)

Recent Advances in Urological Cancer

edited by Andrea Zivi and Sara Merler

submission deadline 20 Feb 2026 | 1 articles | Viewed by 4907 | Submission Open

Keywords: genitourinary oncology; urologic surgery; urologic radiotherapy innovations; translational research; emerging therapies

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Treatment Strategies of Myocardial Infarction

edited by Abdul-Majeed Salmasi

submission deadline 20 Feb 2026 | 2 articles | Viewed by 4903 | Submission Open

Keywords: myocardial infarction; genetics; molecular biology; chromosomes; genes; atherosclerosis; coronary artery disease; risk factors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Feature Papers in ‘Physical Chemistry and Chemical Physics’: Fourth Edition

edited by

Dongho Kim

submission deadline 20 Feb 2026 | 8 articles | Viewed by 4841 | Submission Open

Keywords: heterogeneous structures; alignment and surface phenomena; quantum theory; mathematical physics; statistical and classical mechanics; molecular structure; chemical kinetics; laser physics; dynamics; kinetics; photochemistry; spectroscopy; exciton dynamics; statistical mechanics; thermodynamics; electrochemistry; catalysis; surface science; quantum mechanics; theoretical developments; fundamental aspects of catalysis; solar energy conversion; polymer dynamics

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Biosynthesis of Phytochemicals and Their Applications in Novel Drug Lead Development

edited by

Piotr Szymczyk

submission deadline 20 Feb 2026 | 4 articles | Viewed by 4825 | Submission Open

Keywords: biosynthesis of phytochemicals in plants; phytochemical isolation; phytochemical structure; animal and human protein targets of phytochemicals; chemical derivatives of phytochemicals

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Research on Type 1 Diabetes and Its Complications: 2nd Edition

edited by

Jolanta Neubauer-Geryk

submission deadline 20 Feb 2026 | 5 articles | Viewed by 4764 | Submission Open

Keywords: type 1 diabetes mellitus; diabetic microangiopathy; diabetic macroangiopathy; continuous glucose monitoring; experimental diabetic models; biomarkers; endothelium dysfunction; diabetes-related diseases; comorbidities; pregnancy; pathophysiology; metabolic syndrome; treatment; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Autoimmunity in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder

edited by Yang Mao-Draayer

submission deadline 20 Feb 2026 | 1 articles | Viewed by 4689 | Submission Open

Keywords: multiple sclerosis (MS); neuromyelitis optica spectrum disorder (NMOSD); myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD); immunomodulatory; neuroprotection; neuroregeneration; biomarker; imaging

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Diagnosis in Cardiovascular Diseases

edited by Calogera Pisano,

Carmela Rita Balistreri

and Giuseppe Raffa

submission deadline 20 Feb 2026 | 4 articles | Viewed by 4687 | Submission Open

Keywords: cardiac diseases; molecular diagnosis; aortopathy; aneurysm; dissection; heart failure

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanism of Extracellular Vesicles in Human Diseases

edited by Eszter Ágnes Tóth

submission deadline 20 Feb 2026 | 1 articles | Viewed by 4673 | Submission Open

Keywords: extracellular vesicles; intercellular communication; disease pathophysiology; biomarkers; nanoscience; biomolecular interactions

(This special issue belongs to the Section Molecular Biology)

Research on Gene Mutations in Cancer and Chronic Diseases

edited by Adam Szpechciński

submission deadline 20 Feb 2026 | 2 articles | Viewed by 4625 | Submission Open

Keywords: germline and somatic mutation; pathogenesis of cancer and chronic diseases; molecular techniques for gene mutation detection; biomarkers; molecular diagnostics; bioinformatics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Sperm Oxidative Stress and Male Infertility

edited by

Kamil Gill

submission deadline 20 Feb 2026 | 3 articles | Viewed by 4584 | Submission Open

Keywords: oxidative stress; antioxidant system; free radical scavengers; sperm DNA oxidation; sperm DNA fragmentatio; antioxidant therapy; male infertility; male oxidative stress infertility

(This special issue belongs to the Section Molecular Biology)

Essential Molecules in Life: Regulation, Defense, and Longevity, 2nd Edition

edited by

Eva E. Rufino Palomares

Amalia Pérez-Jiménez

and

José Antonio Lupiáñez

submission deadline 20 Feb 2026 | 2 articles | Viewed by 4583 | Submission Open

Keywords: glucose metabolism and its regulation; enzimology and kinetics; metabolism and evolution; cell growth; protein synthesis and degradation; cell proliferation and apoptosis; cancer; metastasis and angiogenesis; oxidative stress; genomic; proteomic and metab

(This special issue belongs to the Section Molecular Immunology)

Non-Coding RNA in Physiology and Pathophysiology: Second Edition

edited by Maria Rosaria Tumolo

submission deadline 20 Feb 2026 | 3 articles | Viewed by 4492 | Submission Open

Keywords: microRNA; long non-coding RNA; circular RNA; epigenetics; musculoskeletal pain; cardiovascular disease; metabolic disease; nervous system disorders; cancer; aging

(This special issue belongs to the Section Molecular Biology)

Advanced Research on Enzymes in Biocatalysis

edited by

Simona Varriale

Samuel De Visser

and

Salvatore Fusco

submission deadline 20 Feb 2026 | 6 articles | Viewed by 4442 | Submission Open

Keywords: biocatalysis; bioprocess; enzyme immobilization; enzyme production; response surface methodology (RSM); enzymatic-assisted extraction; enzymatic-catalyzed synthesis; enzyme modelling; bioreactor; bioconversion; cascade biocatalysis; enzymatic kinetic; enzyme engineering; ultrasound-assisted enzymatic reaction; directed evolution; machine learning-assisted enzyme engineering; waste-to-value bioprocesses

(This special issue belongs to the Section Biochemistry)

Advancements in Hematology: Molecular Biology and Targeted Therapies

edited by Fabio Stagno and

Stefania Stella

submission deadline 20 Feb 2026 | 5 articles | Viewed by 4412 | Submission Open

Keywords: hematological disorders; leukemia; lymphoma; anemia; blood malignancies; targeted therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Roles of Lipid Rafts in the Regulation of Cellular Processes and Diseases

edited by

Kohji Kasahara

submission deadline 20 Feb 2026 | 1 articles | Viewed by 4376 | Submission Open

Keywords: lipid rafts; glycosphingolipid; ganglioside; sphingomyelin; cholesterol; GPI-anchored proteins; caveolae; detergent-resistant membrane; signal transduction; disease

(This special issue belongs to the Section Biochemistry)

Recent Research of Nanomaterials in Molecular Science: 2nd Edition

edited by

Giovanna Iezzi

submission deadline 20 Feb 2026 | 4 articles | Viewed by 4291 | Submission Open

Keywords: nanomaterials; medical research; synthesis and characterization; molecular formula; molecular dynamics; molecular imaging; cell signaling; cellular metabolism; tissue regeneration; biocompatibility; molecular biology; nanomedicine; functional nanomaterials; drug and gene delivery; tissue engineering; cancer therapy

(This special issue belongs to the Section Molecular Nanoscience)

Artificial Intelligence and Computer-Aided Design: Molecular Simulation Technology in Exploring Bioactive Compounds for Health Promotion

edited by

Baojun Xu

submission deadline 20 Feb 2026 | 3 articles | Viewed by 4242 | Submission Open

Keywords: molecular simulation; bioactive compounds; molecular docking; molecular dynamics; quantum mechanics; functional mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Marine Natural Compounds: Biotechnological Potential and Pharmacological Targets

edited by

Elena Leychenko

submission deadline 20 Feb 2026 | 3 articles | Viewed by 4132 | Submission Open

Keywords: marine natural compounds; structure elucidation; biologic activity; structure-activity relationships; biosynthesis; biotechnology; pharmacology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Research in Asthma and Allergy

edited by

Sylwia Smolińska

submission deadline 20 Feb 2026 | 3 articles | Viewed by 4087 | Submission Open

Keywords: asthma; allergy; molecular mechanisms; exposome; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Osteoimmunology: Interactions of the Bone and Immune System

edited by

Galliera Emanuela Rita

submission deadline 20 Feb 2026 | 1 articles | Viewed by 4087 | Submission Open

Keywords: osteoimmunology markers; bone infection; inflammation and bone; immune response and bone; diagnostic and prognostic markers; bone remodeling; osteoclasts; immune-mediated bone diseases; bone– immune interface

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms of Neutrophil Extracellular Traps (Nets) in Human Diseases

edited by Eisuke F. Sato

submission deadline 20 Feb 2026 | 1 articles | Viewed by 4001 | Submission Open

Keywords: neutrophil extracellular traps (NETs); neutrophils; inflammation; autoimmune diseases; cardiovascular diseases; tumor metastasis; thrombosis; molecular mechanisms; disease progression; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Metabolic Engineering and Synthetic Biology of Yeasts

edited by

Justyna Ruchała

submission deadline 20 Feb 2026 | 1 articles | Viewed by 3936 | Submission Open

Keywords: yeast metabolic engineering; synthetic biology; CRISPR-Cas9; metabolic pathways; bio-based chemicals; bioprocess engineering; yeast strain optimization; industrial biotechnology

(This special issue belongs to the Section Molecular Microbiology)

Gut Microbiome Stability in Health and Disease

edited by

Tomomi Kuwahara

and Yoshitohi Ogura

submission deadline 20 Feb 2026 | 3 articles | Viewed by 3919 | Submission Open

Keywords: gut microbiome stability; immune system; epithelial cell; mucous layer; antibiotics; diet; inflammatory bowel disease; gut microbial metabolites

(This special issue belongs to the Section Molecular Microbiology)

Omics-Driven Unveiling of the Structure and Function of Nanoparticles

edited by

Elva Morretta

submission deadline 20 Feb 2026 | 3 articles | Viewed by 3900 | Submission Open

Keywords: nanoparticles; nanotechnology; drug delivery; protein corona; proteomics; nano-proteomics; matabolomics; lipidomics

(This special issue belongs to the Section Molecular Biophysics)

Molecular Research of Gut Microbiota in Human Health and Diseases

edited by

Juan Francisco Martínez-Blanch

submission deadline 20 Feb 2026 | 2 articles | Viewed by 3835 | Submission Open

Keywords: gut microbiota; gut metabolites; gastroenterology; microbiology; inflammation; human diseases

(This special issue belongs to the Section Molecular Microbiology)

Immune Mechanisms and Biomarkers in Systemic Lupus Erythematosus—Second Edition

edited by

Ioannis Parodis

submission deadline 20 Feb 2026 | 2 articles | Viewed by 3786 | Submission Open

Keywords: systemic lupus erythematosus; lupus nephritis; neuropsychiatric lupus; autoimmunity; biomarkers; B lymphocyte; interferons

(This special issue belongs to the Section Molecular Immunology)

Advances in Stem Cell-Based Regenerative Medicine for Renal Disorders

edited by In-Yong Kim

submission deadline 20 Feb 2026 | 1 articles | Viewed by 3763 | Submission Open

Keywords: chronic kidney disease; acute kidney injury; stem cells; regenerative medicine; stem cell therapy; cellular reprogramming; cell transplantation

(This special issue belongs to the Section Molecular Biology)

Brain-Body Interactions in Mental Disorders: Molecular Mechanisms and Therapeutics

edited by Yan-Xue Xue

submission deadline 20 Feb 2026 | 1 articles | Viewed by 3717 | Submission Open

Keywords: mental disorders; brain– body interactions; neural mechanisms; therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antimicrobial Resistology: A New Approach in the Fight Against Antimicrobial Resistance

edited by

Ziad Daoud

submission deadline 20 Feb 2026 | 2 articles | Viewed by 3696 | Submission Open

Keywords: antimicrobial resistance; resistology; ESBL; AmpC; carbapenem resistance; one health

(This special issue belongs to the Section Molecular Pharmacology)

The Extracellular Matrix in Physiopathology

edited by

Eric Huet

submission deadline 20 Feb 2026 | 3 articles | Viewed by 3530 | Submission Open

Keywords: extracellular matrix; glycosaminoglycans; matrix metalloproteinases; tissue remodeling; cell interactions; physiopathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Diagnosis and Treatment of Colorectal Cancer

edited by Steven T. Brower and Robert Pergolizzi

submission deadline 20 Feb 2026 | 3 articles | Viewed by 3517 | Submission Open

Keywords: colorectal cancer; biomarkers; epigenetics; targeted therapy; chemoresistance; personalized cancer therapy

(This special issue belongs to the Section Molecular Oncology)

Drug Therapy of Systemic Lupus Erythematosus

edited by Dionysis Nikolopoulos

submission deadline 20 Feb 2026 | 2 articles | Viewed by 3469 | Submission Open

Keywords: systemic lupus erythematosus; treatment; drugs; tailored strategies; precision medicine; biologics; cell therapy; randomized clinical trials

(This special issue belongs to the Section Molecular Pharmacology)

Cutting-Edge Innovations in Molecular and Nanoscale Engineering for Energy Applications

edited by

Mohammad R. Thalji

and

Farzaneh Mahmoudi

submission deadline 20 Feb 2026 | 2 articles | Viewed by 3442 | Submission Open

Keywords: nanostructured electrode materials; energy storage; energy conversion; energy materials

(This special issue belongs to the Section Materials Science)

Progress in the Use of Graphene and Graphene-Like Materials in Various Applications

edited by Piotr Kamedulski

submission deadline 20 Feb 2026 | 2 articles | Viewed by 3422 | Submission Open

Keywords: graphene; porous carbons; carbon-based materials; 3D graphene; graphene exfoliation; nanotubes; nanomaterials; N-rich nano-porous carbon matrixes; N-rich activated carbons; carbon molecular sieves; hybrid materials; medical applications

(This special issue belongs to the Section Materials Science)

Functional Genomics of Insects: Unraveling Genetic Mechanisms and Applications

edited by

Bin Li

submission deadline 20 Feb 2026 | 4 articles | Viewed by 3385 | Submission Open

Keywords: genomics; comparative genomics; gene regulation networks; developmental biology; metamorphosis; vector biology; insecticide resistance mechanisms; insect– plant interactions; environmental adaptation

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances in Structural and Functional Properties of G-Quadruplexes and Aptamers

edited by

Antonella Virgilio

Veronica Esposito

and

Aldo Galeone

submission deadline 20 Feb 2026 | 5 articles | Viewed by 3369 | Submission Open

Keywords: G-quadruplex structure; aptamer; DNAzyme; catalytic G-quadruplexes

(This special issue belongs to the Section Molecular Biology)

Erythrocyte Cell Death: Molecular Insights

edited by

Anton Tkachenko

submission deadline 20 Feb 2026 | 2 articles | Viewed by 3349 | Submission Open

Keywords: cell death signaling; eryptosis; erythrocyte senescence; erythrocytes; necroptosis; regulated cell death

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Osteoarthritis Pathways and Biomarker Research

edited by

Előd Ernő Nagy

submission deadline 20 Feb 2026 | 5 articles | Viewed by 3298 | Submission Open

Keywords: osteoarthritis; low-grade inflammation; cartilage chondrocyte; synovial membrane; synovial fluid; subchondral bone; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Neuroscience: Molecular Biological Insights

edited by

Palsamy Periyasamy

submission deadline 20 Feb 2026 | 1 articles | Viewed by 3280 | Submission Open

Keywords: neurodegenerative diseases; neurodevelopmental disorders; neurohiv; drug abuse; neuropharmacology; epigenetics; exosomes; inflammasomes; biomarkers; gene therapy; stem cell therapy; deep brain stimulation; Alzheimer’ s disease; Parkinson’ s disease; Huntington’ s disease; autism spectrum disorder; ADHD; dyslexia; neuroinflammation

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms and Targeted Regulation of Autoimmune Diseases

edited by

Davide Raineri

submission deadline 20 Feb 2026 | 2 articles | Viewed by 3166 | Submission Open

Keywords: autoimmunity; autoimmune diseases; multiple sclerosis; rheumatoid arthritis; lupus; type 1 diabetes; inflammatory bowel disease; biomarkers; immune cells; signaling molecules

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Forensics and the Genetic Foundations of Forensic Biology

edited by

Laura Caine

submission deadline 20 Feb 2026 | 2 articles | Viewed by 3161 | Submission Open

Keywords: molecular forensics; forensic genetics; epigenetics; biological fluid identification; forensic microbiology; sexual assault

(This special issue belongs to the Section Molecular Biology)

Skin Microbiome and Skin Health: Molecular Interactions

edited by

Terenzio Cosio

submission deadline 20 Feb 2026 | 2 articles | Viewed by 3109 | Submission Open

Keywords: skin microbiota; human disease; human health; omics; microbiota– host interactions; microbiota manipulation; microbiota; virota; inflammatory diseases; dysbiosis

(This special issue belongs to the Section Molecular Immunology)

Molecular and Cellular Aspects of Breast Cancer Metastasis

edited by

Hideki Furuya

submission deadline 20 Feb 2026 | 1 articles | Viewed by 3082 | Submission Open

Keywords: precision medicine; omics-based discovery research (genomics; proteomics; transcriptomics; and radiomics); non-invasive test; liquid biopsy; first-in-class medications

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 1651-1700 on page 34 of 70.

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