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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Multifunctional Nanocomposites for Bioapplications

edited by

Athina Angelopoulou

submission deadline 25 Feb 2026 | 5 articles | Viewed by 7121 | Submission Open

Keywords: nanocomposites; biomedical applications; molecular characteristics; metabolic pathways; biomarkers; external stimuli

(This special issue belongs to the Section Molecular Nanoscience)

Interactions of Microbiome in Skin, Gastrointestinal, and Mucocutaneous Diseases

edited by Capercomorin S. Pitchumoni and

Bijan Safai

submission deadline 25 Feb 2026 | 2 articles | Viewed by 6645 | Submission Open

Keywords: human microbiome; immune system; skin disease; gut– skin axis; gut flora; microbe-host interactions; microbial metabolites; dysbiosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancements in Host-Directed Antiviral Therapies

edited by

Raquel Bello-Morales

submission deadline 25 Feb 2026 | 1 articles | Viewed by 6586 | Submission Open

Keywords: antiviral drugs; drug discovery; host cell targets; HIV; HCV; influenza; SARS-CoV-2

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Understanding Aging in Health and Disease

edited by

Laura Cianfruglia

submission deadline 25 Feb 2026 | 2 articles | Viewed by 5932 | Submission Open

Keywords: immunosenescence; age-related disease; ageing; oxidative stress; inflammaging

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Forensic Toxicology: Innovative Approaches in Detection of New Psychoactive Substances

edited by Roberta Tittarelli and Giulio Mannocchi

submission deadline 25 Feb 2026 | 2 articles | Viewed by 5589 | Submission Open

Keywords: addiction; new psychoactive substances; mass spectrometry; biological matrices; diversion; forensic toxicology; drug testing

(This special issue belongs to the Section Molecular Toxicology)

Reproductive Genetics and Epigenetics: Insights into Infertility Failures and Treatment Pathways

edited by

Hossam H. Shawki

submission deadline 25 Feb 2026 | 3 articles | Viewed by 5422 | Submission Open

Keywords: infertility; epigenetics; polymorphism; gametogenesis; fertilization; embryo development; reproductive organs; congenital malformations

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advancements in Understanding Protein Misfolding Disorders and Cancer

edited by

Marijn Speeckaert

submission deadline 25 Feb 2026 | 2 articles | Viewed by 4689 | Submission Open

Keywords: protein misfolding; cancer; amyloidosis

(This special issue belongs to the Section Molecular Oncology)

Peptide Self-Assembly

edited by

Yi Jia

submission deadline 25 Feb 2026 | 3 articles | Viewed by 4434 | Submission Open

Keywords: peptide assembly; aromatic short peptides; bioinspired supramolecular architectures; functional materials; peptide microfabrication; anticancer therapy; supercapacitor; biosensing

(This special issue belongs to the Section Macromolecules)

Molecular Advances in Electrochemical Materials

edited by

Raj Karthik

submission deadline 25 Feb 2026 | 2 articles | Viewed by 4287 | Submission Open

Keywords: electrochemical materials; molecular design; energy storage; electrocatalysis; sensing applications; nanomaterials; sustainable materials; hybrid systems; interface engineering; green chemistry

(This special issue belongs to the Section Materials Science)

From Macrophage Biology to Cell and EV-Based Immunotherapies

edited by

Katarzyna Nazimek

and

Krzysztof Bryniarski

submission deadline 25 Feb 2026 | 2 articles | Viewed by 4241 | Submission Open

Keywords: macrophage-based; macrophage-targeting; cancer immunotherapies; autoimmunity

(This special issue belongs to the Section Molecular Immunology)

Chemistry Triggered by Low-Energy Particles

edited by Hassan Abdoul-Carime

submission deadline 25 Feb 2026 | 3 articles | Viewed by 4097 | Submission Open

Keywords: low energy (< 50 eV); photons; electrons; ions; gas phase; single molecules; clusters; condensed phase liquids and films; experimental techniques; density functional theory; IA-based prediction models

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Heart Failure Risk Factors and Therapies on a Molecular Basis

edited by

Tomasz Urbanowicz

submission deadline 25 Feb 2026 | 2 articles | Viewed by 3814 | Submission Open

Keywords: heart failure; risk factors; inflammatory; neutrophils; cytokines; pharmacological; therapies; molecular-based processes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cellular and Molecular Mechanisms of Cardiovascular Repair

edited by

Isotta Chimenti

submission deadline 25 Feb 2026 | 3 articles | Viewed by 3356 | Submission Open

Keywords: fibroblasts; injury repair; cardiac scar; extracellular matrix; fibrosis; angiogenesis; inflammation; cardioprotection

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Phytochemical Dynamics: Plant Metabolite Responses to Environmental Factors

edited by

Ivana Sola

submission deadline 25 Feb 2026 | 2 articles | Viewed by 2844 | Submission Open

Keywords: plant metabolites; phytochemicals; biotic and abiotic factors; environmental influences; biochemical pathways; interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Advances and Current Challenges in Plasma Medicine

edited by

Andrei Vasile Nastuta

submission deadline 25 Feb 2026 | 2 articles | Viewed by 2750 | Submission Open

Keywords: plasma medicine; plasma pharmacology; plasma oncology; plasma bioengineering; plasma agronomy; plasma and food; plasma and automotive; plasma and aerospace; plasma diagnostics; plasma material processing; plasma polymerization and coating; simulation of plasma phenomena during interaction with matter

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cell Fate Decisions: Autophagy, Apoptosis, Pyroptosis, Necroptosis, Ferroptosis and PANoptosis in Health and Disease

edited by

Yaqiu Wang

submission deadline 25 Feb 2026 | 1 articles | Viewed by 2170 | Submission Open

Keywords: inflammation; autophagy; apoptosis; pyroptosis; necroptosis; PANoptosis; ferroptosis; cell death; cell survival

(This special issue belongs to the Section Molecular Biology)

Heavy Metal Exposure on Health

edited by

Rosanna Mallamaci

submission deadline 25 Feb 2026 | 2 articles | Viewed by 1785 | Submission Open

Keywords: heavy metals; toxic metal exposure; oxidative stress; mitochondrial dysfunction; epigenetic alterations; physiological and molecular pathways of cellular toxicology; biomarkers of toxicity; chelating agents; antioxidants; therapies or treatments

(This special issue belongs to the Section Molecular Toxicology)

Immune Regulation in Lung Diseases

edited by

Chiara Colarusso

and

Rosalinda Sorrentino

submission deadline 25 Feb 2026 | 3 articles | Viewed by 1751 | Submission Open

Keywords: lung disease; immune system; lung immune cells; lung epithelial cells; therapy

(This special issue belongs to the Section Molecular Immunology)

The Regulation of Microorganisms on Human Endocrine and Metabolic Systems

edited by Thi Phuong Nam Bui and Valentina Tremaroli

submission deadline 25 Feb 2026 | 1 articles | Viewed by 1007 | Submission Open

Keywords: human gut microbiome; endocrine signaling; metabolism; obesity; type 2 diabetes; cardiometabolic diseases

(This special issue belongs to the Section Molecular Microbiology)

Extracellular Vesicles: Functions and Therapeutic Applications

edited by Deepshikha Tewari

submission deadline 25 Feb 2026 | Viewed by 930 | Submission Open

Keywords: extracellular vesicles; exosome; cell-to-cell communication; diagnosis; treatment; molecular markers; diseases

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanism and Pathogenesis of Neuroinflammation in Neurological Disorders

edited by

Masashi Tanaka

submission deadline 25 Feb 2026 | Viewed by 517 | Submission Open

Keywords: age-related disorders; Alzheimer’ s disease; amyloid-β ; bioactive molecules; cognitive impairment; dementia; glial activation; microglia; neuroinflammation; neurological disorders; neurotherapeutics; tau hyperphosphorylation

(This special issue belongs to the Section Molecular Neurobiology)

New Insights into Molecular Mechanisms of Chronic Kidney Disease

edited by

Lǎcrǎmioara Ionela Butnariu

submission deadline 25 Feb 2026 | Viewed by 461 | Submission Open

Keywords: chronic kidney disease; molecular mechanism; signaling pathways; endothelial dysfunction; inflammation; genetic variants; epigenetics; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Thyroid Cancer: From Pathophysiology to Novel Therapies

edited by Miklós Bodor

submission deadline 25 Feb 2026 | Viewed by 459 | Submission Open

Keywords: thyroid cancer; therapies; cell signaling; biomarker; kinase inhibitors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Shaping Macrophages Polarization as an Emerging Therapeutic Approach

edited by

Cristina Maccallini

submission deadline 25 Feb 2026 | Viewed by 395 | Submission Open

Keywords: macrophage polarization; M1 macrophages; M2 macrophages; immune modulation; small molecules; therapeutic strategies; inflammation; cancer immunotherapy; drug resistance

(This special issue belongs to the Section Molecular Immunology)

Advanced Molecular Research in Thromboinflammation

edited by Emanuele Valeriani

submission deadline 25 Feb 2026 | Viewed by 359 | Submission Open

Keywords: blood coagulation factors; blood platelets; endothelium; inflammation; thromboinflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Brain Cancers: Molecular Diagnostic and Therapeutic Approaches

edited by

Carmine Antonio Donofrio

submission deadline 25 Feb 2026 | Viewed by 335 | Submission Open

Keywords: brain tumors; gliomas; meningiomas; pituitary tumors; molecular diagnosis; liquid biopsy; targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Perspectives in Nanoadsorption

edited by Carmen María Del Hoyo Martinez

submission deadline 25 Feb 2026 | Viewed by 330 | Submission Open

Keywords: nanoadsorption; nanomaterials; molecular mechanism; emerging contaminants removal in pharmaceutical and food industries; X-ray diffraction (XRD); thermal analysis techniques (DSC); Fourier-transform infrared spectroscopy (FTIR); Raman spectroscopy; molecular functionalization in nanoadsorption

(This special issue belongs to the Section Materials Science)

Research on Signal Transduction Mechanisms of Cancer Cells

edited by

Anuraag Shrivastav

submission deadline 25 Feb 2026 | Viewed by 306 | Submission Open

Keywords: signal transduction mechanisms; cancer cell invasion; cancer cell metastasis; tumorigenesis; cell proliferation

(This special issue belongs to the Section Molecular Oncology)

New Advances in Type 2 Diabetes and Its Complications: 2nd Edition

edited by

Anca Pantea Stoian

submission deadline 25 Feb 2026 | Viewed by 267 | Submission Open

Keywords: diabetes type 2; diabetes complications; pathophysiology of type 2 diabetes; new diabetes treatment; cardiovascular disease; stroke; peripheral artery disease; chronic kidney disease; retinopathy; neuropathy; non-alcoholic fatty liver disease in diabetes

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Advancements in Functional Materials

edited by

Joanna Karasiewicz

submission deadline 25 Feb 2026 | Viewed by 216 | Submission Open

Keywords: synthesis of specialty compounds; specialty compounds in functional materials; special applications: self-cleaning; anti-icing; self-healing; biocidal; etc.; properties; special-purpose functional materials

(This special issue belongs to the Section Materials Science)

Obesity: From Cellular Mechanism to Potential Molecular Therapies

edited by

Veronica Jimenez

submission deadline 25 Feb 2026 | Viewed by 146 | Submission Open

Keywords: metabolic pathways; gene expression; epigenetics; obesity-related comorbidities; molecular biomarkers; adipogenesis; therapeutic interventions; small molecules; gene therapy/gene editing; obesity and cancer

(This special issue belongs to the Section Molecular Biology)

Endothelial Cells in Vascular Health and Immunity

edited by

Junjie Yang

submission deadline 25 Feb 2026 | Viewed by 139 | Submission Open

Keywords: endothelial cells; vascular health; cardiovascular disease; kidney disease; lung injury; inflammation; regenerative medicine; molecular therapy

(This special issue belongs to the Section Biochemistry)

Nanocompounds for Drug Delivery

edited by

Angela Staicu

Ana Maria Udrea

and

Andra Dinache

submission deadline 25 Feb 2026 | Viewed by 84 | Submission Open

Keywords: nanocompounds; drug delivery systems; targeted delivery; stimuli-responsive nanocarriers; hybrid nanostructures; controlled release; biocompatibility; photodynamic therapy (PDT); photothermal therapy (PTT)

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Research in Chronic Inflammatory Sinonasal Diseases

edited by Santos Tiago Soares

submission deadline 25 Feb 2026 | Viewed by 68 | Submission Open

Keywords: chronic rhinosinusitis; nasal polyps; type 2 inflammation; sinonasal immunopathology; molecular pathways; host– microbiome interaction; precision medicine; upper airway disease; translational research

(This special issue belongs to the Section Molecular Immunology)

JAK/STAT Pathway in Stem Cell Biology

edited by Willis Li

submission deadline 25 Feb 2026 | Viewed by 67 | Submission Open

Keywords: JAK/STAT signaling; stem cell self-renewal; cellular differentiation; pluripotency; hematopoietic stem cells; signal transduction; cytokine receptors; transcriptional regulation; stem cell niche; regenerative medicine

(This special issue belongs to the Section Molecular Biology)

Angiotensin II in Cardiac Fibrosis and Heart Failure

edited by Argyrios S. Ntalianis

submission deadline 25 Feb 2026 | Viewed by 59 | Submission Open

Keywords: angiotensin II; aldosterone; molecular genetics; cardiac remodeling; cardiac fibrosis; cardiomyopathy; heart failure

(This special issue belongs to the Section Molecular Pharmacology)

Advances in the Design, Synthesis, and Characterization of Metal Complexes with Multifaceted Biological Activities

edited by

Luca Conti

submission deadline 25 Feb 2026 | Viewed by 58 | Submission Open

Keywords: metal complexes; molecular design; biological activity; structure– activity relationships; therapeutic applications

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Recent Research on Natural Compounds in Cancer Treatment and Prevention

edited by

Katarzyna Lubecka-Gajewska

submission deadline 25 Feb 2026 | Viewed by 53 | Submission Open

Keywords: natural compounds; bioactive phytochemicals; anticancer therapy; chemoprevention

(This special issue belongs to the Section Molecular Oncology)

Molecular Pathophysiology and Treatments of Diabetes

edited by

Carlo Acierno

submission deadline 26 Feb 2026 | Viewed by 153 | Submission Open

Keywords: diabetes mellitus; molecular pathophysiology; insulin resistance; beta-cell dysfunction; chronic inflammation; epigenetics; metabolic syndrome; SGLT2 inhibitors; GLP-1 receptor agonists; gut microbiota

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Application of Mass Spectrometry and Chromatography in Biomedicine: 2nd Edition

edited by

Giovanni Ventura

submission deadline 27 Feb 2026 | Viewed by 527 | Submission Open

Keywords: mass spectrometry; chromatography; LC-MS; GC-MS; biomarker discovery; pharmaceuticals; metabolomics; proteomics; lipidomics

(This special issue belongs to the Section Molecular Biophysics)

Current Trends in Nanophotonics and Molecular-Scale Light Control

edited by Mitradeep Sarkar

submission deadline 27 Feb 2026 | Viewed by 91 | Submission Open

Keywords: nanophotonics; light– matter interaction; metamaterials and 2D materials; photonic crystals; molecular sensing and imaging; quantum and nonlinear optics

(This special issue belongs to the Section Molecular Nanoscience)

Recent Prospects in Neurons

edited by

Tam Thanh Quach

submission deadline 27 Feb 2026 | Viewed by 85 | Submission Open

Keywords: DNA damage/repair; genetic/epigenetic; 3D genomic; global transcriptome analysis; transgenic animals; neuron polarization/genesis/network; neuro-developmental/psychiatric diseases; brain structures; intelligence/intellectual disability

(This special issue belongs to the Section Molecular Neurobiology)

Lung Diseases Molecular Pathogenesis and Therapy

edited by

Kazufumi Nakamura

submission deadline 28 Feb 2026 | 6 articles | Viewed by 17323 | Submission Open

Keywords: lung diseases; drug therapy; chronic obstructive pulmonary disease; lung cancer; lung fibrosis; pulmonary hypertension; asthma

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Rare Diseases Biomarkers: 2nd Edition

edited by

Andrea Bernini

submission deadline 28 Feb 2026 | 5 articles | Viewed by 16843 | Submission Open

Keywords: orphan diseases; rare diseases; inborn errors of metabolism; mitochondrial disorders; biomarker discovery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Cell Signaling Pathways and Signal Transduction

edited by Katsuhiko Muraki and

Susumu Ohya

submission deadline 28 Feb 2026 | 6 articles | Viewed by 15508 | Submission Open

Keywords: Ca2+ signaling; transcriptional and post-transcriptional pathways; growth factors; second messengers; cell metabolism; cell senescence; protein phosphorylation/dephosphorylation; membrane trafficking; cell proliferation; differentiation; and apoptosis; cytokine/chemokine signaling

(This special issue belongs to the Section Biochemistry)

Drug Discovery Based on Natural Products

edited by Woo-kyung Kim

submission deadline 28 Feb 2026 | 6 articles | Viewed by 11850 | Submission Open

Keywords: drug discovery; bioactive compounds; pharmacological activities and mechanisms; omics technologies

(This special issue belongs to the Section Molecular Pharmacology)

Anti-Cancer Drugs: Natural Products, Synthetic Compounds and Potential Pharmacological Effects and Applications

edited by Kaiqun Ren and Hui Zou

submission deadline 28 Feb 2026 | 3 articles | Viewed by 7830 | Submission Open

Keywords: cancer; natural product; synthetic compounds; mechanism; structural modification; pharmacological action

(This special issue belongs to the Section Molecular Pharmacology)

Plant–Microbe Interactions: 2nd Edition

edited by Jian Jin

submission deadline 28 Feb 2026 | 6 articles | Viewed by 7482 | Submission Open

Keywords: plant; crop; rhizosphere microbiome; microbial colonization; quorum sensing; endophytic microbes

(This special issue belongs to the Section Molecular Plant Sciences)

The Molecular Role of Platelets in Human Diseases

edited by

Lukasz Szarpak

and

Michał Pruc

submission deadline 28 Feb 2026 | 3 articles | Viewed by 5387 | Submission Open

Keywords: platelet; biomarkers; platelet membrane proteins; platelet-derived microparticles; platelet-related diseases; thrombosis; inflammatory diseases; cardiovascular disease; cancer; tumor growth and metastasis

(This special issue belongs to the Section Molecular Biology)

Blood Cells in Human Health and Disease

edited by Leonid Livshits

submission deadline 28 Feb 2026 | 4 articles | Viewed by 5248 | Submission Open

Keywords: red blood cell; RBC membrane; RBC biophysical properties; RBC rheology; RBC mechanical properties; RBC membrane vesiculation; RBC clearance; RBC in diabetes; hemoglobinopathies; RBC storage TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back // This page is in English Translate to Simplified Chinese Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com

(This special issue belongs to the Section Biochemistry)

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