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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Emerging Trends in Adductomics: From Adduct Detection to Environmental Implications

edited by

Mu-Rong Chao

Marcus S. Cooke

and

Chiung Wen Hu

submission deadline 20 Dec 2025 | Viewed by 245 | Submission Open

Keywords: adductomics; covalent adducts; crosslinks; biomarkers; electrophilic species; exposome; environmental toxicants; high-resolution tandem mass spectrometry; post-data analysis

(This special issue belongs to the Section Molecular Toxicology)

Advances in Targeted Cancer Therapy and Side-Effect Management

edited by Wei-Min Chang

submission deadline 20 Dec 2025 | Viewed by 229 | Submission Open

Keywords: targeted cancer therapy; novel therapy approaches; personalized treatment; small molecule inhibitors; combination strategies; multi-omics integration; proton therapy; reduced cancer treatment side effects; therapeutic resistance; biomarkers

(This special issue belongs to the Section Molecular Oncology)

Immunology and Immunotherapy for Head and Neck Cancer

edited by

Aurora Mirabile

submission deadline 20 Dec 2025 | Viewed by 223 | Submission Open

Keywords: immunotherapy; head and neck cancer; toxicity management; immune system; nutrition; immune therapy and organ failure; mechanisms of immunotherapy resistance

(This special issue belongs to the Section Molecular Immunology)

Acute Leukemia: From Basic Research to Clinical Application, Second Edition

edited by

Luca Lo Nigro

submission deadline 20 Dec 2025 | Viewed by 222 | Submission Open

Keywords: acute lymphoblastic leukemia (ALL); acute myeloid leukemia (AML); genomic findings; post-genomic findings; targeted therapies; immunotherapies; novel markers

(This special issue belongs to the Section Molecular Oncology)

Bioactives in Processed Foods: Profiling and Bioavailability Assessment

edited by Cong Wang

submission deadline 20 Dec 2025 | Viewed by 211 | Submission Open

Keywords: food processing; food bioactives; composition; bioavailability; functionality; novel food processing techniques; structure/constituents– bioactivity relationship

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Myosin: Structure, Function and Evolution

edited by Barbara Baryłko and

Joseph P. Albanesi

submission deadline 20 Dec 2025 | Viewed by 209 | Submission Open

Keywords: myosins; actin; molecular motors; organelle trafficking; endocytosis; secretion; membrane tension; RNA transport; force generation; ATPase activity

(This special issue belongs to the Section Macromolecules)

Cracking the Molecular Code of Breast Cancer

edited by Bartlomiej Taciak

submission deadline 20 Dec 2025 | Viewed by 200 | Submission Open

Keywords: breast cancer; TNBC; immunotherapy; microRNAs; NGS; therapeutics; biomarkers; epigenetics

(This special issue belongs to the Section Molecular Oncology)

Molecular Research Advances in Metabolic Syndrome

edited by

Phileno Pinge-Filho

submission deadline 20 Dec 2025 | Viewed by 198 | Submission Open

Keywords: metabolic syndrome; sepsis; molecular mechanisms; inflammation; insulin resistance; cardiovascular parameters; immune– metabolic crosstalk; experimental models; biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Ion Channels in Health and Disease

edited by

Joohyun Nam

submission deadline 20 Dec 2025 | Viewed by 194 | Submission Open

Keywords: ion channel; molecular mechanisms; channelopathies; drug discovery; electrophysiology

(This special issue belongs to the Section Molecular Biology)

Molecular Basis of Inorganic Phosphate Transport Regulation in Protozoan Parasites

edited by

Jose Roberto Meyer-Fernandes

submission deadline 20 Dec 2025 | Viewed by 187 | Submission Open

Keywords: inorganic phosphate transport; protozoan parasites; cell proliferation

(This special issue belongs to the Section Molecular Biology)

The Molecular Life of Sperm: New Horizons in Male Infertility

edited by

Mónica Vazquez-Levin

and

Robert John Aitken

submission deadline 20 Dec 2025 | Viewed by 186 | Submission Open

Keywords: human sperm; fertilization; infertility; biomarkers; genetics

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Molecular Mechanisms of Human Papillomavirus Family (HPV) Induced Oncogenesis, 2nd Edition

edited by

Subhasis B. Biswas

submission deadline 20 Dec 2025 | Viewed by 134 | Submission Open

Keywords: human papillomavirus (HPV); oncogenesis; mechanism; diagnosis; classification; etiology; pathophysiology; biochemistry; genetics; molecular biology; epidemiology; cervical cancer; oropharyngeal cancer; oncology

(This special issue belongs to the Section Molecular Oncology)

Male Reproduction: Unveiling the Molecular Revolution

edited by

Anthony Archibong

submission deadline 20 Dec 2025 | Viewed by 133 | Submission Open

Keywords: testosterone; spermatogenesis; capacitation; acrosome reaction; endocrine disruptors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research of Neonicotinoid Toxicity

edited by

Fatima Smagulova

submission deadline 20 Dec 2025 | Viewed by 132 | Submission Open

Keywords: neonicotinoids; sex-specific effects; brain– gut– microbiome; endocrine organs; genotoxic effects; epigenetic effects

(This special issue belongs to the Section Molecular Toxicology)

Advancing Mental Disorder Therapies: Drug Repositioning and Translational Insights from Animal Models

edited by Claudia Bregonzio and Mariela Fernanda Pérez

submission deadline 20 Dec 2025 | Viewed by 127 | Submission Open

Keywords: anxiety; depression; Parkinson's disease; Alzheimer; schizophrenia; neurotransmitter imbalance; novel treatments; new pharmacological targets; preclinical studies

(This special issue belongs to the Section Molecular Neurobiology)

Stress Adaptation and Immune Surveillance: Extracellular Vesicles, Autophagy, and Inflammasomes in Cancer and Neurodegeneration

edited by Seema Singh

submission deadline 20 Dec 2025 | Viewed by 119 | Submission Open

Keywords: autophagy; ferroptosis; inflammasome activation; extracellular vesicle (EV); cancer; neurodegeneration; chronic infections

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms of Stem Cell-Mediated Tendon Regeneration: From Signaling Pathways to Therapeutic Applications

edited by

Mohammad El Khatib

submission deadline 20 Dec 2025 | Viewed by 104 | Submission Open

Keywords: regenerative medicine; tissue engineering; stem cells; scaffolds; 3D in vitro models; tenogenic differentiation; tendon regeneration; molecular mechanisms; intercellular crosstalk; paracrine signaling; extracellular matrix remodeling

(This special issue belongs to the Section Molecular Biology)

Molecular Aspects of Tumor Radiotherapy

edited by

Johann Matschke

submission deadline 20 Dec 2025 | Viewed by 93 | Submission Open

Keywords: radiotherapy resistance; tumor microenvironment; DNA damage response; metabolic reprogramming; combination therapies

(This special issue belongs to the Section Molecular Oncology)

Redox Physiology

edited by Mateusz Mołoń

submission deadline 21 Dec 2025 | Viewed by 399 | Submission Open

Keywords: redox physiology; reactive oxygen species (ROS); reactive nitrogen species (RNS); oxidative stress; oxidation; redox signaling

(This special issue belongs to the Section Molecular Biology)

Spectroscopic Techniques in Molecular Sciences

edited by

Angela Staicu

submission deadline 25 Dec 2025 | 5 articles | Viewed by 3075 | Submission Open

Keywords: spectroscopy; the structure; dynamics; interactions; and functions of molecules; chemical; biological; pharmaceutical; and materials systems

(This special issue belongs to the Section Molecular Biology)

25th Anniversary of IJMS: Updates and Advances in “Molecular Immunology”

edited by

Julia Kzhyshkowska

submission deadline 25 Dec 2025 | 2 articles | Viewed by 2272 | Submission Open

Keywords: inflammation; innate immunity; adaptive immunity; genetics; epigenetics; immunometabolism; receptors; cytokines; cell therapy; immune checkpoint inhibitors

(This special issue belongs to the Section Molecular Immunology)

Epigenetic Regulation and Molecular Mechanisms in Cardiovascular Diseases

edited by

Paschalis Karakasis

submission deadline 25 Dec 2025 | 1 articles | Viewed by 2101 | Submission Open

Keywords: epigenetic regulation; cardiovascular disease; DNA methylation; histone modifications; non-coding RNAs; vascular inflammation; myocardial remodeling; molecular mechanisms; thera-peutic targets

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Endocrine Regulation in Health and Diseases

edited by Fady Hannah-Shmouni

submission deadline 25 Dec 2025 | 1 articles | Viewed by 2027 | Submission Open

Keywords: exposome and endocrine disruptors; endocrine-disrupting chemicals (EDCs); environmental toxicology and hormonal health; epigenetics and endocrine function; endocrine regulation and chronic disease; public health and exposure mitigation; endocrine disruptors in the home and community

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular and Genetic Advances in Plant Breeding

edited by Francesca Taranto

submission deadline 25 Dec 2025 | 2 articles | Viewed by 1939 | Submission Open

Keywords: genetic diversity; next-generation sequencing; marker-assisted selection; GWAS/QTL mapping; KASP genotyping; molecular biology TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back // This page is in English Translate to Simplified Chinese Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com

(This special issue belongs to the Section Molecular Plant Sciences)

Therapeutic Horizons of Oligosaccharides: Molecular Mechanisms and Therapeutic Potential

edited by

Abdelali Daddaoua

and

María Núñez-Núñez

submission deadline 25 Dec 2025 | 2 articles | Viewed by 1907 | Submission Open

Keywords: oligosaccharides; bacterial infection; multidrug-resistant

(This special issue belongs to the Section Molecular Microbiology)

Skin Cancer: From Molecular Pathophysiology to Novel Treatment

edited by Soon-Hyo Kwon

submission deadline 25 Dec 2025 | 2 articles | Viewed by 1839 | Submission Open

Keywords: basal cell carcinoma; malignant melanoma; molecular genetics; epigenetics; signaling pathways; tumor microenvironment; tumor resistance; biomarkers; molecular target; multiomics; genomics; transcriptomics; proteomics; metabolomics; skin cancer; squamous cell carcinoma

(This special issue belongs to the Section Molecular Oncology)

New Insights into Tryptophan Metabolism

edited by

Katsunori Nonogaki

submission deadline 25 Dec 2025 | Viewed by 254 | Submission Open

Keywords: tryptophan; serotonin; kynurenine; indole; metabolism; IPA; Tph; IDO1; health; disease

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Roots, Transporters, and Signals: Molecular Insights into Plant Mineral Nutrition and Heavy Metals Stress

edited by

Alessio Aprile

submission deadline 25 Dec 2025 | Viewed by 182 | Submission Open

Keywords: plant mineral nutrition; heavy metals; toxic element; transporter; signaling pathway

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Insights in Diabetes

edited by

Mariann Harangi

and

Ferenc Sztanek

submission deadline 25 Dec 2025 | Viewed by 178 | Submission Open

Keywords: insulin signalling pathway; pancreatic beta-cell dysfunction; oxidative stress; epigenetic modifications; metabolic memory; small regulatory RNAs (miRNAs); inflammation and insulin resistance; glucagon-like peptide-1 (GLP-1); glucose-dependent insulinotropic polypeptide (GIP); molecular therapeutic targets; glucose homeostasis regulation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Microbial Bioconversion of Agri-Food Waste for the Production of Pharmacologically Active Compound

edited by Alicia Paz

submission deadline 25 Dec 2025 | Viewed by 110 | Submission Open

Keywords: microbial bioconversion; agri-food waste valorization; bioactive compounds; bioprocess optimization; pharmaceuticals; functional foods; cosmetic bioactives

(This special issue belongs to the Section Molecular Microbiology)

Emerging Strategy in Bacterial Antibiotic Resistance

edited by Lili Li

submission deadline 28 Dec 2025 | Viewed by 90 | Submission Open

Keywords: fast detection; antimicrobial resistance; virulence; antibacterial action of natural compounds

(This special issue belongs to the Section Molecular Microbiology)

Molecular Investigations in Neurodevelopmental Disorders

edited by Giorgio Medici

submission deadline 30 Dec 2025 | 9 articles | Viewed by 32354 | Submission Open

Keywords: neurodevelopmental disorders; brain; neurons; synapses; molecular research; regulatory networks; molecular pathways; biomarkers; therapies

(This special issue belongs to the Section Molecular Neurobiology)

Recent Research on Hypertension and Related Complications

edited by

Marijn Speeckaert

submission deadline 30 Dec 2025 | 5 articles | Viewed by 21716 | Submission Open

Keywords: arterial hypertension; cardiovascular disease; pathophysiology; molecular mechanisms; complications

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Musculoskeletal Disorders: From Molecular Pathology to Novel Therapeutic Approach

edited by

María Orosia Lucha López

submission deadline 30 Dec 2025 | 8 articles | Viewed by 20082 | Submission Open

Keywords: joints; skeletal muscles; tendons; ligaments; fascia; articular cartilage; intervertebral discs; physiotherapy; novel therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Traumatic Brain Injury/Chronic Traumatic Encephalopathy as Cause of Alzheimer’s Disease: Physics and Molecular Biology in the Genesis of Neurodegeneration?

edited by

Dimitrios Kanakis

submission deadline 30 Dec 2025 | 6 articles | Viewed by 19756 | Submission Open

Keywords: traumatic brain injury (TBI); chronic traumatic encephalopathy (CTE); head impacts; Alzheimer's disease (AD）; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Biomedical Applications of Mesenchymal Stem Cells

edited by

Giuliana Mannino

and

Debora Lo Furno

submission deadline 30 Dec 2025 | 7 articles | Viewed by 19072 | Submission Open

Keywords: mesenchymal stem cells; cell differentiation; cell therapy; regenerative medicine; tissue homeostasis; cartilage

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms and Treatments in Neurodegenerative Diseases

edited by

Ermanna Turano

and

Raffaella Mariotti

submission deadline 30 Dec 2025 | 7 articles | Viewed by 18569 | Submission Open

Keywords: neurodegenerative diseases; regenerative therapy; neuroprotection; neurodegeneration; pathogenetic mechanisms; cell therapy

(This special issue belongs to the Section Molecular Neurobiology)

Neurobiological Mechanisms of Addictive Disorders

edited by Liliana Marina Cancela

submission deadline 30 Dec 2025 | 7 articles | Viewed by 18418 | Submission Open

(This special issue belongs to the Section Molecular Neurobiology)

The Characterization and Application of Enzymes in Bioprocesses

edited by

Loredana Marcolongo

submission deadline 30 Dec 2025 | 9 articles | Viewed by 16293 | Submission Open

Keywords: biocatalysts; enzymatic characterization; enzymatic action; protein engineering; biocatalysts application; bioprocessing

(This special issue belongs to the Section Biochemistry)

Potential Prevention and Treatment of Neurodegenerative Disorders

edited by

Maria Paola Bertuccio

submission deadline 30 Dec 2025 | 5 articles | Viewed by 16149 | Submission Open

Keywords: neurodegenerative disorders; molecular biomarkers; oxidative stress; therapeutic strategies; disease prevention

(This special issue belongs to the Section Molecular Neurobiology)

Challenges and Innovation in Neurodegenerative Diseases, 2nd Edition

edited by

King-Ho Cheung

submission deadline 30 Dec 2025 | 7 articles | Viewed by 15492 | Submission Open

Keywords: neurodegenerative diseases; pathogenesis; biomarkers; disease model; natural product; new drug discovery; therapy; machine learning; stem cell therapy

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms and Signalling Pathways in Cardiovascular Pathophysiology

edited by Ernesto Alejandro Aiello

submission deadline 30 Dec 2025 | 5 articles | Viewed by 15411 | Submission Open

Keywords: heart; vascular; signaling; cardiovascular disease; mechanism

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Animal Research Model for Neurological Diseases, 2nd Edition

edited by

Giuseppe Montalbano

and

Sepand Rastegar

submission deadline 30 Dec 2025 | 5 articles | Viewed by 13655 | Submission Open

Keywords: experimental models; mouse; rat; zebrafish; neurological disease; Alzheimer’ s disease; Parkinson’ s disease; neurodegeneration; neuroregeneration

(This special issue belongs to the Section Molecular Neurobiology)

Host-Pathogen Interaction, 6th Edition

edited by

Andreas Burkovski

submission deadline 30 Dec 2025 | 5 articles | Viewed by 12303 | Submission Open

Keywords: microorganisms; pathogen; bacteria; yeasts; protozoa; host organisms

(This special issue belongs to the Section Molecular Microbiology)

The Role of Toll-Like Receptors (TLRs) in Infection and Inflammation: Third Edition

edited by

Ralf Kircheis

and

Oliver Planz

submission deadline 30 Dec 2025 | 7 articles | Viewed by 11806 | Submission Open

Keywords: toll-like receptors (TLR); pathogen associated molecular patterns (PAMPs); sepsis; bacterial infections; viral infections; Myd88; TRIF; NF-kappaB; COVID-19; coagulopathies

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms and Therapeutic Innovations in Neurodegenerative Diseases: 2nd Edition

edited by Melania Maria Serafini and

Nicoletta Marchesi

submission deadline 30 Dec 2025 | 4 articles | Viewed by 10100 | Submission Open

Keywords: Alzheimer’ s disease; strokes; multiple sclerosis; amyotrophic lateral sclerosis; polyneuropathies; pain; diabetic retinopathy; neuroinflammation; dietary supplements; microbiome

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Advances in Cancer and Cell Metabolism—2nd Edition

edited by

Maria Concetta Faniello

Maria Mesuraca

and

Barbara Quaresima

submission deadline 30 Dec 2025 | 7 articles | Viewed by 9851 | Submission Open

Keywords: cell metabolism; cancer metabolism; cancer cell; oxidative stress; gene expression; signaling pathways; metabolic regulation; tumor growth; energy metabolism; metabolic phenotype; metabolic substrates

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Applications of Stem Cells and Extracellular Vesicles in Regenerative Medicine

edited by

Ramya Lakshmi Rajendran

and

Prakash Gangadaran

submission deadline 30 Dec 2025 | 3 articles | Viewed by 9281 | Submission Open

Keywords: regenerative medicine; pluripotent stem cells; cell differentiation; tissue engineering; gene editing; therapeutic potential; clinical applications; neurodegenerative disorders; disease modeling

(This special issue belongs to the Section Molecular Biology)

Central and Local Modulators of Reproduction and Fertility: An Update (4th Edition)

edited by

Rosaria Meccariello

submission deadline 30 Dec 2025 | 4 articles | Viewed by 8523 | Submission Open

Keywords: reproduction; fertility; HPG axis; testis; ovary; spermatogenesis; ovogenesis; gametes; GnRH; gonadotropins; sex steroids; kisspeptins; GnIH; metabolic sensors; leptin; endocannabinoids; autocrine/paracrine regulators; protein/peptide hormones; lipid mediators; epigenetics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Genetic and Molecular Mechanisms of Obesity

edited by

Maria Elisabeth Street

and

Giuseppina Rosaria Umano

submission deadline 30 Dec 2025 | 3 articles | Viewed by 8456 | Submission Open

Keywords: obesity; insulin signal transduction; insulin sensitivity; co-morbidities; genetics; epigenetics; miRNAs; DNA methylation; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 751-800 on page 16 of 69.

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