Intestinal 3D Culture, Organoids and Gut-on-Chip in Intestinal Disorders
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 February 2026 | Viewed by 3406
Special Issue Editors
Interests: inflammatory bowel disease; phytochemicals; prebiotics; probiotics; small molecules; gut–brain axis; enteric glial network; pharmacological approaches; obesity; intestinal organoids
Special Issues, Collections and Topics in MDPI journals
Interests: inflammatory bowel diseases; inflammation; intestinal functional disorders; animal models; gut–brain axis; obesity; patients
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Three-dimensional (3D) culture systems, including relatively simple cell aggregates (spheroids) and increasingly functional organ-like or organotypic microtissues (organoids and tissue-on-a-chip), have recently garnered significant attention because they often promote levels of cell differentiation and tissue organization not possible in conventional 2D culture systems. Indeed, 3D cultures represent an ideal model for studying the pathophysiological mechanisms underlying the intestinal functional diseases and inflammatory diseases—including inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), obesity, and colorectal cancer—and for testing new drugs. The application of these innovative techniques will provide a great advances in human medicine, contributing to the identification of new molecular targets and personalized medicine.
On these bases, this Special Issue, entitled “Intestinal 3D Culture, Organoids and Gut-on-Chip in Intestinal Disorders”, invites researchers to contribute original research articles, review articles, and short communications related to current knowledge on 3D culture systems used , both technically and scientifically in this research field.
Dr. Vanessa D’Antongiovanni
Dr. Carolina Pellegrini
Guest Editors
Manuscript Submission Information
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Keywords
- 3D cultures
- gut-on-chip
- intestinal organoids
- spheroids
- organotypic cultures
- morphological studies
- pharmacological studies
- intestinal cancer
- inflammatory bowel disease
- intestinal functional disorders
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