Molecular Biology of Periodontal Disease and Periodontal Pathogens
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 February 2026 | Viewed by 724
Special Issue Editors
Interests: dentistry; periodontitis; inflammation; infection; education; comorbidities; systemic health
Interests: periodontal diseases; periodontitis; systemic inflammation; cardiovascular diseases; neurological conditions; metabolic disorders; systematic review; meta-analysis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Periodontitis is one of the most prevalent diseases worldwide. The pathophysiology of this disease is complex, and several molecular mechanisms have been described on the interaction between the host and the bacterial challenge. In individuals with susceptibility to periodontitis, the host response is ineffective, dysregulated, and destructive. While the bacteria are required for disease pathogenesis, it is predominantly the host inflammatory response to this microbial challenge that can ultimately lead to damage on the periodontal tissues. In the last decade, periodontitis has been associated with a wide variety of systemic conditions, mainly with atherosclerotic vascular diseases and diabetes. Different biological mechanisms have been proposed to explain these associations including bacteraemia and increased systemic inflammatory response.
This Special Issue aims to advance our knowledge of different biological and molecular pathways through which periodontal tissue breakdown could occur. Novel biological pathways linking periodontitis with systemic diseases are also relevant for this issue. Therefore, we welcome preclinical and clinical original papers and review articles dealing with novel molecular pathways of periodontitis as well as scientific contributions describing biological mechanisms underlying the perio-systemic link. In addition, we encourage authors to submit papers with educational content dealing with methods to explain complex biological processes in periodontitis and its systemic impact.
Dr. Yago Leira
Dr. João Botelho
Guest Editors
Manuscript Submission Information
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Keywords
- periodontitis
- general medicine
- inflammation
- bacteraemia
- education
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