Drug-Induced Neurotoxicity and Neurodegeneration: Mechanisms, Models and Implications
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 20 September 2025 | Viewed by 1057
Special Issue Editors
2. UCIBIO—Applied Molecular Biosciences Unit, Translational Toxicology Research Laboratory, University Institute of Health Sciences (1H-TOXRUN, IUCS-CESPU), 4585-116 Gandra, Portugal
Interests: molecular motors; intracellular transport; cell biology; molecular biology; neurodegeneration; drugs of abuse; pharmacology; toxicology; neurotoxicology; forensic sciences
Special Issues, Collections and Topics in MDPI journals
2. UCIBIO—Applied Molecular Biosciences Unit, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal
Interests: toxicology; pharmacology; ADME/toxicokinetics; membrane transporters; P-glycoprotein; neurodegeneration; drugs of abuse; drug discovery
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Drug-induced neurotoxicity and neurodegeneration are emerging as important triggers of human diseases, significantly impacting individual health and public healthcare systems worldwide. In contemporary society, the rapid development of drugs and the increasing exposure to diverse pharmaceutical agents, abused substances, and environmental toxins make a deeper understanding of the mechanisms underlying neurotoxic damage essential to develop effective mitigation strategies.
In this Special Issue, we are particularly interested in contributions on the mechanisms of drug-induced neurotoxicity and neurodegeneration at molecular, cellular and organismal levels, innovative in vitro, in vivo, and in silico models that depicts the dynamics of neuronal damage, biomarkers and altered pathways useful for early diagnosis, translational studies linking experimental findings to clinical outcomes, and putative therapeutic strategies to prevent or mitigate neurotoxic insults. Thus, this Special Issue aims to bridge the gap between experimental research and clinical practice by broadly exploring how toxic exposures affect the nervous system.
Dr. Daniel José Barbosa
Dr. Renata Silva
Guest Editors
Manuscript Submission Information
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Keywords
- drugs of abuse
- pharmaceutical drugs
- environmental toxins
- drug exposure
- neurotoxicity
- neurodegeneration
- brain health
- substance use disorders
- therapeutic interventions
- in vivo models
- in vitro models
- in silico models
- biomarkers of damage
- translational studies
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