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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advancing Mental Disorder Therapies: Drug Repositioning and Translational Insights from Animal Models

edited by Claudia Bregonzio and Mariela Fernanda Pérez

submission deadline 20 Jul 2026 | Viewed by 212 | Submission Open

Keywords: anxiety; depression; Parkinson's disease; Alzheimer; schizophrenia; neurotransmitter imbalance; novel treatments; new pharmacological targets; preclinical studies

(This special issue belongs to the Section Molecular Neurobiology)

Non-Coding RNAs as Key Regulators in Human Disease Processes

edited by

Beatrice Polini

submission deadline 20 Jul 2026 | Viewed by 183 | Submission Open

Keywords: non-coding RNAs; microRNAs; long non-coding RNAs; circular RNAs; biomarkers; therapeutic targets; molecular mechanisms; RNA-based therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Small Molecules in Tissue Repair and Regeneration

edited by

Ildiko Bock-Marquette

submission deadline 20 Jul 2026 | Viewed by 179 | Submission Open

Keywords: small molecules; organ and tissue regeneration; development; aging

(This special issue belongs to the Section Molecular Biology)

Adhesion, Invasion, and Metastasis in Cancer Progression

edited by

Pinar Uysal-Onganer

submission deadline 20 Jul 2026 | Viewed by 175 | Submission Open

Keywords: cancer metastasis; cellular adhesion; invasion and migration; noncoding RNAs; EMT; Wnt/β -catenin signalling; tumour microenvironment; biomarkers; AI-driven metastasis prediction

(This special issue belongs to the Section Molecular Oncology)

Role of DNA Methylation Signatures in Genetic Disorders

edited by

Jair Tenorio-Castano

submission deadline 20 Jul 2026 | Viewed by 146 | Submission Open

Keywords: DNA methylation; genetic disorders; episignature; genomic medicine; differentially methylated regions

(This special issue belongs to the Section Molecular Genetics and Genomics)

Natural Product-Inspired Anticancer Drug Development

edited by

Erzsébet Mernyák

submission deadline 20 Jul 2026 | Viewed by 143 | Submission Open

Keywords: anticancer; antiproliferative; cytotoxic; natural product; drug development; semi-synthesis; total synthesis; structure– activity relationship; computational simulation; enzyme inhibition

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Molecular Research on Photocatalytic Applications

edited by Hassan Ait Ahsaine

submission deadline 20 Jul 2026 | Viewed by 140 | Submission Open

Keywords: photocatalysis; photocatalytic degradation; molecular catalysts; photocatalysts; functional materials

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

From Biology to Biomechanics: Molecular Advances in Orthodontic Remodeling and Acceleration

edited by

Marcin Derwich

and

Alessandra Lucchese

submission deadline 20 Jul 2026 | Viewed by 139 | Submission Open

Keywords: orthodontic tooth movement; bone remodeling; root resorption; molecular mechanisms; inflammatory response; corticotomy-assisted orthodontics; biomechanics; periodontal ligament; cellular signaling; accelerated orthodontic treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Regenerative Medicine for Tendon: Harnessing Stem Cell Potential

edited by

Maria Camilla Ciardulli

submission deadline 20 Jul 2026 | Viewed by 128 | Submission Open

Keywords: stem cells; endogenic differentiation; three-dimensional in vitro tendon models; immunomodulation; biomimetic scaffolds; in vivo tendon models; dynamic cultures

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Chronic Airway Diseases: Molecular Basis and Advanced Therapeutics

edited by

S. Lorraine Martin

submission deadline 20 Jul 2026 | Viewed by 120 | Submission Open

Keywords: chronic airway diseases; asthma; chronic obstructive pulmonary disease (COPD); cystic fibrosis; bronchiectasis; pulmonary fibrosis; airway remodeling; cytokines; inflammation; immune dysregulation; mucociliary clearance; microbiome; epithelial– mesenchymal transition (EMT); molecular mechanisms; biomarkers; proteases; protease inhibitors; precision medicine; targeted therapeutics; RNA-based and gene therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Rhizospheric Microbial Interactions

edited by

Jelena Lozo

submission deadline 20 Jul 2026 | Viewed by 108 | Submission Open

Keywords: plant– microorganism interactions; rhizosphere community; secretory systems; secondary metabolites; volatile compounds

(This special issue belongs to the Section Molecular Microbiology)

Bioactive Natural Compounds in the Prevention and Treatment of Human and Veterinary Diseases

edited by

Fabiana Superti

and

Anna Scotto D'Abusco

submission deadline 20 Jul 2026 | Viewed by 68 | Submission Open

Keywords: bioactive natural substances; nutraceuticals; drug discovery; drug resistance; inflammation; antioxidant; health promotion; prevention; treatment; synergistic effect; molecular mechanism; computational analysis; repurposed molecules

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Docking Method and Application

edited by

Yigui Wang

submission deadline 20 Jul 2026 | Viewed by 5 | Submission Open

Keywords: drug discovery; docking scores; docking poses; traditional methods of drug discovery; ligand-based virtual screening (LBVS); structure-based virtual screening (SBVS); machine learning (ML)

(This special issue belongs to the Section Molecular Informatics)

Evolving Landscape of Cardiovascular Pathophysiology

edited by

Pooja Shivshankar

submission deadline 25 Jul 2026 | Viewed by 74 | Submission Open

Keywords: biomarker discovery in cardiovascular pathophysiology; precision diagnostics-novel contrast agents combined with PET/CT; MRI; machine learning/AI and clinical implementations in cardiology; cardio-metabolic disease; inflammation and immunity in cardiovascular diseases; mechanisms of non-coding RNAs and microRNAs in cardiac diseases; translational research in large animals bridging the rodent re-search with human pathophysiology; targeted therapies- genetic therapies/gene editing approach (CRISPR); stem cell therapies; and therapeutic mRNA and siRNA-based approaches

(This special issue belongs to the Section Biochemistry)

Neurodegenerative Diseases: Molecular Mechanisms and Therapies, 4th Edition

edited by

Zhidong Zhou

and

Alexandre Hiroaki Kihara

submission deadline 25 Jul 2026 | Viewed by 8 | Submission Open

Keywords: neurodegeneration; neurodegenerative diseases; protein aggregation; pathogenesis; therapy; mitochondria; neuroinflammation; oxidative stress; cell therapy; clinical trial

(This special issue belongs to the Section Molecular Neurobiology)

Neurobiology Linking Alcohol Addiction to Psychiatry Symptoms

edited by

Jorge Manzanares

and

Francisco Navarrete

submission deadline 30 Jul 2026 | Viewed by 128 | Submission Open

Keywords: alcohol use disorder (AUD); psychiatry; neurobiology; biomarkers; translational

(This special issue belongs to the Section Molecular Neurobiology)

Cancer Drug Resistance and Therapeutic Targets

edited by

Sanjay K. Srivastava

submission deadline 30 Jul 2026 | Viewed by 125 | Submission Open

Keywords: drug resistance; therapeutic targets; efflux transporters’ oncogenic signaling pathways; tumor microenvironment; dna damage/repair; personalized therapies

(This special issue belongs to the Section Molecular Oncology)

Advances in Bone Homeostasis

edited by

John Kelly Smith

submission deadline 30 Jul 2026 | Viewed by 94 | Submission Open

Keywords: bone remodeling; osteoblasts and osteoclasts; osteoimmunology; osteometabolism; signaling pathways; bone diseases; epigenetic regulation; extracellular vesicles; mechanotransduction; therapeutic targets

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Mechanisms Underlying Abiotic Stress Tolerance in Plants: From Gene Regulation to Adaptive Traits

edited by Shijiang Cao

submission deadline 30 Jul 2026 | Viewed by 74 | Submission Open

Keywords: forest molecular biology; tree physiology; plant developmental biology; plant-microbe interactions; abiotic stresses

(This special issue belongs to the Section Molecular Plant Sciences)

Phytochemicals and Antioxidants on Health and Disease Modulation

edited by Natalia Kurhaluk

submission deadline 30 Jul 2026 | Viewed by 56 | Submission Open

Keywords: phytochemical bioactive compounds; antioxidant mechanisms; oxidative stress modulation; chronic disease prevention; inflammatory signalling pathways; molecular health effects; bioavailability and metabolism; flavonoid biological activity; polyphenol therapeutic potential; disease modulation strategies

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Role of Proteomics in Human Diseases and Infections: 2nd Edition

edited by

Mahamud Ur Rashid

submission deadline 30 Jul 2026 | Viewed by 37 | Submission Open

Keywords: proteomics; human diseases; infections; biomarkers; therapeutic targets; disease pathogenesis; host– pathogen interactions; diagnostic tools

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Immunoregulatory Mechanisms of Gut Microbiota

edited by

José Fachi

submission deadline 30 Jul 2026 | Viewed by 30 | Submission Open

Keywords: gut microbiota; mucosal immunity; host– microbe interactions; immune homeostasis; dysbiosis; microbial metabolites; short-chain fatty acids; barrier function; colitis

(This special issue belongs to the Section Molecular Microbiology)

Immunoregulation of Abnormal Cell Proliferation: Molecular Mechanisms and Therapeutic Strategies

edited by

Xingkang Wu

submission deadline 30 Jul 2026 | Viewed by 27 | Submission Open

Keywords: immune microenvironment; cell proliferation; molecular mechanisms; therapeutic strategies; tumor; autoimmune disease; psoriasis; rheumatoid arthritis; lupus erythematosus; type 1 diabetes; inflammatory bowel disease

(This special issue belongs to the Section Molecular Immunology)

Natural Products for Cancer: Cutting-Edge Trends and Future Directions

edited by

Mounir Tilaoui

and Abdelmajid Zyad

submission deadline 30 Jul 2026 | Viewed by 23 | Submission Open

Keywords: natural products; cancer therapy; drug discovery; molecular mechanisms; multi-drug resistance; tumor heterogeneity; structure– activity relationships (SARs); biosynthetic pathway engineering; AI-driven drug discovery; multi-omics approaches

(This special issue belongs to the Section Molecular Pharmacology)

Omics-Driven Advances in Plant Abiotic Stress Tolerance

edited by

Kincső Decsi

submission deadline 30 Jul 2026 | Viewed by 21 | Submission Open

Keywords: omics; abiotic stressors; prevention; cellular biochemical changes; individual or genome-wide analyses

(This special issue belongs to the Section Molecular Plant Sciences)

Application of Molecular Technology to Dental Treatment

edited by

Yoshiya Hashimoto

submission deadline 30 Jul 2026 | Viewed by 15 | Submission Open

Keywords: biotechnology; implant material; titanium; zirconia; PEEK; in vitro; in vivo

(This special issue belongs to the Section Materials Science)

Molecular Signatures in Overt Neurodegenerative Disease: Toward Precision Diagnosis and Classification

edited by

Jose Miguel Laffita-Mesa

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1623 | Submission Open

Keywords: neurodegenerative diseases; molecular biomarkers; disease stratification; Parkinson’ s disease; Alzheimer’ s disease; spinocerebellar ataxia; precision medicine; digital PCR; circRNA; prognostic biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

Systems Genetics of Metabolic Disorders: From Omics Signatures to Molecular Mechanisms

edited by

Seong-Hee Maria Ko

submission deadline 31 Jul 2026 | 1 articles | Viewed by 706 | Submission Open

Keywords: metabolic syndrome; single-nucleotide polymorphism (SNP); genome-wide association study (GWAS); copy number variation; diet; metabolomics; nutritional genetics; lipid metabolism; omics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Physiology and Molecular Biology of Plant Stress Tolerance: 3rd Edition

edited by

De-Guo Han

submission deadline 31 Jul 2026 | 1 articles | Viewed by 578 | Submission Open

Keywords: plant– pathogen interactions; biotic and abiotic stress; plant innate immunity; phytohormones; genes

(This special issue belongs to the Section Molecular Plant Sciences)

Cell–Cell Communication Through Extracellular Vesicles

edited by Federica Fratini

submission deadline 31 Jul 2026 | Viewed by 305 | Submission Open

Keywords: EV biomarkers; EV biogenesis; EV drug delivery; EV trafficking; EV immuno escape

(This special issue belongs to the Section Molecular Biology)

Selected Papers from the HSG-2025 Conference

edited by

Marsel Kabilov

submission deadline 31 Jul 2026 | Viewed by 83 | Submission Open

Keywords: metagenomics; genomics; metabarcoding; next-generation sequencing; transcriptomics; translatomics; NGS data analysis

(This special issue belongs to the Section Molecular Genetics and Genomics)

Bioactive Natural Products: From Molecular Mechanisms to Biological Function

edited by

Noureddine El Aouad

submission deadline 31 Jul 2026 | Viewed by 59 | Submission Open

Keywords: natural products; molecular mechanism; biological activities; drug discovery

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms of GPCR Signaling

edited by

Kyeong-Man Kim

submission deadline 31 Jul 2026 | Viewed by 44 | Submission Open

Keywords: biased signaling; allosteric modulation; receptor conformations; spatiotemporal signaling; allosteric modulation; receptor trafficking; signaling networks; structure-based drug design

(This special issue belongs to the Section Biochemistry)

Molecular Pathogenesis and Novel Therapeutic Targets in Oncologic Cardiotoxicity

edited by

Marco Tana

submission deadline 31 Jul 2026 | Viewed by 43 | Submission Open

Keywords: cardiotoxicity; CTRCD; heart failure; HFrEF; HFpEF

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Glomerular Diseases, 2nd Edition

edited by

Gian Marco Ghiggeri

submission deadline 31 Jul 2026 | Viewed by 41 | Submission Open

Keywords: glomerulonephritis; proteinuria; autoantibodies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Eukaryotic Mitogenomes: Key Insights

edited by

Yuri Kartavtsev

submission deadline 31 Jul 2026 | Viewed by 39 | Submission Open

Keywords: eukaria; genomics; mitogenomes; structure; phylogenetic informativeness; evolution; comparative genomics; diversity; biomarker; function; mitonuclear relations

(This special issue belongs to the Section Molecular Biology)

Computer-Aided Drug Discovery: Insights from Computational Chemistry and Cheminformatics

edited by

Ismail Hdoufane

and

Mehdi Oubahmane

submission deadline 31 Jul 2026 | Viewed by 36 | Submission Open

Keywords: computer-aided drug design (CADD); computational chemistry; cheminformatics; molecular dynamics simulations; molecular modeling; QSAR modeling; virtual screening; artificial intelligence in drug discovery

(This special issue belongs to the Section Molecular Informatics)

Insights in Multiple Sclerosis (MS) and Neuroimmunology: 3rd Edition

edited by

Michael C. Levin

submission deadline 31 Jul 2026 | Viewed by 11 | Submission Open

Keywords: neurodegeneration; neuroimmunology; macrophage; T-cell; B-cell; antibody; neurons; oligodendrocytes; axon; axonal damage; cell death; multiple sclerosis

(This special issue belongs to the Section Molecular Immunology)

Green Gold: Microalgae as a Sustainable Source of Nutrients and Bioactive Compounds

edited by

Blanca Hernández-Ledesma

and Pilar Gómez-Cortés

submission deadline 31 Jul 2026 | Viewed by 10 | Submission Open

Keywords: microalgae; sustainable nutrition; bioactive compounds; functional foods; nutraceuticals; alternative proteins; phycochemistry; circular bioeconomy; biorefinery

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights in Neuro-Ophthalmology

edited by

Toshiyuki Oshitari

submission deadline 31 Jul 2026 | Viewed by 9 | Submission Open

Keywords: neuroprotection; neurodegeneration; neuronal cell death; regeneration; cell death and survival pathways; neurovascular unit; oxidative stress; inflammation; advanced glycation end products; ischemia; optic nerve injuries; glaucoma; optic neuritis; retinitis pigmentosa; diabetic retinopathy; age-related macular degeneration; retinal vein/artery occlusion; gene therapy; cell plantation; nutrients; neuroprotectants; drug delivery; translational research

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Characterization and Utilization of Plant Genetic Resources

edited by

Roel Rabara

submission deadline 31 Jul 2026 | Viewed by 5 | Submission Open

Keywords: molecular markers; genetic resources; genomics; transcriptomics; molecular characterization; genetic diversity; transcriptomics; bioinformatics; germplasm enhancement; epigenetics

(This special issue belongs to the Section Molecular Plant Sciences)

Fluorescent Nanoparticles: Composition, Properties, and Biomedical Applications

edited by Bonghwan Chon

submission deadline 1 Aug 2026 | Viewed by 89 | Submission Open

Keywords: fluorescent nanoparticles; bioimaging; targeted drug delivery; cancer nanotherapy; quantum dots; surface functionalization; biomedical nanotechnology; theragnostic; fluorescence imaging; deep tissue imaging

(This special issue belongs to the Section Molecular Nanoscience)

New Advances in Animal Reproduction

edited by Valdevane Rocha Araújo

submission deadline 10 Aug 2026 | Viewed by 57 | Submission Open

Keywords: folliculogenesis; oogenesis; oocyte maturation; follicle growth; preantral follicles; antral follicles; spermatogenesis; spermatozoa; bioengineering; scaffolds

(This special issue belongs to the Section Molecular Biology)

Molecular Pathogenesis and Treatments of Pediatric Leukemias

edited by

Joanna Zawitkowska

submission deadline 10 Aug 2026 | Viewed by 18 | Submission Open

Keywords: monoclonal antibodies; tyrosine kinase inhibitors; CAR-T; chemotherapy; drug induced toxicity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Development and Hormonal Signaling

edited by

Naoufal Lakhssassi

submission deadline 20 Aug 2026 | 6 articles | Viewed by 13622 | Submission Open

Keywords: plant growth; reproductive growth; phytohormones; signal transduction; transcription factors; root development; shoot development; floral development; seed development; environmental interactions; regulatory networks; apical dominance

(This special issue belongs to the Section Molecular Plant Sciences)

Toxicity Mechanism of Emerging Pollutants: 2nd Edition

edited by

Monika Naumowicz

and

Joanna Kotyńska

submission deadline 20 Aug 2026 | 4 articles | Viewed by 5080 | Submission Open

Keywords: emerging pollutant; toxicology; cancer; EDC; pesticides; microplastic; human cell lines; environment; molecular mechanisms

(This special issue belongs to the Section Molecular Toxicology)

Extracellular Vesicles (EVs) in Cancer Progression and Metastasis: Molecular Insights and Clinical Outlook

edited by Alfredo Cappariello

submission deadline 20 Aug 2026 | 2 articles | Viewed by 4972 | Submission Open

Keywords: mammalian extracellular vesicles; plant-derived extracellular vesicles; bacterial-derived extracellular vesicles; cancer progression; cell migration and invasion; tumor microenvironment; epithelial-to-mesenchymal transition (EMT); drug delivery; diagnostics; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Functional Genomics in Translational Medicine

edited by

Cornelia Braicu

, Oana Zanoaga and

Ștefan Strilciuc

submission deadline 20 Aug 2026 | 2 articles | Viewed by 4824 | Submission Open

Keywords: functional genomics; omics approaches; drug response/resistance; therapeutic targets; genomics and transcriptomic alteration; bioinformatic analysis; data integration; human disease; personalized medicine

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances in Seed Development and Germination

edited by

Sławomir Borek

Łukasz Wojtyla

and

Małgorzata Garnczarska

submission deadline 20 Aug 2026 | 3 articles | Viewed by 4730 | Submission Open

Keywords: seed aging; seed development; seed dormancy; seed germination; seed metabolism; seed preservation; seed priming; seed responses to stress

(This special issue belongs to the Section Molecular Plant Sciences)

Ferroptosis and Cuproptosis: Mechanism and Crosstalk in Cancer, Neurodegeneration, and Metabolic Syndrome

edited by

Rosanna Squitti

submission deadline 20 Aug 2026 | 2 articles | Viewed by 1652 | Submission Open

Keywords: ferroptosis; cuproptosis; Alzheimer's disease; colorectal cancer; neurodegeneration; metabolic syndrome; regulated cell death; iron metabolism; copper metabolism; psychiatric disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 3151-3200 on page 64 of 65.

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