Molecular Pathogenesis and Treatments of Pediatric Leukemias

Dear Colleagues,

In recent years, there has been remarkable progress in the diagnosis and treatment of hematological malignancies in children. The introduction of highly specific molecular techniques has significantly improved the identification of distinct expression profiles in diseases such as acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML).

Advancements in our understanding of the molecular biology of these diseases, genetic predispositions, and mechanisms of drug resistance have paved the way for innovative therapeutic strategies known as precision medicine. The rapid development of sequencing technologies has accelerated the identification of genetic abnormalities, which is crucial for improving outcomes in pediatric cancers. Innovative approaches include tyrosine kinase inhibitors and monoclonal antibodies—targeted therapies that offer low toxicity and are effective in treating leukemia patients. Chimeric antigen receptor T-cell (CAR-T) therapy represents a groundbreaking advancement in the treatment of relapsed or refractory hematological malignancies in children.

We welcome original and review manuscripts focused on these highly relevant and actively debated topics.

Prof. Dr. Joanna Zawitkowska
Guest Editor

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