ijms-logo

Journal Browser

Journal Browser

Adhesion, Invasion, and Metastasis in Cancer Progression

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 20 July 2026 | Viewed by 853

Special Issue Editor

Special Issue Information

Dear Colleagues,

Metastasis is the leading cause of cancer-related mortality and remains a significant challenge in clinical oncology. The process involves a cascade of events including cell adhesion, extracellular matrix remodelling, invasion, intravasation, and colonization of distant tissues. While significant advances have been made in understanding the genetic and molecular basis of tumour progression, the mechanisms underlying metastatic spread, particularly those linked to cellular adhesion and invasion, remain incompletely understood.

This Special Issue aims to highlight recent advances in the molecular and cellular mechanisms driving cancer cell adhesion, invasion, and metastasis. We invite original research articles, reviews, and short communications that address key regulators of metastatic progression, including noncoding RNAs, epithelial–mesenchymal transition (EMT), Wnt signalling, tumour microenvironment and novel therapeutic approaches targeting metastatic niches.

We especially welcome studies that combine molecular biology with translational or clinical insights, as well as bioinformatics analyses that uncover new biomarkers or predictive models for metastatic disease.

Dr. Pinar Uysal-Onganer
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer metastasis
  • cellular adhesion
  • invasion and migration
  • noncoding RNAs
  • EMT
  • Wnt/β-catenin signalling
  • tumour microenvironment
  • biomarkers
  • AI-driven metastasis prediction

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

18 pages, 5628 KB  
Article
Pharmacological Targeting of Midkine (MDK) Reveals Stiffness-Dependent Control of Hepatocellular Carcinoma Invasiveness
by Christiana Christou, Kyriacos Agathangelou, Nikolas Dietis, Andreas Stylianou and Vasiliki Gkretsi
Int. J. Mol. Sci. 2026, 27(4), 1766; https://doi.org/10.3390/ijms27041766 - 12 Feb 2026
Viewed by 536
Abstract
Metastasis accounts for most cancer-related deaths and hepatocellular carcinoma (HCC) is no exception. Midkine (MDK) is a multifunctional secreted protein elevated in HCC with a vague role in HCC. In this study, we used bioinformatics to verify MDK expression in HCC tumors, and [...] Read more.
Metastasis accounts for most cancer-related deaths and hepatocellular carcinoma (HCC) is no exception. Midkine (MDK) is a multifunctional secreted protein elevated in HCC with a vague role in HCC. In this study, we used bioinformatics to verify MDK expression in HCC tumors, and next, we inhibited the MDK protein in invasive Hep3B cells using an MDK inhibitor (iMDK) both in vitro and in vivo. Our results showed that iMDK promoted cell migration and enhanced lamellipodia formation while at the same time downregulating the expression of cell–matrix adhesion genes. In order to also consider forces exerted by the surrounding matrix, we performed cell adhesion, transwell invasion, and 3D tumor spheroid invasion assays in two different stiffness conditions. Adhesion and invasion always exhibited opposite patterns, with adhesion being inhibited in soft matrix environments, accompanied by increased invasion, and a reverse effect in stiff environments. In vivo experiments where cells pre-treated with iMDK were implanted to zebrafish embryos showed overall reduced metastasis, verifying that MDK is a central mechanotransduction regulator that enables HCC cells to adapt their metastatic strategies to ECM stiffness. Thus, MDK inhibition effectively disrupts mechanosensitive coordination during metastasis, highlighting its potential as a therapeutic target. Full article
(This article belongs to the Special Issue Adhesion, Invasion, and Metastasis in Cancer Progression)
Show Figures

Figure 1

Back to TopTop