ijms-logo

Journal Browser

Journal Browser

Role of Proteomics in Human Diseases and Infections: 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 July 2026 | Viewed by 842

Special Issue Editor


E-Mail Website
Guest Editor
Department of Biomedical and Molecular Science, Cancer Research Institute, Room 308, Queen's University, 18 Stuart Street, Kingston, ON K7L 3N6, Canada
Interests: virology; proteomics; influenza virus; zika virus
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The human genome has around 20,000 genes, which translates to over 80,000 proteins. These proteins guide almost every activity in our cells through direct interaction with each other and by regulating a wide range of signaling pathways. Diseases and infections can cause dysregulation of protein expression or impair their functions in critical signaling pathways, eventually reflected in organ-level dysfunction and may lead to severe illness or death.

This Special Issue aims to explore the application of proteomics in understanding and preventing human diseases and infections. Proteomics is pivotal for explaining the mechanisms of diseases at the molecular level, offering insights into protein functions, modifications, and interactions within biological contexts. As we uncover the proteome of cells and tissues in health and disease, we gain valuable information that can lead to the identification of biomarkers, therapeutic targets, and a deeper understanding of disease pathogenesis and host–pathogen interactions.

In this Issue, we encourage submissions that explore the dynamic proteome in various diseases, the interactions between pathogens and host proteomes, and the potential of proteomics in developing novel diagnostic and therapeutic strategies.

Dr. Mahamud Ur Rashid
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • proteomics
  • human diseases
  • infections
  • biomarkers
  • therapeutic targets
  • disease pathogenesis
  • host–pathogen interactions
  • diagnostic tools

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

27 pages, 3353 KB  
Article
Proteomic Signatures of Adiposomes Track Cardiometabolic Risk Reduction Following Bariatric Surgery
by Monica C. Asada, Mohamed Saad Rakab, Imaduddin Mirza, Giorgia Scichilone, Mohammed H. Morsy, Amro Mostafa, Francesco M. Bianco, Mohamed M. Ali, Chandra Hassan, Mario A. Masrur and Abeer M. Mahmoud
Int. J. Mol. Sci. 2026, 27(11), 4939; https://doi.org/10.3390/ijms27114939 - 29 May 2026
Viewed by 77
Abstract
Adipose tissue-derived extracellular vesicles (adiposomes) carry a protein cargo that we previously showed differs between obese and lean individuals. In this study, we investigate how adiposomal protein cargo changes in response to sleeve gastrectomy and examine whether these changes are associated with clinical [...] Read more.
Adipose tissue-derived extracellular vesicles (adiposomes) carry a protein cargo that we previously showed differs between obese and lean individuals. In this study, we investigate how adiposomal protein cargo changes in response to sleeve gastrectomy and examine whether these changes are associated with clinical improvements. Twenty-three obese adults underwent pre- and post-bariatric surgery adipose sampling for adiposome isolation and clinical assessments that included vascular and metabolic profiles and inflammatory markers. The adiposomal protein cargo was analyzed via non-targeted proteomics. Differential protein abundance, pathway enrichment, and correlation analyses were assessed. Twelve weeks after bariatric surgery, BMI and fat mass decreased, accompanied by improved glucose and lipid profiles. Inflammatory markers (leptin, IL-6, CRP) also declined, while adiponectin and nitric oxide increased. Adiposomal proteomics identified 287 proteins, with 138 significantly altered. Downregulated proteins included PRDX2, FN1, SERPIND1, and inflammatory mediators; upregulated proteins included talin-1, fibrinogens, and adiponectin. Correlation analysis linked these changes to improvements in lipid profiles, vascular function, and circulating inflammatory markers. Pathway analysis revealed inhibition of lipid-regulatory pathways alongside enrichment of immune, metabolic, and vascular pathways, including lipoprotein metabolism and endothelial signaling. Bariatric surgery-induced cardiometabolic improvements were accompanied by adiposome proteomic remodeling, characterized by reduced inflammation and metabolic reprogramming. Full article
(This article belongs to the Special Issue Role of Proteomics in Human Diseases and Infections: 2nd Edition)
17 pages, 1958 KB  
Article
Functional Validation of the Proteome-Identified LIC_13056 Putative Lipoprotein of Leptospira interrogans and the Potential Role in Pathogenesis
by Giovanna M. Costa, João P. Gaspar, Aline F. Teixeira and Ana L. T. O. Nascimento
Int. J. Mol. Sci. 2026, 27(5), 2086; https://doi.org/10.3390/ijms27052086 - 24 Feb 2026
Viewed by 508
Abstract
Leptospirosis is a widespread zoonosis of human and veterinary concern. The etiological agent of the disease is the pathogenic bacteria of the genus Leptospira. Transmission typically occurs through mucosal contact and/or injured skin with the urine of infected animals or contaminated environmental [...] Read more.
Leptospirosis is a widespread zoonosis of human and veterinary concern. The etiological agent of the disease is the pathogenic bacteria of the genus Leptospira. Transmission typically occurs through mucosal contact and/or injured skin with the urine of infected animals or contaminated environmental sources. Understanding the biology and pathogenesis of leptospires is the main focus of our study. In this work, we characterized a novel protein encoded by the LIC_13056 gene from L. interrogans serovar Copenhageni, having an OmpA-like domain. We show that this coding sequence (CDS), previously assigned as a hypothetical protein with an unknown function, is capable of binding to the cellular receptor α8 integrin subunit, potentially contributing to kidney colonization. Additionally, the protein bound to both purified and normal human serum (NHS) plasminogen (PLG). In both conditions, PLG bound to protein was able to generate plasmin (PLA). Furthermore, rLIC_13056 interacted with the complement system components C4b, C4BP, C8 and C9. The interaction of recombinant protein to the C9 had a negative impact on C9 polymerization. Taken together, the protein LIC_13056, having an OmpA-like domain, appears to be involved in leptospiral pathogenesis via different stages of the infection process; PLA generation together with the inhibition of the membrane attack complex (MAC) may contribute to the immune evasion mechanism of Leptospira, thus facilitating the infection. Full article
(This article belongs to the Special Issue Role of Proteomics in Human Diseases and Infections: 2nd Edition)
Show Figures

Figure 1

Back to TopTop