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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Viruses as Therapeutic Tools: Medical and Biotechnological Applications
edited by
submission deadline 20 Apr 2026 | 4 articles | Viewed by 12830 | Submission Open
Keywords: molecular virology; virus– host interactions; immunology; gene therapy vectors; vaccines; antivirals
(This special issue belongs to the Section Molecular Microbiology)
Galectins (Gals), 2nd Edition
edited by
submission deadline 20 Apr 2026 | 8 articles | Viewed by 12302 | Submission Open
Keywords: galectin; inhibitors; cancer; inflammation; glycans; drug design; modeling; biomarkers
(This special issue belongs to the Section Molecular Biology)
Molecular Insights in Neurodegeneration submission deadline 20 Apr 2026 | 5 articles | Viewed by 11505 | Submission Open
Keywords: neurodegeneration; molecular mechanisms; protein aggregation; neuroinflammation; oxidative stress; mitochondrial dysfunction; Alzheimer’ s disease; Parkinson’ s disease; biomarkers; therapeutic targets
(This special issue belongs to the Section Molecular Neurobiology)
New Advances in Epigenetics and Epigenomics
edited by Vicki Maltby
submission deadline 20 Apr 2026 | 4 articles | Viewed by 11273 | Submission Open
Keywords: epigenetics; epigenomics; multi-omics; epitranscriptomics; single cell
(This special issue belongs to the Section Molecular Genetics and Genomics)
Plant-Derived Bioactive Compounds for Pharmacological Applications submission deadline 20 Apr 2026 | 6 articles | Viewed by 11242 | Submission Open
Keywords: plant-derived bioactive compounds; pharmacological applications; antioxidant activity; anti-inflammatory agents; antimicrobial properties; neuroprotective effects; drug discovery; high-throughput screening; extraction and isolation techniques; structural characterization; CRISPR technology; genome editing; bioprocess engineering; bioreactor production; therapeutic potential; metabolite profiling
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Boosting the Production of Bioactive Compounds: Biotechnology and Metabolic Engineering of Medicinal Plants submission deadline 20 Apr 2026 | 5 articles | Viewed by 10983 | Submission Open
Keywords: bioactive compounds; plant tissue culture; elicitors; metabolic engineering; gene expression; medicinal plants; metabolic pathway; plant biotechnology
(This special issue belongs to the Section Molecular Plant Sciences)
Physiological Functions and Pathological Effects of Microglia
edited by Hiroshi Nakanishi
submission deadline 20 Apr 2026 | 5 articles | Viewed by 10859 | Submission Open
Keywords: circadian clock; homeostasis; immune response; microglia; neurodegenerative diseases; neuroinflammation; neuropsychiatric disorders; neuromodulation; phagocytosis; synaptic pruning
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Mechanisms and New Markers of Cancer
edited by
submission deadline 20 Apr 2026 | 5 articles | Viewed by 10717 | Submission Open
Keywords: molecular pathology; molecular mechanisms; immunotherapy; cancer; oncology; pathology; biomarkers
(This special issue belongs to the Section Molecular Oncology)
The Role of RNAs in Cancers: Recent Advances
edited by Roman Beňačka
submission deadline 20 Apr 2026 | 4 articles | Viewed by 10459 | Submission Open
Keywords: cancer cells; carcinogenesis; mRNAs; ncRNAs; lncRNAs; miRNAs; circRNAs; piRNAs; RNA-based diagnostics; RNA-based therapy
(This special issue belongs to the Section Molecular Oncology)
Molecular Insight into Skin Infection and Inflammation
edited by
submission deadline 20 Apr 2026 | 2 articles | Viewed by 10424 | Submission Open
Keywords: skin infection; skin inflammation; inflammatory skin diseases; atopic dermatitis; skin microbiome
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Insights into the Immunopathology of Autoimmune and Drug Induced Liver Injury
edited by Eleni Geladari
submission deadline 20 Apr 2026 | 2 articles | Viewed by 10407 | Submission Open
Keywords: liver disease; liver injury; immune system; immune dysregulation
(This special issue belongs to the Section Molecular Immunology)
Therapeutics and Pathophysiology of Cognitive Dysfunction
edited by
submission deadline 20 Apr 2026 | 3 articles | Viewed by 10163 | Submission Open
Keywords: cognition; neurologic diseases; neuroinflammation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biomarkers in Cancer Immunology
edited by
submission deadline 20 Apr 2026 | 3 articles | Viewed by 9899 | Submission Open
Keywords: immunotherapy; adoptive cell transfer; CAR-T cells; immune checkpoint inhibitors; tumor microenvironment; extracellular vesicles; biomarkers; miRNA; DNA
(This special issue belongs to the Section Molecular Immunology)
Editorial Board Members’ Collection Series: “Selenium and Sulfur Chemistry” submission deadline 20 Apr 2026 | 3 articles | Viewed by 9616 | Submission Open
Keywords: selenium; sulfur; redox; catalysis; selenoproteins; green chemistry; materials; stereoselective synthesis
(This special issue belongs to the Section Biochemistry)
Prostate Cancer Research Update: Molecular Diagnostic Biomarkers
edited by Mikhail Baryshev
submission deadline 20 Apr 2026 | 4 articles | Viewed by 9312 | Submission Open
Keywords: prostate cancer; molecular biomarkers; cancer-specific DNA methylation; non-coding genes; gene fusions; lncRNA
(This special issue belongs to the Section Molecular Oncology)
Biomarkers, Treatments, and Clinical Outcomes for Meningiomas and Other Skull Base Tumors
edited by and Philip David Tatman
submission deadline 20 Apr 2026 | 3 articles | Viewed by 9200 | Submission Open
Keywords: skull base tumor; meningioma; biomarkers; diagnosis; prognosis; radiology; surgery; pharmacotherapy; immunology
(This special issue belongs to the Section Molecular Oncology)
Research Advances in Reproductive Immunology
edited by
submission deadline 20 Apr 2026 | 2 articles | Viewed by 9132 | Submission Open
Keywords: reproductive immunology; immune regulation; fertility; pregnancy; immunocontraception
(This special issue belongs to the Section Molecular Immunology)
The Role of Cytokines in Health and Diseases
edited by Hung-Jen Liu
submission deadline 20 Apr 2026 | 5 articles | Viewed by 9113 | Submission Open
Keywords: cytokines; immune regulation; disease management; signaling pathways; translational research; clinical applications
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plant Chloroplasts and Mitochondria: Key Organelles for Sustainable Agriculture
edited by
submission deadline 20 Apr 2026 | 4 articles | Viewed by 8878 | Submission Open
Keywords: ‘ omics’ ; photosynthesis; energy production; crops; climate change; sustainable agriculture; stress response; inter-organelle crosstalk; signaling networks; genetic engineering
(This special issue belongs to the Section Molecular Plant Sciences)
The Role of Protein Kinase in Health and Diseases
edited by
submission deadline 20 Apr 2026 | 4 articles | Viewed by 8766 | Submission Open
Keywords: protein kinases; phosphorylation; cancer; neurological disorder; targeted therapies; metabolic diseases
(This special issue belongs to the Section Biochemistry)
Small Molecule Drug Design and Research: 3rd Edition
edited by
submission deadline 20 Apr 2026 | 5 articles | Viewed by 8738 | Submission Open
Keywords: drug design; diversity-oriented synthesis; combinatorial chemistry; computationally guided synthesis; drug-like compounds; computer modeling techniques
(This special issue belongs to the Section Molecular Pharmacology)
Gynecologic Oncology: Molecular Mechanisms and Therapies
edited by
submission deadline 20 Apr 2026 | 4 articles | Viewed by 8530 | Submission Open
Keywords: cervical cancer; endometrial cancer; ovarian cancer; vulvar cancer; carcinogenesis; microinvairment; immunotherapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Pathophysiology and Pharmacology in Psychiatry
edited by
submission deadline 20 Apr 2026 | 3 articles | Viewed by 8486 | Submission Open
Keywords: psychiatric disorders; mental health; pathophysiology; neuropsychopharmacology; brain
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Advances in Blood Disorders
edited by
submission deadline 20 Apr 2026 | 4 articles | Viewed by 8449 | Submission Open
Keywords: acquired and inherited blood disorders; diagnostic; prognostic and predictive biomarkers; molecular profiling; molecular monitoring; targeted therapy; leukaemia; lymphoma; disorders of haemostasis and thrombosis; genetic predisposition; germline pathogenic variants; molecular mechanisms; (epi)genomics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Progress in Molecular Mechanisms of Sperm Metabolism and Development
edited by Karl Kerns
submission deadline 20 Apr 2026 | 3 articles | Viewed by 8194 | Submission Open
Keywords: sperm development  ; germ cell proliferation  ; sperm cell metabolism  ; seminal fluid biochemical composition  ; spermatogenesis  ; epididymal maturation  ; sperm capacitation  ; oocyte activation  
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Nanofibrous Biomaterials for Biomedicine and Medical Applications
edited by Jong-Young Kwak
submission deadline 20 Apr 2026 | 3 articles | Viewed by 7712 | Submission Open
Keywords: nanofibers; biomaterials; 3D scaffold; 3D cell culture; tissue engineering; drug release
(This special issue belongs to the Section Materials Science)
Editorial Board Members’ Collection Series: “Molecular Dynamics” submission deadline 20 Apr 2026 | 3 articles | Viewed by 7687 | Submission Open
Keywords: quantum mechanics; classical mechanics; hybrid QM/MM; molecular dynamics at the atomic level; steered molecular dynamics; coarse-graining; docking(protein– protein; protein– ligand); the molecular dynamics of protein– ligand interactions; drug design; virtual screening
(This special issue belongs to the Section Molecular Biophysics)
Molecular Insights into Antioxidant and Anti-Inflammatory Properties of Bioactive Compounds
edited by
submission deadline 20 Apr 2026 | 2 articles | Viewed by 7582 | Submission Open
Keywords: antioxidant; anti-inflammatory; bioactive compounds; artificial intelligence; multiomics
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advances in Epigenetics of Mental Disorders
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 7448 | Submission Open
Keywords: mental disorders; epigenetic; epigenomic; gene– environment interactions
(This special issue belongs to the Section Molecular Neurobiology)
Mitochondrial Functions and Dynamics
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 7315 | Submission Open
Keywords: bioenergetics; mitochondrial biogenesis; mitochondrial morphology; apoptosis; mitophagy; reactive oxygen species; calcium homeostasis; cardiovascular diseases; neurodegenerative diseases; in vitro; cellular; and animal models; myopathies; mitochondria and immune system
(This special issue belongs to the Section Molecular Biology)
Advanced Therapy Using Human Mesenchymal Stem Cells (MSCs) and MSC Extracellular Vesicles
edited by Tong Ming Liu and Xiaoman Luo
submission deadline 20 Apr 2026 | 3 articles | Viewed by 7225 | Submission Open
Keywords: mesenchymal stem cells; extracellular vesicles; MSCs; MSC-EVs; regenerative medicine
(This special issue belongs to the Section Molecular Biology)
Genetic and Epigenetic Analyses in Cancer
edited by Jing Gong
submission deadline 20 Apr 2026 | 6 articles | Viewed by 7202 | Submission Open
Keywords: epigenetics; genetic mutations; chromosomal instability; DNA methylation; histone modifications; non-coding rnas; multi-omics; transcriptomics; proteomics; drug resistance in cancer; cancer biomarkers; therapeutic targets in cancer
(This special issue belongs to the Section Molecular Genetics and Genomics)
Microbiome Modulation Through Probiotics: Molecular Insights and Therapeutic Applications
edited by
submission deadline 20 Apr 2026 | 2 articles | Viewed by 7034 | Submission Open
Keywords: live bacterial cells; prebiotic agents; synbiotic formulations; probiotic formulations; microbial dysbiosis; inflammation; oxidative stress; host– microbe interactions
(This special issue belongs to the Section Molecular Microbiology)
Molecules and Mechanisms of Oxidative Stress Relevant in the Pathophysiology of Diseases
edited by
submission deadline 20 Apr 2026 | 6 articles | Viewed by 6722 | Submission Open
Keywords: redox-active iron; reactive oxygen species; antioxidants; oxidative damage; biomarkers; degenerative disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Newer Pharmacological Treatment Concepts for Patients with Acute Coronary Syndrome submission deadline 20 Apr 2026 | 2 articles | Viewed by 6714 | Submission Open
Keywords: acute coronary syndrome (ACS); molecular studies; antiplatelet; anticoagulant drugs; lipid-lowering therapies
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Signalling in Multitrophic Systems Involving Arthropods
edited by
submission deadline 20 Apr 2026 | 4 articles | Viewed by 6673 | Submission Open
Keywords: insects; plants; microorganisms; communication; symbioses; eavesdropping
(This special issue belongs to the Section Molecular Biology)
The Role of Glycans in Immune Regulation
edited by Senlian Hong
submission deadline 20 Apr 2026 | 2 articles | Viewed by 6600 | Submission Open
Keywords: glycoimmunology; glycotherapy; vaccines; glycan synthesis; immune tolerance
(This special issue belongs to the Section Molecular Immunology)
Protein Folding, Misfolding, and Related Diseases submission deadline 20 Apr 2026 | 3 articles | Viewed by 6506 | Submission Open
Keywords: protein folding; misfolding; amyloid; neurodegenerative diseases; chaperons; mechanisms; regulation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Antibody–Drug Conjugates
edited by Bing Sun
submission deadline 20 Apr 2026 | 1 articles | Viewed by 6439 | Submission Open
Keywords: antibody– drug conjugate (ADC); cancer treatment; non-oncology indications; antibody selection; payload; linker; conjugation chemistry
(This special issue belongs to the Section Molecular Immunology)
Recent Advances in Molecular Breeding for Drought and Salt Stress Tolerance in Crops: 2nd Edition
edited by
submission deadline 20 Apr 2026 | 4 articles | Viewed by 6431 | Submission Open
Keywords: drought; salt; heat; cold; gene regulation; genomic research; multiomics; epigenetics; stress signal transduction
(This special issue belongs to the Section Molecular Plant Sciences)
Wheat Genetics and Genomics: 3rd Edition
edited by
submission deadline 20 Apr 2026 | 4 articles | Viewed by 6414 | Submission Open
Keywords: wheat; genetics; molecular breeding; genome variation; multiomics
(This special issue belongs to the Section Molecular Plant Sciences)
Recent Research of Phytochemicals in Health and Disease
edited by Sachiko Koyama, and
submission deadline 20 Apr 2026 | 2 articles | Viewed by 6360 | Submission Open
Keywords: phytochemicals with bioactive properties; health; brain function; regeneration; wound healing; treatment; and prevention of diseases; delivery routes and delivery methods; formulation of phytochemicals to overcome their hydrophobic nature and enhance their stability; drugs; supplements to drugs; and supplements for health maintenance; nourishment and phytochemicals; drug side effects; COVID-19
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Understanding of Allergen Exposome submission deadline 20 Apr 2026 | 4 articles | Viewed by 6311 | Submission Open
Keywords: allergen exposome; profile allergen exposures; climatic change; airborne allergens; molecular triggers; microbial allergens
(This special issue belongs to the Section Molecular Immunology)
Stem Cells in Health and Disease: 3rd Edition
edited by
submission deadline 20 Apr 2026 | 4 articles | Viewed by 6094 | Submission Open
Keywords: stem cell regulation; differentiation; pluripotency; reprogramming; stem cell therapy; cancer stem cell/tumor-initiating cell; therapy resistance; regenerative medicine; metabolic plasticity
(This special issue belongs to the Section Molecular Biology)
Natural Medicines and Functional Foods for Human Health
edited by Qiong Wang
submission deadline 20 Apr 2026 | 2 articles | Viewed by 5968 | Submission Open
Keywords: functional food; natural medicine; traditional Chinese medicine; memory; depression; dementia; Alzheimer’ s disease; Parkinson’ s disease; space medicine; sleeplessness; anti-inflammation
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Musculoskeletal Diseases: Advances in Molecular Mechanisms and Therapeutic Approaches
edited by
submission deadline 20 Apr 2026 | 4 articles | Viewed by 5820 | Submission Open
Keywords: bone; muscle; tendon; cartilage; osteoporosis; sarcopenia; tendinopathy; osteoarthritis; musculoskeletal pathophysiology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Genetic, Epigenetic and Microbiota Molecular Insights for Crop Resilience to Abiotic Stress
edited by
submission deadline 20 Apr 2026 | 3 articles | Viewed by 5755 | Submission Open
Keywords: abiotic stress; tolerance; crop resilience; crop sustainability; environmental conditions; climate change; gene regulation; epigenetic mechanisms; microbiota communities; microbiome
(This special issue belongs to the Section Molecular Plant Sciences)
Novel Approaches for Tissue Repair and Tissue Regeneration
edited by Srinivas Madduri
submission deadline 20 Apr 2026 | 2 articles | Viewed by 5633 | Submission Open
Keywords: injuries; tissue repair; tissue regeneration; tissue engineering; tissue bioengineering; bioactive biomaterial; cell and gene therapeutics; hydrogel; immune modulation
(This special issue belongs to the Section Molecular Biology)
Plant Breeding and Genetics: New Findings and Perspectives
edited by
submission deadline 20 Apr 2026 | 8 articles | Viewed by 5493 | Submission Open
Keywords: quantitative genetics; classical plant breeding; marker-assisted selection; genomic selection; speed breeding; gene editing and biotechnology
(This special issue belongs to the Section Molecular Plant Sciences)
Natural Active Substances in Human Diseases
edited by
submission deadline 20 Apr 2026 | 2 articles | Viewed by 5486 | Submission Open
Keywords: natural active substances; bioactive compounds; molecular mechanisms; traditional medicine; metabolic disorders; inflammatory diseases; neurodegenerative diseases
(This special issue belongs to the Section Bioactives and Nutraceuticals)
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