ijms-logo

Journal Browser

Journal Browser

Plant-Derived Bioactive Compounds for Pharmacological Applications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 20 November 2025 | Viewed by 310

Special Issue Editors

Special Issue Information

Dear Colleagues,

Plant-derived bioactive compounds are integral to advancing human health, revealing their wide-ranging biological properties, including antioxidant, antimicrobial, anti-inflammatory, anticarcinogenic, and neuroprotective effects. These compounds hold significant potential in preventing and managing non-communicable diseases such as cardiovascular disorders, autoimmune conditions, cancer, metabolic syndromes, and neurodegenerative diseases. The exploration and application of these natural molecules continue to be central pursuits across various scientific disciplines, including phytochemistry, biochemistry, pharmacology, molecular biology, biotechnology, medicinal chemistry, and pharmaceutical innovation.

This Special Issue seeks contributions highlighting recent advancements in the discovery, characterization, and application of plant-based bioactive compounds. Topics of interest include high-throughput screening techniques, novel extraction and isolation methods, structural analysis, and in vivo or in vitro evaluations of pharmacological activities. We also encourage studies leveraging state-of-the-art technologies, such as CRISPR, genome editing, bioprocess engineering, and bioreactor-based production, to optimize the identification, synthesis, and therapeutic application of these bioactive molecules.

We look forward to your valuable submissions.

Dr. Ilian Badjakov
Dr. Ivayla Dincheva
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • plant-derived bioactive compounds
  • pharmacological applications
  • antioxidant activity
  • anti-inflammatory agents
  • antimicrobial properties
  • neuroprotective effects
  • drug discovery
  • high-throughput screening
  • extraction and isolation techniques
  • structural characterization
  • CRISPR technology
  • genome editing
  • bioprocess engineering
  • bioreactor production
  • therapeutic potential
  • metabolite profiling

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Jump to: Review

14 pages, 2095 KiB  
Article
Syringin and Phillygenin—Natural Compounds with a Potential Role in Preventing Lipid Deposition in Macrophages in the Context of Human Atherosclerotic Plaque
by Agnieszka Filipek, Agnieszka Sadowska, Monika Skłodowska, Maja Muskała and Edyta Czepielewska
Int. J. Mol. Sci. 2025, 26(13), 6444; https://doi.org/10.3390/ijms26136444 - 4 Jul 2025
Abstract
Syringin is a phenylpropanoid glycoside isolated from the bark of Syringa vulgaris. Phillygenin is a lignan obtained mainly from the fruits and flowers of Forsythia intermedia. Both compounds have shown potent anti-inflammatory and antioxidant properties. We investigated the potential role of [...] Read more.
Syringin is a phenylpropanoid glycoside isolated from the bark of Syringa vulgaris. Phillygenin is a lignan obtained mainly from the fruits and flowers of Forsythia intermedia. Both compounds have shown potent anti-inflammatory and antioxidant properties. We investigated the potential role of syringin and phillygenin in preventing lipid deposition in macrophages. Syringin and phillygenin significantly (p < 0.001) reduced lipid deposition in macrophages in a dose-dependent manner. For syringin, the greatest reduction in CD36 receptor expression was found to be over 80% (50 μg/mL) compared to the cholesterol-stimulated control (p < 0.001). Phillygenin inhibited CD36 receptor expression by approximately 25% (50 μg/mL), compared to the stimulated control (p < 0.05). For syringin, the CD36 receptor regulation pathway was PPAR-γ dependent. Phillygenin showed a statistically significant (p < 0.001) increase in the expression of the ABCA1 transporter: 2.5-fold (10 μg/mL), 3-fold (20 μg/mL) and 4-fold (50 μg/mL) compared to the cholesterol-stimulated control. Syringin did not significantly increase ABCA1 expression. For phillygenin, the activation pathway of the ABCA1 transporter was HO-1dependent. Our study showed that syringin inhibits the cholesterol-induced differentiation of macrophages into foam cells. Moreover, phillygenin increased cholesterol efflux from macrophages. Therefore, syringin and phillygenin may be valuable agents in the prevention of early and late atherosclerosis. Full article
(This article belongs to the Special Issue Plant-Derived Bioactive Compounds for Pharmacological Applications)
Show Figures

Figure 1

Review

Jump to: Research

35 pages, 3582 KiB  
Review
Polyphenols in the Central Nervous System: Cellular Effects and Liposomal Delivery Approaches
by Mateusz Kaluza, Dominika Ksiazek-Winiarek, Piotr Szpakowski, Joanna Czpakowska, Julia Fijalkowska and Andrzej Glabinski
Int. J. Mol. Sci. 2025, 26(13), 6477; https://doi.org/10.3390/ijms26136477 (registering DOI) - 4 Jul 2025
Abstract
Neurodegenerative and neuroinflammatory diseases of the central nervous system are closely linked to aging and sustained oxidative and inflammatory stress. Polyphenols, plant-derived secondary metabolites, exhibit broad biological activities, including antioxidant and anti-inflammatory effects, the modulation of pathways such as PI3K/Akt, MAPK, Nrf2, and [...] Read more.
Neurodegenerative and neuroinflammatory diseases of the central nervous system are closely linked to aging and sustained oxidative and inflammatory stress. Polyphenols, plant-derived secondary metabolites, exhibit broad biological activities, including antioxidant and anti-inflammatory effects, the modulation of pathways such as PI3K/Akt, MAPK, Nrf2, and CREB, and the regulation of neurogenesis and microglial activation. This review focuses on the cell-specific actions of selected polyphenols in neurons, astrocytes, microglia, and oligodendrocytes within the context of Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. A major limitation to the therapeutic use of polyphenols is their poor bioavailability, due to instability, low solubility, and limited blood–brain barrier penetration. Liposomal nanocarriers are explored as promising delivery systems to overcome these barriers. Both conventional and functionalized liposomes (e.g., PEGylated, receptor-targeted) are discussed, alongside in vitro and in vivo studies demonstrating enhanced efficacy compared to free compounds. Intranasal delivery is also presented as a viable alternative to oral administration. Overall, polyphenols offer great potential as neuroprotective agents, and liposome-based delivery platforms have the potential to significantly enhance their clinical potential, provided that key formulation and targeting issues are addressed. Full article
(This article belongs to the Special Issue Plant-Derived Bioactive Compounds for Pharmacological Applications)
Show Figures

Figure 1

Back to TopTop