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Molecular Insight into Skin Infection and Inflammation

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 July 2025 | Viewed by 2434

Special Issue Editor


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Guest Editor
Department of Dermatology, Venereology and Allergology, Wrocław Medical University, 50-368 Wrocław, Poland
Interests: cosmetology; cosmetics; aestetic dermatology; skin allergy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Skin inflammation is a sign of an immune response in the body. Symptoms include redness, heat, swelling, pain and itching. Skin inflammation has many potential causes, including allergies, infections and autoimmune diseases.

In this Special Issue, we would like to focus on modern developments in the molecular diagnosis, role and therapy of skin infections. Given how active these fields are, much progress is being made in research into the contribution of infections and the aetipathogenesis of skin diseases such as acne vulgaris, rosacea, psoriasis, atopic dermatitis, etc. The study of the composition and role of the microbiome of healthy skin and that of skin with dermatological diseases and cosmetic defects is also very dynamic.

We invite original research and review articles relating to skin infection and inflammation. Therefore, I hope that the proposed theme for this Special Issue will be of great interest.

Dr. Danuta Nowicka
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • skin infection
  • skin inflammation
  • inflammatory skin diseases
  • atopic dermatitis
  • skin microbiome

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Published Papers (1 paper)

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Review

29 pages, 1669 KiB  
Review
Intralesional Immunotherapy for Non-Genital Viral Warts: A Review of Current Evidence and Future Perspectives
by Emilia Kucharczyk, Karolina Pawłuszkiewicz, Karol Biliński, Joanna Maj and Małgorzata Ponikowska
Int. J. Mol. Sci. 2025, 26(12), 5644; https://doi.org/10.3390/ijms26125644 - 12 Jun 2025
Viewed by 1784
Abstract
Cutaneous warts caused by human papillomavirus (HPV) are among the most common dermatological conditions, affecting the quality of life of numerous people. Although they are widespread, effective and reliable treatment alternatives are limited, emphasizing the necessity for novel treatment options. Intralesional immunotherapy has [...] Read more.
Cutaneous warts caused by human papillomavirus (HPV) are among the most common dermatological conditions, affecting the quality of life of numerous people. Although they are widespread, effective and reliable treatment alternatives are limited, emphasizing the necessity for novel treatment options. Intralesional immunotherapy has emerged as a promising alternative, aiming to stimulate the host immune response to achieve the clearance of both treated and distant lesions. This review explores the immunopathogenesis of cutaneous warts and provides an in-depth analysis of intralesional therapies including measles–mumps–rubella (MMR) vaccine, purified protein derivative (PPD), Bacillus Calmette–Guérin (BCG), Candida antigen, Mycobacterium w vaccine (MWV), vitamin D3, and autoinoculation. We provide a comprehensive analysis of the most promising modalities, highlighting their mechanism of action, outcomes, advantages, and limitations. Although initial data indicate that intralesional immunotherapy offers advantageous efficacy and tolerability, there is a lack of standardized treatment protocols and randomized controlled trials to endorse its broad application. Nevertheless, considering its potential to address local and distant lesions with minimal adverse effects, intralesional immunotherapy may represent a transformative approach to managing cutaneous warts. Full article
(This article belongs to the Special Issue Molecular Insight into Skin Infection and Inflammation)
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