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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Antisense Oligonucleotides: Versatile Tools with Broad Applications
edited by
submission deadline 25 Dec 2026 | 4 articles | Viewed by 8014 | Submission Open
Keywords: antisense oligonucleotide; RNase H; splice switching; exon skipping; therapeutics; pesticide
(This special issue belongs to the Section Molecular Biology)
Food Allergy: Molecular Mechanisms, Clinical Challenges, and Future Directions
edited by
submission deadline 25 Dec 2026 | 5 articles | Viewed by 7958 | Submission Open
Keywords: food allergy; allergen; environmental exposures; gut microbiome; non-IgE-mediated pathways
(This special issue belongs to the Section Molecular Immunology)
Pain in Human Health and Disease
edited by
submission deadline 25 Dec 2026 | 3 articles | Viewed by 7816 | Submission Open
Keywords: pain signaling; molecular pathways; chronic pain; neuropathic pain; inflammation neuro–immune interactions; epigenetics pharmacogenetics; precion medicine; sleep disorders
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Roles of Lipid Rafts in the Regulation of Cellular Processes and Diseases
edited by
submission deadline 25 Dec 2026 | 1 articles | Viewed by 7711 | Submission Open
Keywords: lipid rafts; glycosphingolipid; ganglioside; sphingomyelin; cholesterol; GPI-anchored proteins; caveolae; detergent-resistant membrane; signal transduction; disease
(This special issue belongs to the Section Biochemistry)
Molecular Underpinnings of Schizophrenia Spectrum Disorders, 2nd Edition
edited by and
submission deadline 25 Dec 2026 | 4 articles | Viewed by 7564 | Submission Open
Keywords: schizophrenia spectrum disorders; central nervous system (CNS); psychotic disorders
(This special issue belongs to the Section Molecular Neurobiology)
Inflammatory Bowel Disease: Molecular Advances in Pathogenesis and Therapies, 2nd Edition submission deadline 25 Dec 2026 | 8 articles | Viewed by 7362 | Submission Open
Keywords: Crohn’s disease; inflammatory bowel disease; immunologic and molecular mechanisms; therapies in IBD; ulcerative colitis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Peptide and Protein Drugs Against Infectious Diseases and Allergic Diseases
edited by
submission deadline 25 Dec 2026 | 2 articles | Viewed by 7048 | Submission Open
Keywords: peptide and protein drugs; infectious diseases; allergic diseases; hormones; antimicrobial peptides; neuropeptides; cell-penetrating peptides; enzyme inhibitors; vaccines; antibodies
(This special issue belongs to the Section Molecular Pharmacology)
Molecular and Structural Research Advances in Model Plants (Second Edition) submission deadline 25 Dec 2026 | 3 articles | Viewed by 6723 | Submission Open
Keywords: A. thaliana; plant biology; model organisms; plant models; non-model plant models
(This special issue belongs to the Section Molecular Plant Sciences)
Accelerating Therapeutic Innovation: Advances in Computer-Aided Drug Discovery
edited by Pietro Delre and
submission deadline 25 Dec 2026 | 4 articles | Viewed by 6287 | Submission Open
Keywords: CADD; drug discovery; machine learning; virtual screening; drug-target interaction
(This special issue belongs to the Section Molecular Informatics)
New Research Perspectives in Protein Glycosylation
edited by
submission deadline 25 Dec 2026 | 5 articles | Viewed by 6237 | Submission Open
Keywords: glycan function; glycan structural analysis; glycoproteomics; glycoengineering; systems glycobiology
(This special issue belongs to the Section Biochemistry)
The Roles of Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists in Health and Disease submission deadline 25 Dec 2026 | 2 articles | Viewed by 5968 | Submission Open
Keywords: GLP-1; GLP-1 receptor; GLP-1 signaling pathway; mechanism of action; GLP-1 agonists; human diseases; adverse effects
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Neuroendocrine Tumors: From Molecular Pathology to Novel Therapeutic Approaches, Including Theranostics
edited by
submission deadline 25 Dec 2026 | 3 articles | Viewed by 5967 | Submission Open
Keywords: neuroendocrine tumors; NETs; molecular pathology; therapeutic strategies
(This special issue belongs to the Section Molecular Oncology)
Synthetic Chemistry in Drug Discovery
edited by Kathiravan Suppan
submission deadline 25 Dec 2026 | 3 articles | Viewed by 5925 | Submission Open
Keywords: late-stage functionalization; AI-driven synthesis; drug discovery; synthetic chemistry; transition metal catalysis
(This special issue belongs to the Section Molecular Pharmacology)
Advancements in Inflammatory and Oxidative Disease Research
edited by
submission deadline 25 Dec 2026 | 4 articles | Viewed by 5908 | Submission Open
Keywords: diabetes; cancer; neurological diseases; inflammation; oxidative stress; endocrinology; gastroenterology; pulmonology; rheumatology; cardiology; neurology; nephrology; dermatology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Food Allergens: Latest Molecular Advancements
edited by and
submission deadline 25 Dec 2026 | 4 articles | Viewed by 5833 | Submission Open
Keywords: food allergies; allergen; allergenicity; epitope; desensitization; immunity reaction; hypoallergen; Ig E binding; Abkhazian; Acehnese; Acholi; Afar; Afrikaans; Albanian; Alur; Amharic; Arabic; Armenian; Assamese; Avaric; Awadhi; Aymara; Azerbaijani; Balinese; Baluchi; Bambara; Baoulé; Bashkir; Basque; Batak; Batak Simalungun; Batak Toba; Belarusian; Bemba; Bengali; Betawi; Bhojpuri; Bikol; Bosnian; Breton; Bulgarian; Buryat; Cantonese; Catalan; Cebuano; Chamorro; Chechen; Chichewa; Chuukese; Chuvash; Corsican; Crimean Tatar; Crimean Tatar (Latin); Croatian; Czech; Danish; Dari; Dinka; Divehi; Dogri; Dombe; Dutch; Dyula; Dzongkha; English; English (USA); Esperanto; Estonian; Ewe; Faroese; Fijian; Filipino; Finnish; Fon; French; French (Canadian); Frisian; Friulian; Fulah; Ga; Galician; Georgian; German; Greek; Guarani; Gujarati; Haitian Creole; Hakha Falam; Hausa; Hawaiian; Hebrew; Hiligaynon; Hindi; Hmong; Hungarian; Hunsrik; Iban; Icelandic; Igbo; Ilocano; Indonesian; Inuktitut; Inuktitut (Latin); Irish; Italian; Jamaican Patois; Japanese; Javanese; Jingpho; Kalaallisut; Kannada; Kanuri; Kapampangan; Kazakh; Khasi; Khmer; Kiga; Kikongo; Kinyarwanda; Kokborok; Komi; Konkani (Latin); Korean; Krio; Kurdish (Kurmanji); Kurdish (Sorani); Kyrgyz; Lao; Latgalian; Latin; Latvian; Ligurian; Limburgish; Lingala; Lithuanian; Lombard; Luganda; Luo; Luxembourgish; Macedonian; Madurese; Maithili; Makassarese; Malagasy; Malay; Malay (Arabic); Malayalam; Maltese; Mam; Manx; Maori; Marathi; Mari; Marshallese; Marwari; Mauritian Creole; Meitei/Meetei (Mayek); Minangkabau; Mizo; Mongolian; Myanmar (Burmese); N'Ko Bambara; Nahuatl; Ndau (Zimbabwe); Ndebele; Nepali; Newari; Northern Sami; Norwegian; Nuer; Occitan; Odia; Oromo; Ossetian; Pangasinan; Papiamento; Pashto; Persian; Polish; Portuguese; Portuguese (Portugal); Punjabi; Punjabi (Arabic); Q'eqchi'; Quechua; Romani; Romanian; Rundi; Russian; Samoan; Sango; Sanskrit; Santali; Santali (Latin); Scots Gaelic; Sepedi; Serbian; Sesotho; Seychellois Creole; Shan; Shona; Sicilian; Silesian; Simplified Chinese; Sindhi; Sinhala; Slovak; Slovenian; Somali; Spanish; Sundanese; Susu; Swahili; Swati; Swedish; Tahitian; Tajik; Tamazight; Tamazight (Latin); Tamil; Tatar; Telugu; Tetum; Thai; Tibetan; Tigrinya; Tiv; Tok Pisin; Tongan; Traditional Chinese; Tshiluba; Tsonga; Tswana; Tulu; Tumbuka; Turkish; Turkmen; Tuvan; Twi; Udmurt; Ukrainian; Urdu; Uyghur; Uzbek; Venda; Venetian; Vietnamese; Waray; Welsh; Wolof; Xhosa; Yakut; Yiddish; Yoruba; Yucatec Maya; Zapotec; Zulu
(This special issue belongs to the Section Molecular Biology)
Microbial Genomics in the Omics Era
edited by
submission deadline 25 Dec 2026 | 4 articles | Viewed by 5830 | Submission Open
Keywords: microbe; bioinformatics; DNA; RNA; protein; sequencing; structure; omics
(This special issue belongs to the Section Molecular Microbiology)
Inflammatory Bowel Disease: Pathogenesis and Novel Therapeutic Approaches
edited by Francisco Giner
submission deadline 25 Dec 2026 | 2 articles | Viewed by 5748 | Submission Open
Keywords: coeliac disease; microscopic colitis; Crohn’s disease; ulcerative colitis; microbiota; biological therapies; refractory disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Graphene-Based Nanocomposites and Perspectives on Their Design
edited by Aleksey E. Kuznetsov
submission deadline 25 Dec 2026 | 3 articles | Viewed by 5568 | Submission Open
Keywords: graphene; graphene oxide; nanocomposite; synthesis; computational study; characterization; application; design
(This special issue belongs to the Section Molecular Nanoscience)
Applications of Mass Spectrometry in the Analysis of Bioactive and Plant Organic Compounds
edited by
submission deadline 25 Dec 2026 | 3 articles | Viewed by 5510 | Submission Open
Keywords: mass spectrometry; VOCs; bioactive compounds; plant organic compounds; pharmaceutical research; metabolites
(This special issue belongs to the Section Biochemistry)
Mitigating Metal Toxicity: Contaminated Environment, Animal Studies and Human Health submission deadline 25 Dec 2026 | 3 articles | Viewed by 5385 | Submission Open
Keywords: heavy metal toxicity; heavy metal pollution; heavy metal bioaccumulation and interactions; health risk; mechanistic analysis; dysregulation of cellular homeostasis; natural plant bioactive compounds; human diseases; environmental pollution; in vitro/animal studies; innovative strategies; polyoxometalates (POMs); metal-organic frameworks (MOFs)
(This special issue belongs to the Section Molecular Toxicology)
Nature-Inspired and Synthetic Compounds: New Frontiers in Bioactivity and Drug Discovery
edited by and
submission deadline 25 Dec 2026 | 5 articles | Viewed by 5318 | Submission Open
Keywords: natural and synthetic products; drug discovery and development; drug repurposing; artificial intelligence and machine learning; biological evaluation; healthcare; green and sustainable chemistry; natural and synthetic drug applications
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Liver Disease and Primary Liver Cancer: Translational Advances and Therapeutic Perspectives
edited by
submission deadline 25 Dec 2026 | 6 articles | Viewed by 5283 | Submission Open
Keywords: liver disease; hepatocellular carcinoma; cholangiocarcinoma; molecular mechanisms; translational research; 3D models and organoids; biomarkers and therapeutic strategies; MASH/MASLD: pathogenesis, diagnosis, and management; primary liver cancer: pathogenesis, detection, and treatment; inflammation in liver disease; 3D liver models; microbiota and liver disease; mechanisms of damage and repair: ischemia-reperfusion injury; cellular pathology in acute and chronic liver damage of different origin; biomarkers in liver disease: emerging methods and potential applications; immunology in the liver—from homeostasis to disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Exploring Abiotic Stress in Plants: Mechanisms, Adaptations, and Mitigation Strategies (2nd Edition)
edited by
submission deadline 25 Dec 2026 | 4 articles | Viewed by 5276 | Submission Open
Keywords: abiotic stress; plant physiology; stress tolerance; crop resilience; molecular mechanisms; biotechnological interventions
(This special issue belongs to the Section Molecular Plant Sciences)
Innovative Therapeutic Approaches to Endocrine Disorders submission deadline 25 Dec 2026 | 3 articles | Viewed by 5257 | Submission Open
Keywords: endocrine disorders; osteoporosis; diabetes; obesity; synthetic drugs; nutraceuticals; biomarkers
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Immunological Control of Vascular Plasticity: Insights into Arteriogenesis, Angiogenesis, and Atherosclerosis submission deadline 25 Dec 2026 | 2 articles | Viewed by 5233 | Submission Open
Keywords: vascular plasticity; arteriogenesis; angiogenesis; atherosclerosis; immune modulation; inflammation and vascular remodeling; translational vascular immunology; smooth muscle cell-/endothelial cell proliferation; sterile inflammation; collateral artery growth
(This special issue belongs to the Section Molecular Immunology)
Antimicrobial Nanoparticles: Mechanisms, Applications, and Future Directions submission deadline 25 Dec 2026 | 5 articles | Viewed by 5143 | Submission Open
Keywords: antimicrobial activity; nanoparticles; biofilm nano-modulators; antibiotic resistence; wastewater treatment; preservative properties of nanoparticles
(This special issue belongs to the Section Molecular Microbiology)
Advances in Traits in Animals and Aquatic Species, and Their Improvement Technologies
edited by
submission deadline 25 Dec 2026 | 4 articles | Viewed by 5080 | Submission Open
Keywords: biotechnology; genetic breeding; stress responses; epigenetics; non-coding RNAs; gene regulation; molecular ecology; animals; aquaculture; development
(This special issue belongs to the Section Molecular Biology)
Molecular Endocrine Regulation in Health and Diseases
edited by Fady Hannah-Shmouni
submission deadline 25 Dec 2026 | 1 articles | Viewed by 4949 | Submission Open
Keywords: exposome and endocrine disruptors; endocrine-disrupting chemicals (EDCs); environmental toxicology and hormonal health; epigenetics and endocrine function; endocrine regulation and chronic disease; public health and exposure mitigation; endocrine disruptors in the home and community
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Heat Shock Proteins (HSPs): Biological Functions and Mechanisms of Actions submission deadline 25 Dec 2026 | 4 articles | Viewed by 4778 | Submission Open
Keywords: heat shock proteins; apoptosis; immune cell activation; stress responses; misfolded proteins; cellular chaperones; cell signaling
(This special issue belongs to the Section Biochemistry)
Antiviral Drug Targets: Structure, Function, and Drug Design—3rd Edition
edited by and
submission deadline 25 Dec 2026 | 3 articles | Viewed by 4753 | Submission Open
Keywords: viral infections; drug design; protein structures; functional studies; viruses; antiviral drugs
(This special issue belongs to the Section Molecular Pharmacology)
Targeting Epigenetic Complexes and Alternative Protein Degradation Pathways in Medicinal Chemistry
edited by Jean Leandro Dos Santos
submission deadline 25 Dec 2026 | 2 articles | Viewed by 4743 | Submission Open
Keywords: protein degradation; LYTAC; AUTAC; ATTEC; epigenetics; NuRD; HDAC; BRD; SWI/SNF; PRC2; chromatin; conjugates; lysosome; autophagy; drug discovery
(This special issue belongs to the Section Biochemistry)
Eukaryotic DNA Replication—from Bench to Bedside
edited by Heinz-Peter Nasheuer
submission deadline 25 Dec 2026 | 1 articles | Viewed by 4593 | Submission Open
Keywords: genome stability; cell cycle; DNA replication; chromatin replication; replication origins—selection, licensing and firing; replication forks—smoothly progressing and under stress; role of DNA replication in cancer and other human diseases; disease treatment opportunities
(This special issue belongs to the Section Molecular Genetics and Genomics)
Natural Compounds: Impact on Health and Disease
edited by
submission deadline 25 Dec 2026 | 3 articles | Viewed by 4518 | Submission Open
Keywords: natural compounds; bioactive molecules; disease prevention; phytochemicals; functional food; molecular mechanisms; therapeutic potential; oxidative stress; immune modulation
(This special issue belongs to the Section Bioactives and Nutraceuticals)
New Research on Bioactive Natural Products: 2nd Edition submission deadline 25 Dec 2026 | 1 articles | Viewed by 4252 | Submission Open
Keywords: chronic disorders; bioactives; natural sources; sustainable sources; biomolecular; structure–activity relationship; synergism; health promoting; bio-functional; products; supplements; nutraceuticals; drugs
(This special issue belongs to the Section Bioactives and Nutraceuticals)
MicroRNAs in Physiology and Pathophysiology
edited by Małgorzata Guz
submission deadline 25 Dec 2026 | 3 articles | Viewed by 4245 | Submission Open
Keywords: miRNA; cell physiology; metabolism; cancer; biomarkers; disease; molecular mechanisms; diagnosis; therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Highlights in Pathophysiology of the Musculoskeletal System, 3rd Edition submission deadline 25 Dec 2026 | 2 articles | Viewed by 3937 | Submission Open
Keywords: musculoskeletal; skeletal; tendon; ligament; intervertebral; articular cartilage; osteoarthritis; rheumatoid arthritis; sarcopenia; muscle wasting; osteoporosis; bone necrosis; synovium; pain; inflammation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights in Diabetes submission deadline 25 Dec 2026 | 2 articles | Viewed by 3872 | Submission Open
Keywords: insulin signalling pathway; pancreatic beta-cell dysfunction; oxidative stress; epigenetic modifications; metabolic memory; small regulatory RNAs (miRNAs); inflammation and insulin resistance; glucagon-like peptide-1 (GLP-1); glucose-dependent insulinotropic polypeptide (GIP); molecular therapeutic targets; glucose homeostasis regulation
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Advances in Assisted Reproductive Technologies
edited by
submission deadline 25 Dec 2026 | 1 articles | Viewed by 3780 | Submission Open
Keywords: preimplantation genetic testing; embryo selection; in vitro fertilization; infertility; implantation failure; miscarriage; mosaicism; segmental aneuploidy; non-invasive technology; morpho kinetics; in vitro gametogenesis; in vitro oocyte maturation; reproductive tissue cryopreservation; artificial intelligence (AI)
(This special issue belongs to the Section Molecular Biology)
Molecular Research on the Pathology and Treatment of Sepsis and Non-Infectious Inflammatory Conditions
edited by
submission deadline 25 Dec 2026 | 2 articles | Viewed by 3714 | Submission Open
Keywords: sepsis; comorbidities; inflammation; molecular mechanisms; cytokine signaling; oxidative stress; leukocyte recruitment; therapeutic targets
(This special issue belongs to the Section Molecular Immunology)
Targeting MAPK in Human Diseases
edited by
submission deadline 25 Dec 2026 | 1 articles | Viewed by 3643 | Submission Open
Keywords: ERK; DUSP; cancer; inflammation; neurodegenerative diseases; autoimmune diseases; targeted therapy; cell signaling
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Obesity Research: Metabolic Pathways and Pathophysiological Factors
edited by Aleksandra Stefanović
submission deadline 25 Dec 2026 | 4 articles | Viewed by 3606 | Submission Open
Keywords: obesity; inflammation; oxidative stress; obesity-related diseases; adypocitokines
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Advances in Pulmonary Hypertension and Interstitial Lung Diseases: Mechanisms and Treatments submission deadline 25 Dec 2026 | 2 articles | Viewed by 3602 | Submission Open
Keywords: pulmonary hypertension; interstitial lung disease; lung fibrosis; pulmonary hemodynamics; pulmonary function testing; pathogenesis; prognosis; survival; treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Molecular Targets for Treatment and Drug Delivery in Tumors: 2nd Edition
edited by
submission deadline 25 Dec 2026 | 2 articles | Viewed by 3600 | Submission Open
Keywords: targeted therapy; tumor; molecular target; drug delivery; drug design
(This special issue belongs to the Section Molecular Oncology)
Molecular and Cellular Mechanisms Underlying Taste and Smell submission deadline 25 Dec 2026 | 4 articles | Viewed by 3530 | Submission Open
Keywords: olfaction; anosmia; hyposmia; ageusia; dysgeusia; gustation; chemesthesis; receptors; chemosensory processing; epigenome
(This special issue belongs to the Section Molecular Biology)
Drug and Non-Drug Treatment of Cerebral Diseases
edited by
submission deadline 25 Dec 2026 | 1 articles | Viewed by 3430 | Submission Open
Keywords: cerebral diseases; cerebral ischemia; neonatal hypoxic-ischemic encephalopathy (HIE); neuroprotection; therapeutic hypothermia; neurorehabilitation; oxidative stress; stem cell therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Tools in Environmental Microbiology submission deadline 25 Dec 2026 | 2 articles | Viewed by 3423 | Submission Open
Keywords: environmental microbiology; molecular methods; microbial community analysis; low-abundance microorganisms; microbial identification; environmental DNA; next-generation sequencing (NGS); high-throughput sequencing
(This special issue belongs to the Section Molecular Microbiology)
Advances in the Role of Cytoskeletal Proteins in Diseases
edited by
submission deadline 25 Dec 2026 | 2 articles | Viewed by 3384 | Submission Open
Keywords: cytoskeleton; microtubules; actin filaments; intermediate filaments; neurodegeneration; cancer metastasis; cell migration; cellular mechanotransduction; cytoskeletal remodeling
(This special issue belongs to the Section Molecular Biology)
Molecular Research and Application of Platelet-Rich Plasma
edited by
submission deadline 25 Dec 2026 | 1 articles | Viewed by 3349 | Submission Open
Keywords: platelet-rich plasma; fibrin scaffold; regenerative medicine; molecular biology; translational medicine
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms and Therapeutic Targets in Systemic Vasculitis
edited by Andrés González-García
submission deadline 25 Dec 2026 | 1 articles | Viewed by 3347 | Submission Open
Keywords: vasculitis; ANCA-associated vasculitis; EGPA; complement activation; molecular immunopathogenesis; endothelial dysfunction; cytokine signaling; biomarkers; therapeutic targets; autoimmunity
(This special issue belongs to the Section Molecular Immunology)
Medicinal Plants, Animal-Derived Products, and Natural Compounds: Roles in Health and Disease submission deadline 25 Dec 2026 | 4 articles | Viewed by 3320 | Submission Open
Keywords: natural bioactive compounds; medicinal plants; animal-derived products; marine natural products; chronic diseases; inflammation; oxidative stress; molecular mechanisms; therapeutic peptides; natural toxins; antioxidant activity; anti-inflammatory agents; nanoformulations; nanodelivery systems; drug delivery; pharmacological properties; translational research; integrative medicine; natural therapeutics; disease prevention
(This special issue belongs to the Section Bioactives and Nutraceuticals)
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