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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Biology of the Thyroid Cancer and Thyroid Dysfunctions: 2nd Edition

edited by Vija Lavinia

submission deadline 20 Feb 2026 | Viewed by 102 | Submission Open

Keywords: animal models; apoptosis; autophagy; cancer biomarker; cancer epidemiology; cancer prevention; cancer screening; cholesterol metabolism; clinical trial; DNA repair; epigenomics; genome instability; genomic database; genomics; invasion; metabolomics; metastasis; methylation; microarray; microRNA; molecular diagnostics; molecular tumor pathology; next-generation sequencing; noncoding RNA; omics; personalized medicine; prognosis; proteomics; radionuclide therapy; signaling pathway; SNP genotyping; targeted therapy; theranostics; thyroid cancer; hyperthyroidism; therapeutic targets; translational cancer research; treatment response; tumor microenvironment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biophysical Studies of Protein Structure-Function Relationships

edited by

Almerinda Di Venere

Giampiero Mei

and Velia Minicozzi

submission deadline 20 Feb 2026 | Viewed by 87 | Submission Open

Keywords: protein structure; molecular dynamics; computational modeling; drug discovery

(This special issue belongs to the Section Molecular Biophysics)

Decoding Protein Structure and Protein Dynamics in Cancer

edited by

Umesh Kalathiya

and

Monikaben Padariya

submission deadline 20 Feb 2026 | Viewed by 84 | Submission Open

Keywords: protein structures; oncogenes; post-translational modifications (PTMs); cancer; proteomics; computational biology; structural biology; molecular modeling; bioinformatics

(This special issue belongs to the Section Molecular Biology)

Molecular Progress of Cardiovascular and Metabolic Disease

edited by

Ilenia Calcaterra

submission deadline 20 Feb 2026 | Viewed by 83 | Submission Open

Keywords: cardiometabolic continuum; endothelial dysfunction; heart failure; metabolic complications

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Pathogenesis and Treatment Approaches of Hematological Malignancies

edited by

Yosuke Minami

submission deadline 20 Feb 2026 | Viewed by 83 | Submission Open

Keywords: leukemia; lymphoma; minimal residual disease (MRD); cancer genomic profiling (CGP); molecular targeted therapy

(This special issue belongs to the Section Molecular Oncology)

Advances in Genetic and Epigenetic Research in Skin Diseases

edited by

Nikolai Pace

submission deadline 20 Feb 2026 | Viewed by 58 | Submission Open

Keywords: skin diseases; genodermatoses; psoriasis; atopic dermatitis; hidradenitis; suppurativa; epigenetic regulation; genome-wide association studies (GWAS); next-generation sequencing; translational dermatogenomics; Mendelian randomization; rare disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of the Mitochondria in Human Health and Diseases

edited by

María Isabel Hernández-Alvarez

submission deadline 25 Feb 2026 | 2 articles | Viewed by 13405 | Submission Open

Keywords: mitochondria; mitochondria contact sites; metabolism; lipids; metabolites

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Cell Proliferation, Senescence and Apoptosis

edited by

Chuanxi Cai

submission deadline 25 Feb 2026 | 3 articles | Viewed by 7560 | Submission Open

Keywords: biological molecules; cell proliferation; senescence; apoptosis; human diseases

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Human Retrovirus Infection: 2nd Edition

edited by

Yosuke Maeda

Toshio Hattori

and Kotaro Shirakawa

submission deadline 25 Feb 2026 | 3 articles | Viewed by 7548 | Submission Open

Keywords: retrovirus; ATL; HIV-1; AIDS

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research on Skin Inflammation

edited by

Nabiha Yusuf

submission deadline 25 Feb 2026 | 4 articles | Viewed by 7490 | Submission Open

Keywords: skin inflammation; molecular diagnosis; dermatitis; molecular pathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Multifunctional Nanocomposites for Bioapplications

edited by

Athina Angelopoulou

submission deadline 25 Feb 2026 | 5 articles | Viewed by 7475 | Submission Open

Keywords: nanocomposites; biomedical applications; molecular characteristics; metabolic pathways; biomarkers; external stimuli

(This special issue belongs to the Section Molecular Nanoscience)

Advancements in Host-Directed Antiviral Therapies

edited by

Raquel Bello-Morales

submission deadline 25 Feb 2026 | 1 articles | Viewed by 6818 | Submission Open

Keywords: antiviral drugs; drug discovery; host cell targets; HIV; HCV; influenza; SARS-CoV-2

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Interactions of Microbiome in Skin, Gastrointestinal, and Mucocutaneous Diseases

edited by Capercomorin S. Pitchumoni and

Bijan Safai

submission deadline 25 Feb 2026 | 2 articles | Viewed by 6725 | Submission Open

Keywords: human microbiome; immune system; skin disease; gut– skin axis; gut flora; microbe-host interactions; microbial metabolites; dysbiosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Understanding Aging in Health and Disease

edited by

Laura Cianfruglia

submission deadline 25 Feb 2026 | 2 articles | Viewed by 6166 | Submission Open

Keywords: immunosenescence; age-related disease; ageing; oxidative stress; inflammaging

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Forensic Toxicology: Innovative Approaches in Detection of New Psychoactive Substances

edited by Roberta Tittarelli and Giulio Mannocchi

submission deadline 25 Feb 2026 | 2 articles | Viewed by 5777 | Submission Open

Keywords: addiction; new psychoactive substances; mass spectrometry; biological matrices; diversion; forensic toxicology; drug testing

(This special issue belongs to the Section Molecular Toxicology)

Reproductive Genetics and Epigenetics: Insights into Infertility Failures and Treatment Pathways

edited by

Hossam H. Shawki

submission deadline 25 Feb 2026 | 3 articles | Viewed by 5600 | Submission Open

Keywords: infertility; epigenetics; polymorphism; gametogenesis; fertilization; embryo development; reproductive organs; congenital malformations

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advancements in Understanding Protein Misfolding Disorders and Cancer

edited by

Marijn Speeckaert

submission deadline 25 Feb 2026 | 2 articles | Viewed by 4777 | Submission Open

Keywords: protein misfolding; cancer; amyloidosis

(This special issue belongs to the Section Molecular Oncology)

Peptide Self-Assembly

edited by

Yi Jia

submission deadline 25 Feb 2026 | 3 articles | Viewed by 4530 | Submission Open

Keywords: peptide assembly; aromatic short peptides; bioinspired supramolecular architectures; functional materials; peptide microfabrication; anticancer therapy; supercapacitor; biosensing

(This special issue belongs to the Section Macromolecules)

Molecular Advances in Electrochemical Materials

edited by

Raj Karthik

submission deadline 25 Feb 2026 | 2 articles | Viewed by 4403 | Submission Open

Keywords: electrochemical materials; molecular design; energy storage; electrocatalysis; sensing applications; nanomaterials; sustainable materials; hybrid systems; interface engineering; green chemistry

(This special issue belongs to the Section Materials Science)

From Macrophage Biology to Cell and EV-Based Immunotherapies

edited by

Katarzyna Nazimek

and

Krzysztof Bryniarski

submission deadline 25 Feb 2026 | 2 articles | Viewed by 4400 | Submission Open

Keywords: macrophage-based; macrophage-targeting; cancer immunotherapies; autoimmunity

(This special issue belongs to the Section Molecular Immunology)

Chemistry Triggered by Low-Energy Particles

edited by Hassan Abdoul-Carime

submission deadline 25 Feb 2026 | 3 articles | Viewed by 4188 | Submission Open

Keywords: low energy (< 50 eV); photons; electrons; ions; gas phase; single molecules; clusters; condensed phase liquids and films; experimental techniques; density functional theory; IA-based prediction models

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Heart Failure Risk Factors and Therapies on a Molecular Basis

edited by

Tomasz Urbanowicz

submission deadline 25 Feb 2026 | 2 articles | Viewed by 3844 | Submission Open

Keywords: heart failure; risk factors; inflammatory; neutrophils; cytokines; pharmacological; therapies; molecular-based processes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cellular and Molecular Mechanisms of Cardiovascular Repair

edited by

Isotta Chimenti

submission deadline 25 Feb 2026 | 3 articles | Viewed by 3806 | Submission Open

Keywords: fibroblasts; injury repair; cardiac scar; extracellular matrix; fibrosis; angiogenesis; inflammation; cardioprotection

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Phytochemical Dynamics: Plant Metabolite Responses to Environmental Factors

edited by

Ivana Sola

submission deadline 25 Feb 2026 | 2 articles | Viewed by 2901 | Submission Open

Keywords: plant metabolites; phytochemicals; biotic and abiotic factors; environmental influences; biochemical pathways; interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Advances and Current Challenges in Plasma Medicine

edited by

Andrei Vasile Nastuta

submission deadline 25 Feb 2026 | 2 articles | Viewed by 2803 | Submission Open

Keywords: plasma medicine; plasma pharmacology; plasma oncology; plasma bioengineering; plasma agronomy; plasma and food; plasma and automotive; plasma and aerospace; plasma diagnostics; plasma material processing; plasma polymerization and coating; simulation of plasma phenomena during interaction with matter

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cell Fate Decisions: Autophagy, Apoptosis, Pyroptosis, Necroptosis, Ferroptosis and PANoptosis in Health and Disease

edited by

Yaqiu Wang

submission deadline 25 Feb 2026 | 1 articles | Viewed by 2204 | Submission Open

Keywords: inflammation; autophagy; apoptosis; pyroptosis; necroptosis; PANoptosis; ferroptosis; cell death; cell survival

(This special issue belongs to the Section Molecular Biology)

Immune Regulation in Lung Diseases

edited by

Chiara Colarusso

and

Rosalinda Sorrentino

submission deadline 25 Feb 2026 | 3 articles | Viewed by 1840 | Submission Open

Keywords: lung disease; immune system; lung immune cells; lung epithelial cells; therapy

(This special issue belongs to the Section Molecular Immunology)

Heavy Metal Exposure on Health

edited by

Rosanna Mallamaci

submission deadline 25 Feb 2026 | 2 articles | Viewed by 1839 | Submission Open

Keywords: heavy metals; toxic metal exposure; oxidative stress; mitochondrial dysfunction; epigenetic alterations; physiological and molecular pathways of cellular toxicology; biomarkers of toxicity; chelating agents; antioxidants; therapies or treatments

(This special issue belongs to the Section Molecular Toxicology)

The Regulation of Microorganisms on Human Endocrine and Metabolic Systems

edited by Thi Phuong Nam Bui and Valentina Tremaroli

submission deadline 25 Feb 2026 | 1 articles | Viewed by 1049 | Submission Open

Keywords: human gut microbiome; endocrine signaling; metabolism; obesity; type 2 diabetes; cardiometabolic diseases

(This special issue belongs to the Section Molecular Microbiology)

Extracellular Vesicles: Functions and Therapeutic Applications

edited by Deepshikha Tewari

submission deadline 25 Feb 2026 | Viewed by 935 | Submission Open

Keywords: extracellular vesicles; exosome; cell-to-cell communication; diagnosis; treatment; molecular markers; diseases

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanism and Pathogenesis of Neuroinflammation in Neurological Disorders

edited by

Masashi Tanaka

submission deadline 25 Feb 2026 | Viewed by 517 | Submission Open

Keywords: age-related disorders; Alzheimer’ s disease; amyloid-β ; bioactive molecules; cognitive impairment; dementia; glial activation; microglia; neuroinflammation; neurological disorders; neurotherapeutics; tau hyperphosphorylation

(This special issue belongs to the Section Molecular Neurobiology)

New Insights into Molecular Mechanisms of Chronic Kidney Disease

edited by

Lǎcrǎmioara Ionela Butnariu

submission deadline 25 Feb 2026 | Viewed by 471 | Submission Open

Keywords: chronic kidney disease; molecular mechanism; signaling pathways; endothelial dysfunction; inflammation; genetic variants; epigenetics; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Thyroid Cancer: From Pathophysiology to Novel Therapies

edited by Miklós Bodor

submission deadline 25 Feb 2026 | Viewed by 461 | Submission Open

Keywords: thyroid cancer; therapies; cell signaling; biomarker; kinase inhibitors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Shaping Macrophages Polarization as an Emerging Therapeutic Approach

edited by

Cristina Maccallini

submission deadline 25 Feb 2026 | Viewed by 396 | Submission Open

Keywords: macrophage polarization; M1 macrophages; M2 macrophages; immune modulation; small molecules; therapeutic strategies; inflammation; cancer immunotherapy; drug resistance

(This special issue belongs to the Section Molecular Immunology)

Advanced Molecular Research in Thromboinflammation

edited by Emanuele Valeriani

submission deadline 25 Feb 2026 | Viewed by 359 | Submission Open

Keywords: blood coagulation factors; blood platelets; endothelium; inflammation; thromboinflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Brain Cancers: Molecular Diagnostic and Therapeutic Approaches

edited by

Carmine Antonio Donofrio

submission deadline 25 Feb 2026 | Viewed by 338 | Submission Open

Keywords: brain tumors; gliomas; meningiomas; pituitary tumors; molecular diagnosis; liquid biopsy; targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Perspectives in Nanoadsorption

edited by Carmen María Del Hoyo Martinez

submission deadline 25 Feb 2026 | Viewed by 330 | Submission Open

Keywords: nanoadsorption; nanomaterials; molecular mechanism; emerging contaminants removal in pharmaceutical and food industries; X-ray diffraction (XRD); thermal analysis techniques (DSC); Fourier-transform infrared spectroscopy (FTIR); Raman spectroscopy; molecular functionalization in nanoadsorption

(This special issue belongs to the Section Materials Science)

Research on Signal Transduction Mechanisms of Cancer Cells

edited by

Anuraag Shrivastav

submission deadline 25 Feb 2026 | Viewed by 306 | Submission Open

Keywords: signal transduction mechanisms; cancer cell invasion; cancer cell metastasis; tumorigenesis; cell proliferation

(This special issue belongs to the Section Molecular Oncology)

New Advances in Type 2 Diabetes and Its Complications: 2nd Edition

edited by

Anca Pantea Stoian

submission deadline 25 Feb 2026 | Viewed by 270 | Submission Open

Keywords: diabetes type 2; diabetes complications; pathophysiology of type 2 diabetes; new diabetes treatment; cardiovascular disease; stroke; peripheral artery disease; chronic kidney disease; retinopathy; neuropathy; non-alcoholic fatty liver disease in diabetes

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Advancements in Functional Materials

edited by

Joanna Karasiewicz

submission deadline 25 Feb 2026 | Viewed by 216 | Submission Open

Keywords: synthesis of specialty compounds; specialty compounds in functional materials; special applications: self-cleaning; anti-icing; self-healing; biocidal; etc.; properties; special-purpose functional materials

(This special issue belongs to the Section Materials Science)

Obesity: From Cellular Mechanism to Potential Molecular Therapies

edited by

Veronica Jimenez

submission deadline 25 Feb 2026 | Viewed by 149 | Submission Open

Keywords: metabolic pathways; gene expression; epigenetics; obesity-related comorbidities; molecular biomarkers; adipogenesis; therapeutic interventions; small molecules; gene therapy/gene editing; obesity and cancer

(This special issue belongs to the Section Molecular Biology)

Endothelial Cells in Vascular Health and Immunity

edited by

Junjie Yang

submission deadline 25 Feb 2026 | Viewed by 144 | Submission Open

Keywords: endothelial cells; vascular health; cardiovascular disease; kidney disease; lung injury; inflammation; regenerative medicine; molecular therapy

(This special issue belongs to the Section Biochemistry)

Nanocompounds for Drug Delivery

edited by

Angela Staicu

Ana Maria Udrea

and

Andra Dinache

submission deadline 25 Feb 2026 | Viewed by 85 | Submission Open

Keywords: nanocompounds; drug delivery systems; targeted delivery; stimuli-responsive nanocarriers; hybrid nanostructures; controlled release; biocompatibility; photodynamic therapy (PDT); photothermal therapy (PTT)

(This special issue belongs to the Section Molecular Nanoscience)

JAK/STAT Pathway in Stem Cell Biology

edited by Willis Li

submission deadline 25 Feb 2026 | Viewed by 70 | Submission Open

Keywords: JAK/STAT signaling; stem cell self-renewal; cellular differentiation; pluripotency; hematopoietic stem cells; signal transduction; cytokine receptors; transcriptional regulation; stem cell niche; regenerative medicine

(This special issue belongs to the Section Molecular Biology)

Molecular Research in Chronic Inflammatory Sinonasal Diseases

edited by Santos Tiago Soares

submission deadline 25 Feb 2026 | Viewed by 68 | Submission Open

Keywords: chronic rhinosinusitis; nasal polyps; type 2 inflammation; sinonasal immunopathology; molecular pathways; host– microbiome interaction; precision medicine; upper airway disease; translational research

(This special issue belongs to the Section Molecular Immunology)

Angiotensin II in Cardiac Fibrosis and Heart Failure

edited by Argyrios S. Ntalianis

submission deadline 25 Feb 2026 | Viewed by 59 | Submission Open

Keywords: angiotensin II; aldosterone; molecular genetics; cardiac remodeling; cardiac fibrosis; cardiomyopathy; heart failure

(This special issue belongs to the Section Molecular Pharmacology)

Advances in the Design, Synthesis, and Characterization of Metal Complexes with Multifaceted Biological Activities

edited by

Luca Conti

submission deadline 25 Feb 2026 | Viewed by 59 | Submission Open

Keywords: metal complexes; molecular design; biological activity; structure– activity relationships; therapeutic applications

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Recent Research on Natural Compounds in Cancer Treatment and Prevention

edited by

Katarzyna Lubecka-Gajewska

submission deadline 25 Feb 2026 | Viewed by 56 | Submission Open

Keywords: natural compounds; bioactive phytochemicals; anticancer therapy; chemoprevention

(This special issue belongs to the Section Molecular Oncology)

Molecular Pathophysiology and Treatments of Diabetes

edited by

Carlo Acierno

submission deadline 26 Feb 2026 | Viewed by 154 | Submission Open

Keywords: diabetes mellitus; molecular pathophysiology; insulin resistance; beta-cell dysfunction; chronic inflammation; epigenetics; metabolic syndrome; SGLT2 inhibitors; GLP-1 receptor agonists; gut microbiota

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Application of Mass Spectrometry and Chromatography in Biomedicine: 2nd Edition

edited by

Giovanni Ventura

submission deadline 27 Feb 2026 | Viewed by 529 | Submission Open

Keywords: mass spectrometry; chromatography; LC-MS; GC-MS; biomarker discovery; pharmaceuticals; metabolomics; proteomics; lipidomics

(This special issue belongs to the Section Molecular Biophysics)

Displaying special issue 1601-1650 on page 33 of 67.

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