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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Artificial Intelligence and Computer-Aided Design: Molecular Simulation Technology in Exploring Bioactive Compounds for Health Promotion
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 4436 | Submission Open
Keywords: molecular simulation; bioactive compounds; molecular docking; molecular dynamics; quantum mechanics; functional mechanisms
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Recent Research of Nanomaterials in Molecular Science: 2nd Edition
edited by
submission deadline 20 Feb 2026 | 5 articles | Viewed by 4385 | Submission Open
Keywords: nanomaterials; medical research; synthesis and characterization; molecular formula; molecular dynamics; molecular imaging; cell signaling; cellular metabolism; tissue regeneration; biocompatibility; molecular biology; nanomedicine; functional nanomaterials; drug and gene delivery; tissue engineering; cancer therapy
(This special issue belongs to the Section Molecular Nanoscience)
Marine Natural Compounds: Biotechnological Potential and Pharmacological Targets
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 4269 | Submission Open
Keywords: marine natural compounds; structure elucidation; biologic activity; structure-activity relationships; biosynthesis; biotechnology; pharmacology
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Research in Asthma and Allergy
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 4231 | Submission Open
Keywords: asthma; allergy; molecular mechanisms; exposome; treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Osteoimmunology: Interactions of the Bone and Immune System submission deadline 20 Feb 2026 | 1 articles | Viewed by 4159 | Submission Open
Keywords: osteoimmunology markers; bone infection; inflammation and bone; immune response and bone; diagnostic and prognostic markers; bone remodeling; osteoclasts; immune-mediated bone diseases; bone– immune interface
(This special issue belongs to the Section Molecular Immunology)
Molecular Research of Gut Microbiota in Human Health and Diseases submission deadline 20 Feb 2026 | 2 articles | Viewed by 4128 | Submission Open
Keywords: gut microbiota; gut metabolites; gastroenterology; microbiology; inflammation; human diseases
(This special issue belongs to the Section Molecular Microbiology)
Molecular Mechanisms of Neutrophil Extracellular Traps (Nets) in Human Diseases
edited by Eisuke F. Sato
submission deadline 20 Feb 2026 | 1 articles | Viewed by 4114 | Submission Open
Keywords: neutrophil extracellular traps (NETs); neutrophils; inflammation; autoimmune diseases; cardiovascular diseases; tumor metastasis; thrombosis; molecular mechanisms; disease progression; therapeutic targets
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Advances in Metabolic Engineering and Synthetic Biology of Yeasts
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 4060 | Submission Open
Keywords: yeast metabolic engineering; synthetic biology; CRISPR-Cas9; metabolic pathways; bio-based chemicals; bioprocess engineering; yeast strain optimization; industrial biotechnology
(This special issue belongs to the Section Molecular Microbiology)
Omics-Driven Unveiling of the Structure and Function of Nanoparticles
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 4027 | Submission Open
Keywords: nanoparticles; nanotechnology; drug delivery; protein corona; proteomics; nano-proteomics; matabolomics; lipidomics
(This special issue belongs to the Section Molecular Biophysics)
Gut Microbiome Stability in Health and Disease
edited by and Yoshitohi Ogura
submission deadline 20 Feb 2026 | 3 articles | Viewed by 4013 | Submission Open
Keywords: gut microbiome stability; immune system; epithelial cell; mucous layer; antibiotics; diet; inflammatory bowel disease; gut microbial metabolites
(This special issue belongs to the Section Molecular Microbiology)
Brain-Body Interactions in Mental Disorders: Molecular Mechanisms and Therapeutics
edited by Yan-Xue Xue
submission deadline 20 Feb 2026 | 1 articles | Viewed by 3829 | Submission Open
Keywords: mental disorders; brain– body interactions; neural mechanisms; therapeutics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Immune Mechanisms and Biomarkers in Systemic Lupus Erythematosus—Second Edition
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3827 | Submission Open
Keywords: systemic lupus erythematosus; lupus nephritis; neuropsychiatric lupus; autoimmunity; biomarkers; B lymphocyte; interferons
(This special issue belongs to the Section Molecular Immunology)
Advances in Stem Cell-Based Regenerative Medicine for Renal Disorders
edited by In-Yong Kim
submission deadline 20 Feb 2026 | 1 articles | Viewed by 3797 | Submission Open
Keywords: chronic kidney disease; acute kidney injury; stem cells; regenerative medicine; stem cell therapy; cellular reprogramming; cell transplantation
(This special issue belongs to the Section Molecular Biology)
Antimicrobial Resistology: A New Approach in the Fight Against Antimicrobial Resistance
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3758 | Submission Open
Keywords: antimicrobial resistance; resistology; ESBL; AmpC; carbapenem resistance; one health
(This special issue belongs to the Section Molecular Pharmacology)
The Extracellular Matrix in Physiopathology
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 3692 | Submission Open
Keywords: extracellular matrix; glycosaminoglycans; matrix metalloproteinases; tissue remodeling; cell interactions; physiopathology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cutting-Edge Innovations in Molecular and Nanoscale Engineering for Energy Applications submission deadline 20 Feb 2026 | 2 articles | Viewed by 3607 | Submission Open
Keywords: nanostructured electrode materials; energy storage; energy conversion; energy materials
(This special issue belongs to the Section Materials Science)
Molecular Diagnosis and Treatment of Colorectal Cancer
edited by Steven T. Brower and Robert Pergolizzi
submission deadline 20 Feb 2026 | 3 articles | Viewed by 3571 | Submission Open
Keywords: colorectal cancer; biomarkers; epigenetics; targeted therapy; chemoresistance; personalized cancer therapy
(This special issue belongs to the Section Molecular Oncology)
Drug Therapy of Systemic Lupus Erythematosus
edited by Dionysis Nikolopoulos
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3541 | Submission Open
Keywords: systemic lupus erythematosus; treatment; drugs; tailored strategies; precision medicine; biologics; cell therapy; randomized clinical trials
(This special issue belongs to the Section Molecular Pharmacology)
Advances in Structural and Functional Properties of G-Quadruplexes and Aptamers submission deadline 20 Feb 2026 | 5 articles | Viewed by 3508 | Submission Open
Keywords: G-quadruplex structure; aptamer; DNAzyme; catalytic G-quadruplexes
(This special issue belongs to the Section Molecular Biology)
Progress in the Use of Graphene and Graphene-Like Materials in Various Applications
edited by Piotr Kamedulski
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3488 | Submission Open
Keywords: graphene; porous carbons; carbon-based materials; 3D graphene; graphene exfoliation; nanotubes; nanomaterials; N-rich nano-porous carbon matrixes; N-rich activated carbons; carbon molecular sieves; hybrid materials; medical applications
(This special issue belongs to the Section Materials Science)
Functional Genomics of Insects: Unraveling Genetic Mechanisms and Applications
edited by
submission deadline 20 Feb 2026 | 4 articles | Viewed by 3466 | Submission Open
Keywords: genomics; comparative genomics; gene regulation networks; developmental biology; metamorphosis; vector biology; insecticide resistance mechanisms; insect– plant interactions; environmental adaptation
(This special issue belongs to the Section Molecular Genetics and Genomics)
Recent Advances in Osteoarthritis Pathways and Biomarker Research
edited by
submission deadline 20 Feb 2026 | 5 articles | Viewed by 3402 | Submission Open
Keywords: osteoarthritis; low-grade inflammation; cartilage chondrocyte; synovial membrane; synovial fluid; subchondral bone; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Erythrocyte Cell Death: Molecular Insights
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3384 | Submission Open
Keywords: cell death signaling; eryptosis; erythrocyte senescence; erythrocytes; necroptosis; regulated cell death
(This special issue belongs to the Section Molecular Biology)
New Advances in Neuroscience: Molecular Biological Insights
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 3328 | Submission Open
Keywords: neurodegenerative diseases; neurodevelopmental disorders; neurohiv; drug abuse; neuropharmacology; epigenetics; exosomes; inflammasomes; biomarkers; gene therapy; stem cell therapy; deep brain stimulation; Alzheimer’ s disease; Parkinson’ s disease; Huntington’ s disease; autism spectrum disorder; ADHD; dyslexia; neuroinflammation
(This special issue belongs to the Section Molecular Neurobiology)
Skin Microbiome and Skin Health: Molecular Interactions
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3277 | Submission Open
Keywords: skin microbiota; human disease; human health; omics; microbiota– host interactions; microbiota manipulation; microbiota; virota; inflammatory diseases; dysbiosis
(This special issue belongs to the Section Molecular Immunology)
Molecular Forensics and the Genetic Foundations of Forensic Biology
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3249 | Submission Open
Keywords: molecular forensics; forensic genetics; epigenetics; biological fluid identification; forensic microbiology; sexual assault
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms and Targeted Regulation of Autoimmune Diseases
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3220 | Submission Open
Keywords: autoimmunity; autoimmune diseases; multiple sclerosis; rheumatoid arthritis; lupus; type 1 diabetes; inflammatory bowel disease; biomarkers; immune cells; signaling molecules
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Advances in Cervical Cancer and Its Therapy
edited by Ilaria Cuccu and
submission deadline 20 Feb 2026 | 1 articles | Viewed by 3215 | Submission Open
Keywords: cervical cancer; cervical cancer surgery; fertility-sparing techniques; targeted therapy; immunotherapy; immune checkpoint inhibitors; DNA damage repair inhibitors; antibody– drug conjugates; precision medicine; oncological outcomes
(This special issue belongs to the Section Molecular Oncology)
Inflammation in Pregnancy and Childbirth
edited by and Maciej Ziętek
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3195 | Submission Open
Keywords: pregnancy; labor; eicosanoid; chronic inflammation; cytokines; intestinal dysbiosis; mitogen-activated protein kinase; nuclear factor kappa-light-enhancer-activated B cell; maresins; resolvins and protectins
(This special issue belongs to the Section Molecular Immunology)
Melanoma: Molecular Mechanism and New Agents for Prevention and Therapy
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 3195 | Submission Open
Keywords: melanoma; therapy resistance; melanoma microenvironment (MME); melanoma plasticity; epigenetic mechanism; predictive markers; prognostic markers; extracellular vesicles; molecular therapy; natural molecules
(This special issue belongs to the Section Molecular Oncology)
Molecular and Cellular Aspects of Breast Cancer Metastasis
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3142 | Submission Open
Keywords: precision medicine; omics-based discovery research (genomics; proteomics; transcriptomics; and radiomics); non-invasive test; liquid biopsy; first-in-class medications
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Crop Stress Biology and Molecular Breeding: 5th Edition
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 3020 | Submission Open
Keywords: biotic and abiotic stress; variety improvement; crop stress biology; molecular breeding; biological basis; signal transduction pathway; agronomic traits; excellent germplasm
(This special issue belongs to the Section Molecular Plant Sciences)
Current Developments in Glioblastoma Research and Therapy: 2nd Edition submission deadline 20 Feb 2026 | 2 articles | Viewed by 2977 | Submission Open
Keywords: diagnostic; prognostic and predictive biomarkers of glioblastoma; ways to target glioma stem cells; targeting glioblastoma-related signaling pathways; epigenetics of glioblastoma; treatment resistance mechanisms; novel treatment options for glioblastoma; combinatorial therapies; immunotherapy; nanotherapy; the application of CRISPR/Cas9 in glioma research; molecular testing of long-term glioblastoma survivors
(This special issue belongs to the Section Molecular Neurobiology)
Modulating the Niche: Targeting the Tumor Microenvironment for Enhanced Therapy
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2953 | Submission Open
Keywords: microenvironment dynamics; immune modulation; biomarker discovery; tumor microenvironment; extracellular matrix; cancer therapy
(This special issue belongs to the Section Molecular Oncology)
CRISPR/Cas Systems and Genome Editing—3rd Edition
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2883 | Submission Open
Keywords: CRISPR/Cas; bacterial argonauts; transcription regulation; genome editing; genome editing tools
(This special issue belongs to the Section Molecular Genetics and Genomics)
Micro(nano) Plastics and Estrogens as Endocrine Disruptors Meet the Female Reproductive System, Breast and Colon: What Is Going On? submission deadline 20 Feb 2026 | 1 articles | Viewed by 2856 | Submission Open
Keywords: micro(nano) plastics; estrogens; endocrine disruptors; female reproductive system; breast; colon
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms Study of Functional Foods and Nutrients in Human Health Interventions
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 2835 | Submission Open
Keywords: functional foods; molecular mechanisms; nutrient bioavailability; chronic disease prevention; health interventions
(This special issue belongs to the Section Bioactives and Nutraceuticals)
The Molecular Network, Key Biomarkers, and Therapeutic Targets in Colorectal Cancer submission deadline 20 Feb 2026 | 1 articles | Viewed by 2835 | Submission Open
Keywords: inflammation; metabolism; tumor-associated macrophages; tumor microenvironment; early-onset colorectal cancer; colorectal neoplasms; obesity; immunotherapy; epigenetics; cytokines; microbiome
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Aging: From Molecular Mechanisms and Pathophysiology to Novel Therapeutic Approaches (3rd Edition) submission deadline 20 Feb 2026 | 4 articles | Viewed by 2711 | Submission Open
Keywords: human aging; molecular clock; aging genes; epigenetics; nutrigenomics; inflammaging; stem cells; telomeres; mitochondria; brain-gut axis; brain-muscle axis; gut microbiota; chronodisruption
(This special issue belongs to the Section Molecular Biology)
Drug-Induced Neurotoxicity and Neurodegeneration: Mechanisms, Models and Implications submission deadline 20 Feb 2026 | 2 articles | Viewed by 2702 | Submission Open
Keywords: drugs of abuse; pharmaceutical drugs; environmental toxins; drug exposure; neurotoxicity; neurodegeneration; brain health; substance use disorders; therapeutic interventions; in vivo models; in vitro models; in silico models; biomarkers of damage; translational studies
(This special issue belongs to the Section Molecular Neurobiology)
Nucleic Acid Recognition and Pharmaceutical Ligand Design submission deadline 20 Feb 2026 | 1 articles | Viewed by 2694 | Submission Open
Keywords: nucleic acid recognition; ligand design; analytical techniques; computational chemistry; therapeutics
(This special issue belongs to the Section Macromolecules)
Drugs—from Chemical Structure to Biological Activity
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 2643 | Submission Open
Keywords: hit molecule; lead optimization; drug design; virtual screening; molecule descriptors; structure– activity relationship; pharmacokinetic/ADME profile; in vitro biological activity
(This special issue belongs to the Section Molecular Pharmacology)
Towards Complex Molecular Cancer Therapies
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 2619 | Submission Open
Keywords: precision medicine; immune system harnessing; targeted therapies TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in English   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com
(This special issue belongs to the Section Molecular Oncology)
Molecular Research on Immune Response to Virus Infection and Vaccines
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2600 | Submission Open
Keywords: immunogenicity; emerging pathogen vaccination; molecular and cellular determinants of vaccine responses in immunocompromised individuals; predictive markers of immune response; laboratory methods to dissect immune responses to infections and vaccinations
(This special issue belongs to the Section Molecular Immunology)
Elucidating How Chondrocytes Maintain Cartilage Stability
edited by James A. Martin
submission deadline 20 Feb 2026 | 4 articles | Viewed by 2581 | Submission Open
Keywords: chondrocytes; articular cartilage; chondrogenesis; osteoarthritis; mechano-transduction; aging; extracellular matrix
(This special issue belongs to the Section Molecular Biology)
Redox Systems in Humans, Animals, Plants and Aquatic Ecosystems and Their Microbiomes submission deadline 20 Feb 2026 | 1 articles | Viewed by 2573 | Submission Open
Keywords: redox systems; aging and disease; nutraceuticals; probiotics; animals; plants; aquatic ecosystems; microbiomes
(This special issue belongs to the Section Molecular Biology)
Editorial Board Member's Collection Series: The Memory of the Immune Cells submission deadline 20 Feb 2026 | 2 articles | Viewed by 2530 | Submission Open
Keywords: immunological memory; innate immune memory; dendritic cells; natural killer cells; macrophage memory
(This special issue belongs to the Section Molecular Immunology)
Molecular Research and Applications of Nanomaterials
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 2490 | Submission Open
Keywords: molecular research; application; functionality of nanomaterials; catalysis; environmental science
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Studies of Bone Biology and Bone Tissue: 2nd Edition
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 2421 | Submission Open
Keywords: bone; stem cells; immunomodulation; biomaterials; bone regeneration; bone repair; bone diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Viral Vector-Mediated Genome Editing Therapy
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 2409 | Submission Open
Keywords: genome editing; adenovirus vector; knock-in; inherited disease; viral vectors
(This special issue belongs to the Section Molecular Genetics and Genomics)
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