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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Gynecologic Diseases: From Molecular Basis to Therapy

edited by Domenico Baldini

submission deadline 20 Mar 2026 | 2 articles | Viewed by 10000 | Submission Open

Keywords: infertility; sterility; gynecologic desease; genetic; IVF; gynecologic therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research Progress of Skin and Skin Diseases: 2nd Edition

edited by

Ji Hyun Lee

submission deadline 20 Mar 2026 | 5 articles | Viewed by 9384 | Submission Open

Keywords: atopic dermatitis; psoriasis; alopecia; vitiligo; acne; skin cancer; JAK-STAT; inflammatory skin disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Therapies and Strategies in the Treatment of Neurodegenerative Diseases

edited by

Polina Petkova-Kirova

submission deadline 20 Mar 2026 | 3 articles | Viewed by 9292 | Submission Open

Keywords: neurodegenerative diseases; Alzheimer’ s disease; Parkinson’ s disease; Huntington’ s disease; aging; memory; dementia; motor dysfunction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring Biological Mechanisms and Therapeutic Strategies for Substance Use Disorders

edited by Thomas Paparrigopoulos

submission deadline 20 Mar 2026 | 3 articles | Viewed by 9202 | Submission Open

Keywords: addiction; alcohol use disorder; opioid use disorder; substance use disorders; physical exercise; physical activity; molecular mechanisms; neuroendocrine system

(This special issue belongs to the Section Molecular Neurobiology)

Ocular Ischemic Diseases: From Molecular Mechanisms to Therapeutics

edited by

Deokho Lee

submission deadline 20 Mar 2026 | 4 articles | Viewed by 8838 | Submission Open

Keywords: diabetic retinopathy; retinopathy of prematurity; retinal vein occlusion; retinal artery occlusion; pathologic myopia; age-related macular degeneration; glaucoma; ocular ischemic syndrome

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Hormone Replacement Therapy

edited by

Marco Antonio Botelho

and

Raouf A. Khalil

submission deadline 20 Mar 2026 | 2 articles | Viewed by 8750 | Submission Open

Keywords: hormone replacement therapy; molecular insights; endocrine signaling; precision medicine; gene expression; epigenetics; non-coding RNAs; personalized regimens

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Recent Advances in Chromatin Structure and Dynamics

edited by Stephanie Portillo-Ledesma

submission deadline 20 Mar 2026 | 5 articles | Viewed by 8575 | Submission Open

Keywords: chromatin structure and dynamics; genome architecture; epigenetic regulation

(This special issue belongs to the Section Biochemistry)

Molecular Mechanism in Cardiovascular Pathology

edited by Andrea Marzullo

submission deadline 20 Mar 2026 | 6 articles | Viewed by 8547 | Submission Open

Keywords: cardiovascular diseases; molecular biology; sudden death; cardiomyopathies; heart failure; coronary artery diseases; pericarditis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Toxicity of Metals, Metal-Based Drugs, and Microplastics

edited by

Agnieszka Scibior

Manuel Aureliano

and

Juan Llopis

submission deadline 20 Mar 2026 | 4 articles | Viewed by 8434 | Submission Open

Keywords: metal toxicity and pollution; microplastic toxicity and pollution; metal and microplastic bioaccumulation; metal-based drugs; protein metalation; human health problems; diseases; in vitro/in vivo studies; human studies

(This special issue belongs to the Section Molecular Toxicology)

New Advances in Autoimmune Diseases

edited by

Tsvetelina Velikova

submission deadline 20 Mar 2026 | 4 articles | Viewed by 8304 | Submission Open

Keywords: autoimmunity; autoimmune mechanisms; molecular pathogenesis; immune signalling pathways; cytokine regulation; epigenetics in autoimmunity; molecular biomarkers; gene expression profiling; regulatory T cells; immunogenetics; molecular therapeutics; signal transduction; immunometabolism; microRNA in autoimmunity

(This special issue belongs to the Section Molecular Immunology)

Protein Methyltransferases in Human Health and Diseases

edited by

Byron Baron

submission deadline 20 Mar 2026 | 3 articles | Viewed by 8258 | Submission Open

Keywords: lysine and arginine methylation; mass spectrometry; PTM cross talk; functional proteomics; cancer; neurological disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Applications of Bacteriophages

edited by

Grzegorz Wegrzyn

submission deadline 20 Mar 2026 | 1 articles | Viewed by 8197 | Submission Open

Keywords: bacteriophages; gene cloning; phage display technology; phage

(This special issue belongs to the Section Molecular Biology)

Recent Progress in Advanced Computing Techniques for Molecules and Nanomaterials

edited by

Joonho Bae

submission deadline 20 Mar 2026 | 1 articles | Viewed by 8174 | Submission Open

Keywords: nanomaterials; machine learning; artificial intelligence; computing techniques; modeling; energy storage; catalysis

(This special issue belongs to the Section Molecular Nanoscience)

Pathophysiology and New Therapies of Alopecia

edited by Jong-Hyuk Sung

submission deadline 20 Mar 2026 | 2 articles | Viewed by 8073 | Submission Open

Keywords: alopecia; pathophysiology; novel pharmacological treatments; regenerative medicines; gene therapy; cell therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

MAPK Signaling Cascades in Human Health and Diseases, 2nd Edition

edited by Galia Maik-Rachline

submission deadline 20 Mar 2026 | 2 articles | Viewed by 7873 | Submission Open

Keywords: ERK1/2; p38; JNK; ERK5; MEK; MEKK; raf; stimulated nuclear translocation; targeted therapy; resistance mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Strategies to Improve the Detection of Human Papillomavirus (HPV) Persisting Infections

edited by

Marianna Martinelli

submission deadline 20 Mar 2026 | 4 articles | Viewed by 7790 | Submission Open

Keywords: human papillomavirus; HPV; viral load; genotyping; oncogenic transcripts; biomarkers

(This special issue belongs to the Section Molecular Microbiology)

Protein Aggregation and Proteinopathies

edited by Hongyu Hu

submission deadline 20 Mar 2026 | 2 articles | Viewed by 7674 | Submission Open

Keywords: protein aggregation; inclusion; sequestration; interaction; phase transition; proteostasis; proteinopathy

(This special issue belongs to the Section Molecular Biology)

Mitochondria: Central Players in Cancer

edited by

Annamaria Piscazzi

and

Domenica Mangieri

submission deadline 20 Mar 2026 | 4 articles | Viewed by 7638 | Submission Open

Keywords: mitochondria; cancer; tumorigenesis; oxidative phosphorylation; glycolysis; Warburg effect; reactive oxygen species (ROS); apoptosis; mitochondrial dysfunction; metabolic reprogram-ming; cancer therapy

(This special issue belongs to the Section Molecular Biology)

Understanding Allergy and Asthma at the Molecular Level

edited by

Cenk Suphioglu

submission deadline 20 Mar 2026 | 1 articles | Viewed by 7634 | Submission Open

Keywords: allergy; asthma; allergens; allergic asthma; thunderstorm asthma; cell culture; biomarkers; proteomics; metabolomics; lipidomics; genomics; recombinant allergens; recombinant hypoallergens; signalling; inhibitors; cytokines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cutting-Edge Research on Nanosensors and Microsensors

edited by

Beata Paczosa-Bator

submission deadline 20 Mar 2026 | 2 articles | Viewed by 7205 | Submission Open

Keywords: nanosensors and microsensors; innovations; nanomaterials; nanotechnology; biomedical devices; point-of-care and point-of-use testing; environmental control

(This special issue belongs to the Section Materials Science)

Virus Engineering and Applications: 3rd Edition

edited by

Laura Menotti

submission deadline 20 Mar 2026 | 3 articles | Viewed by 7050 | Submission Open

Keywords: virus engineering; oncolytic virotherapy; immunovirotherapy; viral biotechnology

(This special issue belongs to the Section Molecular Microbiology)

Modulation of the Immune System and Oxidative Stress in Liver Illnesses

edited by

Vlad Pădureanu

and Dan Ionuț Gheonea

submission deadline 20 Mar 2026 | 2 articles | Viewed by 7047 | Submission Open

Keywords: oxidative stress; liver illnesses; immune system; inflammatory

(This special issue belongs to the Section Molecular Immunology)

Mitochondrial Metabolism Alterations in Health and Disease: 2nd Edition

edited by

Vincenza Dolce

Rosita Curcio

and

Graziantonio Lauria

submission deadline 20 Mar 2026 | 2 articles | Viewed by 7031 | Submission Open

Keywords: mitochondrial Metabolism; mitochondrial disorders; cellular processes; dysregulation organisms’ physiology

(This special issue belongs to the Section Biochemistry)

Advanced Research in Retina: 3rd Edition

edited by

Juan J. Salazar

and

José A. Fernández-Albarral

submission deadline 20 Mar 2026 | 4 articles | Viewed by 6839 | Submission Open

Keywords: glaucoma; age-related macular degeneration; diabetic retinopathy; neurodegenerative diseases; diagnostic techniques; therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research and Insight into Endocannabinoid System

edited by

Jorge Manzanares

and

Francisco Navarrete

submission deadline 20 Mar 2026 | 3 articles | Viewed by 6279 | Submission Open

Keywords: endocannabinoid system; molecular research; biomarker; translational

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Breeding for Abiotic Stress Tolerance in Crops (Second Edition)

edited by

Mario A. Pagnotta

submission deadline 20 Mar 2026 | 6 articles | Viewed by 6278 | Submission Open

Keywords: plant breeding; advance molecular approach; molecular characterization; environmental stresses plant tolerance; resistant genes; QTLs; drought; salinity; climatic changes

(This special issue belongs to the Section Molecular Plant Sciences)

Induced Pluripotent Stem and Extracellular Vesicles in Biomedicine

edited by

Ylenia Della Rocca

Francesca Diomede

and

Jacopo Pizzicannella

submission deadline 20 Mar 2026 | 2 articles | Viewed by 6237 | Submission Open

Keywords: induced pluripotent stem; embryonic stem cells; extracellular vesicles; tissue development; translational medicine

(This special issue belongs to the Section Molecular Biology)

New Advances in Molecular Research in Leukemia

edited by

Akiyoshi Takami

Jorge Luis Espinoza

and

Carla Di Stefano

submission deadline 20 Mar 2026 | 2 articles | Viewed by 5936 | Submission Open

Keywords: acute lymphoblastic leukemia (ALL); chronic lymphocytic leukemia (CLL); acute myelogenous leukemia (AML); chronic myelogenous leukemia (CML); hairy cell leukemia (HCL); T-cell prolymphocytic leukemia (T-PLL); large granular lymphocytic leukemia; measurable residual disease (MRD)

(This special issue belongs to the Section Molecular Oncology)

Mechanism and Treatment Progress of Liver Disease

edited by Yohei Shirakami

submission deadline 20 Mar 2026 | 3 articles | Viewed by 5922 | Submission Open

Keywords: liver diseases; MASLD; alcoholic liver disease; liver cancer; viral hepatitis; sarcopenia

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Discovery, Extraction, Synthesis, and Application of Natural Products

edited by

Hah Young Yoo

, Kang Hyun Lee and

Taek Lee

submission deadline 20 Mar 2026 | 2 articles | Viewed by 5893 | Submission Open

Keywords: antibiotics; antioxidants; biomass; bioactive molecule; biological activity; biosynthesis; biosensor; biomedicine; biotechnology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Big Data in Multi-Omics

edited by

Dimitrios Vlachakis

and

George P. Chrousos

submission deadline 20 Mar 2026 | 2 articles | Viewed by 5758 | Submission Open

Keywords: data science; big data; omics; data management; data analytics TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back // This page is in Shona Translate to Simplified Chinese Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh Always translate Shona to Simplified Chinese Never translate Shona Never translate admin.mdpi.com

(This special issue belongs to the Section Molecular Informatics)

Recent Advances and Challenges in Colorectal Cancer: From Molecular Research to Treatment

edited by

Premila Leiphrakpam

submission deadline 20 Mar 2026 | 1 articles | Viewed by 5615 | Submission Open

Keywords: tumor biology; tumor heterogeneity; molecular mechanism involved in cancer initiation; progression; and metastasis; compensatory pathways; cancer screening; cancer biomarkers discovery; tumor molecular profiling methods; early cancer diagnosis; novel therapeutic strategies; targeted therapies; drug resistance

(This special issue belongs to the Section Molecular Oncology)

Blueprints of Enzymatic Function and Structure in Biocatalysis

edited by

Francesco Malatesta

submission deadline 20 Mar 2026 | 2 articles | Viewed by 5589 | Submission Open

Keywords: enzyme; biocatalysis; enzyme structure; enzyme kinetics and thermodynamics; enzyme engineering; synthetic biology applications; sustainable biocatalyst design

(This special issue belongs to the Section Biochemistry)

Parkinson’s Disease and Related Diseases: Mechanisms, Genetic Factors and Treatments

edited by

Stergios Boussios

submission deadline 20 Mar 2026 | 3 articles | Viewed by 5553 | Submission Open

Keywords: Parkinson’ s disease; neurodegenerative disorders; α -synuclein aggregation; neuroinflammation; gene therapy; biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

Exploring the Molecular Basis of Cellular Responses to Microgravity-Induced Oxidative Stress

edited by

Caterina Morabito

and

Simone Guarnieri

submission deadline 20 Mar 2026 | 2 articles | Viewed by 5508 | Submission Open

Keywords: microgravity; reactive oxygen species (ROS); oxidative damage; cellular antioxidant systems; cell metabolism; cell responses; molecular pathways; simulated microgravity; protective countermeasures

(This special issue belongs to the Section Molecular Biology)

Genetic Analysis Based on CRISPR/Cas9 Technology: 2nd Edition

edited by

Yong-Gu Cho

and

Kwon-Kyoo Kang

submission deadline 20 Mar 2026 | 2 articles | Viewed by 5489 | Submission Open

Keywords: gene targeting (GT); homology-directed repair (HDR); homology-directed gene targeting (HGT); CRISPR/Cas; targeted mutagenesis; precision breeding; genetic analysis

(This special issue belongs to the Section Molecular Genetics and Genomics)

New Trends and Challenges in Chronic Diseases

edited by

Guan-Jhong Huang

submission deadline 20 Mar 2026 | 2 articles | Viewed by 5121 | Submission Open

Keywords: chronic diseases; ER stress; oxidative stress; immune regulation; new pathways of pathogenesis; cancer development

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Lymphoma: Molecular Pathologies and Therapeutic Strategies

edited by

Francesco Gaudio

and

Stefano Martinotti

submission deadline 20 Mar 2026 | 2 articles | Viewed by 5099 | Submission Open

Keywords: targeted therapy; molecular pathway; Hodgkin’ s lymphoma; non-Hodgkin’ s lymphoma; hematopathology biomarker; new therapeutic approaches

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Pathophysiology of Cystic Fibrosis

edited by

Stefanie Krick

and George M. Solomon

submission deadline 20 Mar 2026 | 2 articles | Viewed by 5017 | Submission Open

Keywords: cystic fibrosis; aging; CF airway disease; CF complications; CF molecular pathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cancer Biology and Epigenetic Modifications

edited by

Tamer E. Fandy

submission deadline 20 Mar 2026 | 1 articles | Viewed by 4979 | Submission Open

Keywords: epigenetics; DNA methylation; epigenetic modifiers; histone acetylation; histone methylation; miRNA; ncRNA; chrmoatin remodelling

(This special issue belongs to the Section Molecular Oncology)

Eye Diseases: From Pathophysiology to Novel Therapeutic Approaches

edited by

Tomasz Chorągiewicz

and

Joanna Dolar-Szczasny

submission deadline 20 Mar 2026 | 3 articles | Viewed by 4922 | Submission Open

Keywords: eye diseases; genetic; biochemical; proteomic; cellular and physiological level; innovative therapeutic approaches

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Steatotic Liver Disease: From Bench to Bedside and Back

edited by

Federico Salomone

submission deadline 20 Mar 2026 | 2 articles | Viewed by 4775 | Submission Open

Keywords: MASLD; ALD; MetALD; fibrosis; hepatocellular carcinoma; molecular mechanisms; molecular markers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Natural Compounds: Protecting Plants and Promoting Human Health, 2nd Edition

edited by

Gina Rosalinda De Nicola

submission deadline 20 Mar 2026 | 3 articles | Viewed by 4667 | Submission Open

Keywords: natural products; molecular biology; chemical characterization; bioactivity; mechanism of action; plant protection; human health promotion; antioxidant; anti-inflammation; biopesticides; biostimulants; nutraceuticals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Perspective in Autoimmune Diseases

edited by Andrés González-García and

Montserrat Fernández-Guarino

submission deadline 20 Mar 2026 | 3 articles | Viewed by 4522 | Submission Open

Keywords: interferon; cytokines; lupus nephritis; lupus; type I interferon; vasculitis; IgG4-related disease; B cell; NETs; IL-6; biomarkers

(This special issue belongs to the Section Molecular Immunology)

Drug Discovery: Natural Products and Compounds

edited by

Vincenzo Summa

Maria Maisto

and

Vincenzo Piccolo

submission deadline 20 Mar 2026 | 6 articles | Viewed by 4511 | Submission Open

Keywords: natural products; drug discovery; bioactive compounds; phytochemicals; marine natural compounds; microorganisms; structure– activity relationships (SARs); pharmacological activity; cheminformatics; metabolomics

(This special issue belongs to the Section Molecular Pharmacology)

Cellular and Molecular Study of Neurodevelopmental and Neurological Disorders

edited by

Kazuhito Toyooka

submission deadline 20 Mar 2026 | 1 articles | Viewed by 4470 | Submission Open

Keywords: autism spectrum disorder; ADHD; schizophrenia; intellectual disability; Alzheimer’ s disease; Parkinson’ s disorder; traumatic brain injury; epilepsy; neurodevelopmental disorders; neurological diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Regenerative Medicine and Therapeutics

edited by

Diana Torge

submission deadline 20 Mar 2026 | 2 articles | Viewed by 4406 | Submission Open

Keywords: regenerative medicine; morphology; regenerative dentistry; biomaterials; scaffolds; organoids; tissue regeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Molecules from Food or Other Natural Sources Against Cancer: 2nd Edition

edited by

Alessandro Maugeri

and

Michele Navarra

submission deadline 20 Mar 2026 | 3 articles | Viewed by 4366 | Submission Open

Keywords: cancer; natural bioactive molecules; natural products; tumor

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Latest Advances in Oxidative Stress and Brain Injury

edited by

Vittorio Fineschi

submission deadline 20 Mar 2026 | 2 articles | Viewed by 4355 | Submission Open

Keywords: measurement of ROS; pathology of brain injuries; traumatic brain injuries; hypoxic– ischemic brain damage; experimental models of brain injury; targeted therapy of brain injuries; drug abuse and ROS; histological diagnosis of brain injuries; epigenetics of brain injuries; miRNA and prognosis of neural damage; novel approaches and proofs of principle in therapy; quality of life after brain injury

(This special issue belongs to the Section Molecular Neurobiology)

Regulation and Application of Bioactive Metabolites in Plants

edited by