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Pathophysiology and New Therapies of Alopecia

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 September 2025 | Viewed by 973

Special Issue Editor


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Guest Editor
Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon 21983, Republic of Korea
Interests: hair loss; siRNA; hair follicles; nanoparticle; dermatology; alopecia

Special Issue Information

Dear Colleagues,

As the Guest Editor, I am pleased to invite submissions for our upcoming Special Issue on “Pathophysiology and New Therapies of Alopecia”. This Special Issue aims to explore the underlying mechanisms of alopecia and to highlight innovative therapeutic approaches for this condition.

Alopecia, characterized by hair loss, significantly affects the quality of life and psychological well-being of individuals worldwide. Despite extensive research, the pathophysiology of various forms of alopecia, including androgenetic alopecia, alopecia areata, and scarring alopecia, remains complex and not fully understood. We welcome original research, reviews, and case studies that provide new insights into the cellular and molecular mechanisms driving alopecia.

Additionally, we are particularly interested in manuscripts that discuss emerging therapies and advancements in the treatment of alopecia. This includes novel pharmacological treatments, regenerative medicine approaches, gene therapy, and other innovative therapeutic strategies. Studies on the efficacy and safety of these treatments, as well as their impact on patients’ quality of life, are highly encouraged.

Submissions should provide a comprehensive understanding of the current state of research and offer perspectives on future directions in the study and treatment of alopecia.

For detailed submission guidelines, please visit the journal’s website. We look forward to your valuable contributions to this significant field.

Thank you.

Prof. Dr. Jong-Hyuk Sung
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • alopecia
  • pathophysiology
  • novel pharmacological treatments
  • regenerative medicines
  • gene therapy
  • cell therapy

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Published Papers (1 paper)

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Research

12 pages, 2007 KiB  
Article
The Involvement of RIPK1 in Alopecia Areata
by Hyunju Kim, Mei Zheng, Seungchan An, In Guk Park, Leegu Song, Minsoo Noh and Jong-Hyuk Sung
Int. J. Mol. Sci. 2025, 26(4), 1565; https://doi.org/10.3390/ijms26041565 - 13 Feb 2025
Viewed by 792
Abstract
We have previously demonstrated that receptor-interacting serine threonine kinase 1 (RIPK1) is expressed in hair follicles and regulates the hair cycle. In a mouse model, RIPK1 inhibitors also accelerated the telogen-to-anagen transition and elongated the anagen period. Here, we first investigated the involvement [...] Read more.
We have previously demonstrated that receptor-interacting serine threonine kinase 1 (RIPK1) is expressed in hair follicles and regulates the hair cycle. In a mouse model, RIPK1 inhibitors also accelerated the telogen-to-anagen transition and elongated the anagen period. Here, we first investigated the involvement of RIPK1 in alopecia areata (AA). The mRNA and protein expression of RIPK1 was increased in the skin of an AA mouse model. Single-cell RNA sequencing and immunohistochemistry showed that RIPK1 was highly increased in dendritic cells (DCs) and CD8+ T cells. RIPK1 inhibitors (i.e., Necrostatin-1s and GSK2982772) delayed the onset of AA in the mouse model and reduced the numbers of DCs and CD8+ T cells in AA skin. The RIPK1 inhibitors also increased the hair length in a mouse hair organ culture mimicking AA. Collectively, these results suggest that RIPK1 is involved in AA onset via modulating immune cells, and RIPK1 inhibitors could prevent AA onset. Full article
(This article belongs to the Special Issue Pathophysiology and New Therapies of Alopecia)
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