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Ocular Ischemic Diseases: From Molecular Mechanisms to Therapeutics

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 August 2025 | Viewed by 4191

Special Issue Editor

Laboratory of Photobiology, Keio University School of Medicine, Tokyo 160-8582, Japan
Interests: neuroprotection; ischemia; hypoxia; neovascularization; macular degeneration; stroke; glucose and lipid metabolism; oxidative stress; anti-aging; nicotinamide adenine dinucleotide; vitamin supplements; hypoxia-inducible factors
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Special Issue Information

Dear Colleagues,

Ocular ischemia is one of the leading causes of visual loss. Many eye diseases, including diabetic retinopathy, retinopathy of prematurity, retinal vein/artery occlusion, pathologic myopia, age-related macular degeneration, glaucoma, and ocular ischemic syndrome, are highly related to ocular ischemia. To develop or find promising preventive or protective drugs in ocular ischemic diseases, the complex molecular mechanisms of pathologies in ocular ischemia need to first be well understood.

This Special Issue aims to collect original research and review articles that summarize recent state-of-the-art findings, focusing on unravelling the pathologic molecular pathways in various types of ocular ischemic diseases and suggesting novel therapeutic molecular targets in terms of the prevention and treatment of ocular ischemia.

Topics include, but are not limited to, the following:

  • Diabetic retinopathy.
  • Retinopathy of prematurity.
  • Retinal vein occlusion.
  • Retinal artery occlusion.
  • Pathologic myopia.
  • Age-related macular degeneration.
  • Glaucoma.
  • Ocular ischemic syndrome.

Dr. Deokho Lee
Guest Editor

Manuscript Submission Information

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Keywords

  • diabetic retinopathy
  • retinopathy of prematurity
  • retinal vein occlusion
  • retinal artery occlusion
  • pathologic myopia
  • age-related macular degeneration
  • glaucoma
  • ocular ischemic syndrome

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Published Papers (2 papers)

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Review

14 pages, 767 KiB  
Review
Interplay Between Ocular Ischemia and Glaucoma: An Update
by Valeria Coviltir, Miruna Gabriela Burcel, George Baltă and Maria Cristina Marinescu
Int. J. Mol. Sci. 2024, 25(22), 12400; https://doi.org/10.3390/ijms252212400 - 19 Nov 2024
Cited by 2 | Viewed by 1150
Abstract
Glaucoma is a main cause of irreversible blindness worldwide, with a high impact on productivity and quality of life. The mechanical and ischemic theories are currently the most recognized pathophysiological pathways that explain the neurodegeneration of retinal nerve fibers in glaucoma. In this [...] Read more.
Glaucoma is a main cause of irreversible blindness worldwide, with a high impact on productivity and quality of life. The mechanical and ischemic theories are currently the most recognized pathophysiological pathways that explain the neurodegeneration of retinal nerve fibers in glaucoma. In this narrative review, aspects of ischemia in glaucoma are discussed, including vascular dysregulation, retinal ischemia signaling pathways, roles of vascular endothelial growth factors, and future research and therapeutic directions. In conclusion, a better understanding of the ischemic processes in glaucoma may lead to innovative treatment options and improved management and follow-up of our patients. Full article
(This article belongs to the Special Issue Ocular Ischemic Diseases: From Molecular Mechanisms to Therapeutics)
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13 pages, 1140 KiB  
Review
Recent Insights into Roles of Hypoxia-Inducible Factors in Retinal Diseases
by Deokho Lee, Yohei Tomita, Yukihiro Miwa, Hiromitsu Kunimi, Ayaka Nakai, Chiho Shoda, Kazuno Negishi and Toshihide Kurihara
Int. J. Mol. Sci. 2024, 25(18), 10140; https://doi.org/10.3390/ijms251810140 - 21 Sep 2024
Cited by 4 | Viewed by 2277
Abstract
Hypoxia-inducible factors (HIFs) are transcriptional factors that function as strong regulators of oxygen homeostasis and cellular metabolisms. The maintenance of cellular oxygen levels is critical as either insufficient or excessive oxygen affects development and physiologic and pathologic conditions. In the eye, retinas have [...] Read more.
Hypoxia-inducible factors (HIFs) are transcriptional factors that function as strong regulators of oxygen homeostasis and cellular metabolisms. The maintenance of cellular oxygen levels is critical as either insufficient or excessive oxygen affects development and physiologic and pathologic conditions. In the eye, retinas have a high metabolic demand for oxygen. Retinal ischemia can cause visual impairment in various sight-threating disorders including age-related macular degeneration, diabetic retinopathy, and some types of glaucoma. Therefore, understanding the potential roles of HIFs in the retina is highly important for managing disease development and progression. This review focuses on the physiologic and pathologic roles of HIFs as regulators of oxygen homeostasis and cellular metabolism in the retina, drawing on recent evidence. Our summary will promote comprehensive approaches to targeting HIFs for therapeutic purposes in retinal diseases. Full article
(This article belongs to the Special Issue Ocular Ischemic Diseases: From Molecular Mechanisms to Therapeutics)
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