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Applications of Bacteriophages

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 October 2025 | Viewed by 2725

Special Issue Editor


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Guest Editor
Depratment of Molecular Biology, University of Gdańsk, Wita Stwosza 59, 80-308 Gdańsk, Poland
Interests: regulation of DNA replication; control of gene expression; oxidative stress in bacterial virulence; molecular mechanisms of mucopolysaccharidoses; development of novel therapeutic options
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Special Issue Information

Dear Colleagues,

Bacteriophages (or shortly phages), the viruses infecting prokaryotic cells, have been discovered over a century ago. When their nature was discovered, they became excellent models in basic biological studies, especially at the molecular level. However, subsequent studies indicated that they have properties that make them useful in various applications. They were recognized as tools in various fields of genetic engineering and biotechnology and in many medical aspects.

This Special Issue is devoted to disseminating studies and opinions on the applications of bacteriophages in different areas, from gene cloning to phage display technology, from developing new materials to phage therapy. Both original and review articles are welcome because they focus on bacteriophage applications in at least one specific field. The manuscripts may describe the development or optimization of laboratory methods, as well as the presentation of the use of phages in specific fields of science, technology, medicine, and other areas. Papers on bacteriophages infecting any kind of prokaryotic organisms are welcome. Studies conducted using molecular methods are especially encouraged for submission.

Prof. Dr. Grzegorz Wegrzyn
Guest Editor

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Keywords

  • bacteriophages
  • gene cloning
  • phage display technology
  • phage

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Published Papers (1 paper)

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Review

21 pages, 3467 KiB  
Review
Overview of Phage Defense Systems in Bacteria and Their Applications
by Xiaomei Xu and Pengfei Gu
Int. J. Mol. Sci. 2024, 25(24), 13316; https://doi.org/10.3390/ijms252413316 - 12 Dec 2024
Cited by 3 | Viewed by 2373
Abstract
As natural parasites of bacteria, phages have greatly contributed to bacterial evolution owing to their persistent threat. Diverse phage resistance systems have been developed in bacteria during the coevolutionary process with phages. Conversely, phage contamination has a devastating effect on microbial fermentation, resulting [...] Read more.
As natural parasites of bacteria, phages have greatly contributed to bacterial evolution owing to their persistent threat. Diverse phage resistance systems have been developed in bacteria during the coevolutionary process with phages. Conversely, phage contamination has a devastating effect on microbial fermentation, resulting in fermentation failure and substantial economic loss. Accordingly, natural defense systems derived from bacteria can be employed to obtain robust phage-resistant host cells that can overcome the threats posed by bacteriophages during industrial bacterial processes. In this review, diverse phage resistance mechanisms, including the remarkable research progress and potential applications, are systematically summarized. In addition, the development prospects and challenges of phage-resistant bacteria are discussed. This review provides a useful reference for developing phage-resistant bacteria. Full article
(This article belongs to the Special Issue Applications of Bacteriophages)
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