MAPK Signaling Cascades in Human Health and Diseases, 2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 July 2025 | Viewed by 2532
Special Issue Editor
Special Issue Information
Dear Colleagues,
Mitogen-activated protein kinase (MAPK) cascades are a group of signaling pathways that regulate a multitude of intracellular processes, including metabolism, proliferation, differentiation, motility, apoptosis, and cell-specific functions. For this purpose, the cascades induce a stimulated phosphorylation of hundreds of substrates that are localized in various cellular compartments, particularly the cytoplasm in resting cells and the nucleus upon stimulation. Importantly, dysregulation of the cascades leads to various diseases, including cancer, inflammation, and developmental disorders. Therefore, MAPK cascades are recognized as important drug targets for treating all these pathologies. In this Special Issue, we aim to highlight the role and mode of regulation of the MAPK cascades, with a special emphasis on their nuclear activities.
As the Guest Editor, I am pleased to announce the opening for submission to this Special Issue entitled “MAPK Signaling Cascades in Human Health and Diseases 2.0”. This Special Issue is open to both original research articles and review articles.
I look forward to your response regarding your contribution to this Special Issue.
Dr. Galia Maik-Rachline
Guest Editor
Manuscript Submission Information
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Keywords
- ERK1/2
- p38
- JNK
- ERK5
- MEK
- MEKK
- raf
- stimulated nuclear translocation
- targeted therapy
- resistance mechanisms
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