MAPK Signaling Cascades in Human Health and Diseases 2.0

Dear Colleagues,

Mitogen-activated protein kinase (MAPK) cascades are a group of signaling pathways that regulate a multitude of intracellular processes, including metabolism, proliferation, differentiation, motility, apoptosis, and cell-specific functions. For this purpose, the cascades induce a stimulated phosphorylation of hundreds of substrates that are localized in various cellular compartments, particularly the cytoplasm in resting cells and the nucleus upon stimulation. Importantly, dysregulation of the cascades leads to various diseases, including cancer, inflammation, and developmental disorders. Therefore, MAPK cascades are recognized as important drug targets for treating all these pathologies. In this Special Issue, we aim to highlight the role and mode of regulation of the MAPK cascades, with a special emphasis on their nuclear activities.

As the Guest Editor, I am pleased to announce the opening for submission to this Special Issue entitled “MAPK Signaling Cascades in Human Health and Diseases 2.0”. This Special Issue is open to both original research articles and review articles.

I look forward to your response regarding your contribution to this Special Issue.

Dr. Galia Maik-Rachline
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• ERK1/2
• p38
• JNK
• ERK5
• MEK
• MEKK
• raf
• stimulated nuclear translocation
• targeted therapy
• resistance mechanisms

• MAPK Signaling Cascades in Human Health and Diseases in International Journal of Molecular Sciences (8 articles)