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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Periodontal Disease: From Molecular Pathogenesis to Precision Diagnostics and Innovative Therapeutics
edited by
submission deadline 30 Aug 2025 | 1 articles | Viewed by 476 | Submission Open
Keywords: periodontitis; gingivitis; oral microbiome; host– pathogen interactions; periodontal immunology; systemic inflammation; salivary diagnostics; periodontal regeneration; precision dentistry; oral-systemic connections; inflammatory biomarkers; antimicrobial peptides; peri-implantitis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Physics and Chemistry of Molecular Materials for Optoelectronic Applications submission deadline 30 Aug 2025 | Viewed by 429 | Submission Open
Keywords: polarization of matter; non-linear optics and non-linear optical phenomena; optical phenomena; quantum chemistry; density functional theory; physics and chemistry of molecular materials; molecular-based optoelectronics
(This special issue belongs to the Section Materials Science)
Chemical Elicitors and Microbial Metabolites: Synergistic Mechanisms in Plant Systemic Resistance Induction
edited by Heewan Kang
submission deadline 30 Aug 2025 | 1 articles | Viewed by 409 | Submission Open
Keywords: chemical elicitors; Bacillus spp.; microbial metabolites; amino acids; defense induction; resistance mechanisms
(This special issue belongs to the Section Molecular Plant Sciences)
Role of Quorum Sensing in Plant Microbiome: Advances and Prospects
edited by
submission deadline 30 Aug 2025 | Viewed by 397 | Submission Open
Keywords: quorum sensing; quorum quenching; rhizosphere signaling; signaling molecules; N-Acyl-L-homoserine lactones; AHLs; microbiome; chemical molecules; sustainable agriculture
(This special issue belongs to the Section Molecular Plant Sciences)
Latest Advances in Computational Drug Discovery
edited by
submission deadline 30 Aug 2025 | Viewed by 397 | Submission Open
Keywords: design; synthesis; molecular docking; methodological reviews; novel docking approaches; ADME; toxicity; AI-driven molecular docking; molecular dynamics; bioisosteric replacement in drug design; rational drug design and synthesis; computational tools and algorithms; lead optimization and structure-based drug design; virtual screening of drug candidates; QSAR modelling; DFT
(This special issue belongs to the Section Molecular Pharmacology)
Recent Advances in Osteoarthritis Pathways and Biomarker Research
edited by
submission deadline 30 Aug 2025 | 1 articles | Viewed by 393 | Submission Open
Keywords: osteoarthritis; low-grade inflammation; cartilage chondrocyte; synovial membrane; synovial fluid; subchondral bone; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Artificial Intelligence and Computer-Aided Design: Molecular Simulation Technology in Exploring Bioactive Compounds for Health Promotion
edited by
submission deadline 30 Aug 2025 | Viewed by 339 | Submission Open
Keywords: molecular simulation; bioactive compounds; molecular docking; molecular dynamics; quantum mechanics; functional mechanisms
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Application and Molecular Mechanisms of Microwaves for Materials Processing
edited by
submission deadline 30 Aug 2025 | Viewed by 198 | Submission Open
Keywords: microwaves; non-ionizing radiation; molecular materials characterizations; molecular materials synthesis; microwave processing and engineering
(This special issue belongs to the Section Materials Science)
Recent Advances in Molecular Mechanisms and Targeted Therapies for Leukemia
edited by
submission deadline 30 Aug 2025 | Viewed by 198 | Submission Open
Keywords: targeted therapy; acute myeloid leukemia; genetic mutations
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced Research on Nanosensors for Molecular Sensing Applications
edited by
submission deadline 30 Aug 2025 | Viewed by 196 | Submission Open
Keywords: nanostructure; microfabrication; nanoparticles; nanotechnology; nanomaterials; sensor response; sensitivity; miniaturization; analyte selectivity; molecular recognition; biosensor; sensing mechanism; nanowires; affinity sensor
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Insights into Agrifood Waste Valorization: From By-Products to Sustainable Resources submission deadline 30 Aug 2025 | Viewed by 195 | Submission Open
Keywords: antioxidants; by-products; antimicrobials; nutraceuticals; food industry; circular economy
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Environmental Sensitivity Illnesses: Advances in Mechanisms and Molecular Signatures
edited by
submission deadline 30 Aug 2025 | Viewed by 193 | Submission Open
Keywords: electromagnetic hypersensitivity; multiple chemical sensitivity; fibromyalgia; chronic fatigue syndrome; chronic pain disorder; toxicant-induced loss of tolerance; total allergy syndrome; circulating biomarkers; genetic susceptibility factors; immune system alterations
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Associations Between Adipose Tissue and Diseases submission deadline 30 Aug 2025 | Viewed by 181 | Submission Open
Keywords: lipedema; adipose tissue; adipocyte; adipose organ; body fat; miRNA; ketogenic diet
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Heavy Metal Exposure on Health
edited by
submission deadline 30 Aug 2025 | Viewed by 164 | Submission Open
Keywords: heavy metals; toxic metal exposure; oxidative stress; mitochondrial dysfunction; epigenetic alterations; physiological and molecular pathways of cellular toxicology; biomarkers of toxicity; chelating agents; antioxidants; therapies or treatments
(This special issue belongs to the Section Molecular Toxicology)
New Insights in Biomarkers of Autoimmune and Autoinflammatory Diseases: 2nd Edition
edited by
submission deadline 30 Aug 2025 | Viewed by 162 | Submission Open
Keywords: inflammaging; inflammasome; autoantibodies; free light chains; cytokines; receptor; signal transduction; innate immunity; adaptive immunity
(This special issue belongs to the Section Molecular Immunology)
Molecular Applications of Antioxidants and Anti-Inflammatory Activities of Natural Products submission deadline 30 Aug 2025 | Viewed by 162 | Submission Open
Keywords: antioxidants; anti-inflammatory agents; natural products; molecular mechanisms; oxidative stress; signaling pathways; inflammation; bioactive compounds; proteomics; metabolomics
(This special issue belongs to the Section Bioactives and Nutraceuticals)
RNA-Based Regulation in Human Health and Disease submission deadline 30 Aug 2025 | Viewed by 161 | Submission Open
Keywords: non-coding RNAs (ncRNAs); small nucleolar RNAs (snoRNAs); long non-coding RNAs (lncRNAs); microRNAs (miRNAs); piwi-interacting RNAs (piRNAs); circular RNAs (circRNAs); RNA modifications (m6A; pseudouridylation); RNA-protein interactions; post-transcriptional gene regulation; RNA interference (RNAi); antisense oligonucleotides (ASOs); RNA-binding proteins (RBPs); epitranscriptomics; RNA-based therapeutics; cancer-associated ncRNAs; neurodegenerative diseases and RNA regulation; cardiovascular RNA biology; metabolic disorders and RNA; ribosomal RNA modifications; RNA-targeted drug discovery
(This special issue belongs to the Section Molecular Genetics and Genomics)
Advancements in Novel Drug Delivery Systems for Gene and Drug Delivery
edited by
submission deadline 30 Aug 2025 | Viewed by 160 | Submission Open
Keywords: drug and gene delivery; novel drug delivery systems; nanoparticle-based delivery systems
(This special issue belongs to the Section Molecular Biology)
Molecular Advances in Primary Colorectal Cancer and Liver Metastases
edited by Alexandros E. Giakoustidis
submission deadline 30 Aug 2025 | Viewed by 156 | Submission Open
Keywords: colorectal cancer; metastasis; treatment; management; screening; genetic alterations; epigenetic alterations; genomics; epigenomics; methylation; liver-directed therapy; radiation; immunotherapy; peritoneal carcinomatosis; monotherapy; chemotherapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Lipoprotein in Cardiovascular Disease submission deadline 30 Aug 2025 | Viewed by 151 | Submission Open
Keywords: lipoprotein; cardiovascular disease; atherosclerosis; lipid metabolism; HDL; LDL; VLDL; Lp(a); TRLs
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Advances in Type 2 Diabetes and Its Complications: 2nd Edition
edited by
submission deadline 30 Aug 2025 | Viewed by 149 | Submission Open
Keywords: diabetes type 2; diabetes complications; pathophysiology of type 2 diabetes; new diabetes treatment; cardiovascular disease; stroke; peripheral artery disease; chronic kidney disease; retinopathy; neuropathy; non-alcoholic fatty liver disease in diabetes
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Microbial Pathogens and Drug Resistance in the Environment
edited by
submission deadline 30 Aug 2025 | Viewed by 147 | Submission Open
Keywords: antibiotics; peptides; chemotherapeutics; antimicrobial drugs; molecular mechanism of drug action
(This special issue belongs to the Section Molecular Microbiology)
Molecular Mechanisms and Treatment in Skin Cancer
edited by
submission deadline 30 Aug 2025 | Viewed by 143 | Submission Open
Keywords: skin cancer; early detection; treatment; prevention; pathophysiology; vitamin-C; cell energetics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Progress in Biological and Molecular Mechanisms and Targeted Therapies of Leukemia
edited by Anna Sicuranza
submission deadline 30 Aug 2025 | Viewed by 143 | Submission Open
Keywords: leukemia-targeted therapies; AML; CML; venetoclax combination therapy; tyrosine kinase inhibitors (TKIs); hypomethylating agents; ALL; CLL; CAR-T cell therapy; monoclonal antibodies; immune checkpoint inhibitors; resistance mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms Behind Plant–Virus Interactions: Pathogenesis and Defense submission deadline 30 Aug 2025 | Viewed by 141 | Submission Open
Keywords: plant viruses; plant resistance; plant signaling; plant defense; biotic stress; plant– virus interactions; molecular mechanism
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Advances in Brain Plasticity submission deadline 30 Aug 2025 | Viewed by 135 | Submission Open
Keywords: neurophysiology; neurobiology; synapses; synaptic plasticity; microglia; astrocytes; dendritic spines; neurodevelopment; neurodevelopmental disease; learning and memory; neuropharmacology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Eukaryotic DNA Replication—from Bench to Bedside
edited by Heinz-Peter Nasheuer
submission deadline 30 Aug 2025 | Viewed by 130 | Submission Open
Keywords: genome stability; cell cycle; DNA replication; chromatin replication; replication origins— selection; licensing and firing; replication forks— smoothly progressing and under stress; role of DNA replication in cancer and other human diseases; disease treatment opportunities
(This special issue belongs to the Section Molecular Genetics and Genomics)
Ruminant Physiology: Digestion, Metabolism, and Endocrine System
edited by Rui Hu
submission deadline 30 Aug 2025 | Viewed by 129 | Submission Open
Keywords: ruminant physiology; digestive health; metabolic regulation; endocrine signaling; rumen microbiome; nutrient partitioning; methane mitigation; epigenetic modulation; nutritional stress adaptation
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Health Targeting Cardiovascular and Cerebrovascular Diseases: Molecular Aspects
edited by
submission deadline 30 Aug 2025 | Viewed by 128 | Submission Open
Keywords: cardiovascular disease; cerebrovascular disease; cell therapy; gene therapy; extracellular vesicles; regenerative medicine; brain– heart axis; molecular mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advancements in Pathogen Detection, Microdevice Technologies and AI-Driven Analysis
edited by
submission deadline 30 Aug 2025 | Viewed by 128 | Submission Open
Keywords: pathogen detection; microfluidic; microdevice; AI analysis; virus; bacteria; point-of-care testing; infectious disease; nanotechnology
(This special issue belongs to the Section Molecular Biology)
Liquid Biopsies in Oncology—3rd Edition submission deadline 30 Aug 2025 | Viewed by 128 | Submission Open
Keywords: precision oncology; personalized therapy; cancer biomarkers; liquid biopsy; biological fluids; circulating molecules; circulating tumor cells; CTCs; ctDNA; ctRNA; cell-free DNA; cfDNA; NGS; circulating miRNAs; exosomes; extracellular vesicles
(This special issue belongs to the Section Molecular Oncology)
Bioactive Peptides: Microbial Fermentation-Driven Synthesis and Multifunctional Applications in Health and Industry
edited by
submission deadline 30 Aug 2025 | Viewed by 127 | Submission Open
Keywords: bioactive peptides; foods; probiotics; fermentation; pharmaceutical; herbs
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Cancer Biology and Epigenetic Modifications
edited by Tamer E. Fandy
submission deadline 30 Aug 2025 | Viewed by 126 | Submission Open
Keywords: epigenetics; DNA methylation; epigenetic modifiers; histone acetylation; histone methylation; miRNA; ncRNA; chrmoatin remodelling
(This special issue belongs to the Section Molecular Oncology)
Application of Large Language Models in Bioinformatics: Deep Exploration from Protein to Gene Networks
edited by Dukka B. Kc
submission deadline 30 Aug 2025 | Viewed by 122 | Submission Open
Keywords: large language models; protein language models; DNA language model; RNA language model; deep learning; bioinformatics; protein structure; sequence alignment; prediction of gene; protein function; gene networks
(This special issue belongs to the Section Molecular Informatics)
Electron or Ion Transport in Electrochemistry
edited by Simone Sanna
submission deadline 30 Aug 2025 | Viewed by 120 | Submission Open
Keywords: solid oxide fuel cells; mixed ionic and electronic conductors; perovskite; fluorite; hydrogen; CO2 reduction; water splitting; energy conversion and storage
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
The Toxicity of Bisphenol A and Its Analogs
edited by
submission deadline 30 Aug 2025 | Viewed by 120 | Submission Open
Keywords: bisphenols; endocrine disruptors; bisphenol A and analogs; toxicology
(This special issue belongs to the Section Molecular Toxicology)
Phytochemicals in Health and Disease: From Molecular Mechanisms to Evidence-Based Applications
edited by Olga Silva
submission deadline 30 Aug 2025 | Viewed by 119 | Submission Open
Keywords: phytochemicals; bioactive natural products; medicinal plants; chronic and inflammatory diseases; ethnopharmacology and phytotherapy
(This special issue belongs to the Section Molecular Biology)
Molecular and Histological Approaches in Oral Tissue Regeneration and Diagnostics
edited by
submission deadline 30 Aug 2025 | Viewed by 117 | Submission Open
Keywords: dentistry; histological analysis; immunofluorescence; molecular pathogenesis; tissue
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular and Cellular Research on Cardiac Repair and Regeneration submission deadline 30 Aug 2025 | Viewed by 115 | Submission Open
Keywords: cardiac repair; cardiomyocyte differentiation; cardiac fibroblast activation; cardiac fibrosis; cardiac tissue microenvironment; cardiac remodeling
(This special issue belongs to the Section Molecular Biology)
Transgenic Mouse Models in Human Disease Research in Epithelial Tissues: Insights and Advances submission deadline 30 Aug 2025 | Viewed by 114 | Submission Open
Keywords: transgenic animals; kideny diseases; heart failure; cystic diseases
(This special issue belongs to the Section Molecular Biology)
Exosomes in the Processes of Tumorigenesis, Cancer Progression, Metastasis, and Treatment submission deadline 30 Aug 2025 | Viewed by 104 | Submission Open
Keywords: exosomes; extracellular vesicles; metastasis; cancer; prognosis; prediction; biomarker; cancer treatment
(This special issue belongs to the Section Molecular Oncology)
Molecular Advancements in Functional Materials
edited by
submission deadline 30 Aug 2025 | Viewed by 102 | Submission Open
Keywords: synthesis of specialty compounds; specialty compounds in functional materials; special applications: self-cleaning; anti-icing; self-healing; biocidal; etc.; properties; special-purpose functional materials
(This special issue belongs to the Section Materials Science)
Cutaneous Biology, Molecular Dermatology and Dermatopathology, 2nd Edition
edited by
submission deadline 30 Aug 2025 | Viewed by 101 | Submission Open
Keywords: molecular dermatology; targeted therapy; cutaneous oncology; immunodermatology; cutaneous biology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Chessboard: How Plants and Insects Outsmart Each Other
edited by
submission deadline 30 Aug 2025 | Viewed by 98 | Submission Open
Keywords: acarology; biotic stress; entomology nitric oxide; oxidative stress; phytopathology; reactive nitrogen species; reactive oxygen species
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Advances in Adsorbing Materials
edited by Mounia Achak
submission deadline 30 Aug 2025 | Viewed by 97 | Submission Open
Keywords: adsorption process; adsorbing materials; bio-based adsorbents; regeneration and reusability; pollutant removal; wastewater treatment; industrial and environmental applications
(This special issue belongs to the Section Materials Science)
Modulating the Niche: Targeting the Tumor Microenvironment for Enhanced Therapy
edited by
submission deadline 30 Aug 2025 | Viewed by 93 | Submission Open
Keywords: microenvironment dynamics; immune modulation; biomarker discovery; tumor microenvironment; extracellular matrix; cancer therapy
(This special issue belongs to the Section Molecular Oncology)
Cardiovascular Diseases: Molecular Mechanisms, Biomarkers, and Therapies: 2nd Edition submission deadline 30 Aug 2025 | Viewed by 91 | Submission Open
Keywords: cardiovascular diseases; oxidative stress; inflammation; risk factors; biomarkers; omics technology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Insight into Biomaterials for Tissue Engineering and Regenerative Medicine
edited by
submission deadline 30 Aug 2025 | Viewed by 89 | Submission Open
Keywords: biomaterials; tissue regeneration; regenerative medicine; bone regeneration; periodontal disease; morphology; tissue engineering
(This special issue belongs to the Section Molecular Biology)
Molecular Pathways and Mechanisms of Lung Injury: From Environmental Agents to Clinical Implications
edited by and Cristina Porta
submission deadline 30 Aug 2025 | Viewed by 88 | Submission Open
Keywords: lung injury; lung cancer; pulmonary fibrosis; chronic obstructive pulmonary disease; acute respiratory distress syndrome; environmental pollutants and toxins; molecular and cellular mechanisms; biomarkers; therapeutic approaches
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Nutrition from Cereal Foods: Molecular Insights into Nutrition, Metabolism and Health Regulation
edited by Genyi Zhang
submission deadline 30 Aug 2025 | Viewed by 87 | Submission Open
Keywords: molecular breeding; cereal crops; bioactive compounds; metabolic syndrome; inflammation; gut health
(This special issue belongs to the Section Bioactives and Nutraceuticals)
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