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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Platelet-Mediated Immune Regulation in Cancer

edited by

Bennett D. Elzey

submission deadline 31 May 2026 | Viewed by 49 | Submission Open

Keywords: platelets; tumor immunity; megakaryocyte; immunotherapy; lymphocytes; microvesicles; immune suppression; metastasis

(This special issue belongs to the Section Molecular Immunology)

Cryo-EM and Cryo-Tomography in Macromolecular Structure Analysis

edited by

R. Holland Cheng

submission deadline 31 May 2026 | Viewed by 48 | Submission Open

Keywords: macromolecular structure; precision nanomedicine; cryo-electron microscopy (cryo-EM); cryo-electron tomography (cryo-ET); viral capsids; AI/ML in structural analysis; time-resolved imaging; nanoparticle delivery; in-cell tomography; structural dynamics; molecular mechanisms; protein complexes; membrane proteins; macromolecular assemblies; conformational changes; integrative structural biology; cellular structural biology; drug delivery systems; therapeutic design

(This special issue belongs to the Section Macromolecules)

The Role of Ferroptosis in Cancer Biology and Therapy

edited by Alessandra Di Paola and Elvira Pota

submission deadline 31 May 2026 | Viewed by 46 | Submission Open

Keywords: ferroptosis; cancer biology; tumor microenvironment; therapeutic targeting; anticancer immunity; targeted therapy

(This special issue belongs to the Section Molecular Oncology)

Metabolic Alterations in Health and Disease: From Molecular Mechanisms to Biomarkers in Clinical Applications

edited by

Ramona D'Amico

and

Rosalba Siracusa

submission deadline 31 May 2026 | Viewed by 42 | Submission Open

Keywords: metabolic syndrome; diabetes; oxidative stress; cellular metabolism; biomarkers; molecular pathways; metabolic disorders

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular and Computational Innovations in Forensic Genetics: From Degraded DNA to Predictive Models

edited by Eugenio Alladio and

Elena Pilli

submission deadline 31 May 2026 | Viewed by 42 | Submission Open

Keywords: degraded DNA; low-template DNA; molecular forensics; NGS; machine learning; deep learning; chemometrics; data integration; predictive models; forensic applications

(This special issue belongs to the Section Molecular Genetics and Genomics)

Exploring the Functional Activity of Natural Products

edited by

Antonio Speciale

submission deadline 31 May 2026 | Viewed by 41 | Submission Open

Keywords: natural products; natural drug discovery; bioactive compounds; biological activity; molecular mechanisms; anti-inflammatory activity; anticancer properties; therapeutic potential

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Eosinophils: Function and Related Disorders

edited by Giulia Costanzo

submission deadline 31 May 2026 | Viewed by 41 | Submission Open

Keywords: eosinophils; polymorphonuclear cells; interleukin; cytotoxic proteins; host defense; tissue remodeling; dysregulation; eosinophilic disorders; therapeutics

(This special issue belongs to the Section Biochemistry)

Molecular and Cellular Mechanisms of Myocardial Disease

edited by

Maicon Landim-Vieira

submission deadline 31 May 2026 | Viewed by 40 | Submission Open

Keywords: cardiac muscle; calcium; sarcomere; troponin; desmossomal complex; hypertrophic cardiomyopathy; dilated cardiomyopathy; arrhythmogenic cardiomyopathy; mitochondria; calmodulin

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Drug Treatment for Bacterial Infections: 2nd Edition

edited by Janusz Madaj

submission deadline 31 May 2026 | Viewed by 38 | Submission Open

Keywords: bacterial infection; antibiotic-resistant bacteria; new agents in the treatment of bacterial infections; optimization of the use of already registered drugs; single antibacterial agents; combined antibacterial agents; new drug forms

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Biology, Genetics, Diagnosis, Management and Therapy of Dermatological Diseases

edited by

Elisa Molinelli

and Corrado Tagliati

submission deadline 31 May 2026 | Viewed by 36 | Submission Open

Keywords: genodermatoses; hydradenitis suppurativa; inflammatory dermatoses; metabolic disorders; infections; esthetic medicine; neoplastic diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Lung Research: From Mechanisms to Therapeutic Innovation

edited by Johnatas D Silva and Fernanda Ferreira Cruz

submission deadline 31 May 2026 | Viewed by 35 | Submission Open

Keywords: lung disease; molecular mechanisms; lung injury and repair; regeneration; biomarkers; therapeutic innovation; translational research; personalized medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Adaptive Strategies of Plants to Water Stress

edited by Weitao Jia

submission deadline 31 May 2026 | Viewed by 35 | Submission Open

Keywords: adaptive strategies; submergence; post-submergence; waterlogging; drought; plant physiology; phenotypic plasticity; omics; epigenetic regulation; molecular mechanism

(This special issue belongs to the Section Molecular Plant Sciences)

The Next Chapter in HIV: Molecular Pathways and Novel Therapeutic Strategies

edited by

Isabella Abbate

submission deadline 31 May 2026 | Viewed by 34 | Submission Open

Keywords: HIV; transcription; provirus; microRNA; epigenetic silencing; reservoir; integration site; latency; immune activation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Individualised Therapies for Rare Disorders

edited by Paul Gissen

submission deadline 31 May 2026 | Viewed by 33 | Submission Open

Keywords: individualised therapies; personalised medicine; rare diseases; omics; gene therapy; molecular pathways; mechanistic discovery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Metabolic Dysfunction in Brain Disorders: Molecular Pathways and Therapeutic Approach

edited by

Janusz Błaszczyk

submission deadline 31 May 2026 | Viewed by 32 | Submission Open

Keywords: molecular basis; brain metabolism; brain aging; neurodegenerative disorders; Alzheimer disease; Parkinson disease; mood disorders

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research of Gastrointestinal Disease, 3rd Edition

edited by

Ainsley Robinson

and

Kulmira Nurgali

submission deadline 31 May 2026 | Viewed by 32 | Submission Open

Keywords: gastrointestinal health; gastrointestinal disorders; gastrointestinal disease; gastrointestinal homeostasis; molecular targets; mechanisms; pathways; molecular markers; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biocatalysis: Mechanisms of Proteolytic Enzymes, 3rd Edition

edited by

Peter Goettig

submission deadline 31 May 2026 | Viewed by 31 | Submission Open

Keywords: aspartic proteases; catalytic mechanisms; cysteine proteases; enzyme kinetics; metalloproteases; non-natural amino acids; protease engineering; real time activity monitoring; serine proteases; viral proteases

(This special issue belongs to the Section Molecular Biophysics)

Post-Translational Modifications Regulating Transcription Factors Activity in Biology and Pathology

edited by Laura Tosatto

submission deadline 31 May 2026 | Viewed by 31 | Submission Open

Keywords: transcription factors; transcription regulation; post-translational modification; phase separation; cell signalling; disorder-to-order and order-to-disorder transition; protein– protein interaction; protein– DNA interaction

(This special issue belongs to the Section Biochemistry)

Advances in Research on Antimicrobial Resistance Mechanism

edited by

Davide Carcione

submission deadline 31 May 2026 | Viewed by 31 | Submission Open

Keywords: horizontal gene transfer; efflux pumps; biofilm formation; plasmid-mediated resistance; antibiotic stewardship

(This special issue belongs to the Section Molecular Microbiology)

Foodomics: Challenges and Opportunities for a Sustainable Future

edited by

Mónica Carrera

submission deadline 31 May 2026 | Viewed by 30 | Submission Open

Keywords: foodomics; sustainable food systems; omics; food quality; safety and innovation; green and circular technologies; personalized nutrition

(This special issue belongs to the Section Biochemistry)

Understanding Reproductive Health and Infertility: Molecular and Genetic Insights: 2nd Edition

edited by

Jan Tesarik

submission deadline 31 May 2026 | Viewed by 30 | Submission Open

Keywords: sperm quality; oocyte quality; uterine receptivity

(This special issue belongs to the Section Molecular Biology)

Signaling and Stress Adaptation in Plants: 2nd Edition

edited by

Kangdi Hu

submission deadline 31 May 2026 | Viewed by 29 | Submission Open

Keywords: plants; environmental stress; stress signaling; reactive oxygen/nitrogen species; calcium; protein kinases; stress resistance; adaptive mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Innovations in Analytical Chemistry for Environmental and Food Safety: Methodologies and Molecular Insights

edited by

Cosima Damiana Calvano

and

Francesco Longobardi

submission deadline 31 May 2026 | Viewed by 28 | Submission Open

Keywords: innovative sample preparation; food quality and safety; advanced analytical techniques; risk assessment

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Exploring Abiotic Stress in Plants: Mechanisms, Adaptations, and Mitigation Strategies (2nd Edition)

edited by

Tarek Ali Ahmed Ibrahim Alshaal

submission deadline 31 May 2026 | Viewed by 27 | Submission Open

Keywords: abiotic stress; plant physiology; stress tolerance; crop resilience; molecular mechanisms; biotechnological interventions

(This special issue belongs to the Section Molecular Plant Sciences)

Functions and Mechanisms of Hepatic Cancer-Associated Genes and miRNAs

edited by Eleni-Myrto Trifylli

submission deadline 31 May 2026 | Viewed by 27 | Submission Open

Keywords: microRNAs (miRNAs); hepatocellular carcinoma (HCC); hepatic cancer; extracellular vesicles; noncoding RNAs; circular RNAs (circRNAs); gene regulation; epigenetics; drug resistance; biomarkers

(This special issue belongs to the Section Molecular Oncology)

Genetics and Molecular Mechanisms of Cancer Immunotherapy Response

edited by

Javier Oliver

submission deadline 31 May 2026 | Viewed by 27 | Submission Open

Keywords: cancer immunotherapy; genetic biomarkers; immunogenomics; immune checkpoint inhibitors; resistance mechanisms; precision oncology; germline variants; molecular response prediction; immune-related adverse events

(This special issue belongs to the Section Molecular Oncology)

Cardiometabolic Disease: Molecular Biomarkers and Treatment Strategies

edited by Mehrnaz Abbasi

submission deadline 31 May 2026 | Viewed by 27 | Submission Open

Keywords: cardiometabolic diseases; molecular biomarkers; omics technologies; personalized medicine; early detection; machine learning; disease progression; metabolic pathways; transcriptomics; genomic profiling; bioinformatics; therapeutic targets; metabolic dysregulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Sphingolipids: Health and Disease

edited by

Paola Giussani

submission deadline 31 May 2026 | Viewed by 27 | Submission Open

Keywords: sphingolipids; ceramide; sphingosine-1-phosphate; complex sphingolipids; gangliosides

(This special issue belongs to the Section Biochemistry)

Theoretical and Computational Chemistry: New Insights into Molecular Modeling and Design

edited by

Alejandro Morales-Bayuelo

and

Cleber Melo-Filho

submission deadline 31 May 2026 | Viewed by 26 | Submission Open

Keywords: theoretical chemistry; computational chemistry; molecular modeling; quantum chemistry; density functional theory (DFT); molecular dynamics (MD); molecular structure prediction; reaction mechanism modeling

(This special issue belongs to the Section Molecular Informatics)

DNA, Chromatin and Genome Structure

edited by Myakishev-Rempel Max and

Alexandre Vetcher

submission deadline 31 May 2026 | Viewed by 25 | Submission Open

Keywords: DNA structure and dynamics; non-B DNA structures (G-quadruplexes; Z-DNA); DNA topology; R-loops; RNA-DNA triplexes; extrachromosomal DNA (eccDNA); chromatin conformation (Hi-C; Micro-C; 3C); chromatin compaction; TADs and chromatin loops; three-dimensional genome organization; transcription regulation; gene regulation; DNA replication; DNA repair; transposable elements; chromosomal rearrangements; epigenetics; molecular modeling of DNA; molecular modeling of DNA hydration; molecular modeling of chromatin; telomeres; centromeres; introns; noncoding DNA

(This special issue belongs to the Section Molecular Biology)

Advances in Genetics of Arthritis

edited by

Bouchra Edderkaoui

submission deadline 31 May 2026 | Viewed by 25 | Submission Open

Keywords: arthritis; genetic susceptibility; genome-wide association studies; population genetics; genetic loci; epigenetics; gene-environmental interaction; polygenic risk scores; transcriptomics; single-cell sequencing; genomics; rare variants; polymorphisms; candidate genes; autoimmunity genetics; genetics of cartilage; degeneration; regeneration; and inflammatory pathways; genetic biomarkers; pharmacogenomics; functional genomics; precision medicine/ personalized treatments

(This special issue belongs to the Section Molecular Genetics and Genomics)

Discovery of Plant-Derived Compounds and Their Immunomodulatory Applications

edited by

Jun Jiang

submission deadline 31 May 2026 | Viewed by 24 | Submission Open

Keywords: plant-derived compounds; immunomodulators; phytochemicals; immune signaling; natural products; autoimmune diseases; intestinal flora; in vitro evaluation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Latest Advances on Natural Bioactive Molecules and Polysaccharides

edited by Loredana Marcolongo

submission deadline 31 May 2026 | Viewed by 24 | Submission Open

Keywords: natural products; bioactive compounds; polysaccharides; extraction technologies; bioprocesses; value-added products; one-health

(This special issue belongs to the Section Bioactives and Nutraceuticals)

From Pathogenic Mechanisms to Therapy in Gynecological Diseases

edited by

David B. Alexander

submission deadline 31 May 2026 | Viewed by 22 | Submission Open

Keywords: malignant gynecological diseases; screening for gynecological cancers; benign gynecological conditions; screening for benign gynecological diseases; endometriosis; polycystic ovaries syndrome; ovarian cysts; uterine fibroids; leiomyomas; adenomyosis; pelvic inflammatory disease; vaginitis; vaginal dysbiosis; treatment targets for gynecological diseases

(This special issue belongs to the Section Molecular Oncology)

Integrative Mechanisms and Translational Outcomes of Excitatory–Inhibitory Neurotransmission Switching in Neuropathic Pain

edited by

Poppy Schoenberg

submission deadline 31 May 2026 | Viewed by 22 | Submission Open

Keywords: neuropathic pain; excitatory– inhibitory balance (E/I balance); neurotransmission switching; microglia; spinal dorsal horn; circuit remodeling; translational biomarkers; computational modeling; glutamatergic signaling; neuromodulation

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Pathogenesis, Biomarkers, and Therapeutic Development in Huntington’s Disease

edited by Jesús Pérez-Pérez

submission deadline 31 May 2026 | Viewed by 20 | Submission Open

Keywords: Huntington’ s disease; somatic instability; genetic modifiers; HD RNA biology; mutant huntingtin; molecular pathogenesis; biomarkers; neurobiology of chorea; cognition and psychiatric disturbances; HTT-lowering therapies; gene therapy

(This special issue belongs to the Section Molecular Neurobiology)

Synthesis and Activity Studies of Anticancer Compounds

edited by Agata Pacuła-Miszewska

submission deadline 31 May 2026 | Viewed by 20 | Submission Open

Keywords: anticancer agents; structure-activity relationship; cytotoxicity mechanisms; medicinal chemistry; drug design

(This special issue belongs to the Section Molecular Pharmacology)

The Circadian Clock in Aging and Age-Related Diseases

edited by

Gianluigi Mazzoccoli

Tommaso Colangelo

and

Giovanni Damiani

submission deadline 31 May 2026 | Viewed by 20 | Submission Open

Keywords: circadian timing system; molecular clockwork; rhythmicity; biological clock; aging inflammation; metabolism; endoplasmic reticulum stress

(This special issue belongs to the Section Molecular Immunology)

Neurological Mechanisms of Action of Natural Products

edited by Damião Pergentino De Sousa

submission deadline 31 May 2026 | Viewed by 19 | Submission Open

Keywords: Alzheimer's disease; Parkinson's disease; epilepsy; dementia; pain; essential oils; medicinal plants; alkaloids; flavonoids; natural products

(This special issue belongs to the Section Molecular Neurobiology)

Determinants of Chronic Diseases: Cellular Mechanisms and the Role of Natural Compounds

edited by Andrei Lobiuc

submission deadline 31 May 2026 | Viewed by 18 | Submission Open

Keywords: chronic diseases; natural compounds; cellular mechanisms; bioactive molecules; signal transduction; oxidative stress; inflammation; apoptosis; mitochondrial dysfunction; therapeutic targets

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Curcumin Derivatives and Curcuminoids with Potential Biomedical Applications

edited by

Paola Bonaccorsi

and

Chiara Maria Antonietta Gangemi

submission deadline 31 May 2026 | Viewed by 18 | Submission Open

Keywords: curcumin; curcuminoids; synthesis; biomedicine; bioimaging; supramolecular; sensors; photodynamic therapy; antitumor properties; antiviral properties; antibacterial properties; antioxidant properties

(This special issue belongs to the Section Molecular Pharmacology)

Genetic Variations in Human Diseases: 3rd Edition

edited by

Paweł Niemiec

submission deadline 31 May 2026 | Viewed by 17 | Submission Open

Keywords: genetic polymorphism; gene– gene interaction; gene– environment interaction; monogenic disorder; mutation phenotype; quantitative trait locus; family-based study; cohort study; association study

(This special issue belongs to the Section Molecular Genetics and Genomics)

Small-Molecule Fluorescent Probes: From Design to Biological Applications

edited by Qinglong Qiao

submission deadline 31 May 2026 | Viewed by 12 | Submission Open

Keywords: fluorescent probes; fluorescence imaging; biosensors; molecular design; biological applications

(This special issue belongs to the Section Molecular Biophysics)

Advanced Materials for Next-Generation Energy Storage: Molecular Design, Functional Properties, and Applications

edited by

Carlos Miguel Costa

and

Senentxu Lanceros-Mendez

submission deadline 31 May 2026 | Viewed by 7 | Submission Open

Keywords: energy storage devices; molecular materials; smart functionalities; structure-property relationships; molecular design and engineering; advanced applications

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Bioinformatics Study in Human Diseases: Integration of Omics Data for Personalized Medicine (Third Edition)

edited by

Hung-Yu Lin

submission deadline 31 May 2026 | Viewed by 6 | Submission Open

Keywords: cancers; ageing-related diseases; bioinformatics; multi-omics; pharmacogenetics; deep learning; evolutionary learning; diagnosis; prognosis; companion biomarker; drug screening; mechanism dissection

(This special issue belongs to the Section Molecular Informatics)

Emerging Trends of Biotechnology in Bioremediation and Biodegradation

edited by

Marta Alejandra Polti

submission deadline 31 May 2026 | Viewed by 5 | Submission Open

Keywords: emerging technologies; biological treatment; environmental sustainability; innovative methodologies; ecosystem restoration

(This special issue belongs to the Section Molecular Biology)

Molecular Strategies for Vital Pulp Therapy and Endodontic Regeneration

edited by

Matthias Widbiller

submission deadline 31 May 2026 | Viewed by 4 | Submission Open

Keywords: endodontics; biomaterials; vital pulp therapy; tissue engineering; regeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pathogenesis of Pathogenic Fungi: The Era of AI and New Technologies

edited by

Paul Wai Kei Tsang

submission deadline 31 May 2026 | Submission Open

Keywords: artificial intelligence; molecular diagnosis and detection; therapeutic targeting; resistance and prediction; host relationships; immunity

(This special issue belongs to the Section Molecular Microbiology)

Long-COVID and Its Complications

edited by

Alexey Sarapultsev

submission deadline 20 Jun 2026 | 9 articles | Viewed by 38139 | Submission Open

Keywords: acquired immune deficiency; auto-immunity; blood– brain barrier dysfunction; complication; COVID-19; gut microbiome; hypothalamic– pituitary– adrenal axis; immune dysfunction; long COVID; multisystem dysfunction; neurological complications; SARS-CoV-2; systemic inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Therapeutic Targeting of Inflammatory Complications

edited by

Kota V. Ramana

submission deadline 20 Jun 2026 | 10 articles | Viewed by 22122 | Submission Open

Keywords: inflammation; oxidative stress; cytokines; autoimmune diseases; infectious diseases; cancer; targeted therapies; molecular pathways; asthma; sepsis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 2951-3000 on page 60 of 67.

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