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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Immunotherapy Versus Immune Modulation of Leukemia
edited by Helga Maria Schmetzer
submission deadline 20 Feb 2026 | 6 articles | Viewed by 10188 | Submission Open
Keywords: leukemia; immunotherapy; immune modulation; antileukemic; drug resistance
(This special issue belongs to the Section Molecular Oncology)
Role of MicroRNAs in Human Diseases: 2nd Edition
edited by
submission deadline 20 Feb 2026 | 8 articles | Viewed by 9939 | Submission Open
Keywords: microRNAs; miRNAs; miRs; preclinical models; target interaction; regulatory networks; oncology; cancer biology; cardiovascular disease; neurodegenerative conditions; diagnostic applications; therapeutic development and clinical trials
(This special issue belongs to the Section Molecular Genetics and Genomics)
Genes and Human Diseases: 3rd Edition submission deadline 20 Feb 2026 | 8 articles | Viewed by 9504 | Submission Open
Keywords: genes; human diseases; genetic-epidemiological studies; genetic factors; susceptibility
(This special issue belongs to the Section Molecular Genetics and Genomics)
Health-Promoting Effects of Medicinal and Edible Plants and Their Molecular Mechanism
edited by and
submission deadline 20 Feb 2026 | 5 articles | Viewed by 9153 | Submission Open
Keywords: medicinal plants; edible plants; health-promoting effect; molecular mechanism; phytochemicals; diseases; curing targets; signaling pathway
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Studies in Aging, 2nd Edition
edited by
submission deadline 20 Feb 2026 | 4 articles | Viewed by 9019 | Submission Open
Keywords: senescence; active aging; sarcopenia; osteoporosis; oxidative stress; brain aging; cardiovascular aging
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
In Silico Methods of Assessing the Therapeutic Potential of Natural Substances submission deadline 20 Feb 2026 | 5 articles | Viewed by 8985 | Submission Open
Keywords: in silico screening; natural products; molecular docking; computational drug discovery; QSAR modeling; molecular dynamics simulations; natural compounds; drug-target interactions; virtual screening; structure-activity relationships; computational chemistry; cheminformatics; ADMET prediction; bioinformatics; phytochemicals; machine learning in drug discovery; computer-aided drug design; pharmacophore modeling; natural therapeutics; computational pharmacology
(This special issue belongs to the Section Molecular Informatics)
Advances in the Genetics, Epidemiology and Management of Myopathies submission deadline 20 Feb 2026 | 1 articles | Viewed by 8386 | Submission Open
Keywords: myopathies; muscle disorders; muscle weakness; muscle pain; myalgia
(This special issue belongs to the Section Molecular Biology)
The Role of Cytokines and Autoantibodies Against Cytokines in Health and Disease submission deadline 20 Feb 2026 | 1 articles | Viewed by 8248 | Submission Open
Keywords: cytokine; autoantibodies; cytokine therapy; cytokine inhibition
(This special issue belongs to the Section Molecular Immunology)
New Advances in Bioactive Compounds in Health and Disease
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 8133 | Submission Open
Keywords: phenolic compounds; bioactive compounds; health-promoting properties; human diseases; chronic diseases
(This special issue belongs to the Section Bioactives and Nutraceuticals)
MicroRNAs as Biomarkers and Therapeutic Targets in Human Diseases
edited by Elena V. Bichenkova
submission deadline 20 Feb 2026 | 6 articles | Viewed by 8085 | Submission Open
Keywords: microRNA biomarkers; diagnostic profiling; expression patterns; miRNA therapeutics; antimiRs; miRNA mimics; hybridisation; sequence-specificity; miRNA knockdown
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biocatalysis of Compounds for Pharmaceutical and Biomedical Applications
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 8046 | Submission Open
Keywords: biocatalysis; biomedical application; biotechnology; compounds for pharmacy; compounds for biomedicine; enantiomers; enzyme activity; enzyme engineering; enzyme immobilization; kinetic resolution; pharmaceutical application; supports materials
(This special issue belongs to the Section Molecular Pharmacology)
Endothelial Dysfunction and Its Related Cardiometabolic Disorders: From Mechanisms to Targeted Therapies
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 7961 | Submission Open
Keywords: endothelial dysfunction; endothelial activation; endothelial nitric oxide synthase; cardiometabolic disease; vascular inflammation; chemokines; adipocytokines; atherosclerosis; diabetes; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Role of Diet and Nutrition in Metabolic Diseases submission deadline 20 Feb 2026 | 3 articles | Viewed by 7786 | Submission Open
Keywords: nutrients; biomarkers; molecular targets; pahodiagnosis; treatment
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Fish Genomics and Developmental Biology, 2nd Edition submission deadline 20 Feb 2026 | 6 articles | Viewed by 7659 | Submission Open
Keywords: development; teleost; gene regulation; comparative genomics; genomics; aquaculture; transcriptomics; gene expression; environment; genomes; population genomics; selective breeding; biomarker
(This special issue belongs to the Section Molecular Biology)
Progression of Multiple Sclerosis: Environmental Factors, Genetics, Therapeutics and Immunopathogenesis
edited by Alberto Gajofatto
submission deadline 20 Feb 2026 | 4 articles | Viewed by 7635 | Submission Open
Keywords: multiple sclerosis; disability progression; neurodegeneration; pathogenesis; immunology; risk factor; environment; genetics; treatment
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Tea Tree Metabolism and Genetics
edited by Xiaoling Sun
submission deadline 20 Feb 2026 | 4 articles | Viewed by 7521 | Submission Open
Keywords: tea tree; secondary metabolite; genetic transformation; genetic breeding; tea germplasm improvement
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mechanisms, Pathophysiology and Therapeutic Strategies of Chronic Obstructive Pulmonary Disease (COPD)
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 7467 | Submission Open
Keywords: chronic obstructive pulmonary disease (COPD); pathophysiology; novel therapeutic approaches; biomarkers; pulmonary rehabilitation; inflammation; oxidative stress; genetic factors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Computer-Aided Drug Design Strategies submission deadline 20 Feb 2026 | 3 articles | Viewed by 7376 | Submission Open
Keywords: computer-aided drug design; artificial intelligence in drug discovery; molecular docking; molecular dynamics simulations; macromolecular systems; quantum mechanics/molecular mechanics (QM/MM); big data analytics in drug development; pharmacokinetics optimization; structure-based drug design (SBDD); ligand-based drug design; virtual screening techniques
(This special issue belongs to the Section Molecular Informatics)
Embryonic Development and Differentiation: 2nd Edition submission deadline 20 Feb 2026 | 3 articles | Viewed by 7089 | Submission Open
Keywords: blastocyte; embryogenesis; endometrium; implantation; in vitro fertilization (IFV); ICSI; oocyte; pregnancy; seminal plasma; sperm
(This special issue belongs to the Section Molecular Biology)
Identification of Novel Biomarkers Towards Improved Diagnosis and Management of Peripheral Vascular Diseases
edited by
submission deadline 20 Feb 2026 | 5 articles | Viewed by 7079 | Submission Open
Keywords: vascular pathophysiology; peripheral atherosclerosis; aneurysm; venous disorders; congenital vascular malformations; molecular biomarkers; diagnostic biomarkers; therapeutic targets
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Transcription Factors in Plant Gene Expression Regulation, 2nd Edition
edited by
submission deadline 20 Feb 2026 | 5 articles | Viewed by 7026 | Submission Open
Keywords: plant trans-factor; cis-active sequence; post-translational modification; dimerization and oligomerization; DNA modules
(This special issue belongs to the Section Molecular Plant Sciences)
Peripheral Neuropathies: Molecular Research and Novel Therapy—2nd Edition
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 7018 | Submission Open
Keywords: axonal degeneration; demyelination; schwann cells; dorsal root ganglia; diabetic neuropathy; chemotherapy-induced peripheral neuropathies; immune-mediated neuropathies; immune checkpoint inhibitors; charcot-marie-tooth disease; autonomic neuropathies
(This special issue belongs to the Section Molecular Neurobiology)
Molecular and Neuromuscular Mechanisms in Skeletal Muscle Aging, 2nd Edition
edited by
submission deadline 20 Feb 2026 | 5 articles | Viewed by 6806 | Submission Open
Keywords: aging; sarcopenia; neuromuscular junction; molecular muscle modifications; myokines
(This special issue belongs to the Section Molecular Biology)
Food-Derived Bioactive Peptides submission deadline 20 Feb 2026 | 3 articles | Viewed by 6774 | Submission Open
Keywords: peptides identification; peptides characterization; functional foods; biological activity; peptidomics; proteomics
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Hearing Loss: Recent Progress in Molecular Genomics
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 6759 | Submission Open
Keywords: hearing loss; high-throughput sequencing; prognostic analyses; translational medicine; gene therapy
(This special issue belongs to the Section Molecular Genetics and Genomics)
Exploring Novel Molecular, Metabolic and Cellular Mechanisms for Developing New Therapeutic Targets Against Childhood Cancers, 2nd Edition submission deadline 20 Feb 2026 | 3 articles | Viewed by 6733 | Submission Open
Keywords: childhood cancers; rhabdomyosarcoma; leukemias; lymphomas; central nervous system tumors; sarcomas of bone and soft tissue; neuroblastoma; retinoblastoma; rhabdoid tumors; rare cancers; genomic alterations; molecular drivers; tissue microenvironment; development of drugs; therapies
(This special issue belongs to the Section Molecular Oncology)
Advancements in Hematology: Molecular Biology and Targeted Therapies
edited by Fabio Stagno and
submission deadline 20 Feb 2026 | 5 articles | Viewed by 6630 | Submission Open
Keywords: hematological disorders; leukemia; lymphoma; anemia; blood malignancies; targeted therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Insights into Plant and Insect Interactions (Second Edition)
edited by and Xiaoling Sun
submission deadline 20 Feb 2026 | 5 articles | Viewed by 6572 | Submission Open
Keywords: plant defense responses; elicitors; effectors; defense-related signaling; insect– plant interactions; tritrophic interactions; detoxification; defensive compounds; defensive genes
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Research of Gut Microbiota in Human Health and Diseases submission deadline 20 Feb 2026 | 3 articles | Viewed by 6506 | Submission Open
Keywords: gut microbiota; gut metabolites; gastroenterology; microbiology; inflammation; human diseases
(This special issue belongs to the Section Molecular Microbiology)
Molecular Research of Cancer Metabolism and Biomarkers
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 6408 | Submission Open
Keywords: metabolic reprogramming; tumor microenvironment (TME); resistance; metabolic modulator; multidisciplinary omics approach; cancer metabolism; biomarkers; cancer stem cells
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Feature Papers in ‘Physical Chemistry and Chemical Physics’: Fourth Edition
edited by
submission deadline 20 Feb 2026 | 8 articles | Viewed by 6392 | Submission Open
Keywords: heterogeneous structures; alignment and surface phenomena; quantum theory; mathematical physics; statistical and classical mechanics; molecular structure; chemical kinetics; laser physics; dynamics; kinetics; photochemistry; spectroscopy; exciton dynamics; statistical mechanics; thermodynamics; electrochemistry; catalysis; surface science; quantum mechanics; theoretical developments; fundamental aspects of catalysis; solar energy conversion; polymer dynamics
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Gut Microbiota and Nutrition in Human Health (2nd Edition)
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 6383 | Submission Open
Keywords: microbiome; gut; brain; obesity; diabetes; inflammation; liver; nutrition; probiotic; prebiotic
(This special issue belongs to the Section Molecular Microbiology)
Molecular Pathology and Treatment of Spinal Cord Injury
edited by James Hong
submission deadline 20 Feb 2026 | 1 articles | Viewed by 6312 | Submission Open
Keywords: spinal cord injury; neuroinflammation; gene targets; neural regeneration; synaptic plasticity; molecular pathways; biomarkers; oxidative stress; apoptosis; translational research
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Circulating Non-Coding RNAs as Diagnostic and Prognostic Markers of Human Diseases: 3rd Edition submission deadline 20 Feb 2026 | 7 articles | Viewed by 6203 | Submission Open
Keywords: miRNA; gene expression regulation; diagnosis; prognosis; therapy; biomarkers
(This special issue belongs to the Section Biochemistry)
Advanced Research on Enzymes in Biocatalysis submission deadline 20 Feb 2026 | 7 articles | Viewed by 6053 | Submission Open
Keywords: biocatalysis; bioprocess; enzyme immobilization; enzyme production; response surface methodology (RSM); enzymatic-assisted extraction; enzymatic-catalyzed synthesis; enzyme modelling; bioreactor; bioconversion; cascade biocatalysis; enzymatic kinetic; enzyme engineering; ultrasound-assisted enzymatic reaction; directed evolution; machine learning-assisted enzyme engineering; waste-to-value bioprocesses
(This special issue belongs to the Section Biochemistry)
The Interplay Between Cellular Stress and Human Diseases
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 6013 | Submission Open
Keywords: cellular stress; DNA damage response; unfolded protein response; autophagy; senescence; apoptosis; repair pathways; mitochondrial stress; nutrient deprivation; oxidative stress
(This special issue belongs to the Section Biochemistry)
Recent Advances in Urological Cancer
edited by Andrea Zivi and Sara Merler
submission deadline 20 Feb 2026 | 1 articles | Viewed by 5858 | Submission Open
Keywords: genitourinary oncology; urologic surgery; urologic radiotherapy innovations; translational research; emerging therapies
(This special issue belongs to the Section Molecular Oncology)
Biosynthesis of Phytochemicals and Their Applications in Novel Drug Lead Development
edited by
submission deadline 20 Feb 2026 | 4 articles | Viewed by 5745 | Submission Open
Keywords: biosynthesis of phytochemicals in plants; phytochemical isolation; phytochemical structure; animal and human protein targets of phytochemicals; chemical derivatives of phytochemicals
(This special issue belongs to the Section Molecular Pharmacology)
Artificial Intelligence and Computer-Aided Design: Molecular Simulation Technology in Exploring Bioactive Compounds for Health Promotion
edited by
submission deadline 20 Feb 2026 | 4 articles | Viewed by 5691 | Submission Open
Keywords: molecular simulation; bioactive compounds; molecular docking; molecular dynamics; quantum mechanics; functional mechanisms
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanisms and Treatment Strategies of Myocardial Infarction
edited by Abdul-Majeed Salmasi
submission deadline 20 Feb 2026 | 2 articles | Viewed by 5669 | Submission Open
Keywords: myocardial infarction; genetics; molecular biology; chromosomes; genes; atherosclerosis; coronary artery disease; risk factors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advancing Climate Resilience in Horticultural Crops Through Omics Technologies
edited by and
submission deadline 20 Feb 2026 | 4 articles | Viewed by 5601 | Submission Open
Keywords: horticultural crops; climate change; omics technologies; stress responses; abiotic stresses; food security; agricultural sustainability; genomics; transcriptomic; proteomics
(This special issue belongs to the Section Molecular Plant Sciences)
Exploring the Molecular, Physiological, and Biochemical Responses of Crops to Stress
edited by
submission deadline 20 Feb 2026 | 4 articles | Viewed by 5581 | Submission Open
Keywords: molecular signaling pathways in response to biotic stresses (e.g.; bacteria; viruses; fungi; and insects); plant responses to abiotic stresses (e.g.; salinity; cold; drought; waterlogging; heat; heavy metals; and UV light); mechanisms of stress adaptation and tolerance; stress adaptation
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Diagnosis in Cardiovascular Diseases
edited by Calogera Pisano, and Giuseppe Raffa
submission deadline 20 Feb 2026 | 4 articles | Viewed by 5571 | Submission Open
Keywords: cardiac diseases; molecular diagnosis; aortopathy; aneurysm; dissection; heart failure
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research Progress of Cereal Crop Disease Resistance
edited by and Zhenqi Su
submission deadline 20 Feb 2026 | 3 articles | Viewed by 5488 | Submission Open
Keywords: cereal crops; disease resistance; resistance genes; breeding; molecular marker-assisted selection; molecular regulatory network
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Research on Type 1 Diabetes and Its Complications: 2nd Edition submission deadline 20 Feb 2026 | 5 articles | Viewed by 5464 | Submission Open
Keywords: type 1 diabetes mellitus; diabetic microangiopathy; diabetic macroangiopathy; continuous glucose monitoring; experimental diabetic models; biomarkers; endothelium dysfunction; diabetes-related diseases; comorbidities; pregnancy; pathophysiology; metabolic syndrome; treatment; precision medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Autoimmunity in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder
edited by Yang Mao-Draayer
submission deadline 20 Feb 2026 | 1 articles | Viewed by 5345 | Submission Open
Keywords: multiple sclerosis (MS); neuromyelitis optica spectrum disorder (NMOSD); myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD); immunomodulatory; neuroprotection; neuroregeneration; biomarker; imaging
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Research in Asthma and Allergy submission deadline 20 Feb 2026 | 3 articles | Viewed by 5258 | Submission Open
Keywords: asthma; allergy; molecular mechanisms; exposome; treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Sperm Oxidative Stress and Male Infertility
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 5214 | Submission Open
Keywords: oxidative stress; antioxidant system; free radical scavengers; sperm DNA oxidation; sperm DNA fragmentatio; antioxidant therapy; male infertility; male oxidative stress infertility
(This special issue belongs to the Section Molecular Biology)
Molecular Pharmacology of Medicinal Plants
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 5209 | Submission Open
Keywords: medicinal plants; drug development; molecular pharmacology; clinical phytopharmacology
(This special issue belongs to the Section Molecular Pharmacology)
Non-Coding RNA in Physiology and Pathophysiology: Second Edition
edited by Maria Rosaria Tumolo
submission deadline 20 Feb 2026 | 3 articles | Viewed by 5190 | Submission Open
Keywords: microRNA; long non-coding RNA; circular RNA; epigenetics; musculoskeletal pain; cardiovascular disease; metabolic disease; nervous system disorders; cancer; aging
(This special issue belongs to the Section Molecular Biology)
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