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Genes publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Basis in Rare Genetic Disorders

edited by

Miao Sun

submission deadline 10 Mar 2026 | Viewed by 235 | Submission Open

Keywords: nucleotide and mitochondrial DNA; RNA modification; epigenetics; gene expression; rare disease and inheritance; clinical pathology; disease mechanism; bioinformatics and tools; functional studies; treatment and therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic Insights into Immunity and Pathogen Resistance

edited by

Fabiana Neves

and Tereza Almeida

submission deadline 10 Mar 2026 | Viewed by 181 | Submission Open

Keywords: immunogenetics; host– pathogen coevolution; genetic variation; functional genomics; comparative immunology; CRISPR; pathogen resistance; evolutionary immunology; epigenetics; genome-wide association studies (GWASs)

(This special issue belongs to the Section Molecular Genetics and Genomics)

Precision Genome Engineering in Plants

edited by

Weibin Song

and Zhiyong Zhang

submission deadline 10 Mar 2026 | Viewed by 57 | Submission Open

Keywords: CRISPR-Cas9; genome editing; base editing; prime editing; crop improvement; gene targeting; synthetic biology; plant biotechnology; off-target effects; sustainable agriculture

(This special issue belongs to the Section Plant Genetics and Genomics)

Physiological and Molecular Mechanisms of Plant Stress Response

edited by

Yakupjan Haxim

submission deadline 15 Mar 2026 | 2 articles | Viewed by 1750 | Submission Open

Keywords: drought stress; heat stress; cold stress; salinity stress; pathogen infection; multi-omic approaches; gene expression; plant resistance

(This special issue belongs to the Section Plant Genetics and Genomics)

Epigenetic Regulation in Tumors

edited by

Anca Botezatu

submission deadline 15 Mar 2026 | Viewed by 1036 | Submission Open

Keywords: cancer epigenetics; epigenetic mechanisms; tumor microenvironment; epigenetic biomarkers; multi-omics and bioinformatics

(This special issue belongs to the Section Epigenomics)

Harnessing Multi-Omics Approaches to Unravel Plant–Microbe Interactions in Cultivated Plants: Implications for Climate Resilience and Sustainable Agriculture

edited by Samathmika Ravi,

Maria Cristina Della Lucia

and

Piergiorgio Stevanato

submission deadline 15 Mar 2026 | Viewed by 292 | Submission Open

Keywords: multi-omics; plant– microbe interactions; climate resilience; agricultural sustainability; microbial dynamics

(This special issue belongs to the Section Plant Genetics and Genomics)

Unveiling Human Microbiome Composition and Functions to Improve Health and Disease Research

edited by

Valeria D’Argenio

submission deadline 15 Mar 2026 | Viewed by 274 | Submission Open

Keywords: human microbiome; health and disease; precision medicine; host– microbe interactions; translational research; metagenomics; multi-omics approaches

(This special issue belongs to the Section Microbial Genetics and Genomics)

Genetics of Host–Pathogen Interactions

edited by

Transito Garcia-Garcia

and Sara Zaldívar López

submission deadline 15 Mar 2026 | Viewed by 212 | Submission Open

Keywords: pathogen virulence factors; infection susceptibility; immune evasion; genomics of infectious diseases; host– pathogen co-evolution; host– pathogen dynamics; microbiome– host interactions; emerging infectious diseases; crispr and gene editing in host– pathogen studies; transcriptomics and gene expression profiling

(This special issue belongs to the Section Molecular Genetics and Genomics)

Epigenetic Dynamics in Cancer and Aging

edited by

Hayan Lee

submission deadline 15 Mar 2026 | Viewed by 174 | Submission Open

Keywords: DNA methylation; histone modification; chromatin 3D modeling; non-coding RNA; long-read sequencing technology; single-cell epigenetics; cancer initiation and development; epigenetic alterations in the aging process; aging-specific epigenetic alterations; cancer-specific epigenetic alterations

(This special issue belongs to the Section Epigenomics)

Genetic Markers in Targeted Therapies: From Biomarker Discovery to Personalized Therapy

edited by

Maciej Wnuk

submission deadline 15 Mar 2026 | Viewed by 148 | Submission Open

Keywords: cancer diagnosis; molecular; cytogenetic biomarkers; genomic instability; cellular senescence; human disease; clinical applications; personalized therapy; theranostics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Epigenetic Landscape of Neurodevelopmental Disorders

edited by Bimal Jana

submission deadline 15 Mar 2026 | Viewed by 60 | Submission Open

Keywords: epigenetics; neurodevelopmental disorders (NDDs); DNA methylation; 3D genome architecture; histone modifications; non-coding RNA; autism spectrum disorder (ASD); Rett syndrome; neurodevelopment; gene-environment interaction; epigenetic biomarkers; single-cell epigenomics; epigenetic therapy

(This special issue belongs to the Section Neurogenomics)

Cancer Epigenetics: From Laboratory Studies and Clinical Trials to Precision Medicine

edited by Rajendra Pangeni

submission deadline 15 Mar 2026 | Viewed by 58 | Submission Open

Keywords: cancer; epigenetics; laboratory studies; tumor biology; precision medicine; clinical trials; therapy resistance; biomarkers; personalized care; therapeutic interventions

(This special issue belongs to the Section Epigenomics)

Forensic DNA Profiling: PCR Techniques and Innovations

edited by

António Amorim

and

Laura Mendes Cainé

submission deadline 16 Mar 2026 | Viewed by 280 | Submission Open

Keywords: forensic DNA profiling; PCR-based forensics; DNA analysis; next-generation sequencing; short tandem repeat (STR); Y-STR; single-nucleotide polymorphisms (SNPs); Y-SNP

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

RNA Biology and Diseases

edited by Sharon Moshitch-Moshkovitz

submission deadline 20 Mar 2026 | 1 articles | Viewed by 395 | Submission Open

Keywords: mechanisms of RNA processing; RNA modification and epitranscriptomics; regulatory RNAs; RNA-based therapy (ASOs; targeted modifications); RNA– protein interactions; non-coding RNAs and diseases; post-translational modifications in shaping the epitranscriptome; RNA structures and restructuring mechanisms

(This special issue belongs to the Section RNA)

Genetic Diagnosis and Genomics of Neurological Diseases

edited by

Avi Fellner

and Penina Ponger

submission deadline 20 Mar 2026 | Viewed by 316 | Submission Open

Keywords: neurogenetics; hereditary neurological diseases; genetic diagnosis; genotype– phenotype correlation; next-generation sequencing; precision neurology; clinical genomics; diagnostic yield; genomic technologies; data-driven approaches

(This special issue belongs to the Section Genetic Diagnosis)

The Regulation of mRNA Translation in Health and Disease

edited by Jun Ling

submission deadline 20 Mar 2026 | Viewed by 304 | Submission Open

Keywords: mRNA translation; mRNA biology; transcriptional regulation; cell signaling; cancer therapies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic Mouse Models of Human Disease

edited by Jiale Wang

submission deadline 20 Mar 2026 | Viewed by 268 | Submission Open

Keywords: mouse models; human disease; genetic disorders; genome editing; CRISPR; inflammation; cancer biology; disease mechanisms; preclinical models; translational research

(This special issue belongs to the Section Molecular Genetics and Genomics)

The Role of Non-Coding RNA in Cancer

edited by Amil M. Shah

submission deadline 20 Mar 2026 | Viewed by 179 | Submission Open

Keywords: non-coding RNA (ncRNA); ncRNA classification; ncRNA biogenesis; ncRNA functions; diagnostic and prognostic biomarkers; targeted therapy; nucleic acid-based therapy; cell regulatory networks; cancer attractor states; computational network models; omics technology (single-cell RNA-seq; spatial transcriptomics; and single-cell multi-omics)

(This special issue belongs to the Section RNA)

Canine Genomics and Disease Research

edited by

Jeffrey Kidd

submission deadline 20 Mar 2026 | Viewed by 140 | Submission Open

Keywords: canine genetics; trait mapping; genome structure and function; population genetics; association studies; canine evolution; canine disease

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetics and Reproduction in Pigs

edited by Rui Cai

submission deadline 20 Mar 2026 | Viewed by 119 | Submission Open

Keywords: pig; spermatogenesis; semen preservation; reproductive technology; genomic selection

(This special issue belongs to the Section Animal Genetics and Genomics)

Machine Learning in Cancer and Disease Genomics

edited by

Piero Fariselli

and Giovanni Birolo

submission deadline 25 Mar 2026 | 5 articles | Viewed by 13627 | Submission Open

Keywords: machine learning; cancer genomics; disease genomics; bioinformatics; genomic data analysis; biomarker discovery; multi-omics integration; personalized medicine; computational biology

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics and Epigenetics of Cellular Differentiation

edited by

Theodora Sideri

submission deadline 25 Mar 2026 | Viewed by 649 | Submission Open

Keywords: stem cells; differentiation; gene expression; genetics; histone modifications; DNA methylation

(This special issue belongs to the Section Epigenomics)

Genetics and Genomics of Insects

edited by Hui Ai

submission deadline 25 Mar 2026 | 2 articles | Viewed by 614 | Submission Open

Keywords: insect molecular biology; genomics; molecular systematics; transcriptomics; genetic; genomic; pest management strategies; gene function; insect chemical ecology

(This special issue belongs to the Section Animal Genetics and Genomics)

Utilizing Multi-Omics to Investigate Neurodegenerative Disorders

edited by Muhammad Ali

submission deadline 25 Mar 2026 | Viewed by 379 | Submission Open

Keywords: neurodegeneration; central nervous system; diagnosis; prognosis; biomarkers; predictive modeling; brain; cerebrospinal fluid; plasma; multi-omics

(This special issue belongs to the Section Neurogenomics)

Mitochondrial Genetics: Progress and Challenges

edited by

Konstantin Khrapko

submission deadline 25 Mar 2026 | Viewed by 338 | Submission Open

Keywords: Mitochondria; ; mtDNA; ; mutation; ; selection; ; germline; ; mitchondrial disease; ; inheritance; ; population; ; evolution; ; NUMT

(This special issue belongs to the Section Molecular Genetics and Genomics)

Livestock Germplasm Resources, Genetics, and Breeding

edited by

Enrico D’ Alessandro

and Marco Tolone

submission deadline 25 Mar 2026 | Viewed by 290 | Submission Open

Keywords: animal genetics; genomics; animal production; metagenomics; genome-wide association study (GWAS); product quality; fertility; health; coat color; molecular traceability; biodiversity

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetic Mechanisms of Obesity

edited by

Thangiah Geetha

submission deadline 25 Mar 2026 | Viewed by 147 | Submission Open

Keywords: obesity; genetic mechanisms; epigenetics; DNA methylation; genome-wide association studies; multi-omics; transcriptomics; foundtional genomics; gene– environment interactions; childhood obesity; energy metabolism; precision medicine; gut microbiota

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Aspects of Autoimmune Diseases

edited by Cheuk Wun Li

submission deadline 25 Mar 2026 | Viewed by 91 | Submission Open

Keywords: autoimmune diseases; genetics; genetic variants; polygenic; therapies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Reviews in Aquaculture Genetics: Insights and Advances

edited by

Antonio Figueras

Beatriz Novoa

, Magali Rey-Campos and

Amaro Saco

submission deadline 25 Mar 2026 | Viewed by 75 | Submission Open

Keywords: aquaculture genetics; fish genomics; shellfish breeding; quantitative trait loci; marker-assisted selection; genomic selection; transcriptomics; epigenomics; disease resistance; growth traits; aquatic species; genome assembly; population genomics; selective breeding; sustainable aquaculture

(This special issue belongs to the Section Animal Genetics and Genomics)

Chromatin Modifications and RNA-Based Regulation of Gene Expression

edited by Alonso Javier Pardal

submission deadline 25 Mar 2026 | Viewed by 51 | Submission Open

Keywords: chromatin modifications; RNA; gene expression; transcription; chromatin boundaries; RNA-binding proteins

(This special issue belongs to the Section Molecular Genetics and Genomics)

The Genetic Lens: A New Era in Ophthalmology

edited by

Stefania Zampatti

and

Emiliano Giardina

submission deadline 25 Mar 2026 | Viewed by 48 | Submission Open

Keywords: ophthalmology; genomics; artificial intelligence; inherited retinal disease; blindness

(This special issue belongs to the Section Genetic Diagnosis)

Genetics and Genomics of Aging and Longevity, Pathways and Response to Nutrients in Mammals and Simple Model Organisms

edited by

Mario G. Mirisola

submission deadline 30 Mar 2026 | Viewed by 191 | Submission Open

Keywords: nutrigenetics; nutrigenomics; signal transduction

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Application of CRISPR/Cas9 Technology in Insects

edited by

Sanyuan Ma

submission deadline 31 Mar 2026 | Viewed by 129 | Submission Open

Keywords: genome editing; gene targeting; CRISPR/Cas9; insect genetics; pest control; disease vector control; gene drive; off-target effects; delivery systems; ecological impact; transgenic insects; functional genomics

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetics of Neuropsychiatric Disorders

edited by Melloni Cook and Kristin Hamre

submission deadline 5 Apr 2026 | 6 articles | Viewed by 6524 | Submission Open

Keywords: major depressive disorder; schizophrenia; post-traumatic stress disorder; addiction; alcohol; drugs; anxiety disorder; stress-related disorders; genes; epigenetics; mRNA; optogenetics; miRNA; causal variant

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genes and Gene Therapies in Chronic Renal Disease

edited by Thomas Kitzler

submission deadline 5 Apr 2026 | 3 articles | Viewed by 4012 | Submission Open

Keywords: chronic renal disease; personalized medicine; exome and genome sequencing; nephrogenetics; genetic kidney disease; small molecules; mRNA therapies; gene editing; gene delivery

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic and Epigenetic Factors for Autoimmune Diseases

edited by

Ulises De La Cruz-Mosso

submission deadline 5 Apr 2026 | 1 articles | Viewed by 1164 | Submission Open

Keywords: single nucleotide variants; polymorphism; mutations; microRNAs; HLA genes; cytokine gene; DNA methylation; rheumatoid arthritis; systemic lupus erythematosus; exposome

(This special issue belongs to the Section Epigenomics)

Conservation Genetics of Birds

edited by Robert Rutkowski

submission deadline 6 Apr 2026 | Viewed by 133 | Submission Open

Keywords: conservation genetics; birds; aves; endangered species; molecular markers; genetic diversity; genetic distance; isolated populations; non-invasive sampling; genetic monitoring; reintroduction; inbreeding; outbreeding; evolutionary significant units; management unit

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetic Status and Perspectives of Fisheries Resources

edited by Wei Wang

submission deadline 10 Apr 2026 | 1 articles | Viewed by 446 | Submission Open

Keywords: population genetics; aquaculture breeding and biotechnology; fisheries resource conservation and sustainable utilization; fisheries resource management; genetic technology and methods; climate change and genetic responses

(This special issue belongs to the Section Animal Genetics and Genomics)

Coordinating Regulation of Gene Expression in Cardiovascular Disease

edited by

Nirmal Parajuli

submission deadline 10 Apr 2026 | Viewed by 228 | Submission Open

Keywords: microRNA; oxidative stress; cardiovascular disease; chronic obstructive pulmonary disease (COPD); pulmonary hypertension; gene regulation; inflammation; reactive oxygen species (ROS); molecular biomarkers; precision medicine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Insights and Molecular Pathways in Alzheimer's Disease: Unveiling the Complexity of Neurodegeneration

edited by Marta Rusek and

Alessandro Romano

submission deadline 10 Apr 2026 | Viewed by 126 | Submission Open

Keywords: Alzheimer’ s disease; neurodegeneration; amyloid-β pathology; tau pathology; APOE ε 4; APP; PSEN1; PSEN2; GWAS; neuroinflammation; mitochondrial dysfunction; oxidative stress; proteostasis; precision medicine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics in Canines: From Evolution to Conservation

edited by

Marco Galaverni

and

Romolo Caniglia

submission deadline 15 Apr 2026 | 3 articles | Viewed by 10769 | Submission Open

Keywords: Canis lupus; genetics; genomics; conservation; evolution; adaptation; hybridization

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetic and Genomic Advances in Livestock

edited by Karel Vališ

submission deadline 15 Apr 2026 | Viewed by 303 | Submission Open

Keywords: NGS; SNP calling; bioinformatic tools; livestock phenotype; livestock welfare

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetics in Thyroid Cancer

edited by

Tatjana Bogovic Crncic

and Tomislav Jukić

submission deadline 15 Apr 2026 | Viewed by 200 | Submission Open

Keywords: genetic mutations; thyroid cancer; molecular diagnostics; risk stratification; novel therapies; MAPK/PI3K-AKT signalling; radioiodine-refractory; redifferentiation therapeutic strategies; tumour genomic profiling; targeted therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genes, Genomes, and Systems Biology in Agriculture

edited by Nick Hudson and

Pâmela A. Alexandre

submission deadline 15 Apr 2026 | Viewed by 187 | Submission Open

Keywords: systems biology; modelling; omics technologies; big data; machine learning; genetics; genomics; transcriptomics; microbiome; metabolomics

(This special issue belongs to the Section Technologies and Resources for Genetics)

Non-Coding RNAs in Osteoarthritis: From Epigenetic Regulation to Therapeutic Targets

edited by Ioanna Papathanasiou

submission deadline 15 Apr 2026 | Viewed by 148 | Submission Open

Keywords: osteoarthritis; microRNAs; long non-coding RNAs; circular RNAs; biomarkers; therapeutic strategies

(This special issue belongs to the Section RNA)

From Genes to Systems: Genetic and Epigenetic Control of the Metastatic Cascade

edited by Eric Rahrmann

submission deadline 15 Apr 2026 | Viewed by 123 | Submission Open

Keywords: cancer metastasis; genetic alterations; epigenetic reprogramming; tumor heterogeneity; lineage plasticity; metastatic niche formation; dormancy; circulating tumor cells (CTCs); immune evasion; therapy resistance; tumor microenvironment

(This special issue belongs to the Section Epigenomics)

Genetic and Genomic Analysis of Inflammatory Bowel Disease

edited by Mario Gorenjak and

Gregor Jezernik

submission deadline 15 Apr 2026 | Viewed by 30 | Submission Open

Keywords: inflammatory bowel disease; crohn’ s disease; ulcerative colitis; genomics; transcriptomics; biologicals; small-molecule drugs

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances in Human Reproductive and Prenatal Genetics

edited by Edith Said

submission deadline 15 Apr 2026 | Viewed by 10 | Submission Open

Keywords: reproductive genetics; female infertility; male infertility; recurrent pregnancy loss; preconception genetic testing; pre-implantation genetic testing; prenatal genetics; non-invasive prenatal testing; molecular genetics; cytogenetics; molecular cytogenetics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advances in Forensic Genetics and DNA

edited by

Maria Saiz

submission deadline 20 Apr 2026 | 4 articles | Viewed by 2649 | Submission Open

Keywords: human identification; crime scene investigation; next generation sequencing; forensic investigative genetic genealogy; lineage markers; DNA methylation; disaster victim identification

(This special issue belongs to the Section Molecular Genetics and Genomics)

Pharmacogenomics and Pharmacoepigenomics in Autoimmune Diseases: How Close We Are to Personalised Medicine

edited by