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Genes publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cancer Driver Mutations and Tumor Evolution

edited by Yusi Fu

submission deadline 10 Oct 2026 | Viewed by 121 | Submission Open

Keywords: driver mutations; tumor evolution; clonal dynamics; intratumor heterogeneity; somatic mosaicism; single-cell genomics; mutational signatures; clonal hematopoiesis; tumor microenvironment

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic and Morphological Diversity in Plants

edited by

P. Roxanne Kellar

submission deadline 15 Oct 2026 | 6 articles | Viewed by 6068 | Submission Open

Keywords: biodiversity; conservation; genetic structure; genetics; genotype; germplasm; haplotype; high-throughput sequencing; invasive species; microsatellites; molecular markers; morphological characters; morphology; morphometrics; morphotype; next-generation sequencing; phenotype; systematics; taxonomy; variation

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetic and Epigenetic Factors for Autoimmune Diseases

edited by

Ulises De La Cruz-Mosso

submission deadline 15 Oct 2026 | 2 articles | Viewed by 3852 | Submission Open

Keywords: single nucleotide variants; polymorphism; mutations; microRNAs; HLA genes; cytokine gene; DNA methylation; rheumatoid arthritis; systemic lupus erythematosus; exposome

(This special issue belongs to the Section Epigenomics)

Diagnosis, Management and Therapy of Rare Diseases

edited by Giorgia Girotto

submission deadline 15 Oct 2026 | 5 articles | Viewed by 2935 | Submission Open

Keywords: rare and ultrarare genetic diseases; genetic mechanisms; gene-tailored management; personalized therapeutic approaches

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

The Function and Molecular Mechanism for Immune Responses in Human Diseases

edited by Zsofia Banlaki

submission deadline 15 Oct 2026 | 3 articles | Viewed by 1956 | Submission Open

Keywords: leukocyte; cytokine; immune receptor; signal transduction; gene expression; antibody-antigen; major histocompatibility complex; complement system; inflammation

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advances in Human Reproductive and Prenatal Genetics

edited by Edith Said

submission deadline 15 Oct 2026 | 1 articles | Viewed by 1867 | Submission Open

Keywords: reproductive genetics; female infertility; male infertility; recurrent pregnancy loss; preconception genetic testing; pre-implantation genetic testing; prenatal genetics; non-invasive prenatal testing; molecular genetics; cytogenetics; molecular cytogenetics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Aquatic Germplasm Resources and Genetic Breeding

edited by Wei Song

submission deadline 15 Oct 2026 | 1 articles | Viewed by 781 | Submission Open

Keywords: fish; shrimp; shellfish; algae; geographical population; morphological difference; cytochrome oxidase subunit I (COI); microsatellites; genetic structure; genetic diversity; gene cloning; cellular localization; RNAi; gene overexpression

(This special issue belongs to the Section Animal Genetics and Genomics)

Chromatin Modifications and RNA-Based Regulation of Gene Expression

edited by Alonso Javier Pardal

submission deadline 15 Oct 2026 | 1 articles | Viewed by 678 | Submission Open

Keywords: chromatin modifications; RNA; gene expression; transcription; chromatin boundaries; RNA-binding proteins

(This special issue belongs to the Section Molecular Genetics and Genomics)

The Spatial Organisation of Chromosomes and Genes

edited by Yu Liu and Lingluo Chu

submission deadline 15 Oct 2026 | Viewed by 492 | Submission Open

Keywords: 3D genome; cohesin; CTCF; TAD; compartment; loop extrusion; gene regulation; enhancer– promoter interactions

(This special issue belongs to the Section Molecular Genetics and Genomics)

From Genes to Systems: Genetic and Epigenetic Control of the Metastatic Cascade

edited by

Eric Rahrmann

submission deadline 15 Oct 2026 | Viewed by 361 | Submission Open

Keywords: cancer metastasis; genetic alterations; epigenetic reprogramming; tumor heterogeneity; lineage plasticity; metastatic niche formation; dormancy; circulating tumor cells (CTCs); immune evasion; therapy resistance; tumor microenvironment

(This special issue belongs to the Section Epigenomics)

Genomics for Smart and Greener Agriculture

edited by Loan Nguyen and Christie Warburton

submission deadline 15 Oct 2026 | Viewed by 295 | Submission Open

Keywords: genomics; transcriptomics; metagenomics; microbiome; gene editing

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Mechanisms and Applications of Forensic Genetics

edited by Sara C Zapico

submission deadline 15 Oct 2026 | Viewed by 243 | Submission Open

Keywords: forensic biology ; forensic genetic genealogy; next-generation sequencing (NGS); epigenetic markers/DNA methylation/non-coding RNAs; microbiome forensics; biomarker detection; DNA phenotyping; DNA degradation and preservation

(This special issue belongs to the Section Molecular Genetics and Genomics)

Gene Editing Technology for Xenotransplantation in Human Genetic Diseases

edited by Brendan J. Keating

submission deadline 15 Oct 2026 | Viewed by 190 | Submission Open

Keywords: xenotransplantation; gene editing; CRISPR/Cas; genetically modified donor animals; genome engineering; immunologic incompatibility

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Mechanisms of Inflammation and Immune Regulation in Tumors

edited by

Fuduan Peng

submission deadline 15 Oct 2026 | Viewed by 142 | Submission Open

Keywords: bioinformatics; computational biology; tumor microenvironment; single-cell RNA sequencing; spatial omics; microbiome– immune interaction; immunotherapy targets; pan-cancer; machine learning

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic and Genomic Basis of Agronomical, Quality and Functional Traits in Plants

edited by

Limin Zhang

submission deadline 15 Oct 2026 | Viewed by 138 | Submission Open

Keywords: agronomic traits; quality traits; functional genomics; quantitative trait loci (QTL); genome-wide association study (GWAS); gene editing; crop improvement; molecular breeding; transcriptomics; plant development

(This special issue belongs to the Section Plant Genetics and Genomics)

Molecular Epidemiology, Genomics and Drug Resistance Mechanisms of Pathogenic Bacteria

edited by Ming Jiang

submission deadline 15 Oct 2026 | Viewed by 136 | Submission Open

Keywords: molecular epidemiology; antimicrobial resistance; pathogenic bacteria; drug resistance mechanisms; bacterial evolution; multi-omics integration; metabolomics; antibiotic tolerance and persistence

(This special issue belongs to the Section Microbial Genetics and Genomics)

Research on Genomics and Genetics of Parasites

edited by

Kapila Gunasekera

and

Xinzhuan Su

submission deadline 15 Oct 2026 | Viewed by 111 | Submission Open

Keywords: comparative genomics; host– parasite interactions; drug resistance mechanisms; functional genomics (CRISPR-Cas9); transcriptomics and proteomics; population genetics; molecular epidemiology; vaccine target discovery; machine learning in parasitology; molecular diagnostics

(This special issue belongs to the Section Microbial Genetics and Genomics)

Unraveling the Genetic Landscape of Colorectal Cancer: The Latest Breakthroughs and Insights

edited by Nadia Saoudi Gonzalez

submission deadline 20 Oct 2026 | 3 articles | Viewed by 2146 | Submission Open

Keywords: personalized medicine; target therapy; metastatic colorectal cancer; precision oncology; biomarker discovery

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic and Molecular Mechanisms in Animal Reproduction

edited by

Xianfeng Yu

submission deadline 20 Oct 2026 | Viewed by 402 | Submission Open

Keywords: gamete; embryo; gene regulation; epigenetics; cloning; IVP; ET

(This special issue belongs to the Section Animal Genetics and Genomics)

Molecular Genetics and Breeding in Pigs

edited by

Linyuan Shen

submission deadline 20 Oct 2026 | Viewed by 173 | Submission Open

Keywords: pig genetics; molecular breeding; genotype-by-environment interaction; genomic selection; gene editing; intelligent phenotyping; sustainable livestock production

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetic Insights into Species Evolution: From Phylogeny to Adaptation

edited by Wei Zhang

submission deadline 20 Oct 2026 | Viewed by 139 | Submission Open

Keywords: phylogeny; phylogenomics; adaptive traits; population genomics; species diversity; economic species; marine biology; organellar genome; nuclear genome

(This special issue belongs to the Section Population and Evolutionary Genetics and Genomics)

Genetic Epidemiology and Gene-Environment Interactions

edited by Fen Yang

submission deadline 20 Oct 2026 | Viewed by 137 | Submission Open

Keywords: genetic epidemiology; gene– environment interaction; polygenic risk scores; exposome; genome-wide association studies; whole-genome sequencing; multi-omics integration; mendelian randomization; causal inference; population diversity; translational genetics; artificial intelligence in genomics

(This special issue belongs to the Section Genes & Environments)

3D Chromatin Architecture: From Computational Algorithms to Biological Functions

edited by

Minji Kim

submission deadline 20 Oct 2026 | Viewed by 101 | Submission Open

Keywords: 3D genomics; computational algorithm; genome organization; gene regulation; molecular mechanism; functional elements

(This special issue belongs to the Section Bioinformatics)

Genetic Diagnosis and Therapeutics of Eye Diseases

edited by

Suzana Konjevoda

and

Snježana Kaštelan

submission deadline 25 Oct 2026 | 3 articles | Viewed by 4082 | Submission Open

Keywords: genetic eye diseases; inherited retinal disorders; ophthalmic genetics; gene therapy; genetic diagnosis; retinitis pigmentosa; leber congenital amaurosis; personalised medicine; ocular therapeutics; genomic medicine; molecular diagnostics; precision ophthalmology

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Pharmacogenomics and Pharmacoepigenomics in Autoimmune Diseases: How Close We Are to Personalised Medicine

edited by

Yiannis Vasilopoulos

and

Ioannis S. Vizirianakis

submission deadline 25 Oct 2026 | 2 articles | Viewed by 1464 | Submission Open

Keywords: pharmacogenomics; pharmacoepigenomics; drug efficacy; drug toxicity; molecular pharmacology; autoimmune diseases

(This special issue belongs to the Section Pharmacogenetics)

Genetic Mechanisms of Synaptic Plasticity in Neuropsychiatric Disorders

edited by Lace Riggs

submission deadline 25 Oct 2026 | Viewed by 612 | Submission Open

Keywords: synaptic plasticity; neuropsychiatric disorders; autism spectrum disorder; schizophrenia; depression; epigenetic regulation; synaptic signaling; circuit dysfunction; gene– circuit interactions; molecular neuroscience; translational neurogenetics; epigenetics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genes, Genomes, and Systems Biology in Agriculture

edited by Nick Hudson and

Pâmela A. Alexandre

submission deadline 25 Oct 2026 | Viewed by 439 | Submission Open

Keywords: systems biology; modelling; omics technologies; big data; machine learning; genetics; genomics; transcriptomics; microbiome; metabolomics

(This special issue belongs to the Section Technologies and Resources for Genetics)

Genetic and Genomic Analysis of Inflammatory Bowel Disease

edited by Mario Gorenjak and

Gregor Jezernik

submission deadline 25 Oct 2026 | Viewed by 410 | Submission Open

Keywords: inflammatory bowel disease; crohn’ s disease; ulcerative colitis; genomics; transcriptomics; biologicals; small-molecule drugs

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic Mechanisms and Functional Insights in Microbiome Research

edited by

Tsute Chen

submission deadline 25 Oct 2026 | Viewed by 388 | Submission Open

Keywords: microbiome; marker genes; genomics; meta-genomics; meta-transcriptomics; proteomics; meta-proteomics; metabolomics; functional microbiome; microbiome-host interaction; microbiome-environment interaction; genetic mechanism

(This special issue belongs to the Section Microbial Genetics and Genomics)

Recent Progress in Forensic Genetics and Molecular Identification

edited by

Maria Saiz

submission deadline 25 Oct 2026 | Viewed by 217 | Submission Open

Keywords: forensic genetics; molecular identification; next generation sequencing; trace DNA analysis; challenging samples

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic and Genomic Insights in Kidney Diseases: Mechanisms, Diagnosis and Therapeutics

edited by Maria Amicone and

Ersilia Nigro

submission deadline 25 Oct 2026 | Viewed by 203 | Submission Open

Keywords: cystic kidney disease; ADPKD; kidney stones; nephronophtisis; ADTKD; cystinuria; primary hyperoxaluria; NGS; MLPA; CGH array

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Tropical Plant Genetics and Breeding

edited by Jiaming Zhang

submission deadline 25 Oct 2026 | Viewed by 146 | Submission Open

Keywords: tropical crops; genomic selection; abiotic stress tolerance; disease resistance; CRISPR/Cas9; genome-wide association study (GWAS); molecular markers

(This special issue belongs to the Section Plant Genetics and Genomics)

Plant Stress Tolerance: Genetic and Genomic Mechanisms and Expression Regulation

edited by Chao Ma

submission deadline 25 Oct 2026 | Viewed by 111 | Submission Open

Keywords: plant stress tolerance; gene expression regulation; epigenetics; functional genomics; non-coding RNA; abiotic and biotic stress; multi-omics integration; transcriptional regulation; signal transduction; secondary metabolism

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetic Diagnosis and Treatment of Rare Diseases

edited by

Miao Sun

submission deadline 25 Oct 2026 | Viewed by 80 | Submission Open

Keywords: rare genetic diseases; clinical genomics; next-generation sequencing (NGS); exome and whole-genome sequencing; mitochondrial DNA (mtDNA) disorders; epigenetics and DNA methylation; RNA modification and transcriptomics; gene expression profiling; genotype– phenotype correlation; disease mechanisms; functional genomics; bioinformatics and variant interpretation; molecular diagnosis; precision medicine; gene- and RNA-based therapies

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Insights into Diseases Related to Mitochondrial Dysfunction: From Diagnosis to Treatment

edited by Luigi Citrigno and Annamaria Cerantonio

submission deadline 5 Nov 2026 | Viewed by 482 | Submission Open

Keywords: mitochondrial dysfunction; mtDNA mutations; genetic diagnosis; next-generation sequencing; neurodegeneration; metabolic disorders; mitochondrial therapeutics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genomic Landscapes and Precision Therapeutics of Central Nervous System Malignancies

edited by

Richard J. Tancredi

submission deadline 5 Nov 2026 | Viewed by 204 | Submission Open

Keywords: CNS malignancies; genomic profiling; precision therapeutics; tumor microenvironment; biomarker discovery

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Emerging Insights in Single-Cell and Spatial Omics for Disease Mechanisms

edited by

Yang Liu

submission deadline 5 Nov 2026 | Viewed by 154 | Submission Open

Keywords: single-cell omics; spatial omics; disease mechanisms; tissue microenvironment; cell– cell communication; multi-omics integration; cellular heterogeneity; systems biology; computational biology; precision medicine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics of Neuromuscular Disorders: From Gene Diagnosis to Treatment

edited by

Marie-Claude Sincennes

submission deadline 5 Nov 2026 | Viewed by 144 | Submission Open

Keywords: neuromuscular disorders; muscular dystrophy; myopathies; myogenesis; muscle physiology; genetics; gene therapy; functional genomics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advancing Crop Quality with Genomics, Genetics and Biotechnology

edited by

Xiquan Gao

and

José Á. Mercado Carmona

submission deadline 10 Nov 2026 | 2 articles | Viewed by 1000 | Submission Open

Keywords: crop quality; high throughput phenotyping; genome editing; genomic selection; nutritional quality; postharvest traits; precision breeding

(This special issue belongs to the Section Plant Genetics and Genomics)

Fetal Genetic Disorders: Prenatal Genomics for Diagnosis and Clinical Management

edited by

Katia Margiotti

submission deadline 10 Nov 2026 | Viewed by 314 | Submission Open

Keywords: prenatal diagnosis; genomic testing; NGS analysis; variant classification; pathogenic variants; precision medicine; fetal genetics; clinical utility

(This special issue belongs to the Section Genetic Diagnosis)

Human Evolution, Paleopathology, and Genetics

edited by Mauro Rubini

submission deadline 10 Nov 2026 | Viewed by 183 | Submission Open

Keywords: human evolution; paleogenomics; morphological analysis; paleopathology; (A) infectious diseases; (B) parassitosis; (C) genetic disorders; (D) neoplastic diseases; (E) nutritional deficiencies; human population

(This special issue belongs to the Section Population and Evolutionary Genetics and Genomics)

The Genetics of Prostate Cancer: From Susceptibility to Clinical Outcomes

edited by

Ludovica Pepe

submission deadline 10 Nov 2026 | Viewed by 51 | Submission Open

Keywords: prostate cancer; genetics; genomics; hereditary susceptibility; germline variants; somatic alterations; DNA damage repair; biomarkers; liquid biopsy; precision oncology

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Epigenetic Insights into Stress-Related Disorders

edited by Lei Cao

submission deadline 15 Nov 2026 | 1 articles | Viewed by 1204 | Submission Open

Keywords: stress; epigenetics; stress-related disorders; intervention; resilience

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

The Origin and Evolution of Genetic Code

edited by

Kenji Ikehara

submission deadline 15 Nov 2026 | 1 articles | Viewed by 911 | Submission Open

Keywords: origin of the genetic code; evolution of the genetic code; origin of gene; evolution of gene; origin of protein; evolution of protein; origin of life; evolution of life

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic Insights into Pediatric Neurological Disorders: From Mechanisms to Therapies

edited by Ji Yoon Han

submission deadline 15 Nov 2026 | 1 articles | Viewed by 880 | Submission Open

Keywords: pediatric neurological disorders; neurogenetics; multi-omics integration; precision medicine; brain organoid models

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Mouse Models of Human Disease

edited by Jiale Wang

submission deadline 15 Nov 2026 | Viewed by 563 | Submission Open

Keywords: mouse models; human disease; genetic disorders; genome editing; CRISPR; inflammation; cancer biology; disease mechanisms; preclinical models; translational research

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic Profiling and Molecular Analysis in Autism Spectrum Disorders

edited by John Jay Gargus

submission deadline 15 Nov 2026 | Viewed by 431 | Submission Open

Keywords: whole-exome and genome sequencing in ASD; functional genomics of high-confidence ASD risk genes; transcriptomics and splicing variants in the autistic brain; calcium signaling and ion channelopathies; chromatin and epigenetic dysregulation in ASD; mitochondrial dysfunction and oxidative stress; immune– neural signaling cross-talk; systemic extracerebral traits associated with ASD; stratification of ASD subtypes; sex-biased molecular mechanisms in ASD; integrative omics for therapeutic target discovery

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Linking Phenotypic and Molecular Evolution: Mechanisms and Models

edited by Wen Wei

submission deadline 15 Nov 2026 | Viewed by 419 | Submission Open

Keywords: genomic and phenotypic evolution; adaptive evolution; selection and genetic drift; genotype– phenotype– fitness landscape; accumulation of mutations; evolvability of complex traits; molecular evolution drivers; transcriptomic agaianst protein-coding evolution; experimental evolution

(This special issue belongs to the Section Population and Evolutionary Genetics and Genomics)

Genetic Studies of Cancer Therapy

edited by Nikos G. Gavalas

submission deadline 15 Nov 2026 | Viewed by 258 | Submission Open

Keywords: genetics; cancer; oncology; genetic variations; response; treatment; epigenetics; genomics; biomarkers; modifications

(This special issue belongs to the Section Molecular Genetics and Genomics)

Chromatin and DNA Transcription, Replication, Repair and Recombination

edited by Adam Yongxin Ye

submission deadline 15 Nov 2026 | Viewed by 245 | Submission Open

Keywords: chromatin structure; 3D genome organization; loop extrusion; DNA transcription; DNA replication; DNA repair; DNA recombination

(This special issue belongs to the Section Molecular Genetics and Genomics)

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