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Genes publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Genetic and Epigenetic Mechanisms Underlying Cancer Stem Cells and Their Implications for Novel Therapeutic Approaches

edited by

Fumihiko Kakizaki

and

Frank Buchholz

submission deadline 15 Jan 2026 | Viewed by 174 | Submission Open

Keywords: cancer stem cell; metastasis; cancer-associated gene; model organism for cancer research; therapeutics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Insights into Aortic Aneurysm Disease

edited by

John Alex Elefteriades

and Bulat A. Ziganshin

submission deadline 15 Jan 2026 | Viewed by 169 | Submission Open

Keywords: aneurysm; thoracic aortic aneurysm; abdominal aortic aneurysm; aorta; thoracic aorta; genetics; aortic syndromes; Marfan; Loeys– Dietz; Ehlers– Danlos; aortopathy; medial degeneration; aneurysm genes

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Next-Gen Omics in Animal and Microbial Science

edited by Loan To Nguyen

submission deadline 15 Jan 2026 | Viewed by 97 | Submission Open

Keywords: Oxford nanopore technologies; genomics; transcriptomics; metagenomics; microbiome

(This special issue belongs to the Section Animal Genetics and Genomics)

Molecular and Genetic Mechanisms of Floral Development

edited by Kaifeng Ma

submission deadline 16 Jan 2026 | Viewed by 70 | Submission Open

Keywords: floral induction and differentiation; flower bud formation and dormancy; floral organ; flower pattern; flower color and fragrance; blooming period; molecular and genetic mechanism

(This special issue belongs to the Section Plant Genetics and Genomics)

New Insight into the Genetic and Molecular Aspects of Yeast Nutrient Metabolism

edited by Roman Maslanka and

Renata Zadrag-Tecza

submission deadline 20 Jan 2026 | Viewed by 245 | Submission Open

Keywords: yeasts as a model organism; yeast metabolism; nutrient sensing; sugar/hexose transport; central carbon metabolism; catabolite repression; nutrient availability; resource allocation; calorie restriction; cAMP-PKA signaling; metabolic flux; metabolic adaptation; genetic and transcriptional regulation; cellular homeostasis; molecular biology of yeast

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic Studies on Cotton Stress Resistance, Quality Traits, and Drought Response Mechanisms

edited by Xueyuan Li, Juyun Zheng,

Jie Sun

and Fenglei Sun

submission deadline 20 Jan 2026 | Viewed by 237 | Submission Open

Keywords: cotton; drought stress; growth and development; gene editing; molecular marker-assisted selection

(This special issue belongs to the Section Plant Genetics and Genomics)

Reviews in Genetic Bioinformatics: Tools and Analyses

edited by

Hongyan Xu

submission deadline 20 Jan 2026 | Viewed by 210 | Submission Open

Keywords: genetics; genomics; machine learning; computational biology; big data; bioinformatics

(This special issue belongs to the Section Bioinformatics)

Cytogenetics/Cytogenomics and Functional Genomics in Human Health and Disease

edited by

Patrick R. Gonzales

submission deadline 20 Jan 2026 | Viewed by 163 | Submission Open

Keywords: functional genomics; cytogenetics; cytogenomics; microarray; optical genome mapping (OGM); Hi-C; genomic proximity mapping (GPM); intergenic; topologically associating domains (TAD); expression

(This special issue belongs to the Section Cytogenomics)

Advances in Molecular Genetics of Psychiatric Diseases

edited by Fotis Tsetsos

submission deadline 20 Jan 2026 | Viewed by 116 | Submission Open

Keywords: psychiatric genetics; molecular psychiatry; GWAS; rare variants; transcriptomics; epigenetics; gene-environment interactions; precision psychiatry; schizophrenia; bipolar disorder; depression; autism spectrum disorder; anxiety; functional genomics; neurodevelopmental disorders

(This special issue belongs to the Section Molecular Genetics and Genomics)

Application of Bioinformatics in Complex Traits

edited by

Xiang-Yang Lou

submission deadline 20 Jan 2026 | Viewed by 102 | Submission Open

Keywords: complex traits; bioinformatics; multi-omics integration; gene– environment interactions; polygenic risk scores; machine learning; systems biology; network analysis; statistical genetics; causal inference

(This special issue belongs to the Section Bioinformatics)

Molecular Genetics of Neurodevelopmental Disorders: 2nd Edition

edited by

Richard Eugene Frye

and

Richard Boles

submission deadline 25 Jan 2026 | 1 articles | Viewed by 417 | Submission Open

Keywords: neurodevelopmental disorders; attention deficit hyperactivity disorder; intellectual disabilities; autism spectrum disorder; mitochondria; neuroinflammation; epigenetics; transcriptomics; genetic syndromes; polygenetic interactions

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Testing and Clinical Management of Hereditary Cancer

edited by

Xia Wang

submission deadline 25 Jan 2026 | Viewed by 233 | Submission Open

Keywords: genetic cancer predisposition; hereditary cancer risk; polygenic risk; cancer screening; genetic testing; genomic testing; DNA sequencing; RNA sequencing; cascade genetic testing; precision medicine; germline genetic testing; tumor molecular profiling; paired analysis; hematological malignancy

(This special issue belongs to the Section Epigenomics)

Genomics and Proteomics-Based Molecular Diagnostics and Targeted Therapies in Cancer

edited by

Hilal Arnouk

submission deadline 25 Jan 2026 | Viewed by 212 | Submission Open

Keywords: molecular diagnostics; targeted therapies; biomarkers; precision medicine oncology; chemotherapy; small-molecule drugs; monoclonal antibodies; cancer immunotherapy

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Unraveling Genomic Mechanisms of Stress Tolerance and Antimicrobial Resistance in Foodborne Pathogens

edited by

Eduardo Eustáquio de Souza Figueiredo

and

Vinicius Silva Castro

submission deadline 25 Jan 2026 | Viewed by 208 | Submission Open

Keywords: foodborne pathogens; AMR; survivability; thermal resistance; in silico analysis; DNA sequencing; RNA sequencing; environmental stress condition

(This special issue belongs to the Section Microbial Genetics and Genomics)

Genetic Epidemiology of Multifactorial Diseases

edited by

Maria Tziastoudi

and Ioannis Stefanidis

submission deadline 25 Jan 2026 | Viewed by 145 | Submission Open

Keywords: genetic association studies; polygenic risk scores; functional genomics; causal inference; mendelian randomization; translational applications

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetics and Environmental Factors in Psychiatric Disorders

edited by

Sarah Tosato

submission deadline 25 Jan 2026 | Viewed by 86 | Submission Open

Keywords: PGS; environmental factors; epigenetics; prenatal environmental exposures; GWAS; GxE interactions

(This special issue belongs to the Section Genes & Environments)

5Gs in Crop Genetic and Genomic Improvement: 2025–2026

edited by

Xinjie Shen

submission deadline 25 Jan 2026 | Viewed by 80 | Submission Open

Keywords: crop gene functional analysis; crop protemics; crop metabonomics; new crop breeding methods; crop GWAS analysis; crop gene edit technology; crop gene epigenetic modification

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetics and Physiology of Multiple-Stress Tolerance in Plants

edited by Jin Wang

submission deadline 25 Jan 2026 | Viewed by 54 | Submission Open

Keywords: plant; genetics; genomics; physiology; biotic stress; abiotic stress; genetic breeding; molecular biology

(This special issue belongs to the Section Plant Genetics and Genomics)

Novel Insights into Forensic Genetics

edited by

Simone Grassi

Sarah Gino

and

Paola A. Magni

submission deadline 31 Jan 2026 | Viewed by 206 | Submission Open

Keywords: forenscic genetics; molecular autopsy; forensic omics; post-mortem genetic testing; legal medicine

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetics and Treatment in Neurodegenerative Diseases

edited by Valentino Rački and

Gaber Bergant

submission deadline 5 Feb 2026 | 3 articles | Viewed by 2424 | Submission Open

Keywords: neurodegeneration; genetics; Alzheimer’ s disease; Parkinson’ s disease; gene therapy; pharmacogenomics; precision medicine

(This special issue belongs to the Section Neurogenomics)

Molecular Genetics Reviews: Current Understanding and Future Directions

edited by

Valeria D’Argenio

and

Orazio Palumbo

submission deadline 5 Feb 2026 | Viewed by 449 | Submission Open

Keywords: molecular genetics; gene expression regulation; genome structure and function; epigenetics; mutation and DNA repair; genomic technologies; functional genomics; human genetics; multi-omics integration; future directions in genomics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetics, Diversity and Evolution of Molluscs

edited by Marianna Soroka

submission deadline 5 Feb 2026 | Viewed by 198 | Submission Open

Keywords: molluscs; genetics; DNA; genomes; Barcode DNA; DNA sequencing; DUI; diversity; evolution; native; alien and invasive species; hybridisation zones

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetics and Genomics of Pancreatitis

edited by

Jian-Min Chen

submission deadline 10 Feb 2026 | Viewed by 235 | Submission Open

Keywords: recurrent acute pancreatitis; chronic pancreatitis; gene– environment interaction; genetics; genomics; pharmacogenomics; personalized medicine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Identifying Fertility Biomarkers Using Omics Approach

edited by

Muhammet Rasit Ugur

submission deadline 10 Feb 2026 | Viewed by 176 | Submission Open

Keywords: fertility; infertility; biomarker; omics; multi-omics; genomics; transcriptomics; proteomics; metabolomics; epigenomics; lipidomic; microbiomics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Decoding the Plant Epigenome: Interactions Between Genomics, Transcription, and Epigenetic Regulation

edited by Zaifeng Li

submission deadline 10 Feb 2026 | Viewed by 49 | Submission Open

Keywords: integration of multi-omics; functional genomics; gene mining and expression; phenotype prediction; plant epigenomics

(This special issue belongs to the Section Plant Genetics and Genomics)

Molecular Breeding and Genetics of Plant Drought Resistance

edited by

Ivan Pejić

and Miroslav Bukan

submission deadline 15 Feb 2026 | 2 articles | Viewed by 1215 | Submission Open

Keywords: climate change; abiotic stress; drought assessment; plant phenotyping; drought resistance; molecular breeding; marker assisted selection

(This special issue belongs to the Section Molecular Genetics and Genomics)

Abiotic Stress in Plant: Molecular Genetics and Genomics

edited by Weicong Qi and

Hongyan Wang

submission deadline 15 Feb 2026 | 1 articles | Viewed by 961 | Submission Open

Keywords: abiotic stress; molecular genetics; genomics; plant stress response; epigenetics; crop improvement; sustainable agriculture

(This special issue belongs to the Section Plant Genetics and Genomics)

Genomics and Breeding of Wheat

edited by

Shuaifeng Geng

and Jiajia Zhao

submission deadline 15 Feb 2026 | Viewed by 409 | Submission Open

Keywords: wheat; disease resistance; gene; gene editing; genome analysis; genomic diversity; functional analysis

(This special issue belongs to the Section Plant Genetics and Genomics)

Batch Effects in High Dimensional Biological Data—Detection, Correction and Challenges

edited by

Miguel Andrade

and Maximilian Sprang

submission deadline 15 Feb 2026 | Viewed by 279 | Submission Open

Keywords: batch effects; artifacts; RNA seq; omics; quality control; single cell; bioinformatics

(This special issue belongs to the Section Technologies and Resources for Genetics)

Genetics of Pediatric Neuro-Oncology

edited by Yiran Guo

submission deadline 15 Feb 2026 | Viewed by 277 | Submission Open

Keywords: pediatric neuro-oncology; central nervous system tumors; brain tumors; genetics; transcriptomics; artificial intelligence; multi-modal datasets

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Molecular Basis and Therapeutics of Neurodegenerative Diseases

edited by

Tânia Soares Martins

submission deadline 15 Feb 2026 | Viewed by 239 | Submission Open

Keywords: Alzheimer’ s disease; Parkinson’ s disease; amyotrophic lateral sclerosis (ALS); molecular mechanisms; protein misfolding and aggregation; mitochondrial dysfunction; neuroinflammation; extracellular vesicles (EVs); gene therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Unraveling the Genetic Landscape of Colorectal Cancer: The Latest Breakthroughs and Insights

edited by Nadia Saoudi Gonzalez

submission deadline 15 Feb 2026 | Viewed by 155 | Submission Open

Keywords: personalized medicine; target therapy; metastatic colorectal cancer; precision oncology; biomarker discovery

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Insights into Diseases Related to Mitochondrial Dysfunction: From Diagnosis to Treatment

edited by Luigi Citrigno and Annamaria Cerantonio

submission deadline 16 Feb 2026 | Viewed by 168 | Submission Open

Keywords: mitochondrial dysfunction; mtDNA mutations; genetic diagnosis; next-generation sequencing; neurodegeneration; metabolic disorders; mitochondrial therapeutics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Computational Genomics and Bioinformatics of Cancer

edited by

Ilya Ioshikhes

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1655 | Submission Open

Keywords: cancer; data analysis; bioinformatics; complex diseases; dimensionality reduction; genetics; epigenetics; gene regulation; molecular mechanism; environmental factors

(This special issue belongs to the Section Bioinformatics)

Genetic and Molecular Mechanisms of Crop Resistance

edited by

Quanle Xu

submission deadline 20 Feb 2026 | Viewed by 214 | Submission Open

Keywords: abiotic and biotic stress; crop resilience; molecular mechanism; molecular breeding; resilient crops

(This special issue belongs to the Section Plant Genetics and Genomics)

Extracellular Vesicles in Genetic Diseases: Emerging Biomarkers and Clinical Applications

edited by Benedetta Niccolini and

Elisabetta Tabolacci

submission deadline 20 Feb 2026 | Viewed by 39 | Submission Open

Keywords: extracellular vesicles; inherited diseases; EV-derived microRNAs; biomarkers; genetic disorders; patient stratification; therapeutic monitoring; disease progression; intercellular communication; molecular diagnostics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

DNA Repair, Genomic Instability and Cancer

edited by

Karen M. Vasquez

submission deadline 25 Feb 2026 | 1 articles | Viewed by 868 | Submission Open

Keywords: DNA structure; DNA damage; DNA repair; genomic instability; mutagenesis

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advancing Nephrogenetics: Diagnosis, Genetic Testing, and Treatment Innovations

edited by

Katarina Vukojević

, Anita Racetin and

Nela Kelam

submission deadline 25 Feb 2026 | Viewed by 305 | Submission Open

Keywords: nephrogenetics; hereditary kidney disease; genetic testing; next-generation sequencing; renal genomics; precision nephrology; gene therapy; targeted treatment; personalized medicine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Host Genetics Shapes the Gut Microbiome: From Genes to Microbiota

edited by

Shaoqiu Chen

submission deadline 25 Feb 2026 | Viewed by 171 | Submission Open

Keywords: gut microbiome; host genetics; microbiota; multi-omics; host– microbe interaction; genetic variation; 16S rRNA sequencing; bioinformatics; personalized medicine

(This special issue belongs to the Section Microbial Genetics and Genomics)

Genetics in Headache and Neurogenic Pain

edited by Yohannes W. Woldeamanuel and Xianghong Arakaki

submission deadline 25 Feb 2026 | Viewed by 120 | Submission Open

Keywords: genetics; headache; neurogenic pain; migraine; genomics; epigenetics; polygenic risk; biomarkers; precision medicine; CRISPR; neuropathic pain; gene– environment interactions; translational research; molecular mechanisms; therapeutic targets

(This special issue belongs to the Section Neurogenomics)

Genetics of Ehlers–Danlos Syndrome and Related Connective Tissue Disorders

edited by Irman Forghani

submission deadline 25 Feb 2026 | Viewed by 112 | Submission Open

Keywords: Ehlers– Danlos syndrome; Marfan syndrome; connective tissue disorders; extracellular matrix; Loeys– Dietz syndrome; genotype– phenotype correlation; aortopathies; hypermobility syndromes

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Unraveling the Genetic Tapestry of Human Populations: New Insights from Population Genetics and Identification in Anthropology

edited by

Lovorka Barać Lauc

submission deadline 25 Feb 2026 | Viewed by 96 | Submission Open

Keywords: human genetic diversity; population genetics; migration patterns; admixture; isolated populations; ancestry reconstruction; anthropological genomics; biomedical relevance; forensic identification

(This special issue belongs to the Section Population and Evolutionary Genetics and Genomics)

Genomics and Gene Expression of the Oral Microbiome

edited by

Johan Samot

and

Mahmoud Rouabhia

submission deadline 25 Feb 2026 | Viewed by 74 | Submission Open

Keywords: oral microbiome; gene expression regulation; metagenomics; transcriptome; horizontal gene transfer; antimicrobial resistance; biofilms; bacteriophages; virulence factors

(This special issue belongs to the Section Microbial Genetics and Genomics)

Driver Genes in Prostate Carcinogenesis and Resistance to Treatment

edited by

Daotai Nie

submission deadline 25 Feb 2026 | Viewed by 55 | Submission Open

Keywords: genomic instability; driver genes; prostate cancer prevention; castration therapy; drug resistance

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic and Genomic Mechanisms of Heat Stress in Disease Modulation: From Molecular Pathways to Clinical Manifestations

edited by

Hisahide Nishio

and

Hiroyuki Awano

submission deadline 25 Feb 2026 | Viewed by 41 | Submission Open

Keywords: heatstroke; global warming; heat stress; neurodegenerative diseases; molecular pathogenesis; gene– environment interactions

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics and Breeding of Tea Tree and Tea Plant

edited by Lianyu Yuan

submission deadline 25 Feb 2026 | Viewed by 40 | Submission Open

Keywords: gene function analysis; genome analysis; biotechnological breeding; genetic diversity; breeding technology; multi-omics analysis; tea plant

(This special issue belongs to the Section Plant Genetics and Genomics)

Research on Genetics and Breeding of Cattle

edited by

Borhan Shokrollahi

submission deadline 5 Mar 2026 | 2 articles | Viewed by 1792 | Submission Open

Keywords: reproductive genetics and biotechnology; biotechnology in cattle; genomic selection; marker-assisted breeding; genetic diversity; assisted reproductive technologies; molecular genetics; fertility and reproduction; cattle breeding strategies; epigenetics

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetic Profiling and Molecular Analysis in Autism Spectrum Disorders

edited by John Jay Gargus

submission deadline 5 Mar 2026 | Viewed by 102 | Submission Open

Keywords: whole-exome and genome sequencing in ASD; functional genomics of high-confidence ASD risk genes; transcriptomics and splicing variants in the autistic brain; calcium signaling and ion channelopathies; chromatin and epigenetic dysregulation in ASD; mitochondrial dysfunction and oxidative stress; immune– neural signaling cross-talk; systemic extracerebral traits associated with ASD; stratification of ASD subtypes; sex-biased molecular mechanisms in ASD; integrative omics for therapeutic target discovery

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Insights into Immunity and Pathogen Resistance

edited by

Fabiana Neves

and Tereza Almeida

submission deadline 10 Mar 2026 | Viewed by 163 | Submission Open

Keywords: immunogenetics; host– pathogen coevolution; genetic variation; functional genomics; comparative immunology; CRISPR; pathogen resistance; evolutionary immunology; epigenetics; genome-wide association studies (GWASs)

(This special issue belongs to the Section Molecular Genetics and Genomics)

Precision Genome Engineering in Plants

edited by

Weibin Song

and Zhiyong Zhang

submission deadline 10 Mar 2026 | Viewed by 15 | Submission Open

Keywords: CRISPR-Cas9; genome editing; base editing; prime editing; crop improvement; gene targeting; synthetic biology; plant biotechnology; off-target effects; sustainable agriculture

(This special issue belongs to the Section Plant Genetics and Genomics)

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