Genetic and Epigenetic Factors for Autoimmune Diseases
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Epigenomics".
Deadline for manuscript submissions: 25 October 2025 | Viewed by 40
Special Issue Editor
Interests: immunogenetic; autoimmune diseases; systemic lupus erythematosus; rheumatoid arthritis; epigenetic; immunonutrition; personalized medicine
Special Issue Information
Dear Colleagues,
Autoimmune diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are characterized by an increased and dysregulated immune response against self-antigens, leading to cellular and tissue damage across multiple organs. Despite advances in the research, the current understanding of their etiopathogenesis remains limited. Genetic predisposition is considered a necessary but insufficient factor in the development of these conditions, accounting for only part of their onset and progression. This suggests that additional cofactors—such as epigenetic mechanisms—may play a critical role. Recent studies indicate that immune system dysregulation can be driven by non-heritable influences, involving a complex interplay of genetic and hormonal factors, immune system abnormalities, environmental exposures, and infections. While genetic susceptibility contributes to disease risk, epigenetic factors are being increasingly recognized as key players in the multifaceted development of autoimmunity. This Special Issue aims to explore the complex interplay between genetic and epigenetic factors in the development, progression, and clinical manifestation of diseases such as RA, SLE, and other autoimmune disorders. By bringing together cutting-edge original research and comprehensive reviews, this Issue seeks to provide a deeper understanding of how genetic predisposition and epigenetic modifications contribute to immune dysregulation and autoimmunity. We invite contributions that examine molecular mechanisms, identify novel genetic and epigenetic biomarkers, and highlight emerging therapeutic strategies that target the genetic and epigenetic pathways in autoimmune disorders.
Dr. Ulises De La Cruz-Mosso
Guest Editor
Manuscript Submission Information
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Keywords
- single nucleotide variants
- polymorphism
- mutations
- microRNAs
- HLA genes
- cytokine gene
- DNA methylation
- rheumatoid arthritis
- systemic lupus erythematosus
- exposome
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