Genetics in Thyroid Cancer
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 25 November 2025 | Viewed by 72
Special Issue Editors
2. Clinical Department of Nuclear Medicine, Clinical Hospital Centre Rijeka, Krešimirova 42, 51000 Rijeka, Croatia
Interests: thyroid diseases; thyroid cancer; nuclear medicine diagnostics; molecular imaging; theranostics
2. Department of Oncology and Nuclear Medicine, Sestre Milosrdnice University Hospital Centre, 10000 Zagreb, Croatia
Interests: thyroid diseases; thyroid cancer; iodine intake and iodine physiology; nuclear medicine diagnostics and radionuclide therapy
Special Issue Information
Dear Colleagues,
Thyroid cancer, the most common endocrine malignancy, presents a unique model among solid tumours due to its relatively simple genomic profile and diverse histological behaviour. Advances in genomic technologies have improved our understanding of key mutations, such as BRAF V600E, RAS, RET/PTC, TERT, and TP53, which commonly activate MAPK and PI3K/AKT signalling pathways, leading to thyroid carcinogenesis. Early detection of these molecular alterations enables more precise risk stratification, tumour grading, and personalised treatment, particularly for aggressive or radioiodine-refractory cancers.
The complex biology of thyroid cancer underscores the need for an integrative approach that connects molecular research with clinical decision-making. Preoperative molecular testing is increasingly used to guide surgical strategies and treatment intensity. Furthermore, novel therapies, including immunotherapy, redifferentiation therapeutic strategies and targeted therapies based on tumour genomic profiling, are available and still evolving to expand treatment options and improve patient outcomes.
This Special Issue welcomes original research and reviews focused on the genetic and molecular basis of thyroid cancer. Topics of interest include genomic alterations, mutation-driven treatment approaches, biomarker development, and the clinical application of molecular diagnostics. Submissions offering new insights into the relationship between genetic changes and clinical behaviour in thyroid malignancies are especially encouraged.
We look forward to your valuable contributions.
Dr. Tatjana Bogovic Crncic
Dr. Tomislav Jukić
Guest Editors
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Keywords
- genetic mutations
- thyroid cancer
- molecular diagnostics
- risk stratification
- novel therapies
- MAPK/PI3K-AKT signalling
- radioiodine-refractory
- redifferentiation therapeutic strategies
- tumour genomic profiling
- targeted therapy
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