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Genes publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Function and Molecular Mechanism for Immune Responses in Human Diseases

edited by Zsofia Banlaki

submission deadline 25 Dec 2025 | 1 articles | Viewed by 700 | Submission Open

Keywords: leukocyte; cytokine; immune receptor; signal transduction; gene expression; antibody-antigen; major histocompatibility complex; complement system; inflammation

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Research on Genetics and Breeding of Rice

edited by Xiaojin Luo

submission deadline 25 Dec 2025 | Viewed by 179 | Submission Open

Keywords: rice breeding; molecular genetics; rice germplasm; QTL identification and gene cloning; genetic function and genetic network; breeding technologies

(This special issue belongs to the Section Plant Genetics and Genomics)

Genomic, Transcriptome Analysis in Animals

edited by

Min Yang

and Mengxun Li

submission deadline 25 Dec 2025 | Viewed by 140 | Submission Open

Keywords: multi-omics methodologies; genetic and epigenetic regulation; mechanisms of the elucidation of domesticated animal physiological characteristics and economic traits

(This special issue belongs to the Section Animal Genetics and Genomics)

The 15th Anniversary of Genes: Feature Papers in the Human Genomics and Genetic Diseases Section

edited by

Gil Atzmon

and

Mariarosa Anna Beatrice Melone

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2574 | Submission Open

Keywords: genetics of monogenic diseases and complex diseases; genotype– phenotype relationships; population genomics and genetic epidemiology; precision medicine; pharmacogenetics and pharmacogenomics; targeted genome editing; gene therapy and delivery systems; genetically engineered cell therapy; RNA- and small nucleic acid-based therapeutics; genetic testing and molecular diagnostics; biomarker development and application; genome-wide association studies; epigenetic therapy; developmental genetics; epigenetics; and epigenomics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

The 15th Anniversary of Genes: Feature Papers in the "Animal Genetics and Genomics" Section

edited by

Antonio Figueras

and

Pedro Lorite Martínez

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2004 | Submission Open

Keywords: applied genetics and genomics in species of economic importance; companion animal genetics and genomics; breeding and genetic selection; genetics and genomics of aquaculture species; genetics of immune response and disease resistance; genome-edited animals and animal epigenetics; animal population genetics; polymorphisms and genome annotation; genetics applied to the interaction of microbiome and genetic traits of interest; bioinformatics analysis in animal genetics; genomics and evolution; cytogenomics

(This special issue belongs to the Section Animal Genetics and Genomics)

15th Anniversary of Genes: Feature Papers in the “Cytogenomics” Section

edited by

Monica Bullejos

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1852 | Submission Open

Keywords: molecular cytogenetics; cytogenomics; microarray; chromosome biology; karyotyping; high-throughput cytogenetics; genome organization; comparative genomics; karyomapping; optical mapping

(This special issue belongs to the Section Cytogenomics)

15th Anniversary of Genes: Feature Papers in the “Plant Genetics and Genomics” Section

edited by

Jacqueline Batley

and

Roberto Tuberosa

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1726 | Submission Open

Keywords: epigenetic editing; genetics; genomics; pangenome; plants; QTL mapping; QTL cloning; regulation of gene expression; transcriptome

(This special issue belongs to the Section Plant Genetics and Genomics)

Genome Assembly and Annotation in Biology

edited by

Yasukazu Nakamura

Hidemasa Bono

and Mika Sakamoto

submission deadline 31 Dec 2025 | Viewed by 1005 | Submission Open

Keywords: genome assembly; genome annotation; structural gene prediction; functional gene prediction; reference genomes; annotation tools and pipelines; comparative genomics

(This special issue belongs to the Section Bioinformatics)

Research Updates in Forensic Genetics

edited by Massimo Lancia

submission deadline 31 Dec 2025 | 1 articles | Viewed by 568 | Submission Open

Keywords: next generation sequencing; single cell analysis; time since deposition; time since death; DNA phenotyping; biogeographic ancestry; age prediction; familial search; disaster victim identification; trace DNA contextualisation

(This special issue belongs to the Section Molecular Genetics and Genomics)

The 15th Anniversary of Genes: Feature Papers in the "Population and Evolutionary Genetics and Genomics" Section

edited by

Zissis Mamuris

and

Maria-Anna Kyrgiafini

submission deadline 31 Dec 2025 | Viewed by 242 | Submission Open

Keywords: population genetics; evolutionary genomics; genetic diversity; adaptation; natural selection

(This special issue belongs to the Section Population and Evolutionary Genetics and Genomics)

Genomic Data Analysis in Human Health and Disease

edited by Ighli Di Bari and

Zhaohui S. Qin

submission deadline 31 Dec 2025 | Viewed by 206 | Submission Open

Keywords: protein modeling and structure-function prediction; variant pathogenicity prediction tools; functional annotation of genetic variants; machine learning in genomics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

The Development of Genetic Assessment for Neurotoxicity

edited by

and

submission deadline 31 Dec 2025 | Viewed by 167 | Submission Open

Keywords: neurotoxicity; genetics; neurodegenerative disorders; mental disorders

(This special issue belongs to the Section Toxicogenomics)

The 15th Anniversary of Genes: Feature Papers in the "RNA" Section

edited by

Christiane Branlant

submission deadline 31 Dec 2025 | Viewed by 163 | Submission Open

Keywords: tRNAs; rRNAs; mRNAs; miRNAs; lncRNAs; sRNAs; siRNAs; RNA epigenetics; RNA modifications; RNA secondary and tertiary structure; viral RNAs; RNA binding proteins; RNA transcription; RNA translation

(This special issue belongs to the Section RNA)

Advances and Challenges in Forensic Genetics

edited by

Maria Helena Correia Dias

and

Venusia Cortellini

submission deadline 5 Jan 2026 | 2 articles | Viewed by 1585 | Submission Open

Keywords: DNA analysis; DNA methylation applications; biogeographic ancestry; age estimation approaches; discrimination of monozygotic twins; discrimination of tissues; next-generation sequencing; forensic cases

(This special issue belongs to the Section Molecular Genetics and Genomics)

Insights into RNA Coding and Transcriptional Regulation

edited by Zihua Hu

submission deadline 5 Jan 2026 | Viewed by 261 | Submission Open

Keywords: RNA coding; transcriptomics; non-coding RNAs (ncRNA); long non-coding RNA (lncRNA); microRNA (miRNA); RNA modifications; RNA splicing; RNA editing; RNA in transcriptional and post-transcriptional regulation; gene expression regulation; scRNA

(This special issue belongs to the Section RNA)

Fragile X Syndrome and Fragile X Premutation Associated Conditions

edited by

Dragana D. Protic

and

Maja Stojković

submission deadline 10 Jan 2026 | 1 articles | Viewed by 770 | Submission Open

Keywords: FMR1 gene; FMRP; fragile X syndrome; fragile X premutation-associated conditions (FXPAC); molecular mechanisms; targeted treatment and gene therapy

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Epigenetic Mechanisms of Stem Cell Aging

edited by Romeo Blanc

submission deadline 10 Jan 2026 | Viewed by 221 | Submission Open

Keywords: stem cell aging; epigenetics; DNA methylation; histone modifications; chromatin remodeling; single-cell omics; transcriptomics; regenerative decline; cell fate decisions; tissue homeostasis

(This special issue belongs to the Section Epigenomics)

Structural and Evolutionary Perspectives on Immunogenetic Variation in Autoimmune and Related Disorders

edited by Athena Andreou and Catriona Kelly

submission deadline 10 Jan 2026 | Viewed by 219 | Submission Open

Keywords: gene polymorphisms; exonic and intronic variants; structural biology; biophysical analysis; structural evolution; protein molecular function and evolution; immunological biomarkers; human genetic diseases; evolutionary genomics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advances in Genetic Variants in Neurological and Psychiatric Diseases

edited by

Evelina Mocci

submission deadline 10 Jan 2026 | Viewed by 197 | Submission Open

Keywords: pleiotropy; comorbidity; meta-analysis; polygenic risk score; transcriptome; network analysis; psychiatric; neurology

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Germplasm Resource Evaluation and Genetic Breeding of Sheep and Goats

edited by Huihua Wang and

Hangxing Ren

submission deadline 10 Jan 2026 | Viewed by 163 | Submission Open

Keywords: sheep; goat; conservation germplasm resources; genetic breeding; genomic selection; reproductive biotechnology; functional genomics

(This special issue belongs to the Section Animal Genetics and Genomics)

Cytogenetics and Cytogenomics in Clinical Diagnostics: Innovations and Applications

edited by

Jinglan Liu

submission deadline 15 Jan 2026 | 6 articles | Viewed by 8216 | Submission Open

Keywords: karyotyping; cytogenomics; chromosome territory (CT); nuclear architecture; clinical oncology; germline; development; neuropsychiatry; artificial intelligence (AI)

(This special issue belongs to the Section Cytogenomics)

Phenotypic Variability of Genetic Diseases in Children

edited by Ben Pode-Shakked

submission deadline 15 Jan 2026 | 2 articles | Viewed by 2727 | Submission Open

Keywords: phenotypic variability; genetic disorders; rare diseases; neurodevelopmental disorders; craniofacial anomalies; next-generation sequencing

(This special issue belongs to the Section Molecular Genetics and Genomics)

Function and Regulatory Mechanism of MicroRNAs in Cancers

edited by

Alicja Petniak

Paulina Gil-Kulik

and

Janusz Kocki

submission deadline 15 Jan 2026 | 1 articles | Viewed by 1675 | Submission Open

Keywords: microRNAs (miRNAs); cancer biomarkers; gene regulation; miRNA-based therapies; tumor microenvironment; cancer progression; drug resistance; non-coding RNAs; epigenetic regulation; cancer immunology

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances in Veterinary Genetics and Genomics

edited by

Petra Zenke

and

Enikő Fehér

submission deadline 15 Jan 2026 | 1 articles | Viewed by 814 | Submission Open

Keywords: veterinary genetics; animal genomics; infectious diseases and disease resistance; pathogenetics; genomic selection and livestock improvement; conservation genetics; epigenetics; CRISPR gene editing; next-generation sequencing (NGS); forensic genetics; LAMP method

(This special issue belongs to the Section Animal Genetics and Genomics)

Multi-Omics in Psychiatric Disorders

edited by

José Jaime Martínez-Magaña

and

Sheila T. Nagamatsu

submission deadline 15 Jan 2026 | Viewed by 478 | Submission Open

Keywords: methylomics; transcriptomics; epigenomics; genomics; proteomics; metabolomics; multi-omics; psychiatric disorders

(This special issue belongs to the Section Neurogenomics)

Systems Biology of Single Cells: Bridging Genomics and Functional Insights

edited by

Guilherme Targino Valente

submission deadline 15 Jan 2026 | Viewed by 475 | Submission Open

Keywords: systems biology; graph theory; single-cell RNA-Seq; spatial transcriptomics; molecular networks; complex networks

(This special issue belongs to the Section Bioinformatics)

The Molecular Footprint of Fetal Alcohol Spectrum Disorders and Prenatal Alcohol Exposure: Genetics, Epigenetics, Oxidative Stress and Neurodevelopement

edited by

Sergio Terracina

submission deadline 15 Jan 2026 | Viewed by 292 | Submission Open

Keywords: fetal alcohol spectrum disorders; FASD; molecular biology; genetics; epigenetics; oxidative stress; neuroinflammation; neurodevelopment; pathways; diagnosis; management

(This special issue belongs to the Section Epigenomics)

Immunotherapy in Glioblastoma: Genetic Insights and Innovations

edited by

Richard J. Tancredi

submission deadline 15 Jan 2026 | Viewed by 255 | Submission Open

Keywords: glioblastoma; treatment strategy; genetic mutations; immunotherapies; checkpoint inhibitors

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Animal Virus Immunology and Genomics

edited by

Huijun Lu

and

Changzhan Xie

submission deadline 15 Jan 2026 | Viewed by 230 | Submission Open

Keywords: epidemiology; gene editing; genome; transcriptome; and proteome; synthetic biology; high-throughput sequencing; multi-omics; transcription factor; immunology

(This special issue belongs to the Section Animal Genetics and Genomics)

Integrating Traditional and Modern Technology for Cattle Genetic Improvement

edited by

Xibi Fang

and

Tianyu Deng

submission deadline 15 Jan 2026 | Viewed by 222 | Submission Open

Keywords: cattle breeding; animal genetics; genomic selection; functional genomics; epigenetics and epigenomics; functional genes; Quantitative Trait Loci (QTL)

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetic and Epigenetic Mechanisms Underlying Cancer Stem Cells and Their Implications for Novel Therapeutic Approaches

edited by

Fumihiko Kakizaki

and

Frank Buchholz

submission deadline 15 Jan 2026 | Viewed by 208 | Submission Open

Keywords: cancer stem cell; metastasis; cancer-associated gene; model organism for cancer research; therapeutics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Next-Generation Diagnosis and Treatment of Hematologic Diseases

edited by

Thomas David Daniel Kazmirchuk

and

Ashkan Golshani

submission deadline 15 Jan 2026 | Viewed by 206 | Submission Open

Keywords: hematologic disease; hematology; thrombosis and hemostasis; bleeding disorders; artificial intelligence; next-generation theranostics; therapeutics; diagnostics; peptide design; precision medicine

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic Insights into Aortic Aneurysm Disease

edited by

John Alex Elefteriades

and Bulat A. Ziganshin

submission deadline 15 Jan 2026 | Viewed by 199 | Submission Open

Keywords: aneurysm; thoracic aortic aneurysm; abdominal aortic aneurysm; aorta; thoracic aorta; genetics; aortic syndromes; Marfan; Loeys– Dietz; Ehlers– Danlos; aortopathy; medial degeneration; aneurysm genes

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Next-Gen Omics in Animal and Microbial Science

edited by Loan To Nguyen

submission deadline 15 Jan 2026 | Viewed by 123 | Submission Open

Keywords: Oxford nanopore technologies; genomics; transcriptomics; metagenomics; microbiome

(This special issue belongs to the Section Animal Genetics and Genomics)

Molecular and Genetic Mechanisms of Floral Development

edited by Kaifeng Ma

submission deadline 16 Jan 2026 | Viewed by 102 | Submission Open

Keywords: floral induction and differentiation; flower bud formation and dormancy; floral organ; flower pattern; flower color and fragrance; blooming period; molecular and genetic mechanism

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetic Studies on Cotton Stress Resistance, Quality Traits, and Drought Response Mechanisms

edited by Xueyuan Li, Juyun Zheng,

Jie Sun

and Fenglei Sun

submission deadline 20 Jan 2026 | 1 articles | Viewed by 845 | Submission Open

Keywords: cotton; drought stress; growth and development; gene editing; molecular marker-assisted selection

(This special issue belongs to the Section Plant Genetics and Genomics)

Advances in Molecular Genetics of Psychiatric Diseases

edited by Fotis Tsetsos

submission deadline 20 Jan 2026 | 1 articles | Viewed by 668 | Submission Open

Keywords: psychiatric genetics; molecular psychiatry; GWAS; rare variants; transcriptomics; epigenetics; gene-environment interactions; precision psychiatry; schizophrenia; bipolar disorder; depression; autism spectrum disorder; anxiety; functional genomics; neurodevelopmental disorders

(This special issue belongs to the Section Molecular Genetics and Genomics)

Cytogenetics/Cytogenomics and Functional Genomics in Human Health and Disease

edited by

Patrick R. Gonzales

submission deadline 20 Jan 2026 | Viewed by 307 | Submission Open

Keywords: functional genomics; cytogenetics; cytogenomics; microarray; optical genome mapping (OGM); Hi-C; genomic proximity mapping (GPM); intergenic; topologically associating domains (TAD); expression

(This special issue belongs to the Section Cytogenomics)

New Insight into the Genetic and Molecular Aspects of Yeast Nutrient Metabolism

edited by Roman Maslanka and

Renata Zadrag-Tecza

submission deadline 20 Jan 2026 | Viewed by 286 | Submission Open

Keywords: yeasts as a model organism; yeast metabolism; nutrient sensing; sugar/hexose transport; central carbon metabolism; catabolite repression; nutrient availability; resource allocation; calorie restriction; cAMP-PKA signaling; metabolic flux; metabolic adaptation; genetic and transcriptional regulation; cellular homeostasis; molecular biology of yeast

(This special issue belongs to the Section Molecular Genetics and Genomics)

Reviews in Genetic Bioinformatics: Tools and Analyses

edited by

Hongyan Xu

submission deadline 20 Jan 2026 | Viewed by 257 | Submission Open

Keywords: genetics; genomics; machine learning; computational biology; big data; bioinformatics

(This special issue belongs to the Section Bioinformatics)

Application of Bioinformatics in Complex Traits

edited by

Xiang-Yang Lou

submission deadline 20 Jan 2026 | Viewed by 151 | Submission Open

Keywords: complex traits; bioinformatics; multi-omics integration; gene– environment interactions; polygenic risk scores; machine learning; systems biology; network analysis; statistical genetics; causal inference

(This special issue belongs to the Section Bioinformatics)

Molecular Genetics of Neurodevelopmental Disorders: 2nd Edition

edited by

Richard Eugene Frye

and

Richard Boles

submission deadline 25 Jan 2026 | 1 articles | Viewed by 1673 | Submission Open

Keywords: neurodevelopmental disorders; attention deficit hyperactivity disorder; intellectual disabilities; autism spectrum disorder; mitochondria; neuroinflammation; epigenetics; transcriptomics; genetic syndromes; polygenetic interactions

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

5Gs in Crop Genetic and Genomic Improvement: 2025–2026

edited by

Xinjie Shen

submission deadline 25 Jan 2026 | 2 articles | Viewed by 944 | Submission Open

Keywords: crop gene functional analysis; crop protemics; crop metabonomics; new crop breeding methods; crop GWAS analysis; crop gene edit technology; crop gene epigenetic modification

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetic Epidemiology of Multifactorial Diseases

edited by

Maria Tziastoudi

and Ioannis Stefanidis

submission deadline 25 Jan 2026 | 1 articles | Viewed by 342 | Submission Open

Keywords: genetic association studies; polygenic risk scores; functional genomics; causal inference; mendelian randomization; translational applications

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic Testing and Clinical Management of Hereditary Cancer

edited by

Xia Wang

submission deadline 25 Jan 2026 | Viewed by 317 | Submission Open

Keywords: genetic cancer predisposition; hereditary cancer risk; polygenic risk; cancer screening; genetic testing; genomic testing; DNA sequencing; RNA sequencing; cascade genetic testing; precision medicine; germline genetic testing; tumor molecular profiling; paired analysis; hematological malignancy

(This special issue belongs to the Section Epigenomics)

Genomics and Proteomics-Based Molecular Diagnostics and Targeted Therapies in Cancer

edited by

Hilal Arnouk

submission deadline 25 Jan 2026 | Viewed by 284 | Submission Open

Keywords: molecular diagnostics; targeted therapies; biomarkers; precision medicine oncology; chemotherapy; small-molecule drugs; monoclonal antibodies; cancer immunotherapy

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Unraveling Genomic Mechanisms of Stress Tolerance and Antimicrobial Resistance in Foodborne Pathogens

edited by

Eduardo Eustáquio de Souza Figueiredo

and

Vinicius Silva Castro

submission deadline 25 Jan 2026 | Viewed by 248 | Submission Open

Keywords: foodborne pathogens; AMR; survivability; thermal resistance; in silico analysis; DNA sequencing; RNA sequencing; environmental stress condition

(This special issue belongs to the Section Microbial Genetics and Genomics)

Genetics and Environmental Factors in Psychiatric Disorders

edited by

Sarah Tosato

submission deadline 25 Jan 2026 | Viewed by 119 | Submission Open

Keywords: PGS; environmental factors; epigenetics; prenatal environmental exposures; GWAS; GxE interactions

(This special issue belongs to the Section Genes & Environments)

Genetics and Physiology of Multiple-Stress Tolerance in Plants

edited by Jin Wang

submission deadline 25 Jan 2026 | Viewed by 83 | Submission Open

Keywords: plant; genetics; genomics; physiology; biotic stress; abiotic stress; genetic breeding; molecular biology

(This special issue belongs to the Section Plant Genetics and Genomics)