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Genes publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Genetic Mechanisms and Therapeutic Strategies in Ovarian Cancer

edited by Aimee Stablewski

submission deadline 25 Jun 2026 | Viewed by 335 | Submission Open

Keywords: epithelial ovarian cancer (EOC); genetic alterations; epigenetic regulation; tumor microenvironment; therapeutic strategies

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Basis and Molecular Mechanism of Plant Immunity

edited by

Aijun Wang

and Desuo Yin

submission deadline 25 Jun 2026 | Viewed by 305 | Submission Open

Keywords: plant; phytopathogens; immune responses; molecular mechanisms; regulatory pathways; interactions mechanisms

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetic Mechanisms of Wild Animal Adaptation to the Environment

edited by

Jianhai Chen

submission deadline 25 Jun 2026 | Viewed by 301 | Submission Open

Keywords: wild animal adaptation; evolutionary genomics; population genetics; local adaptation; adaptive introgression; natural selection; genomic variation; functional genomics; environmental stress response; climate adaptation; host– pathogen interaction; epigenetic regulation; multi-omics integration; conservation genomics; genotype– phenotype association

(This special issue belongs to the Section Animal Genetics and Genomics)

Plant Pathogenic Fungi: Molecular Systematics, Genomics and Evolution

edited by

Shengxiong Huang

submission deadline 25 Jun 2026 | Viewed by 269 | Submission Open

Keywords: plant pathogenic fungi; pathogen isolation and identification; molecular evolution; multi-omics analysis; genome sequencing; comparative genomics; RNA-seq

(This special issue belongs to the Section Plant Genetics and Genomics)

Monogenic Diabetes—from Basic Scientific Insights to Precision Care and Beyond

edited by Kathy HC Wu

submission deadline 25 Jun 2026 | Viewed by 250 | Submission Open

Keywords: MODY; precision; implementation; diversity; equity; bioinformatics; functional genomics; genotype; phenotype; high throughput

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advances in Veterinary Genetics and Genomics

edited by

Petra Zenke

and

Enikő Fehér

submission deadline 5 Jul 2026 | 2 articles | Viewed by 2907 | Submission Open

Keywords: veterinary genetics; animal genomics; infectious diseases and disease resistance; pathogenetics; genomic selection and livestock improvement; conservation genetics; epigenetics; CRISPR gene editing; next-generation sequencing (NGS); forensic genetics; LAMP method

(This special issue belongs to the Section Animal Genetics and Genomics)

Genomic and Transcriptomic Advances in Amyotrophic Lateral Sclerosis (ALS) and Motor Neuron Diseases (MND)

edited by

Francesca Dragoni

and

Stella Gagliardi

submission deadline 5 Jul 2026 | Viewed by 351 | Submission Open

Keywords: ALS ; transcriptomic studies ; motor neuron diseases ; biomarkers assessment ; pathomechanisms ; genetics ; genotype– phenotype correlation

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advances in Molecular Genetics of Psychiatric Diseases

edited by Fotis Tsetsos

submission deadline 10 Jul 2026 | 1 articles | Viewed by 1940 | Submission Open

Keywords: psychiatric genetics; molecular psychiatry; GWAS; rare variants; transcriptomics; epigenetics; gene-environment interactions; precision psychiatry; schizophrenia; bipolar disorder; depression; autism spectrum disorder; anxiety; functional genomics; neurodevelopmental disorders

(This special issue belongs to the Section Molecular Genetics and Genomics)

Autism: Genetics, Environment, Pathogenesis, and Treatment

edited by

Alessandra Mezzelani

submission deadline 10 Jul 2026 | 2 articles | Viewed by 1663 | Submission Open

Keywords: Autism Spectrum Disorders (ASDs); pathogenesis; genetic factors; environmental factors; epigenetics; gut microbiota; animal models; organoid models; multi-omics; bioinformatics; biostatistics; biomarkers; diagnosis; patient stratification; personalized interventions

(This special issue belongs to the Section Neurogenomics)

Genetic and Molecular Mechanisms of Plant–Fungal Pathogen Interactions

edited by

Guihua Li

submission deadline 10 Jul 2026 | 1 articles | Viewed by 1015 | Submission Open

Keywords: plant– fungal pathogen interactions; fungal pathogenicity; plant immunity; host– pathogen coevolution; effector biology; virulence factors; disease resistance; genetic regulation; molecular mechanisms; omics technologies; genome editing; sustainable crop protection

(This special issue belongs to the Section Plant Genetics and Genomics)

Advances in Molecular Genetics of Rare Disorders

edited by Miriam Lucia Carriero

submission deadline 10 Jul 2026 | 1 articles | Viewed by 638 | Submission Open

Keywords: rare diseases; molecular genetics; gene– disease associations; genotype– phenotype correlation; targeted gene therapy; next-generation sequencing; whole-genome sequencing; genome-wide association studies; functional genomics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Insights into RNA Coding and Transcriptional Regulation

edited by Zihua Hu

submission deadline 10 Jul 2026 | Viewed by 604 | Submission Open

Keywords: RNA coding; transcriptomics; non-coding RNAs (ncRNA); long non-coding RNA (lncRNA); microRNA (miRNA); RNA modifications; RNA splicing; RNA editing; RNA in transcriptional and post-transcriptional regulation; gene expression regulation; scRNA

(This special issue belongs to the Section RNA)

Advances in Genetics and Genomics of Medical Plants

edited by

Mingcheng Wang

submission deadline 15 Jul 2026 | 1 articles | Viewed by 866 | Submission Open

Keywords: medicinal plant genomics; medicinal plant genetics; high-throughput sequencing; functional genomics; multi-omics integration

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetic and Molecular Insights into Migraine

edited by

Maria Papasavva

and Vasileios Siokas

submission deadline 15 Jul 2026 | Viewed by 266 | Submission Open

Keywords: neurosciences; neurology; neurogenetics; molecular neurology; neurodegeneration; neurorehabilitation; rTMS

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic and Epigenetic Mechanisms in Animal Reproduction

edited by Ming Shen

submission deadline 15 Jul 2026 | Viewed by 205 | Submission Open

Keywords: animal reproduction; genetic regulation; epigenetic modification; DNA methylation; histone modification; noncoding rna; chromatin remodeling; gametogenesis; fertilization; embryonic development; reproductive efficiency; reproductive disorders; gene expression; livestock breeding; reproductive biotechnology

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetics of SARS-CoV-2 Virus

edited by

Walter Doerfler

submission deadline 15 Jul 2026 | Viewed by 150 | Submission Open

Keywords: molecular genetics; viral mutagenesis; rapidly arising new viral mutants; four-letter genetic system; illegitimate recombination; novel aspects of molecular or epidemiological virology

(This special issue belongs to the Section Viral Genomics)

5Gs in Crop Genetic and Genomic Improvement: 2025–2026

edited by

Xinjie Shen

submission deadline 20 Jul 2026 | 9 articles | Viewed by 7324 | Submission Open

Keywords: crop gene functional analysis; crop protemics; crop metabonomics; new crop breeding methods; crop GWAS analysis; crop gene edit technology; crop gene epigenetic modification

(This special issue belongs to the Section Plant Genetics and Genomics)

Environmental Genomics and Low-Dose Induced Adaptive Response: Underlying Mechanisms from Cells to Organisms

edited by

Stephka Chankova

, Michaela Beltcheva and

Teodora Todorova

submission deadline 20 Jul 2026 | 1 articles | Viewed by 1009 | Submission Open

Keywords: environmental genomics; ecotoxicology; low-dose induced adaptive response; low-dose radiation; genomic instability; environmental mutagenesis; DNA repair; radio-protection; stress response; toxicogenomics; antioxidant system; chaperone system

(This special issue belongs to the Section Genes & Environments)

Genetics and Genomics of Plant Reproductive Development

edited by

Pingli Lu

submission deadline 20 Jul 2026 | Viewed by 269 | Submission Open

Keywords: genetics; genomics; meiosis; anther development; gametophyte development; fertilization; seed; fruit

(This special issue belongs to the Section Plant Genetics and Genomics)

Fetal Genetic Disorders: Diagnosis and Therapy

edited by Gianluca Campobasso

submission deadline 20 Jul 2026 | Viewed by 236 | Submission Open

Keywords: fetal medicine; malformations; ; genetic anomalies; ; genomic sequencing; ; syndromes; artificial intelligence

(This special issue belongs to the Section Genetic Diagnosis)

Genetics and Genomics of Neurological Disorders

edited by

Andrea L. Gropman

submission deadline 20 Jul 2026 | Viewed by 129 | Submission Open

Keywords: neurogenetics; neuroscience; neurodevelopmental disorders; genetics; genomics; epigenetic

(This special issue belongs to the Section Neurogenomics)

Abiotic Stress in Plant: Molecular Genetics and Genomics

edited by Weicong Qi and

Hongyan Wang

submission deadline 25 Jul 2026 | 7 articles | Viewed by 6171 | Submission Open

Keywords: abiotic stress; molecular genetics; genomics; plant stress response; epigenetics; crop improvement; sustainable agriculture

(This special issue belongs to the Section Plant Genetics and Genomics)

Roles of RNAs in Biology

edited by

Zihua Hu

submission deadline 25 Jul 2026 | 2 articles | Viewed by 3260 | Submission Open

Keywords: regulatory RNAs; non-coding RNAs; RNA in disease and therapy; RNA modifications including editing; RNA-RNA interaction including microRNAs; RNA in transcriptional and post-transcriptional regulation; non-coding RNA in epigenetic regulation

(This special issue belongs to the Section RNA)

Genetic Insights into Aortic Aneurysm Disease

edited by

John Alex Elefteriades

and Bulat A. Ziganshin

submission deadline 25 Jul 2026 | 2 articles | Viewed by 1515 | Submission Open

Keywords: aneurysm; thoracic aortic aneurysm; abdominal aortic aneurysm; aorta; thoracic aorta; genetics; aortic syndromes; Marfan; Loeys– Dietz; Ehlers– Danlos; aortopathy; medial degeneration; aneurysm genes

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Molecular Evolution and Mitochondrial Genomics in Animals

edited by

Jiayong Zhang

submission deadline 25 Jul 2026 | 1 articles | Viewed by 485 | Submission Open

Keywords: mitochondrial genome; gene arrangement; phylogenetic relationship; mitochondrial gene expression; molecular evolution

(This special issue belongs to the Section Animal Genetics and Genomics)

Driver Genes in Prostate Carcinogenesis and Resistance to Treatment

edited by

Daotai Nie

submission deadline 25 Jul 2026 | Viewed by 356 | Submission Open

Keywords: genomic instability; driver genes; prostate cancer prevention; castration therapy; drug resistance

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Molecular Genetic Breeding of Sheep

edited by Bin Tong

submission deadline 25 Jul 2026 | Viewed by 244 | Submission Open

Keywords: omics; molecular markers; economic traits; genetic breeding; sheep

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetic Improvement and Genome Editing Strategies in Silkworm (Bombyx mori) Breeding

edited by

Qingsong Liu

submission deadline 25 Jul 2026 | Viewed by 219 | Submission Open

Keywords: Bombyx mori; silkworm breeding; genetic improvement; genome editing; CRISPR; functional genomics; transgenic silkworm; multi-omics

(This special issue belongs to the Section Animal Genetics and Genomics)

Genomics and Functional Genetics of Marine Shrimp Adaptation and Breeding

edited by Jiajia Wang

submission deadline 25 Jul 2026 | Viewed by 216 | Submission Open

Keywords: shrimp; aquaculture; genomics; functional genetics; environmental adaptation; disease resistance; genetic breeding; stress response; molecular mechanisms; genomic selection

(This special issue belongs to the Section Animal Genetics and Genomics)

Gene Editing and Epigenetic Regulation for Neurological Disorders: From Disease Mechanisms to Therapeutic

edited by

Valentina Imperatore

submission deadline 25 Jul 2026 | Viewed by 204 | Submission Open

Keywords: gene editing; CRISPR-Cas systems; base editing and prime editing; epigenetic regulation; DNA methylation and chromatin remodeling; RNA splicing and splice-site mutations; neurogenetics; neurological disorders; multi omics analysis; transcriptomics and RNA biology; functional genomics; therapeutic genome engineering; RNA based therapeutics; disease mechanisms; precision medicine

(This special issue belongs to the Section Neurogenomics)

Genetics and Breeding in Cassava

edited by

Mengting Geng

submission deadline 25 Jul 2026 | Viewed by 203 | Submission Open

Keywords: cassava; molecular breeding; nutritional quality; storage root development; biotic and abiotic stress

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetic Breeding and Reproduction in Livestock

edited by

Hongmei Zhu

submission deadline 25 Jul 2026 | Viewed by 201 | Submission Open

Keywords: livestock; genomic selection; marker-assisted breeding; gene editing; reproductive technologies; animal health

(This special issue belongs to the Section Animal Genetics and Genomics)

Genomics and Breeding of Wheat

edited by

Shuaifeng Geng

and Jiajia Zhao

submission deadline 26 Jul 2026 | 1 articles | Viewed by 1030 | Submission Open

Keywords: wheat; disease resistance; gene; gene editing; genome analysis; genomic diversity; functional analysis

(This special issue belongs to the Section Plant Genetics and Genomics)

Computational Genomics and Bioinformatics of Cancer

edited by

Ilya Ioshikhes

submission deadline 5 Aug 2026 | 10 articles | Viewed by 13882 | Submission Open

Keywords: cancer; data analysis; bioinformatics; complex diseases; dimensionality reduction; genetics; epigenetics; gene regulation; molecular mechanism; environmental factors

(This special issue belongs to the Section Bioinformatics)

Integrative Genetics and Translational Research in Parkinson’s Disease

edited by Pingping Song

submission deadline 5 Aug 2026 | Viewed by 194 | Submission Open

Keywords: Parkinson’ s disease; human genetics; functional genomics; multi-omics; genome-wide association studies (GWAS); structural genetic variation; autophagy– lysosomal pathway; mitochondrial dysfunction; synaptic dysfunction; precision medicine; targeted therapies

(This special issue belongs to the Section Neurogenomics)

Genetics and Treatment in Neurodegenerative Diseases

edited by

Valentino Rački

and

Gaber Bergant

submission deadline 10 Aug 2026 | 5 articles | Viewed by 8984 | Submission Open

Keywords: neurodegeneration; genetics; Alzheimer’ s disease; Parkinson’ s disease; gene therapy; pharmacogenomics; precision medicine

(This special issue belongs to the Section Neurogenomics)

Genetic and Genomic Mechanisms of Heat Stress in Disease Modulation: From Molecular Pathways to Clinical Manifestations

edited by

Hisahide Nishio

and

Hiroyuki Awano

submission deadline 10 Aug 2026 | 1 articles | Viewed by 2007 | Submission Open

Keywords: heatstroke; global warming; heat stress; neurodegenerative diseases; molecular pathogenesis; gene– environment interactions

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Cytogenetics/Cytogenomics and Functional Genomics in Human Health and Disease

edited by

Patrick R. Gonzales

submission deadline 10 Aug 2026 | Viewed by 600 | Submission Open

Keywords: functional genomics; cytogenetics; cytogenomics; microarray; optical genome mapping (OGM); Hi-C; genomic proximity mapping (GPM); intergenic; topologically associating domains (TAD); expression

(This special issue belongs to the Section Cytogenomics)

Genetic and Epigenetic Mechanisms Underlying Cancer Stem Cells and Their Implications for Novel Therapeutic Approaches

edited by

Fumihiko Kakizaki

and

Frank Buchholz

submission deadline 10 Aug 2026 | Viewed by 484 | Submission Open

Keywords: cancer stem cell; metastasis; cancer-associated gene; model organism for cancer research; therapeutics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics and Diagnosis of Colorectal Cancer

edited by

Shiki Fujino

submission deadline 10 Aug 2026 | Viewed by 245 | Submission Open

Keywords: colorectal cancer; genetics; diagnosis; biomarkers; molecular profiling; cancer stem cell

(This special issue belongs to the Section Genetic Diagnosis)

Genetic Improvement and Reproductive Regulation in Animals

edited by Boqi Zhang

submission deadline 10 Aug 2026 | Viewed by 187 | Submission Open

Keywords: fertility; gametogenesis; embryonic development; reproductive physiology; germ cells; reproductive regulation; genomic selection; functional genomics; multi-omics; genetic improvement; epigenetics

(This special issue belongs to the Section Animal Genetics and Genomics)

Buffalo Genetics and Genomics

edited by

Qingyou Liu

and Laiba Shafique

submission deadline 15 Aug 2026 | 5 articles | Viewed by 10010 | Submission Open

Keywords: buffaloes; ruminant; genomics; genetics; evolution; structural characterization

(This special issue belongs to the Section Animal Genetics and Genomics)

Unraveling the Genetic Tapestry of Human Populations: New Insights from Population Genetics and Identification in Anthropology

edited by

Lovorka Barać Lauc

submission deadline 15 Aug 2026 | 1 articles | Viewed by 864 | Submission Open

Keywords: human genetic diversity; population genetics; migration patterns; admixture; isolated populations; ancestry reconstruction; anthropological genomics; biomedical relevance; forensic identification

(This special issue belongs to the Section Population and Evolutionary Genetics and Genomics)

Genetics and Breeding of Tea Tree and Tea Plant

edited by Lianyu Yuan

submission deadline 15 Aug 2026 | 1 articles | Viewed by 757 | Submission Open

Keywords: gene function analysis; genome analysis; biotechnological breeding; genetic diversity; breeding technology; multi-omics analysis; tea plant

(This special issue belongs to the Section Plant Genetics and Genomics)

Genomic and Molecular Determinants of HPV-Related Reproductive Health

edited by

Nektaria Zagorianakou

and

Efthalia Moustakli

submission deadline 15 Aug 2026 | Viewed by 298 | Submission Open

Keywords: human papillomavirus (HPV); viral genomics; epigenomics; proteomics; vaginal microbiome; intestinal microbiome; metabolic pathways; oxidative stress; infertility genetics; reproductive health; personalized medicine; precision medicine; AI-driven diagnostics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics and Genomics in Wildlife Health and Conservation Research

edited by

Arne Ludwig

and

Zuogang Peng

submission deadline 15 Aug 2026 | Viewed by 227 | Submission Open

Keywords: wildlife; animals; plants; fungi; conservation; health; genetics; genomics; restoration; release; inbreeding; outbreeding; poaching; trade

(This special issue belongs to the Section Animal Genetics and Genomics)

Gene Regulatory Networks in Hematologic Malignancies and Cancer

edited by Renee M. Demarest

submission deadline 15 Aug 2026 | Viewed by 180 | Submission Open

Keywords: gene regulatory networks; hematologic malignancies; cancer genomics; transcriptional regulation; epigenetic regulation; hematopoiesis; single-cell sequencing; systems biology

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Forage and Grass Genetics and Genomics

edited by Peizhi Yang, Jinghui Gao,

Yuman Cao

and Tieyuan Liu

submission deadline 20 Aug 2026 | 1 articles | Viewed by 1743 | Submission Open

Keywords: molecular genetics; proteomics; polyploid genomes; genotype– phenotype association analysis; forage gene editing; biotic or abiotic stress; inter-biological interactions

(This special issue belongs to the Section Plant Genetics and Genomics)

Plant Breeding: Molecular Genetics, Genomics, Challenges, Opportunities and Future Perspectives

edited by

Aphrodite Tsaballa

submission deadline 20 Aug 2026 | Viewed by 173 | Submission Open

Keywords: marker-assisted breeding; high-throughput sequencing; plant genomics; transcriptomics; genome editing; speed breeding; genomic selection; new cultivars; sustainability

(This special issue belongs to the Section Plant Genetics and Genomics)

Epigenomic and Genomic Studies of Cancers

edited by Yuxiang Wang

submission deadline 20 Aug 2026 | Viewed by 149 | Submission Open

Keywords: cancer; mutation; amplification; deletion; epigenetics; 3D epigenetics; next-generation sequencing; ChIP-seq; Hi-C; DamID; sequential FISH; SPRITE; GAM

(This special issue belongs to the Section Epigenomics)

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