Special Issues

Genes publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Psychiatric Pharmacogenomics
edited by Martina Hahn
submission deadline 15 Sep 2025 | Viewed by 54 | Submission Open
Keywords: pharmacogenetics; pharmacogenomics; pharmacokinetics; therapeutic drug monitoring; psychotropic drugs; psychiatric pharmacogenomics
(This special issue belongs to the Section Pharmacogenetics)
Molecular Basis and Genetics of Intellectual Disability submission deadline 20 Sep 2025 | 5 articles | Viewed by 11027 | Submission Open
Keywords: ID-related genes; new syndromic and non-syndromic forms of ID; neurodevelopmental disorders; genotype– phenotype correlations; non-coding RNAs and ID; next-generation sequencing; chromosome microarray analysis; animal models; iPSCs
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
AI and Neurogenomics: Innovations in Precision Medicine for Brain Disorders submission deadline 20 Sep 2025 | 1 articles | Viewed by 542 | Submission Open
Keywords: neurogenetics; genomics; artificial intelligence; brain disorders; neurodegenerative disease
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Batch Effects in High Dimensional Biological Data—Detection, Correction and Challenges
edited by and Maximilian Sprang
submission deadline 20 Sep 2025 | Viewed by 171 | Submission Open
Keywords: batch effects; artifacts; RNA seq; omics; quality control; single cell; bioinformatics
(This special issue belongs to the Section Technologies and Resources for Genetics)
Molecular Evolution, Mitochondrial Genomics and Mitochondrial Genome Expression in Animals: 2024–2025
edited by and
submission deadline 25 Sep 2025 | 13 articles | Viewed by 9933 | Submission Open
Keywords: mitochondrial genome; gene arrangement; phylogenetic relationship; mitochondrial gene expression; molecular evolution
(This special issue belongs to the Section Population and Evolutionary Genetics and Genomics)
Machine Learning in Cancer and Disease Genomics
edited by and Giovanni Birolo
submission deadline 25 Sep 2025 | 4 articles | Viewed by 4642 | Submission Open
Keywords: machine learning; cancer genomics; disease genomics; bioinformatics; genomic data analysis; biomarker discovery; multi-omics integration; personalized medicine; computational biology
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Advanced Research in Forensic Genetics
edited by
submission deadline 25 Sep 2025 | 1 articles | Viewed by 1193 | Submission Open
Keywords: forensic genetics; massive parallel sequencing (MPS); DNA quantification methods; DNA extraction methods; sudden cardiac death; post-mortem interval; microRNA; DNA phenotyping; individual identification; genetic markers; short tandem repeats (STRs); single-nucleotide polymorphism (SNP); mitochondrial DNA (mtDNA); microhaplotype; forensic statistics; artificial intelligence; activity level in forensics
(This special issue belongs to the Section Molecular Genetics and Genomics)
Genetic and Epigenetic Influences on Depression: Emerging Therapies and Biomarkers
edited by Jelena Milić
submission deadline 25 Sep 2025 | 1 articles | Viewed by 1059 | Submission Open
Keywords: depression; epigenetics; genetic predisposition; environmental factors; epigenetic biomarkers; mental health therapies; stress and depression; DNA methylation; histone modifications; transgenerational effects
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Advances in Craniofacial Genetics
edited by Christos Yapijakis
submission deadline 25 Sep 2025 | 1 articles | Viewed by 742 | Submission Open
Keywords: craniofacial syndromes; dysmorphology; genetics; epigenetics; gene– environment interactions; animal models; therapeutic protocols; cranial neural crest; cleft lip and palate; auditory– vestibular malformations
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Genetic and Morphological Diversity in Plants
edited by
submission deadline 25 Sep 2025 | 1 articles | Viewed by 480 | Submission Open
Keywords: biodiversity; conservation; genetic structure; genetics; genotype; germplasm; haplotype; high-throughput sequencing; invasive species; microsatellites; molecular markers; morphological characters; morphology; morphometrics; morphotype; next-generation sequencing; phenotype; systematics; taxonomy; variation
(This special issue belongs to the Section Plant Genetics and Genomics)
Mitochondrial Genetics: Progress and Challenges
edited by
submission deadline 25 Sep 2025 | Viewed by 154 | Submission Open
Keywords: Mitochondria; ; mtDNA; ; mutation; ; selection; ; germline; ; mitchondrial disease; ; inheritance; ; population; ; evolution; ; NUMT
(This special issue belongs to the Section Molecular Genetics and Genomics)
Integrative Epigenetic Regulation in Crop Stress Resistance: Multi-Omics-Guided Gene Mining and Molecular Breeding
edited by Qiutao Xu, Baoqi Li and
submission deadline 25 Sep 2025 | Viewed by 125 | Submission Open
Keywords: epigenetic regulation; DNA methylation; histone modifications; RNA biology; multi-omics; abiotic stress resilience; transgenerational epigenetic inheritance; transcriptional regulation; phenotypic plasticity
(This special issue belongs to the Section Plant Genetics and Genomics)
Advances in Genetic Analysis of Congenital Disorders
edited by , and Katarzyna Ziółkowska
submission deadline 25 Sep 2025 | Viewed by 116 | Submission Open
Keywords: congenital disorders; rare diseases; next-generation sequencing; whole-exome sequencing (WES); whole-genome sequencing (WGS); array comparative genomic hybridization (aCGH); prenatal testing; postnatal testing
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Glioma Diagnostics in the Genetics Era
edited by Scott Ryall
submission deadline 25 Sep 2025 | Viewed by 113 | Submission Open
Keywords: glioma; genetics; diagnostics; therapeutics; histology; sequencing; methylation; optical genome mapping
(This special issue belongs to the Section Genetic Diagnosis)
Harnessing Multi-Omics Approaches to Unravel Plant–Microbe Interactions in Cultivated Plants: Implications for Climate Resilience and Sustainable Agriculture
edited by Samathmika Ravi, and
submission deadline 25 Sep 2025 | Viewed by 113 | Submission Open
Keywords: multi-omics; plant– microbe interactions; climate resilience; agricultural sustainability; microbial dynamics
(This special issue belongs to the Section Plant Genetics and Genomics)
Genetics and Epigenetics in Plant Development
edited by Chao Bian
submission deadline 25 Sep 2025 | Viewed by 106 | Submission Open
Keywords: plant development; genetics; epigenetics; genome editing; epigenetics; gene regulation; DNA methylation; chromatin remodeling; transcriptional networks; environmental signaling
(This special issue belongs to the Section Plant Genetics and Genomics)
Genetics and Epigenetics of Autoimmune Diseases
edited by Sundararajan Jayaraman
submission deadline 25 Sep 2025 | Viewed by 102 | Submission Open
Keywords: autoimmune diseases; biomarkers; DNA; epigenetics; genes; genetics; microRNAs
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Genetic Research on Cerebrovascular Disease and Stroke
edited by Alessandro Pezzini
submission deadline 25 Sep 2025 | Viewed by 97 | Submission Open
Keywords: stroke; genetics; genomics; risk factors; outcome
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Next-Generation Sequencing for Pathogen Detection
edited by Rachel R. Spurbeck
submission deadline 25 Sep 2025 | Viewed by 84 | Submission Open
Keywords: next-generation sequencing; pathogen agnostic detection; infectious disease diagnostics; environmental pathogen surveillance
(This special issue belongs to the Section Technologies and Resources for Genetics)
Maintenance of DNA Structure and Genome Stability
edited by
submission deadline 25 Sep 2025 | Viewed by 73 | Submission Open
Keywords: genome instability; DNA damage; replication restart; recombinational repair; replication fork; DNA repair; recombination; single-strand binding proteins; replisomes; RNA polymerase; transcription and translation
(This special issue belongs to the Section Molecular Genetics and Genomics)
Recent Advances in the Genetics of Inherited Retinal Degenerative Disease
edited by Dalia Zaliuniene
submission deadline 25 Sep 2025 | Viewed by 66 | Submission Open
Keywords: inherited retinal diseases (IRDs); genetic mutations; next-generation sequencing (NGS); gene therapy; genome editing (CRISPR-Cas9); RNA-based therapies; molecular diagnostics; precision medicine; photoreceptor degeneration
(This special issue belongs to the Section Molecular Genetics and Genomics)
Inherited Retinal Diseases: Genetic Research and Novel Therapeutic Prospects
edited by
submission deadline 25 Sep 2025 | Viewed by 63 | Submission Open
Keywords: inherited retinal degeneration; ophthalmogenetics; genotype– phenotype correlations; gene therapy; optogenetics; stem cell therapy; neuroprotection; clinical studies
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Application of Animal Models in Neurological Disease
edited by
submission deadline 5 Oct 2025 | Viewed by 78 | Submission Open
Keywords: neurological diseases; drug development; brain; animal models
(This special issue belongs to the Section Neurogenomics)
Advances in Molecular Microbiology, Genetics, and Bioinformatics of Multiple-Drug-Resistant Bacteria in Public Health
edited by , Dália Dos Prazeres Rodrigues and
submission deadline 10 Oct 2025 | 3 articles | Viewed by 3989 | Submission Open
Keywords: One Health; pathogen genomics; whole genome sequencing (WGS); proteomics; CRISPR technology; infectious disease outbreaks; antimicrobial resistance; genomic epidemiology; public health surveillance; bioinformatics in pathogen research
(This special issue belongs to the Section Microbial Genetics and Genomics)
Molecular Assays for Mutation and Infectious Agent Detection
edited by
submission deadline 10 Oct 2025 | 2 articles | Viewed by 1265 | Submission Open
Keywords: molecular diagnostics; genetic mutations; pathogen detection; PCR; digital PCR; next-generation sequencing (NGS); isothermal amplification; diagnostic technologies; clinical applications; public health
(This special issue belongs to the Section Technologies and Resources for Genetics)
Application of Genome-Wide Association Studies in Rare Diseases Research
edited by Menglu Liang and
submission deadline 10 Oct 2025 | Viewed by 173 | Submission Open
Keywords: rare disease genetics; statistical methods; genomic association; small sample inference; polygenic risk scores; cross-ancestry GWAS; gene– gene interaction; gene– environment interaction; disease biomarkers; precision medicine
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Molecular Basis in Rare Genetic Disorders
edited by
submission deadline 10 Oct 2025 | Viewed by 110 | Submission Open
Keywords: nucleotide and mitochondrial DNA; RNA modification; epigenetics; gene expression; rare disease and inheritance; clinical pathology; disease mechanism; bioinformatics and tools; functional studies; treatment and therapy
(This special issue belongs to the Section Molecular Genetics and Genomics)
Inherited Retinal Dystrophies: Genetic Basis, Genetic Diagnosis and Therapy
edited by
submission deadline 10 Oct 2025 | Viewed by 95 | Submission Open
Keywords: inherited retinal diseases (IRDs); genetic mutations; next-generation sequencing (NGS); gene therapy; genome editing (CRISPR-Cas9); RNA-based therapies; molecular diagnostics; precision medicine; photoreceptor degeneration
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Diagnostics of Adrenal Tumors
edited by Piotr Glinicki
submission deadline 10 Oct 2025 | Viewed by 53 | Submission Open
Keywords: adrenal tumors; pheochromocytoma; paraganglioma; Cushing syndrome; primary aldosteronism; adrenocortical cancer; molecular testing; biomarkers
(This special issue belongs to the Section Genetic Diagnosis)
Genetics in Canines: From Evolution to Conservation submission deadline 15 Oct 2025 | 2 articles | Viewed by 5901 | Submission Open
Keywords: Canis lupus; genetics; genomics; conservation; evolution; adaptation; hybridization  
(This special issue belongs to the Section Animal Genetics and Genomics)
Advances in Bioinformatics of Human Diseases
edited by
submission deadline 15 Oct 2025 | 2 articles | Viewed by 2247 | Submission Open
Keywords: bioinformatics; human disease; sequencing; gene expression analysis; analysis methods; proteomics analysis; metabolomics analysis; microbiome analysis
(This special issue belongs to the Section Bioinformatics)
The Origins and Evolution of Genes, Genetic Code and Proteins
edited by
submission deadline 15 Oct 2025 | 1 articles | Viewed by 1798 | Submission Open
Keywords: origin of genes; evolution of genes; origin of genetic code; evolution of genetic code; origin of tRNA; evolution of tRNA; origin of proteins; evolution of proteins; origin of life; evolution of life
(This special issue belongs to the Section Population and Evolutionary Genetics and Genomics)
Recent Advances in the Molecular Genetics of Lung Cancer submission deadline 15 Oct 2025 | 1 articles | Viewed by 1380 | Submission Open
Keywords: lung cancer; molecular oncology; genetics; epigenetic alterations; proteomics; multi-omics approaches; immunotherapy; targeted therapy
(This special issue belongs to the Section Molecular Genetics and Genomics)
Advances in Genetic Counseling and Genetic Testing in Precision Medicine (2nd Edition)
edited by Hiroki Kurahashi, , Atsushi Watanabe and
submission deadline 15 Oct 2025 | Viewed by 470 | Submission Open
Keywords: clinical integration of genomic data; ethical and socioeconomic implications; family health history; genetic risk assessment; medical genetics education; next-generation sequencing in diagnosis; personalized genomic medicine; bioinformatics in genomics; pharmacogenomics and drug response; genetic counseling and decision making; molecular biomarkers in disease; genomics of rare diseases; population genetics and evolutionary studies; epigenetics and gene regulation; artificial intelligence and machine learning in genomics; genomic data privacy and security; translational genomics and therapeutics; Transition Medicine; Re-contacting; Expanded Newborn Screening
(This special issue belongs to the Section Molecular Genetics and Genomics)
Multi-Omics in Psychiatric Disorders submission deadline 15 Oct 2025 | Viewed by 129 | Submission Open
Keywords: methylomics; transcriptomics; epigenomics; genomics; proteomics; metabolomics; multi-omics; psychiatric disorders
(This special issue belongs to the Section Neurogenomics)
The Regulation of mRNA Translation in Health and Disease
edited by Jun Ling
submission deadline 15 Oct 2025 | Viewed by 56 | Submission Open
Keywords: mRNA translation; mRNA biology; transcriptional regulation; cell signaling; cancer therapies
(This special issue belongs to the Section Molecular Genetics and Genomics)
Enhancing Genetic Prediction in Precision Medicine with Artificial Intelligence submission deadline 20 Oct 2025 | 1 articles | Viewed by 687 | Submission Open
Keywords: AI/ML-based precision medicine models and applications; integration of nanomaterials into AI-based precision medicine; translating big data into healthcare: opportunities; challenges; and legal aspects; synergy between AI and precision medicine; multi-omics profiling; phenotype prediction; risk analysis in relation to genomics in personalized medicine; ML and genomics
(This special issue belongs to the Section Technologies and Resources for Genetics)
Advances in Forensic Genetics and DNA
edited by
submission deadline 20 Oct 2025 | Viewed by 166 | Submission Open
Keywords: human identification; crime scene investigation; next generation sequencing; forensic investigative genetic genealogy; lineage markers; DNA methylation; disaster victim identification
(This special issue belongs to the Section Molecular Genetics and Genomics)
Physiological and Molecular Mechanisms of Plant Stress Response
edited by
submission deadline 20 Oct 2025 | Viewed by 87 | Submission Open
Keywords: drought stress; heat stress; cold stress; salinity stress; pathogen infection; multi-omic approaches; gene expression; plant resistance
(This special issue belongs to the Section Plant Genetics and Genomics)
Genetics and Genomics of Heritable Pediatric Disorders submission deadline 25 Oct 2025 | 3 articles | Viewed by 7782 | Submission Open
Keywords: human genetics; genomics; rare diseases; pediatric disorders; genetics
(This special issue belongs to the Section Molecular Genetics and Genomics)
Buffalo Genetics and Genomics
edited by and Laiba Shafique
submission deadline 25 Oct 2025 | 4 articles | Viewed by 5591 | Submission Open
Keywords: buffaloes; ruminant; genomics; genetics; evolution; structural characterization
(This special issue belongs to the Section Animal Genetics and Genomics)
Genetics of Neuropsychiatric Disorders
edited by Melloni Cook and Kristin Hamre
submission deadline 25 Oct 2025 | 2 articles | Viewed by 2181 | Submission Open
Keywords: major depressive disorder; schizophrenia; post-traumatic stress disorder; addiction; alcohol; drugs; anxiety disorder; stress-related disorders; genes; epigenetics; mRNA; optogenetics; miRNA; causal variant
(This special issue belongs to the Section Molecular Genetics and Genomics)
The Molecular Breeding of Vegetables: Technological Innovations and Breeding Practices
edited by
submission deadline 25 Oct 2025 | Viewed by 159 | Submission Open
Keywords: vegetable breeding; marker-assisted selection; gene editing; genomic selection; trait improvement; omics technologies; disease and stress resistance
(This special issue belongs to the Section Plant Genetics and Genomics)
Utilizing Multi-Omics to Investigate Neurodegenerative Disorders
edited by Muhammad Ali
submission deadline 25 Oct 2025 | Viewed by 145 | Submission Open
Keywords: neurodegeneration; central nervous system; diagnosis; prognosis; biomarkers; predictive modeling; brain; cerebrospinal fluid; plasma; multi-omics
(This special issue belongs to the Section Neurogenomics)
Unveiling Human Microbiome Composition and Functions to Improve Health and Disease Research submission deadline 25 Oct 2025 | Viewed by 131 | Submission Open
Keywords: human microbiome; health and disease; precision medicine; host– microbe interactions; translational research; metagenomics; multi-omics approaches
(This special issue belongs to the Section Microbial Genetics and Genomics)
Chromatin Remodeling and DNA Repair Pathways in Cancer
edited by
submission deadline 25 Oct 2025 | Viewed by 116 | Submission Open
Keywords: chromatin remodeling; chromatin remodelers; nucleosome; histone modification; DNA damage responses
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Genetic and Epigenetic Factors for Autoimmune Diseases submission deadline 25 Oct 2025 | Viewed by 111 | Submission Open
Keywords: single nucleotide variants; polymorphism; mutations; microRNAs; HLA genes; cytokine gene; DNA methylation; rheumatoid arthritis; systemic lupus erythematosus; exposome
(This special issue belongs to the Section Epigenomics)
Genetics of Host–Pathogen Interactions
edited by and Sara Zaldívar López
submission deadline 25 Oct 2025 | Viewed by 104 | Submission Open
Keywords: pathogen virulence factors; infection susceptibility; immune evasion; genomics of infectious diseases; host– pathogen co-evolution; host– pathogen dynamics; microbiome– host interactions; emerging infectious diseases; crispr and gene editing in host– pathogen studies; transcriptomics and gene expression profiling
(This special issue belongs to the Section Molecular Genetics and Genomics)
Opportunities and Prospects of Cancer Gene Therapy
edited by Ruoxi Zhang
submission deadline 25 Oct 2025 | Viewed by 90 | Submission Open
Keywords: cancer gene therapy; tumor suppressor gene activation; oncogene inhibition; suicide gene therapy; antiangiogenic gene therapy; immunogenic therapy; viral and non-viral vectors; targeted gene delivery; translational cancer research
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
The Opportunities and Challenges of Next-Generation Sequencing in Cancer Biology
edited by and Taslim Al-Hilal
submission deadline 25 Oct 2025 | Viewed by 71 | Submission Open
Keywords: bioinformatics; DNA-seq; RNA-seq; Chip-seq; epigenomics
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
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