Chromatin Modifications and RNA-Based Regulation of Gene Expression
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 25 March 2026 | Viewed by 19
Special Issue Editor
Special Issue Information
Dear Colleagues,
RNA molecules are increasingly recognized as active regulators of transcription, adding new dimensions to classical transcription factor and chromatin-based control. During initiation, nascent RNAs can act as a “trapping mesh”, retaining transcription factors in the vicinity of their DNA binding sites, increasing their binding turnover through a local high concentration effect. Architectural proteins such as CTCF rely on RNA binding to maintain certain chromatin loops, while other transcription factors engage RNA directly through canonical or non-canonical RNA-binding domains. Concurrently, RNA modifications occur co-transcriptionally in chromatin contexts. The m6A writer complex, guided by histone marks such as H3K36me3, deposits methylation on newly synthesized transcripts. These marks, read by nuclear proteins, feed back on chromatin by recruiting histone modifiers, thereby linking RNA methylation with chromatin state and transcriptional output. During elongation, RNA itself modulates the phosphorylation dynamics of RNA polymerase II, influencing the activity of cofactors such as P-TEFb. Transcription-coupled deposition of histone modifications further integrates RNA splicing, as chromatin marks recruit components of the spliceosome, ensuring coordination between RNA processing and elongation. Finally, termination also engages RNA-based mechanisms. RNA helicases help couple RNA modifications with genome stability, while interactions with RNA-binding proteins shape the final stages of transcript maturation. Together, these discoveries establish RNA as an integral partner of chromatin modifications, creating feedback loops that fine-tune gene expression across all stages of transcription.
Dr. Alonso Javier Pardal
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- chromatin modifications
- RNA
- gene expression
- transcription
- chromatin boundaries
- RNA-binding proteins
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.