Genetics and Genomics of Aging and Longevity, Pathways and Response to Nutrients in Mammals and Simple Model Organisms
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: 30 March 2026 | Viewed by 20
Special Issue Editor
Interests: nutrition; aging; longevity; signal transduction pathways; cancer; molecular nutrition
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
While aging is unavoidable, lifespans differ even between closely related species. This suggests that minor genetic variations may have a significant impact on survival. The past decades of basic research on longevity identified genes and several mechanisms involved in the aging process. The free radical theory and other simple mechanisms of aging have thus been overridden by a more complex scenario where evolutionarily conserved genes and pathways affect longevity through specific “aging programs”. Although subtle differences between species exist, the key players involved in age progression are DNA repair, heat shock proteins, insulin/IGF1/TOR, SIRT family genes, and long non-coding RNAs. However, despite the inherited genetic factors, the modulation of these pathways by external stimuli is already possible and appears to be a more feasible strategy to counteract the derangement of physiological function driven by the aging process. Nutriepigenome and nutrient cellular and metabolic responses are now areas of interest that promise to uncover the mechanisms of lifespan.
Dr. Mario G. Mirisola
Guest Editor
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Keywords
- nutrigenetics
- nutrigenomics
- signal transduction
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