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Genes, Volume 16, Issue 10

October 2025 - 123 articles

Cover Story: RNA-targeting techniques have emerged as powerful tools in cancer research, offering precise and programmable control over gene expression. Once considered passive messengers, RNA molecules are now recognized as critical regulators of cellular function, involved in oncogenesis, drug resistance, and tumor progression. This review offers a comparative analysis of key RNA-targeting strategies—including antisense oligonucleotides, RNA interference, CRISPR-Cas13, and RNA-binding molecules—focusing on their mechanisms, therapeutic potential, and limitations. We highlight their significant impact in precision oncology, recent FDA approvals, and ongoing clinical trials, underscoring their promise in next-generation cancer therapeutics. View this paper
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Articles (123)

  • Review
  • Open Access
721 Views
18 Pages

Imprinting Disorders and Epigenetic Alterations in Children Conceived by Assisted Reproductive Technologies: Mechanisms, Clinical Outcomes, and Prenatal Diagnosis

  • Antonella Gambadauro,
  • Valeria Chirico,
  • Francesca Galletta,
  • Ferdinando Gulino,
  • Roberto Chimenz,
  • Giorgia Serraino,
  • Immacolata Rulli,
  • Alessandro Manganaro,
  • Eloisa Gitto and
  • Lucia Marseglia

21 October 2025

Assisted reproductive technologies (ARTs) have revolutionized infertility treatment, leading to the birth of over 10 million children worldwide. Despite their success, increasing concerns have been expressed regarding the potential long-term outcomes...

  • Article
  • Open Access
388 Views
17 Pages

Comparative Analysis of Araceae Mitochondrial Genomes: Implications for Adaptation to Ecological Transitions in Plants

  • Yuxiao Chen,
  • Shuai Gao,
  • Jieqiong Wang,
  • Xin Cheng,
  • Yue Chen,
  • Veeranjaneyulu Chinta and
  • Shenglong Kan

21 October 2025

Background/Objectives: Plant mitogenomes display remarkable variation in size, structure, and gene content, yet their evolutionary causes remain unclear. Araceae, the most significant family within Alismatales, encompasses both aquatic and terrestria...

  • Article
  • Open Access
349 Views
10 Pages

Mutation of the Thyroid Hormone Receptor Beta Gene (THRB) Causes Vitelliform Macular Dystrophy with High Intrafamilial Variability

  • Elisa A. Mahler,
  • Lars C. Moeller,
  • Katharina Wall,
  • Marlene Saßmannshausen,
  • Bettina Kron,
  • Hanno J. Bolz,
  • Frank G. Holz and
  • Philipp Herrmann

20 October 2025

Background/Objectives: Herein, we report the clinical cases of two affected first-degree relatives from a family with highly variable macular dystrophy, expanding the known phenotype spectrum with mutations in the thyroid hormone receptor beta gene (...

  • Article
  • Open Access
441 Views
16 Pages

SARS-CoV-2 Infection of Lung Epithelia Leads to an Increase in the Cleavage and Translocation of RNase-III Drosha; Loss of Drosha Is Associated with a Decrease in Viral Replication

  • Michael T. Winters,
  • Emily S. Westemeier-Rice,
  • Travis W. Rawson,
  • Kiran J. Patel,
  • Gabriel M. Sankey,
  • Maya Dixon-Gross,
  • Olivia R. McHugh,
  • Nasrin Hashemipour,
  • McKenna L. Carroll and
  • Isabella R. Wilkerson
  • + 1 author

20 October 2025

Background/Objectives: Since its emergence, COVID-19—caused by the novel coronavirus SARS-CoV-2—has affected millions globally and led to over 1.2 million deaths in the United States alone. This global impact, coupled with the emergence o...

  • Article
  • Open Access
430 Views
14 Pages

19 October 2025

Background: Inbreeding is a major genetic problem that reduces fertility and causes genetic disorders. Some breeders of dromedary camels use the same bull for many years due to its excellent characteristics, leading to mating with offspring and subse...

  • Article
  • Open Access
425 Views
20 Pages

Genome-Wide Identification of GATA Family Genes and Functional Analysis of IbGATA17 Under Drought Stress in Sweetpotato

  • Yinghui Yang,
  • Ruitao Liu,
  • Qingchang Liu,
  • Shaozhen He,
  • Shaopei Gao,
  • Huan Zhang,
  • Ning Zhao and
  • Hong Zhai

19 October 2025

Background/Objectives: GATA transcription factors play pivotal roles in regulating plant growth and development, physiological metabolism, and responses to environmental stress. However, research on GATA genes in sweetpotato remains limited. Methods:...

  • Article
  • Open Access
349 Views
15 Pages

19 October 2025

Background: The family Sperchontidae Thor, 1900 is proposed as a transitional group between the “lower” and “higher” water mites (Subcohort Hydrachnidiae), and is important for understanding the evolutionary history of Hydrach...

  • Article
  • Open Access
310 Views
18 Pages

Cadmium Stress Response of ABC Transporters in Ligusticum chuanxiong: Genome-Wide Identification and Bioinformatic Characterization

  • Yun Zhen,
  • Xiang Chen,
  • Ruoshi Li,
  • Shunlu Chen,
  • Can Wang,
  • Chi Song,
  • Guihua Jiang and
  • Xianmei Yin

18 October 2025

Background: Ligusticum chuanxiong Hort. is a well-known traditional Chinese medicinal herb whose clinical application and international trade had been constrained by cadmium (Cd) contamination. However, the molecular mechanisms underlying its respons...

  • Article
  • Open Access
281 Views
16 Pages

18 October 2025

Background: Cryptochromes (CRYs) are not only blue-light receptors in plants but also participate in abiotic stress responses, making them essential for plant growth and development. Methods: In this study, the CRY gene family in potato (StCRY) was i...

  • Brief Report
  • Open Access
301 Views
7 Pages

CRISPR/Cas Tools for the Detection of Borrelia sensu lato in Human Samples

  • Ermanno Nardon,
  • Eros Azzalini,
  • Dino Paladin,
  • Diego Boscarino and
  • Serena Bonin

18 October 2025

Background/Objectives: Lyme disease diagnosis remains challenging due to the limitations of current methods. While PCR-based assays are widely used, their sensitivity can be affected by sample type and the inhibition of host DNA. This study aimed to...

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Genes - ISSN 2073-4425Creative Common CC BY license