Epigenetic Dynamics in Cancer and Aging
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Epigenomics".
Deadline for manuscript submissions: 30 October 2025 | Viewed by 78
Special Issue Editor
Special Issue Information
Dear Colleagues,
Epigenetic alterations, including DNA methylation, histone modifications, and chromatin remodeling, play a critical role in the initiation, progression, and metastasis of cancer. These modifications not only drive tumorigenesis but also influence patient responses to cancer therapies, including chemotherapy, immunotherapy, and targeted therapies.
We invite submissions of novel research, comprehensive reviews, and interdisciplinary insights that bridge the gap between epigenetics, cancer biology, and precision medicine. We particularly welcome manuscripts with a strong focus on epigenetics, especially those that highlight recent technological advances, such as single-cell epigenetics, long-read sequencing, and artificial intelligence. In this Special Issue, we aim to explore the following topics:
- Epigenetic Mechanisms in Cancer Initiation and Development: The role of epigenetic modifications in driving the transformation of normal cells into cancerous cells.
- Cancer Epigenetics and Tumor Microenvironment: Interactions between epigenetic alterations and the tumor microenvironment, including immune evasion and resistance mechanisms.
- Epigenetic Biomarkers for Cancer Diagnosis and Prognosis: Identification and validation of epigenetic markers that can serve as diagnostic, prognostic, or predictive tools in clinical settings.
- Epigenetic Therapies in Cancer: New approaches and challenges in targeting epigenetic modifications for cancer treatment, including small molecules, gene editing tools, and epigenetic drugs.
- Precision Medicine and Epigenetics: Integrating epigenetic profiles into personalized treatment plans and predicting therapeutic responses based on epigenetic alterations.
- Epigenetic Reprogramming in Cancer Stem Cells: Investigating the role of epigenetic changes in cancer stem cell biology and their contribution to tumor relapse and metastasis.
- Single-Cell Epigenetics in Identifying Rare Cell Populations: Identifying rare cell populations, particularly in cancer biology, is crucial as they can drive tumor initiation, metastasis, and resistance to therapy. Single-cell technologies play a critical role in detecting these rare cells, which are often difficult to identify using traditional bulk tissue analysis.
Dr. Hayan Lee
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- DNA methylation
- histone modification
- chromatin 3D modeling
- non-coding RNA
- long-read sequencing technology
- single-cell epigenetics
- cancer initiation and development
- epigenetic alterations in the aging process
- aging-specific epigenetic alterations
- cancer-specific epigenetic alterations
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
