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Genes publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Genomic and Molecular Landscapes of Cardiac Remodeling and Heart Failure

edited by Dorota Ciołczyk-Wierzbicka

submission deadline 20 Apr 2026 | Viewed by 108 | Submission Open

Keywords: heart failure; genomics; transcriptomics; epigenetics/chromatin remodeling; non-coding RNAs; myocardial fibrosis; cardiac regeneration; multi-omics & AI-driven bioinformatics; precision cardiology; translational therapeutics

(This special issue belongs to the Section Genetic Diagnosis)

Genetic Insights into Aging and Age-Related Diseases

edited by Monica Sanchez-Contreras

submission deadline 20 Apr 2026 | Viewed by 36 | Submission Open

Keywords: somatic mutations; aging; genomic instability; DNA damage; neurodegeneration; cancer

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic and Molecular Mechanisms in Animal Reproduction

edited by

Xianfeng Yu

submission deadline 20 Apr 2026 | Viewed by 26 | Submission Open

Keywords: gamete; embryo; gene regulation; epigenetics; cloning; IVP; ET

(This special issue belongs to the Section Animal Genetics and Genomics)

Application of Genome-Wide Association Studies in Rare Diseases Research

edited by Menglu Liang and

Andrzej Ciechanowicz

submission deadline 25 Apr 2026 | Viewed by 407 | Submission Open

Keywords: rare disease genetics; statistical methods; genomic association; small sample inference; polygenic risk scores; cross-ancestry GWAS; gene– gene interaction; gene– environment interaction; disease biomarkers; precision medicine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

The Origin and Evolution of Genetic Code

edited by

Kenji Ikehara

submission deadline 25 Apr 2026 | Viewed by 40 | Submission Open

Keywords: origin of the genetic code; evolution of the genetic code; origin of gene; evolution of gene; origin of protein; evolution of protein; origin of life; evolution of life

(This special issue belongs to the Section Molecular Genetics and Genomics)

Gene-Regulated Signaling Pathways in Cancer

edited by Alexander Damalas

submission deadline 25 Apr 2026 | Viewed by 20 | Submission Open

Keywords: caveolin-1 (CAV1); caveolae; Ras; EMT; invasion; MAPK; PI3K-Akt; membrane curvature (MC)

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Linking Phenotypic and Molecular Evolution: Mechanisms and Models

edited by Wen Wei

submission deadline 25 Apr 2026 | Viewed by 20 | Submission Open

Keywords: genomic and phenotypic evolution; adaptive evolution; selection and genetic drift; genotype– phenotype– fitness landscape; accumulation of mutations; evolvability of complex traits; molecular evolution drivers; transcriptomic agaianst protein-coding evolution; experimental evolution

(This special issue belongs to the Section Population and Evolutionary Genetics and Genomics)

Advancing Crop Quality with Genomics, Genetics and Biotechnology

edited by

Xiquan Gao

and

José A. Mercado

submission deadline 25 Apr 2026 | Viewed by 15 | Submission Open

Keywords: crop quality; high throughput phenotyping; genome editing; genomic selection; nutritional quality; postharvest traits; precision breeding

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetic Mechanisms and Functional Insights in Microbiome Research

edited by

Tsute Chen

submission deadline 25 Apr 2026 | Viewed by 10 | Submission Open

Keywords: microbiome; marker genes; genomics; meta-genomics; meta-transcriptomics; proteomics; meta-proteomics; metabolomics; functional microbiome; microbiome-host interaction; microbiome-environment interaction; genetic mechanism

(This special issue belongs to the Section Microbial Genetics and Genomics)

Genomics and Evolution of Plant Pathogenic Fungi

edited by Shuming Luo

submission deadline 25 Apr 2026 | Viewed by 6 | Submission Open

Keywords: fungi; virulence mutation; genomic characterization; gene sequencing; population genomics; comparative phylogenetic analysis; genetics and breeding

(This special issue belongs to the Section Microbial Genetics and Genomics)

Genetic Mechanisms of Synaptic Plasticity in Neuropsychiatric Disorders

edited by Lace Riggs

submission deadline 25 Apr 2026 | Viewed by 5 | Submission Open

Keywords: synaptic plasticity; neuropsychiatric disorders; autism spectrum disorder; schizophrenia; depression; epigenetic regulation; synaptic signaling; circuit dysfunction; gene– circuit interactions; molecular neuroscience; translational neurogenetics; epigenetics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics of Intracerebral Hemorrhage

edited by Marialuisa Zedde and Rosario Pascarella

submission deadline 30 Apr 2026 | Viewed by 292 | Submission Open

Keywords: ICH; SVD; cavernous angioma; H-CAA; neuroimaging

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Diagnosis, Management and Therapy of Rare Diseases

edited by Giorgia Girotto

submission deadline 30 Apr 2026 | Viewed by 210 | Submission Open

Keywords: rare and ultrarare genetic diseases; genetic mechanisms; gene-tailored management; personalized therapeutic approaches

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Epigenetic Insights into Stress-Related Disorders

edited by Lei Cao

submission deadline 5 May 2026 | Viewed by 130 | Submission Open

Keywords: stress; epigenetics; stress-related disorders; intervention; resilience

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Fetal Genetic Disorders: Prenatal Genomics for Diagnosis and Clinical Management

edited by

Katia Margiotti

submission deadline 10 May 2026 | Viewed by 108 | Submission Open

Keywords: prenatal diagnosis; genomic testing; NGS analysis; variant classification; pathogenic variants; precision medicine; fetal genetics; clinical utility

(This special issue belongs to the Section Genetic Diagnosis)

Genetic Insights into Pediatric Neurological Disorders: From Mechanisms to Therapies

edited by Ji Yoon Han

submission deadline 15 May 2026 | Viewed by 145 | Submission Open

Keywords: pediatric neurological disorders; neurogenetics; multi-omics integration; precision medicine; brain organoid models

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Studies of Cancer Therapy

edited by Nikos G. Gavalas

submission deadline 15 May 2026 | Viewed by 65 | Submission Open

Keywords: genetics; cancer; oncology; genetic variations; response; treatment; epigenetics; genomics; biomarkers; modifications

(This special issue belongs to the Section Molecular Genetics and Genomics)

The Spatial Organisation of Chromosomes and Genes

edited by Yu Liu and Lingluo Chu

submission deadline 15 May 2026 | Viewed by 17 | Submission Open

Keywords: 3D genome; cohesin; CTCF; TAD; compartment; loop extrusion; gene regulation; enhancer– promoter interactions

(This special issue belongs to the Section Molecular Genetics and Genomics)

Application and Advances in Statistical Genetics

edited by

Zhongxue Chen

submission deadline 20 May 2026 | Viewed by 70 | Submission Open

Keywords: statistics genetics; causal inference; meta-analysis; Mendelian randomization; machine learning; genotype; phenotype; GWAS

(This special issue belongs to the Section Bioinformatics)

Novel Strategies in Forensic Genetics

edited by

Marie Allen

submission deadline 20 May 2026 | Submission Open

Keywords: foresic DNA analysis; sample collection; DNA extraction; novel DNA markers; MPS; bioinformatics

(This special issue belongs to the Section Technologies and Resources for Genetics)

Innovations in Aquaculture Breeding via Genetic Technologies

edited by

Lei Liu

submission deadline 25 May 2026 | Submission Open

Keywords: aquaculture species; molecular breeding; genomic; behavioral traits; reproduction and development; genome editing; whole-genome sequencing

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetic Basis of Pig Breeding and Regulation of Meat Production Efficiency and Quality Control

edited by

Mailin Gan

and Liyuan Shen

submission deadline 10 Jun 2026 | Viewed by 50 | Submission Open

Keywords: pig; meat; molecular mechanism; multi-omics; production efficiency

(This special issue belongs to the Section Animal Genetics and Genomics)

Targeting RNA Coding Mechanisms in Disease Molecular Pathways

edited by

Wangyong Yang

submission deadline 15 Jun 2026 | Viewed by 122 | Submission Open

Keywords: RNA therapeutics; RNA modifications (epitranscriptomics); non-coding RNA (ncRNA); alternative splicing; RNA-binding proteins (RBPs); RNA-targeted small molecules; gene therapy; molecular pathways; disease biomarkers; RNA vaccines

(This special issue belongs to the Section RNA)

Genetics and Genomics in Cancer

edited by

Rina Kansal

submission deadline 20 Jun 2026 | Viewed by 32 | Submission Open

Keywords: solid tumors; breast cancer; colon cancer; lung cancer; prostate cancer; gastrointestinal; gynecologic cancer; genitourinary cancers; brain tumors; hematolymphoid neoplasms; myeloid neoplasms; lymphoid neoplasms; hereditary cancer; precision medicine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genomic and Transcriptomic Advances in Amyotrophic Lateral Sclerosis (ALS) and Motor Neuron Diseases (MND)

edited by

Francesca Dragoni

and

Stella Gagliardi

submission deadline 5 Jul 2026 | Viewed by 134 | Submission Open

Keywords: ALS ; transcriptomic studies ; motor neuron diseases ; biomarkers assessment ; pathomechanisms ; genetics ; genotype– phenotype correlation

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Buffalo Genetics and Genomics

edited by

Qingyou Liu

and Laiba Shafique

submission deadline 15 Aug 2026 | 4 articles | Viewed by 6975 | Submission Open

Keywords: buffaloes; ruminant; genomics; genetics; evolution; structural characterization

(This special issue belongs to the Section Animal Genetics and Genomics)

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