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Genes publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Forensic DNA Profiling: PCR Techniques and Innovations

edited by

António Amorim

and

Laura Mendes Cainé

submission deadline 5 Dec 2026 | 3 articles | Viewed by 4268 | Submission Open

Keywords: forensic DNA profiling; PCR-based forensics; DNA analysis; next-generation sequencing; short tandem repeat (STR); Y-STR; single-nucleotide polymorphisms (SNPs); Y-SNP

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics and Epigenetics of Colorectal Cancer

edited by Kevin Tong

submission deadline 5 Dec 2026 | Viewed by 176 | Submission Open

Keywords: colorectal cancer; genetics; epigenetics; targeted treatment; genome-wide association studies

(This special issue belongs to the Section Epigenomics)

Genetic and Breeding Improvement of Horticultural Crops

edited by

Zhiqiang Wu

and

Xiaoni Zhang

submission deadline 10 Dec 2026 | 5 articles | Viewed by 3911 | Submission Open

Keywords: chloroplast genome; mitochondrial genome; nuclear genome; gene family evolution; functional genomics; genome editing; molecular breeding; horticultural crops

(This special issue belongs to the Section Plant Genetics and Genomics)

The Role of Non-Coding RNA in Cancer

edited by Amil M. Shah

submission deadline 10 Dec 2026 | 2 articles | Viewed by 2414 | Submission Open

Keywords: non-coding RNA (ncRNA); ncRNA classification; ncRNA biogenesis; ncRNA functions; diagnostic and prognostic biomarkers; targeted therapy; nucleic acid-based therapy; cell regulatory networks; cancer attractor states; computational network models; omics technology (single-cell RNA-seq; spatial transcriptomics; and single-cell multi-omics)

(This special issue belongs to the Section RNA)

Genetics and Genomics in Physical Activity, Sports and Injury

edited by

Jon Brazier

, Mark Antrobus and

Alun Williams

submission deadline 10 Dec 2026 | Viewed by 273 | Submission Open

Keywords: sport genetics; musculoskeletal injury; athletic performance; physical activity; exercise; genomics; epigenetics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Beyond Genomics: Leveraging Epigenomics for the Genetic Improvement of Crops

edited by Qiutao Xu and

Xuan Ma

submission deadline 10 Dec 2026 | Viewed by 53 | Submission Open

Keywords: epigenomics; DNA methylation; histone modifications; crop improvement; yield; abiotic stress resilience; transcriptional regulation; molecular breeding

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetic Dissection of Plant Responses to Biotic and Abiotic Stresses: From Gene Discovery to Functional Mechanisms

edited by Wangsheng Zhu

submission deadline 15 Dec 2026 | 1 articles | Viewed by 641 | Submission Open

Keywords: GWAS; genetic variation; gene identification; stress-responsive genes; plant– pathogen interaction

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetics of Head and Neck Disorders

edited by Christos Yapijakis

submission deadline 15 Dec 2026 | Viewed by 233 | Submission Open

Keywords: head and neck pathology; craniofacial genetics; orofacial genetics; developmental genetics; neurogenetics; cancer genetics; genomics and gene variation; epigenetics; personalized medicine and dentistry; genetic counseling and ethics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics and Breeding in Forest Trees

edited by Liwen Wu

submission deadline 15 Dec 2026 | Viewed by 10 | Submission Open

Keywords: germplasm utilization; tree genetics; tree breeding; genomics; molecular breeding; genomic selection; gene editing; trait improvement; genetic function and genetic network

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetic and Molecular Mechanisms of Rare Monogenic Disorders

edited by

Massimiliano Chetta

submission deadline 15 Dec 2026 | Viewed by 7 | Submission Open

Keywords: rare monogenic disorders; functional genomics; genotype–phenotype correlation; next-generation sequencing; multi-omics integration; epigenetic regulation; RNA splicing defects; gene therapy; precision medicine; molecular pathogenesis

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Rare Genetic Disorders: Molecular Diagnosis, Pathogenesis Insights and Precision Medicine Treatment

edited by

Francesca Clementina Radio

submission deadline 15 Dec 2026 | Submission Open

Keywords: genetic disorders; rare disease; neurodevelopmental disorder; genotype-phenotype correlations; precision medicine; genomics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advances in Ophthalmic Genetics

edited by

Se Joon Woo

submission deadline 20 Dec 2026 | Viewed by 132 | Submission Open

Keywords: inherited eye diseases; inherited retinal diseases; retinitis pigmentosa; macular dystrophy; cone dystrophy; genotype; gene therapy; clinical trial; imaging; genetic mechanism; genome editing; phenotype

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics and Genomics in Aquaculture and Fisheries

edited by

Hongyan Wang

submission deadline 20 Dec 2026 | Viewed by 120 | Submission Open

Keywords: genetics and genomics; aquaculture; disease resistance; genomic selection/breeding; functional genomics/multi-omics; sustainable aquatic food production

(This special issue belongs to the Section Animal Genetics and Genomics)

Feature Papers in Toxicogenomics

edited by

Gary Hardiman

submission deadline 20 Dec 2026 | Viewed by 99 | Submission Open

Keywords: single-cell; spatial; and multi-omics toxicogenomics; adverse outcome pathways (AOPs) and mechanism-based toxicity frameworks; translational toxicogenomics and regulatory science applications

(This special issue belongs to the Section Toxicogenomics)

Feature Papers in "Neurogenetics and Neurogenomics": 2026

edited by

Claudia Ricci

and Micheal Palladino

submission deadline 25 Dec 2026 | 7 articles | Viewed by 4226 | Submission Open

Keywords: genomics; neurological diseases; multi-omics studies; brain development and function; precision medicine; pathogenic mechanisms

(This special issue belongs to the Section Neurogenomics)

Feature Papers: Molecular Genetics and Genomics 2026

edited by

Albert Jeltsch

and

Paolo Cinelli

submission deadline 25 Dec 2026 | 1 articles | Viewed by 692 | Submission Open

Keywords: single-cell and spatial omics; genome-targeted RNA therapeutics and diagnostics; next-generation CRISPR genome and epigenome editing; chromatin remodeling and dynamics; epigenetics; DNA methylation; histone modification; histone code; DNA replication; repair; recombination; mobile DNA; mitochondrial DNA; RNA biology and molecular regulation; molecular mechanisms of cell signaling; signal transduction; cell cycle; cell death; and stem cell regulation; post-transcriptional regulation of gene expression; developmental genetics; AI-powered genomics and genetics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Gene Family Evolution and Functional Genomics in Medicinal, Aromatic, and Tropical Plants

edited by

Xiao-Lu Chen

and

Ying Liu

submission deadline 25 Dec 2026 | Viewed by 8 | Submission Open

Keywords: gene family evolution; gene family analysis; functional genomics; genome-wide identification; comparative genomics; medicinal plants; aromatic plants; tropical and subtropical plants; transcriptomics; metabolomics; specialized metabolite biosynthesis; terpenoid biosynthesis; stress response; environmental adaptation; developmental regulation

(This special issue belongs to the Section Plant Genetics and Genomics)

Feature Papers in the Population and Evolutionary Genetics and Genomics Field 2026

edited by

Zissis Mamuris

and

Maria-Anna Kyrgiafini

submission deadline 31 Dec 2026 | 2 articles | Viewed by 1975 | Submission Open

Keywords: population genetics; evolutionary genomics; genetic diversity; adaptation; natural selection

(This special issue belongs to the Section Population and Evolutionary Genetics and Genomics)

Feature Papers in Microbial Genetics and Genomics 2026

edited by

Jose María Requena

submission deadline 31 Dec 2026 | 1 articles | Viewed by 399 | Submission Open

Keywords: virus; bacteria; protists; parasites; genomics; transcriptomics; genetics; drug resistance; molecular evolution; data re-analysis

(This special issue belongs to the Section Microbial Genetics and Genomics)

Feature Papers in Human Genomics and Genetic Diseases 2026

edited by

Mariarosa Anna Beatrice Melone

and

Gil Atzmon

submission deadline 31 Dec 2026 | Viewed by 290 | Submission Open

Keywords: genetics of monogenic diseases and complex diseases; genotype– phenotype relationships; population genomics and genetic epidemiology; precision medicine; pharmacogenetics and pharmacogenomics; targeted genome editing; gene therapy and delivery systems; genetically engineered cell therapy; RNA- and small nucleic acid-based therapeutics; genetic testing and molecular diagnostics; biomarker development and application; genome-wide association studies; epigenetic therapy; developmental genetics; epigenetics; and epigenomics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Feature Papers in the RNA Field

edited by

Isabelle Behm-Ansmant

and

Christiane Branlant

submission deadline 31 Dec 2026 | Viewed by 287 | Submission Open

Keywords: tRNAs; rRNAs; mRNAs; miRNAs; lncRNAs; sRNAs; siRNAs; RNA epigenetics; RNA modifications; RNA secondary and tertiary structure; viral RNAs; RNA binding proteins; RNA transcription; RNA translation

(This special issue belongs to the Section RNA)

Virus Ecology, Diversity and Evolution Through the Lens of Genomics

edited by

Ken Stedman

and Ignacio de la Higuera

submission deadline 31 Dec 2026 | Viewed by 222 | Submission Open

Keywords: virus ecology; viral diversity; virus evolution; viromics; eco-genomics; metagenomics

(This special issue belongs to the Section Viral Genomics)

Feature Papers in the ‘Animal Genetics and Genomics’ Section—2026

edited by

Antonio Figueras

and

Pedro Lorite Martínez

submission deadline 31 Dec 2026 | Viewed by 73 | Submission Open

Keywords: applied genetics and genomics in species of economic importance; companion animal genetics and genomics; breeding and genetic selection; genetics and genomics of aquaculture species; genetics of immune response and disease resistance; genome-edited animals and animal epigenetics; animal population genetics; polymorphisms and genome annotation; genetics applied to the interaction of the microbiome and genetic traits of interest; bioinformatics analysis in animal genetics; genomics and evolution; cytogenomics

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetic Regulation and Molecular Basis of Plant Abiotic Stress Tolerance

edited by

Zhiming Yu

and

Yifeng Wang

submission deadline 31 Dec 2026 | Viewed by 11 | Submission Open

Keywords: abiotic stress; receptors; calcium channels; secondary messengers; reactive oxygen species; phytohormone metabolism; transcription factors; epigenetic mechanism; RNA signaling; hormone-signaling pathways; functional genomics; genome-wide association studies; precise genome-editing tools; integrated multi-omics; systems biology

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetic and Genomic Insights into the Pathogenesis of Kidney Disease

edited by Grazia Maria Virzi

submission deadline 10 Jan 2027 | Viewed by 190 | Submission Open

Keywords: kidney disease; genomics; genetics; molecular pathogenesis; precision medicine; rare nephropathies; common nephropathies; omics technologies

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Insights and Molecular Pathways in Alzheimer's Disease: Unveiling the Complexity of Neurodegeneration

edited by Marta Rusek and

Alessandro Romano

submission deadline 15 Jan 2027 | 1 articles | Viewed by 1316 | Submission Open

Keywords: Alzheimer’ s disease; neurodegeneration; amyloid-β pathology; tau pathology; APOE ε 4; APP; PSEN1; PSEN2; GWAS; neuroinflammation; mitochondrial dysfunction; oxidative stress; proteostasis; precision medicine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Application of Molecular or Genetic Markers in Liquid Biopsy for Urogenital Cancers

edited by

Guorong Li

submission deadline 25 Jan 2027 | 1 articles | Viewed by 2623 | Submission Open

Keywords: liquid biopsy; extracellular vesicle; exosome; biotechnology; precision medicine/personalized medicine; diagnosis/screening; urogenital cancer

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances in Insect Mitochondrial Genomics and Molecular Phylogenetics

edited by Nan Song

submission deadline 10 Feb 2027 | Viewed by 20 | Submission Open

Keywords: mitogenome; insects; gene rearrangement; gene order; phylogeny; evolution; taxonomy; systematics; next-generation sequencing

(This special issue belongs to the Section Animal Genetics and Genomics)

Population Studies on the Genetic Diversity and Evolutionary Adaptability of Amphibian and Reptile Genomes

edited by

Wei Chen

Jie Wang

and Buddhi Dayananda

submission deadline 15 Feb 2027 | Viewed by 20 | Submission Open

Keywords: amphibians; reptiles; population genomics; genetic diversity; evolutionary adaptability; conservation genetics; local adaptation; gene flow; demographic history; climate change

(This special issue belongs to the Section Population and Evolutionary Genetics and Genomics)

Evolutionary Cytogenetics and Phylogenetics of Insects

edited by

Pedro Lorite Martínez

and

Sebastian Pita

submission deadline 15 Feb 2027 | Viewed by 1 | Submission Open

Keywords: evolutionary cytogenetics; insect phylogenetics; cytogenomics; chromosome evolution; sex chromosomes; B chromosomes; repetitive DNA; chromosomal rearrangements; comparative cytogenetics; genome evolution

(This special issue belongs to the Section Animal Genetics and Genomics)

Selected Papers from the 3rd International Online Conference on Genes (IOCGE 2026)

edited by

Silvia Turroni

and

Selvarangan Ponnazhagan

submission deadline 15 Mar 2027 | Viewed by 280 | Submission Open

Keywords: non-coding RNAs in health and disease; advances in the diagnosis; treatment; and prevention of genetic disorders; microbial genetics and metagenomics; epigenetics and chromatin remodeling; cancer genetics; applications of machine learning and bioinformatics; population genetics and genetic epidemiology; pharmacogenomics

Innovations in Aquaculture Breeding via Genetic Technologies

edited by

Lei Liu

submission deadline 5 Apr 2027 | 1 articles | Viewed by 1109 | Submission Open

Keywords: aquaculture species; molecular breeding; genomic; behavioral traits; reproduction and development; genome editing; whole-genome sequencing

(This special issue belongs to the Section Animal Genetics and Genomics)

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