Special Issues

Genes publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Reviews in RNA: Mechanisms and Roles submission deadline 10 Mar 2026 | Viewed by 11 | Submission Open
Keywords: gene regulation; non-coding RNA; RNA world; RNA-related metabolism
(This special issue belongs to the Section RNA)
Epigenetic Regulation in Tumors
edited by
submission deadline 15 Mar 2026 | Viewed by 939 | Submission Open
Keywords: cancer epigenetics; epigenetic mechanisms; tumor microenvironment; epigenetic biomarkers; multi-omics and bioinformatics
(This special issue belongs to the Section Epigenomics)
Genetic Markers in Targeted Therapies: From Biomarker Discovery to Personalized Therapy
edited by
submission deadline 15 Mar 2026 | Viewed by 81 | Submission Open
Keywords: cancer diagnosis; molecular; cytogenetic biomarkers; genomic instability; cellular senescence; human disease; clinical applications; personalized therapy; theranostics
(This special issue belongs to the Section Molecular Genetics and Genomics)
Cancer Epigenetics: From Laboratory Studies and Clinical Trials to Precision Medicine
edited by Rajendra Pangeni
submission deadline 15 Mar 2026 | Viewed by 34 | Submission Open
Keywords: cancer; epigenetics; laboratory studies; tumor biology; precision medicine; clinical trials; therapy resistance; biomarkers; personalized care; therapeutic interventions
(This special issue belongs to the Section Epigenomics)
Epigenetic Landscape of Neurodevelopmental Disorders
edited by Bimal Jana
submission deadline 15 Mar 2026 | Viewed by 7 | Submission Open
Keywords: epigenetics; neurodevelopmental disorders (NDDs); DNA methylation; 3D genome architecture; histone modifications; non-coding RNA; autism spectrum disorder (ASD); Rett syndrome; neurodevelopment; gene-environment interaction; epigenetic biomarkers; single-cell epigenomics; epigenetic therapy
(This special issue belongs to the Section Neurogenomics)
Forensic DNA Profiling: PCR Techniques and Innovations submission deadline 16 Mar 2026 | Viewed by 177 | Submission Open
Keywords: forensic DNA profiling; PCR-based forensics; DNA analysis; next-generation sequencing; short tandem repeat (STR); Y-STR; single-nucleotide polymorphisms (SNPs); Y-SNP
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Genetic Mouse Models of Human Disease
edited by Jiale Wang
submission deadline 20 Mar 2026 | Viewed by 221 | Submission Open
Keywords: mouse models; human disease; genetic disorders; genome editing; CRISPR; inflammation; cancer biology; disease mechanisms; preclinical models; translational research
(This special issue belongs to the Section Molecular Genetics and Genomics)
The Role of Non-Coding RNA in Cancer
edited by Amil M. Shah
submission deadline 20 Mar 2026 | Viewed by 143 | Submission Open
Keywords: non-coding RNA (ncRNA); ncRNA classification; ncRNA biogenesis; ncRNA functions; diagnostic and prognostic biomarkers; targeted therapy; nucleic acid-based therapy; cell regulatory networks; cancer attractor states; computational network models; omics technology (single-cell RNA-seq; spatial transcriptomics; and single-cell multi-omics)
(This special issue belongs to the Section RNA)
RNA Biology and Diseases
edited by Sharon Moshitch-Moshkovitz
submission deadline 20 Mar 2026 | Viewed by 122 | Submission Open
Keywords: mechanisms of RNA processing; RNA modification and epitranscriptomics; regulatory RNAs; RNA-based therapy (ASOs; targeted modifications); RNA– protein interactions; non-coding RNAs and diseases; post-translational modifications in shaping the epitranscriptome; RNA structures and restructuring mechanisms
(This special issue belongs to the Section RNA)
Genetic Diagnosis and Genomics of Neurological Diseases
edited by and Penina Ponger
submission deadline 20 Mar 2026 | Viewed by 1 | Submission Open
Keywords: neurogenetics; hereditary neurological diseases; genetic diagnosis; genotype– phenotype correlation; next-generation sequencing; precision neurology; clinical genomics; diagnostic yield; genomic technologies; data-driven approaches
(This special issue belongs to the Section Genetic Diagnosis)
Genetic Mechanisms of Obesity
edited by
submission deadline 25 Mar 2026 | Viewed by 87 | Submission Open
Keywords: obesity; genetic mechanisms; epigenetics; DNA methylation; genome-wide association studies; multi-omics; transcriptomics; foundtional genomics; gene– environment interactions; childhood obesity; energy metabolism; precision medicine; gut microbiota
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Genetics and Genomics of Aging and Longevity, Pathways and Response to Nutrients in Mammals and Simple Model Organisms
edited by
submission deadline 30 Mar 2026 | Viewed by 153 | Submission Open
Keywords: nutrigenetics; nutrigenomics; signal transduction
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Application of CRISPR/Cas9 Technology in Insects
edited by
submission deadline 31 Mar 2026 | Viewed by 101 | Submission Open
Keywords: genome editing; gene targeting; CRISPR/Cas9; insect genetics; pest control; disease vector control; gene drive; off-target effects; delivery systems; ecological impact; transgenic insects; functional genomics
(This special issue belongs to the Section Animal Genetics and Genomics)
Conservation Genetics of Birds
edited by Robert Rutkowski
submission deadline 6 Apr 2026 | Viewed by 85 | Submission Open
Keywords: conservation genetics; birds; aves; endangered species; molecular markers; genetic diversity; genetic distance; isolated populations; non-invasive sampling; genetic monitoring; reintroduction; inbreeding; outbreeding; evolutionary significant units; management unit
(This special issue belongs to the Section Animal Genetics and Genomics)
Genetic Insights and Molecular Pathways in Alzheimer's Disease: Unveiling the Complexity of Neurodegeneration
edited by Marta Rusek and
submission deadline 10 Apr 2026 | Viewed by 90 | Submission Open
Keywords: Alzheimer’ s disease; neurodegeneration; amyloid-β pathology; tau pathology; APOE ε 4; APP; PSEN1; PSEN2; GWAS; neuroinflammation; mitochondrial dysfunction; oxidative stress; proteostasis; precision medicine
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Coordinating Regulation of Gene Expression in Cardiovascular Disease
edited by
submission deadline 10 Apr 2026 | Viewed by 4 | Submission Open
Keywords: microRNA; oxidative stress; cardiovascular disease; chronic obstructive pulmonary disease (COPD); pulmonary hypertension; gene regulation; inflammation; reactive oxygen species (ROS); molecular biomarkers; precision medicine
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Genetic and Genomic Advances in Livestock
edited by Karel Vališ
submission deadline 15 Apr 2026 | Viewed by 152 | Submission Open
Keywords: NGS; SNP calling; bioinformatic tools; livestock phenotype; livestock welfare
(This special issue belongs to the Section Animal Genetics and Genomics)
From Genes to Systems: Genetic and Epigenetic Control of the Metastatic Cascade
edited by Eric Rahrmann
submission deadline 15 Apr 2026 | Viewed by 92 | Submission Open
Keywords: cancer metastasis; genetic alterations; epigenetic reprogramming; tumor heterogeneity; lineage plasticity; metastatic niche formation; dormancy; circulating tumor cells (CTCs); immune evasion; therapy resistance; tumor microenvironment
(This special issue belongs to the Section Epigenomics)
Genomic and Molecular Landscapes of Cardiac Remodeling and Heart Failure
edited by Dorota Ciołczyk-Wierzbicka
submission deadline 20 Apr 2026 | Viewed by 61 | Submission Open
Keywords: heart failure; genomics; transcriptomics; epigenetics/chromatin remodeling; non-coding RNAs; myocardial fibrosis; cardiac regeneration; multi-omics & AI-driven bioinformatics; precision cardiology; translational therapeutics  
(This special issue belongs to the Section Genetic Diagnosis)
Diagnosis, Management and Therapy of Rare Diseases
edited by Giorgia Girotto
submission deadline 30 Apr 2026 | Viewed by 187 | Submission Open
Keywords: rare and ultrarare genetic diseases; genetic mechanisms; gene-tailored management; personalized therapeutic approaches
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Epigenetic Insights into Stress-Related Disorders
edited by Lei Cao
submission deadline 5 May 2026 | Viewed by 101 | Submission Open
Keywords: stress; epigenetics; stress-related disorders; intervention; resilience
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Genetic Studies of Cancer Therapy
edited by Nikos G. Gavalas
submission deadline 15 May 2026 | Viewed by 40 | Submission Open
Keywords: genetics; cancer; oncology; genetic variations; response; treatment; epigenetics; genomics; biomarkers; modifications
(This special issue belongs to the Section Molecular Genetics and Genomics)
Genetic Basis of Pig Breeding and Regulation of Meat Production Efficiency and Quality Control
edited by and Liyuan Shen
submission deadline 10 Jun 2026 | Viewed by 24 | Submission Open
Keywords: pig; meat; molecular mechanism; multi-omics; production efficiency
(This special issue belongs to the Section Animal Genetics and Genomics)
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