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Genes publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Genetic, Epigenetic and Environmental Factors in Dental Development and Pathologies: Genes, Interactions and Dental Development

edited by

Alan H. Brook

submission deadline 5 Jun 2026 | 21 articles | Viewed by 74587 | Submission Open

Keywords: dental development; genetics; epigenetics; complex adaptive systems; interactive networks

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genes and Pediatrics

edited by

Giorgia Ceravolo

and

Roberto Chimenz

submission deadline 5 Jun 2026 | 5 articles | Viewed by 9220 | Submission Open

Keywords: pediatric disease; genetic variant; clinical observation; diagnosis; patient care

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

The Genetics of Male Infertility and Clinical Implications

edited by

Gianmaria Salvio

submission deadline 5 Jun 2026 | 3 articles | Viewed by 4387 | Submission Open

Keywords: genetics; male infertility; azoospermia; next generation sequencing; genetic variants

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Biomarkers in Cancer: From Discovery to Clinical Application

edited by

Evangelos Koustas

submission deadline 5 Jun 2026 | 1 articles | Viewed by 2147 | Submission Open

Keywords: cancer; tumor biology; biomarkers; cancer therapy; targeted therapy

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Mechanisms of Plant Resistance to Biotic Stress

edited by

Zhuo Chen

submission deadline 5 Jun 2026 | 2 articles | Viewed by 1375 | Submission Open

Keywords: plant diseases; biotic stress; resistance genes; genetics; genomics; plant hosts

(This special issue belongs to the Section Plant Genetics and Genomics)

Single-Cell and Spatial Multi-Omics in Human Diseases

edited by

Xin Wang

submission deadline 10 Jun 2026 | 5 articles | Viewed by 10426 | Submission Open

Keywords: single-cell omics; spatial multi-omics; pathogenesis of disease; biomarkers; computational tools; integrative biology

(This special issue belongs to the Section Bioinformatics)

Genetic and Molecular Insights into Cardiovascular Disease: From Mechanisms to Precision Medicine

edited by

Lingfeng Luo

and

Laurent Metzinger

submission deadline 10 Jun 2026 | 7 articles | Viewed by 5629 | Submission Open

Keywords: cardiovascular disease; genetic variants; precision medicine; epigenetics; non-coding RNAs; polygenic risk scores; mendelian randomization; biomarkers; genome-wide association studies (GWASs); molecular mechanisms

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics and Epidemiology of Parasites

edited by

Joanna Da̧browska

submission deadline 10 Jun 2026 | 1 articles | Viewed by 1764 | Submission Open

Keywords: parasite genetics; parasite genomics; WGS; molecular epidemiology; zoonoses; virulence and pathogenesis; transmission dynamics; genetic diversity

(This special issue belongs to the Section Microbial Genetics and Genomics)

Genetic Basis of Pig Breeding and Regulation of Meat Production Efficiency and Quality Control

edited by

Mailin Gan

and Liyuan Shen

submission deadline 10 Jun 2026 | 1 articles | Viewed by 1151 | Submission Open

Keywords: pig; meat; molecular mechanism; multi-omics; production efficiency

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetics of Substance Use and Addictions

edited by

Eric R. Braverman

submission deadline 10 Jun 2026 | Viewed by 302 | Submission Open

Keywords: genetics of addiction; substance use disorders; dopamine; catecholamines; polygenic risk; epigenetics; neuroendocrine regulation; deep phenotyping; reward deficiency syndrome; GARS; gene– phenotype classification

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advances and Challenges in Forensic Genetics

edited by

Maria Helena Correia Dias

and

Venusia Cortellini

submission deadline 15 Jun 2026 | 8 articles | Viewed by 13945 | Submission Open

Keywords: DNA analysis; DNA methylation applications; biogeographic ancestry; age estimation approaches; discrimination of monozygotic twins; discrimination of tissues; next-generation sequencing; forensic cases

(This special issue belongs to the Section Molecular Genetics and Genomics)

Research Updates in Forensic Genetics

edited by Massimo Lancia

submission deadline 15 Jun 2026 | 3 articles | Viewed by 5247 | Submission Open

Keywords: next generation sequencing; single cell analysis; time since deposition; time since death; DNA phenotyping; biogeographic ancestry; age prediction; familial search; disaster victim identification; trace DNA contextualisation

(This special issue belongs to the Section Molecular Genetics and Genomics)

Plant Genetics, Evolution, Cytogenetics and Cytogenomics for Biodiversity Conservation

edited by

Eric Javier Martínez

Ana Isabel Honfi

and

Anna Reutemann

submission deadline 15 Jun 2026 | 3 articles | Viewed by 4188 | Submission Open

Keywords: plant conservation; cytogenetics; cytogenomics; plant evolution; population genetics; genome evolution; chromosomal variation; polyploidy; biodiversity; genomic resources

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetics and Genomics of Autism Spectrum Disorders

edited by

Roberto Canitano

and

Marco Carotenuto

submission deadline 15 Jun 2026 | 1 articles | Viewed by 2899 | Submission Open

Keywords: autism spectrum disorders; genetics; new techniques for diagnosis

(This special issue belongs to the Section Neurogenomics)

Systems Biology of Single Cells: Bridging Genomics and Functional Insights

edited by

Guilherme Targino Valente

submission deadline 15 Jun 2026 | 1 articles | Viewed by 1600 | Submission Open

Keywords: systems biology; graph theory; single-cell RNA-Seq; spatial transcriptomics; molecular networks; complex networks

(This special issue belongs to the Section Bioinformatics)

Targeting RNA Coding Mechanisms in Disease Molecular Pathways

edited by

Wangyong Yang

submission deadline 15 Jun 2026 | Viewed by 353 | Submission Open

Keywords: RNA therapeutics; RNA modifications (epitranscriptomics); non-coding RNA (ncRNA); alternative splicing; RNA-binding proteins (RBPs); RNA-targeted small molecules; gene therapy; molecular pathways; disease biomarkers; RNA vaccines

(This special issue belongs to the Section RNA)

Mitochondrial Genetics in Health and Disease

edited by Jing Wang

submission deadline 15 Jun 2026 | Viewed by 306 | Submission Open

Keywords: primary mitochondrial disorders; mitochondrial DNA; mitochondrial dysfunction; diagnosis; therapeutic approaches

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetics and Breeding of Forage—2nd Edition

edited by Maofeng Chai

submission deadline 15 Jun 2026 | Viewed by 293 | Submission Open

Keywords: forage genetic improvement; molecular breeding; abiotic stress; biotic stress; population genetics; multi-omics analysis; nutrition absorption

(This special issue belongs to the Section Plant Genetics and Genomics)

Research on Genetics and Breeding of Rice

edited by Xiaojin Luo

submission deadline 20 Jun 2026 | 4 articles | Viewed by 3439 | Submission Open

Keywords: rice breeding; molecular genetics; rice germplasm; QTL identification and gene cloning; genetic function and genetic network; breeding technologies

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetic Studies on Cotton Stress Resistance, Quality Traits, and Drought Response Mechanisms

edited by Xueyuan Li, Juyun Zheng,

Jie Sun

and Fenglei Sun

submission deadline 20 Jun 2026 | 2 articles | Viewed by 1964 | Submission Open

Keywords: cotton; drought stress; growth and development; gene editing; molecular marker-assisted selection

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetics and Genomics in Cancer

edited by

Rina Kansal

submission deadline 20 Jun 2026 | 1 articles | Viewed by 1006 | Submission Open

Keywords: solid tumors; breast cancer; colon cancer; lung cancer; prostate cancer; gastrointestinal; gynecologic cancer; genitourinary cancers; brain tumors; hematolymphoid neoplasms; myeloid neoplasms; lymphoid neoplasms; hereditary cancer; precision medicine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advancements in Pharmacogenomics for Precision Medicine

edited by

Óscar Teijido Hermida

submission deadline 20 Jun 2026 | Viewed by 393 | Submission Open

Keywords: pharmacogenomics; precision medicine; pharmacoepigenomics; epidrugs; genomic biomarkers; drug response variability; personalized therapy; multi-omics integration; pharmacogenetic testing; clinical implementation; artificial intelligence in pharmacogenomics; genetic polymorphisms; translational genomics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advances in Genomic Surveillance of Pathogens

edited by Rachel R. Spurbeck

submission deadline 20 Jun 2026 | Viewed by 204 | Submission Open

Keywords: biosurveillance; pathogen detection; host response; epigenomics; genomics; transcriptomics; viromics; microbiome analysis; shotgun metagenomics

(This special issue belongs to the Section Microbial Genetics and Genomics)

Function and Regulatory Mechanism of MicroRNAs in Cancers

edited by

Alicja Petniak

Paulina Gil-Kulik

and

Janusz Kocki

submission deadline 25 Jun 2026 | 3 articles | Viewed by 5043 | Submission Open

Keywords: microRNAs (miRNAs); cancer biomarkers; gene regulation; miRNA-based therapies; tumor microenvironment; cancer progression; drug resistance; non-coding RNAs; epigenetic regulation; cancer immunology

(This special issue belongs to the Section Molecular Genetics and Genomics)

The CranioFacial Biology Group at the University of Adelaide Collection: Genetic, Epigenetic and Environmental Factors in Complex Adaptive Systems, Multilayer Complex Interactive Networks, and Multiple Models During Oral Development

edited by

Alan H. Brook

and Matthew Brook O'Donnell

submission deadline 25 Jun 2026 | 2 articles | Viewed by 4483 | Submission Open

Keywords: oral development; genetics; epigenetics; complex adaptive systems; multilayer complex interactive networks; multiple models

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Insights into the Genomic and Genetic Basis of Cardiovascular Disease

edited by Marzia de Biasio and

Donato Gemmati

submission deadline 25 Jun 2026 | 3 articles | Viewed by 3296 | Submission Open

Keywords: recurrent idiopathic pericarditis and perimyocarditis; spontaneous coronary dissection; sudden idiopathic cardiac death; idiopathic atrial fibrillation; cardio-oncology and cardio toxicity of anti anti-cancer drugs

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Epidemiology of Multifactorial Diseases

edited by

Maria Tziastoudi

and Ioannis Stefanidis

submission deadline 25 Jun 2026 | 2 articles | Viewed by 2314 | Submission Open

Keywords: genetic association studies; polygenic risk scores; functional genomics; causal inference; mendelian randomization; translational applications

(This special issue belongs to the Section Molecular Genetics and Genomics)

Application of Bioinformatics in Complex Traits

edited by

Xiang-Yang Lou

submission deadline 25 Jun 2026 | 2 articles | Viewed by 2234 | Submission Open

Keywords: complex traits; bioinformatics; multi-omics integration; gene– environment interactions; polygenic risk scores; machine learning; systems biology; network analysis; statistical genetics; causal inference

(This special issue belongs to the Section Bioinformatics)

Structural and Evolutionary Perspectives on Immunogenetic Variation in Autoimmune and Related Disorders

edited by Athena Andreou and Catriona Kelly

submission deadline 25 Jun 2026 | 1 articles | Viewed by 1707 | Submission Open

Keywords: gene polymorphisms; exonic and intronic variants; structural biology; biophysical analysis; structural evolution; protein molecular function and evolution; immunological biomarkers; human genetic diseases; evolutionary genomics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Multi-Omics in Psychiatric Disorders

edited by

José Jaime Martínez-Magaña

and

Sheila T. Nagamatsu

submission deadline 25 Jun 2026 | Viewed by 808 | Submission Open

Keywords: methylomics; transcriptomics; epigenomics; genomics; proteomics; metabolomics; multi-omics; psychiatric disorders

(This special issue belongs to the Section Neurogenomics)

Animal Virus Immunology and Genomics

edited by

Huijun Lu

and

Changzhan Xie

submission deadline 25 Jun 2026 | Viewed by 490 | Submission Open

Keywords: epidemiology; gene editing; genome; transcriptome; and proteome; synthetic biology; high-throughput sequencing; multi-omics; transcription factor; immunology

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetic Mechanisms and Therapeutic Strategies in Ovarian Cancer

edited by Aimee Stablewski

submission deadline 25 Jun 2026 | Viewed by 340 | Submission Open

Keywords: epithelial ovarian cancer (EOC); genetic alterations; epigenetic regulation; tumor microenvironment; therapeutic strategies

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Basis and Molecular Mechanism of Plant Immunity

edited by

Aijun Wang

and Desuo Yin

submission deadline 25 Jun 2026 | Viewed by 322 | Submission Open

Keywords: plant; phytopathogens; immune responses; molecular mechanisms; regulatory pathways; interactions mechanisms

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetic Mechanisms of Wild Animal Adaptation to the Environment

edited by

Jianhai Chen

submission deadline 25 Jun 2026 | Viewed by 303 | Submission Open

Keywords: wild animal adaptation; evolutionary genomics; population genetics; local adaptation; adaptive introgression; natural selection; genomic variation; functional genomics; environmental stress response; climate adaptation; host– pathogen interaction; epigenetic regulation; multi-omics integration; conservation genomics; genotype– phenotype association

(This special issue belongs to the Section Animal Genetics and Genomics)

Plant Pathogenic Fungi: Molecular Systematics, Genomics and Evolution

edited by

Shengxiong Huang

submission deadline 25 Jun 2026 | Viewed by 275 | Submission Open

Keywords: plant pathogenic fungi; pathogen isolation and identification; molecular evolution; multi-omics analysis; genome sequencing; comparative genomics; RNA-seq

(This special issue belongs to the Section Plant Genetics and Genomics)

Monogenic Diabetes—from Basic Scientific Insights to Precision Care and Beyond

edited by Kathy HC Wu

submission deadline 25 Jun 2026 | Viewed by 259 | Submission Open

Keywords: MODY; precision; implementation; diversity; equity; bioinformatics; functional genomics; genotype; phenotype; high throughput

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advances in Veterinary Genetics and Genomics

edited by

Petra Zenke

and

Enikő Fehér

submission deadline 5 Jul 2026 | 2 articles | Viewed by 2961 | Submission Open

Keywords: veterinary genetics; animal genomics; infectious diseases and disease resistance; pathogenetics; genomic selection and livestock improvement; conservation genetics; epigenetics; CRISPR gene editing; next-generation sequencing (NGS); forensic genetics; LAMP method

(This special issue belongs to the Section Animal Genetics and Genomics)

Genomic and Transcriptomic Advances in Amyotrophic Lateral Sclerosis (ALS) and Motor Neuron Diseases (MND)

edited by

Francesca Dragoni

and

Stella Gagliardi

submission deadline 5 Jul 2026 | Viewed by 361 | Submission Open

Keywords: ALS ; transcriptomic studies ; motor neuron diseases ; biomarkers assessment ; pathomechanisms ; genetics ; genotype– phenotype correlation

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advances in Molecular Genetics of Psychiatric Diseases

edited by Fotis Tsetsos

submission deadline 10 Jul 2026 | 1 articles | Viewed by 1982 | Submission Open

Keywords: psychiatric genetics; molecular psychiatry; GWAS; rare variants; transcriptomics; epigenetics; gene-environment interactions; precision psychiatry; schizophrenia; bipolar disorder; depression; autism spectrum disorder; anxiety; functional genomics; neurodevelopmental disorders

(This special issue belongs to the Section Molecular Genetics and Genomics)

Autism: Genetics, Environment, Pathogenesis, and Treatment

edited by

Alessandra Mezzelani

submission deadline 10 Jul 2026 | 2 articles | Viewed by 1772 | Submission Open

Keywords: Autism Spectrum Disorders (ASDs); pathogenesis; genetic factors; environmental factors; epigenetics; gut microbiota; animal models; organoid models; multi-omics; bioinformatics; biostatistics; biomarkers; diagnosis; patient stratification; personalized interventions

(This special issue belongs to the Section Neurogenomics)

Genetic and Molecular Mechanisms of Plant–Fungal Pathogen Interactions

edited by

Guihua Li

submission deadline 10 Jul 2026 | 1 articles | Viewed by 1077 | Submission Open

Keywords: plant– fungal pathogen interactions; fungal pathogenicity; plant immunity; host– pathogen coevolution; effector biology; virulence factors; disease resistance; genetic regulation; molecular mechanisms; omics technologies; genome editing; sustainable crop protection

(This special issue belongs to the Section Plant Genetics and Genomics)

Advances in Molecular Genetics of Rare Disorders

edited by Miriam Lucia Carriero

submission deadline 10 Jul 2026 | 1 articles | Viewed by 701 | Submission Open

Keywords: rare diseases; molecular genetics; gene– disease associations; genotype– phenotype correlation; targeted gene therapy; next-generation sequencing; whole-genome sequencing; genome-wide association studies; functional genomics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Insights into RNA Coding and Transcriptional Regulation

edited by Zihua Hu

submission deadline 10 Jul 2026 | 1 articles | Viewed by 633 | Submission Open

Keywords: RNA coding; transcriptomics; non-coding RNAs (ncRNA); long non-coding RNA (lncRNA); microRNA (miRNA); RNA modifications; RNA splicing; RNA editing; RNA in transcriptional and post-transcriptional regulation; gene expression regulation; scRNA

(This special issue belongs to the Section RNA)

Advances in Genetics and Genomics of Medical Plants

edited by

Mingcheng Wang

submission deadline 15 Jul 2026 | 1 articles | Viewed by 917 | Submission Open

Keywords: medicinal plant genomics; medicinal plant genetics; high-throughput sequencing; functional genomics; multi-omics integration

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetic and Molecular Insights into Migraine

edited by

Maria Papasavva

and Vasileios Siokas

submission deadline 15 Jul 2026 | Viewed by 274 | Submission Open

Keywords: neurosciences; neurology; neurogenetics; molecular neurology; neurodegeneration; neurorehabilitation; rTMS

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic and Epigenetic Mechanisms in Animal Reproduction

edited by Ming Shen

submission deadline 15 Jul 2026 | Viewed by 212 | Submission Open

Keywords: animal reproduction; genetic regulation; epigenetic modification; DNA methylation; histone modification; noncoding rna; chromatin remodeling; gametogenesis; fertilization; embryonic development; reproductive efficiency; reproductive disorders; gene expression; livestock breeding; reproductive biotechnology

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetics of SARS-CoV-2 Virus

edited by

Walter Doerfler

submission deadline 15 Jul 2026 | Viewed by 154 | Submission Open

Keywords: molecular genetics; viral mutagenesis; rapidly arising new viral mutants; four-letter genetic system; illegitimate recombination; novel aspects of molecular or epidemiological virology

(This special issue belongs to the Section Viral Genomics)

5Gs in Crop Genetic and Genomic Improvement: 2025–2026

edited by

Xinjie Shen

submission deadline 20 Jul 2026 | 9 articles | Viewed by 7610 | Submission Open

Keywords: crop gene functional analysis; crop protemics; crop metabonomics; new crop breeding methods; crop GWAS analysis; crop gene edit technology; crop gene epigenetic modification

(This special issue belongs to the Section Plant Genetics and Genomics)

Environmental Genomics and Low-Dose Induced Adaptive Response: Underlying Mechanisms from Cells to Organisms

edited by

Stephka Chankova

, Michaela Beltcheva and

Teodora Todorova

submission deadline 20 Jul 2026 | 1 articles | Viewed by 1107 | Submission Open

Keywords: environmental genomics; ecotoxicology; low-dose induced adaptive response; low-dose radiation; genomic instability; environmental mutagenesis; DNA repair; radio-protection; stress response; toxicogenomics; antioxidant system; chaperone system

(This special issue belongs to the Section Genes & Environments)

Genetics and Genomics of Plant Reproductive Development

edited by

Pingli Lu

submission deadline 20 Jul 2026 | Viewed by 278 | Submission Open

Keywords: genetics; genomics; meiosis; anther development; gametophyte development; fertilization; seed; fruit

(This special issue belongs to the Section Plant Genetics and Genomics)

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